4xsg - Revision history

OCA at 15:30, 8 November 2023

OCA — Wed, 08 Nov 2023 15:30:42 GMT

←Older revision		Revision as of 15:30, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xsg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XSG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xsg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XSG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xsg OCA], [https://pdbe.org/4xsg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xsg RCSB], [https://www.ebi.ac.uk/pdbsum/4xsg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xsg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xsg OCA], [https://pdbe.org/4xsg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xsg RCSB], [https://www.ebi.ac.uk/pdbsum/4xsg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xsg ProSAT]</span></td></tr>
	</table>		</table>

OCA at 17:50, 26 April 2023

OCA — Wed, 26 Apr 2023 17:50:12 GMT

←Older revision		Revision as of 17:50, 26 April 2023
Line 3:		Line 3:
	<StructureSection load='4xsg' size='340' side='right'caption='[[4xsg]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4xsg' size='340' side='right'caption='[[4xsg]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xsg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_14579 Atcc 14579~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XSG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XSG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xsg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XSG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gy2\|4gy2]], [[4h03\|4h03]], [[4xsh\|4xsh]], [[5bwm\|5bwm]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xsg OCA], [https://pdbe.org/4xsg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xsg RCSB], [https://www.ebi.ac.uk/pdbsum/4xsg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xsg ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RHOA, ARH12, ARHA, RHO12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), c3cer ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1396 ATCC 14579])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xsg OCA], [~~http~~://pdbe.org/4xsg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xsg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xsg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xsg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>	+	[https://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 14579~~]]	+	[[Category: Bacillus cereus]]
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Toda, A]]	+	[[Category: Toda A]]
-	[[Category: Tsuge, H]]	+	[[Category: Tsuge H]]
-	[[Category: Tsurumura, T]]	+	[[Category: Tsurumura T]]
-	[[Category: Yoshida, T]]	+	[[Category: Yoshida T]]
-	~~[[Category: Adp ribose transferase]]~~	+
-	~~[[Category: Bacterial toxin]]~~	+
-	~~[[Category: Signaling protein-transferase complex~~]]	+

OCA at 08:40, 5 February 2020

OCA — Wed, 05 Feb 2020 08:40:24 GMT

←Older revision		Revision as of 08:40, 5 February 2020
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Rho GTPase\|Rho GTPase]]	+	*[[Rho GTPase 3D structures\|Rho GTPase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 23:56, 5 June 2019

OCA — Wed, 05 Jun 2019 23:56:19 GMT

←Older revision		Revision as of 23:56, 5 June 2019
Line 1:		Line 1:

	==The complex structure of C3cer exoenzyme and GTP bound RhoA (NADH-free state)==		==The complex structure of C3cer exoenzyme and GTP bound RhoA (NADH-free state)==
-	<StructureSection load='4xsg' size='340' side='right' caption='[[4xsg]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4xsg' size='340' side='right'caption='[[4xsg]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xsg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XSG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XSG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xsg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XSG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XSG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gy2\|4gy2]], [[4h03\|4h03]], [[4xsh\|4xsh]], [[5bwm\|5bwm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gy2\|4gy2]], [[4h03\|4h03]], [[4xsh\|4xsh]], [[5bwm\|5bwm]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RHOA, ARH12, ARHA, RHO12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), c3cer ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1396 ATCC 14579])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xsg OCA], [http://pdbe.org/4xsg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xsg RCSB], [http://www.ebi.ac.uk/pdbsum/4xsg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xsg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xsg OCA], [http://pdbe.org/4xsg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xsg RCSB], [http://www.ebi.ac.uk/pdbsum/4xsg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xsg ProSAT]</span></td></tr>
	</table>		</table>
Line 26:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 14579]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Toda, A]]		[[Category: Toda, A]]
	[[Category: Tsuge, H]]		[[Category: Tsuge, H]]

OCA at 14:11, 24 May 2017

OCA — Wed, 24 May 2017 14:11:01 GMT

←Older revision		Revision as of 14:11, 24 May 2017
Line 1:		Line 1:
		+
	==The complex structure of C3cer exoenzyme and GTP bound RhoA (NADH-free state)==		==The complex structure of C3cer exoenzyme and GTP bound RhoA (NADH-free state)==
	<StructureSection load='4xsg' size='340' side='right' caption='[[4xsg]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4xsg' size='340' side='right' caption='[[4xsg]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gy2\|4gy2]], [[4h03\|4h03]], [[4xsh\|4xsh]], [[5bwm\|5bwm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gy2\|4gy2]], [[4h03\|4h03]], [[4xsh\|4xsh]], [[5bwm\|5bwm]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xsg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xsg RCSB], [http://www.ebi.ac.uk/pdbsum/4xsg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xsg OCA], [http://pdbe.org/4xsg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xsg RCSB], [http://www.ebi.ac.uk/pdbsum/4xsg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xsg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xsg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Rho GTPase\|Rho GTPase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:49, 24 June 2015

OCA — Wed, 24 Jun 2015 12:49:45 GMT

←Older revision		Revision as of 12:49, 24 June 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==The complex structure of C3cer exoenzyme and GTP bound RhoA (NADH-free state)==
		+	<StructureSection load='4xsg' size='340' side='right' caption='[[4xsg]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xsg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XSG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XSG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4gy2\|4gy2]], [[4h03\|4h03]], [[4xsh\|4xsh]], [[5bwm\|5bwm]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xsg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xsg RCSB], [http://www.ebi.ac.uk/pdbsum/4xsg PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	C3 exoenzyme is a mono-ADP-ribosyltransferase (ART) that catalyzes transfer of an ADP-ribose moiety from NAD+ to Rho GTPases. C3 has long been used to study the diverse regulatory functions of Rho GTPases. How C3 recognizes its substrate and ADP-ribosylation proceeds are still poorly understood. Crystal structures of C3-RhoA complex reveal that C3 recognizes RhoA via switch I, switch II and interswitch regions. In C3-RhoA(GTP) and C3-RhoA(GDP), switch I and II adopt the GDP and GTP conformations, respectively, which explains why C3 can ADP-ribosylate both nucleotide forms. Based on structural information, we successfully changed Cdc42 to active substrate with combined mutations in the C3-Rho GTPase interface. Moreover, the structure reflects the close relationship among Gln183 in the QXE-motif (C3), a modified Asn41 residue (RhoA) and NC1 of NAD(H), which suggests C3 is the prototype ART. The structures show directly for the first time that the ARTT-loop is the key to target protein recognition and also serve to bridge the gaps among independent studies of Rho GTPases and C3.

-	~~The entry 4xsg is ON HOLD until Paper Publication~~	+	Rho GTPase Recognition by C3 Exoenzyme Based on C3-RhoA Complex Structure.,Toda A, Tsurumura T, Yoshida T, Tsumori Y, Tsuge H J Biol Chem. 2015 Jun 11. pii: jbc.M115.653220. PMID:26067270<ref>PMID:26067270</ref>

-	~~Authors: Toda~~, A.~~, Tsurumura, T~~.~~, Yoshida, T., Tsuge, H~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description:~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
-	[[Category: ~~Yoshida~~, T]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Toda, A]]
	[[Category: Tsuge, H]]		[[Category: Tsuge, H]]
	[[Category: Tsurumura, T]]		[[Category: Tsurumura, T]]
-	[[Category: ~~Toda~~, A]]	+	[[Category: Yoshida, T]]
		+	[[Category: Adp ribose transferase]]
		+	[[Category: Bacterial toxin]]
		+	[[Category: Signaling protein-transferase complex]]

OCA at 09:46, 4 March 2015

OCA — Wed, 04 Mar 2015 09:46:41 GMT

←Older revision		Revision as of 09:46, 4 March 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xsg is ON HOLD	+	The entry 4xsg is ON HOLD until Paper Publication

	Authors: Toda, A., Tsurumura, T., Yoshida, T., Tsuge, H.		Authors: Toda, A., Tsurumura, T., Yoshida, T., Tsuge, H.

OCA: Protected "4xsg" [edit=sysop:move=sysop]

OCA — Wed, 28 Jan 2015 15:47:28 GMT

Protected "4xsg" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:47, 28 January 2015

OCA: New page: '''Unreleased structure''' The entry 4xsg is ON HOLD Authors: Toda, A., Tsurumura, T., Yoshida, T., Tsuge, H. Description: Category: Unreleased Structures Category: Yoshida, T...

OCA — Wed, 28 Jan 2015 15:47:26 GMT

New page: '''Unreleased structure''' The entry 4xsg is ON HOLD Authors: Toda, A., Tsurumura, T., Yoshida, T., Tsuge, H. Description: Category: Unreleased Structures Category: Yoshida, T...

New page

'''Unreleased structure'''

The entry 4xsg is ON HOLD

Authors: Toda, A., Tsurumura, T., Yoshida, T., Tsuge, H.

Description:
[[Category: Unreleased Structures]]
[[Category: Yoshida, T]]
[[Category: Tsuge, H]]
[[Category: Tsurumura, T]]
[[Category: Toda, A]]