4xvw - Revision history

OCA at 12:01, 22 November 2023

OCA — Wed, 22 Nov 2023 12:01:11 GMT

←Older revision		Revision as of 12:01, 22 November 2023
Line 3:		Line 3:
	<StructureSection load='4xvw' size='340' side='right'caption='[[4xvw]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4xvw' size='340' side='right'caption='[[4xvw]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xvw]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Proteus_mirabilis_atcc_29906~~ Proteus mirabilis ~~atcc~~ 29906]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XVW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XVW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xvw]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Proteus_mirabilis_ATCC_29906 Proteus mirabilis ATCC 29906]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XVW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XVW FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=MSE:SELENOMETHIONINE'>MSE</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~HMPREF0693_3732 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=525369 Proteus mirabilis ATCC 29906])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xvw OCA], [https://pdbe.org/4xvw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xvw RCSB], [https://www.ebi.ac.uk/pdbsum/4xvw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xvw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xvw OCA], [https://pdbe.org/4xvw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xvw RCSB], [https://www.ebi.ac.uk/pdbsum/4xvw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xvw ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Proteus mirabilis ~~atcc~~ 29906]]	+	[[Category: Proteus mirabilis ATCC 29906]]
-	[[Category: Furlong~~, E J~~]]	+	[[Category: Furlong EJ]]
-	[[Category: Kurth, F]]	+	[[Category: Kurth F]]
-	[[Category: Martin~~, J L~~]]	+	[[Category: Martin JL]]
-	[[Category: Premkumar, L]]	+	[[Category: Premkumar L]]
-	~~[[Category: Antimicrobial resistance]]~~	+
-	~~[[Category: Disulfide isomerase]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Swarming motility]]~~	+
-	~~[[Category: Thioredoxin fold]]~~	+
-	~~[[Category: Trimeric~~]]	+

OCA at 10:44, 16 February 2022

OCA — Wed, 16 Feb 2022 10:44:21 GMT

←Older revision		Revision as of 10:44, 16 February 2022
Line 3:		Line 3:
	<StructureSection load='4xvw' size='340' side='right'caption='[[4xvw]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4xvw' size='340' side='right'caption='[[4xvw]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xvw]] is a 24 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Proteus_mirabilis_atcc_29906 Proteus mirabilis atcc 29906]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XVW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XVW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xvw]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Proteus_mirabilis_atcc_29906 Proteus mirabilis atcc 29906]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XVW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XVW FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HMPREF0693_3732 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=525369 Proteus mirabilis ATCC 29906])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HMPREF0693_3732 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=525369 Proteus mirabilis ATCC 29906])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xvw OCA], [~~http~~://pdbe.org/4xvw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xvw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xvw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xvw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xvw OCA], [https://pdbe.org/4xvw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xvw RCSB], [https://www.ebi.ac.uk/pdbsum/4xvw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xvw ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Copper resistance is a key virulence trait of the uropathogen Proteus mirabilis. Here we show that P. mirabilis ScsC (PmScsC) contributes to this defence mechanism by enabling swarming in the presence of copper. We also demonstrate that PmScsC is a thioredoxin-like disulfide isomerase but, unlike other characterized proteins in this family, it is trimeric. PmScsC trimerization and its active site cysteine are required for wild-type swarming activity in the presence of copper. Moreover, PmScsC exhibits unprecedented motion as a consequence of a shape-shifting motif linking the catalytic and trimerization domains. The linker accesses strand, loop and helical conformations enabling the sampling of an enormous folding landscape by the catalytic domains. Mutation of the shape-shifting motif abolishes disulfide isomerase activity, as does removal of the trimerization domain, showing that both features are essential to foldase function. More broadly, the shape-shifter peptide has the potential for 'plug and play' application in protein engineering.
		+
		+	A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance.,Furlong EJ, Lo AW, Kurth F, Premkumar L, Totsika M, Achard MES, Halili MA, Heras B, Whitten AE, Choudhury HG, Schembri MA, Martin JL Nat Commun. 2017 Jul 19;8:16065. doi: 10.1038/ncomms16065. PMID:28722010<ref>PMID:28722010</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4xvw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:46, 1 January 2020

OCA — Wed, 01 Jan 2020 08:46:37 GMT

←Older revision		Revision as of 08:46, 1 January 2020
Line 1:		Line 1:
-	~~{{Large structure}}~~	+
	==Crystal structure of Proteus mirabilis ScsC in a compact conformation==		==Crystal structure of Proteus mirabilis ScsC in a compact conformation==
-	<StructureSection load='4xvw' size='340' side='right' caption='[[4xvw]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='4xvw' size='340' side='right'caption='[[4xvw]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xvw]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Proteus_mirabilis_atcc_29906 Proteus mirabilis atcc 29906]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XVW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XVW FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xvw]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Proteus_mirabilis_atcc_29906 Proteus mirabilis atcc 29906]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XVW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XVW FirstGlance]. <br>
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xvw OCA], [http://pdbe.org/4xvw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xvw RCSB], [http://www.ebi.ac.uk/pdbsum/4xvw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xvw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xvw OCA], [http://pdbe.org/4xvw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xvw RCSB], [http://www.ebi.ac.uk/pdbsum/4xvw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xvw ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Proteus mirabilis atcc 29906]]		[[Category: Proteus mirabilis atcc 29906]]
	[[Category: Furlong, E J]]		[[Category: Furlong, E J]]

OCA at 07:57, 17 January 2018

OCA — Wed, 17 Jan 2018 07:57:48 GMT

←Older revision		Revision as of 07:57, 17 January 2018
Line 3:		Line 3:
	<StructureSection load='4xvw' size='340' side='right' caption='[[4xvw]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4xvw' size='340' side='right' caption='[[4xvw]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xvw]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XVW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XVW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xvw]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Proteus_mirabilis_atcc_29906 Proteus mirabilis atcc 29906]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XVW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XVW FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xvw OCA], [http://pdbe.org/4xvw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xvw RCSB], [http://www.ebi.ac.uk/pdbsum/4xvw PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HMPREF0693_3732 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=525369 Proteus mirabilis ATCC 29906])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xvw OCA], [http://pdbe.org/4xvw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xvw RCSB], [http://www.ebi.ac.uk/pdbsum/4xvw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xvw ProSAT]</span></td></tr>
	</table>		</table>
	{{Large structure}}		{{Large structure}}
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Proteus mirabilis atcc 29906]]
	[[Category: Furlong, E J]]		[[Category: Furlong, E J]]
	[[Category: Kurth, F]]		[[Category: Kurth, F]]

OCA at 15:17, 20 June 2016

OCA — Mon, 20 Jun 2016 15:17:15 GMT

←Older revision		Revision as of 15:17, 20 June 2016
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	{{Large structure}}
-		+	==Crystal structure of Proteus mirabilis ScsC in a compact conformation==
-	~~The entry~~ 4xvw is ~~ON HOLD~~	+	<StructureSection load='4xvw' size='340' side='right' caption='[[4xvw]], [[Resolution\|resolution]] 2.60Å' scene=''>
-		+	== Structural highlights ==
-	~~Authors~~: ~~Kurth, F~~., ~~Furlong, E~~.J., ~~Premkumar~~, L., ~~Martin, J~~.L.	+	<table><tr><td colspan='2'>[[4xvw]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XVW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XVW FirstGlance]. <br>
-		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~Description: Crystal~~ structure ~~of Proteus mirabilis ScsC in a compact conformation~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xvw OCA], [http://pdbe.org/4xvw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xvw RCSB], [http://www.ebi.ac.uk/pdbsum/4xvw PDBsum]</span></td></tr>
-	~~[[Category: Unreleased Structures]]~~	+	</table>
-	[[Category: ~~Martin~~, J.L]]	+	{{Large structure}}
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Furlong, E J]]
	[[Category: Kurth, F]]		[[Category: Kurth, F]]
-	[[Category: ~~Furlong~~, E.J]]	+	[[Category: Martin, J L]]
	[[Category: Premkumar, L]]		[[Category: Premkumar, L]]
		+	[[Category: Antimicrobial resistance]]
		+	[[Category: Disulfide isomerase]]
		+	[[Category: Isomerase]]
		+	[[Category: Swarming motility]]
		+	[[Category: Thioredoxin fold]]
		+	[[Category: Trimeric]]

OCA at 09:02, 1 June 2016

OCA — Wed, 01 Jun 2016 09:02:41 GMT

←Older revision		Revision as of 09:02, 1 June 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xvw is ON HOLD ~~until Jul 27 2017~~	+	The entry 4xvw is ON HOLD

-	Authors: Kurth, F., Premkumar, L., Martin, J.L.	+	Authors: Kurth, F., Furlong, E.J., Premkumar, L., Martin, J.L.

-	Description: Crystal structure of ~~a novel trimeric disulfide isomerase from~~ Proteus mirabilis	+	Description: Crystal structure of Proteus mirabilis ScsC in a compact conformation
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Martin, J.L]]		[[Category: Martin, J.L]]
	[[Category: Kurth, F]]		[[Category: Kurth, F]]
		+	[[Category: Furlong, E.J]]
	[[Category: Premkumar, L]]		[[Category: Premkumar, L]]

OCA at 08:28, 9 December 2015

OCA — Wed, 09 Dec 2015 08:28:03 GMT

←Older revision		Revision as of 08:28, 9 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xvw is ON HOLD until ~~Paper Publication~~	+	The entry 4xvw is ON HOLD until Jul 27 2017

	Authors: Kurth, F., Premkumar, L., Martin, J.L.		Authors: Kurth, F., Premkumar, L., Martin, J.L.

OCA at 08:53, 30 April 2015

OCA — Thu, 30 Apr 2015 08:53:49 GMT

←Older revision		Revision as of 08:53, 30 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xvw is ON HOLD	+	The entry 4xvw is ON HOLD until Paper Publication

	Authors: Kurth, F., Premkumar, L., Martin, J.L.		Authors: Kurth, F., Premkumar, L., Martin, J.L.

OCA: Protected "4xvw" [edit=sysop:move=sysop]

OCA — Sat, 07 Feb 2015 14:53:24 GMT

Protected "4xvw" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:53, 7 February 2015

OCA: New page: '''Unreleased structure''' The entry 4xvw is ON HOLD Authors: Kurth, F., Premkumar, L., Martin, J.L. Description: Crystal structure of a novel trimeric disulfide isomerase from Proteus...

OCA — Sat, 07 Feb 2015 14:53:23 GMT

New page: '''Unreleased structure''' The entry 4xvw is ON HOLD Authors: Kurth, F., Premkumar, L., Martin, J.L. Description: Crystal structure of a novel trimeric disulfide isomerase from Proteus...

New page

'''Unreleased structure'''

The entry 4xvw is ON HOLD

Authors: Kurth, F., Premkumar, L., Martin, J.L.

Description: Crystal structure of a novel trimeric disulfide isomerase from Proteus mirabilis
[[Category: Unreleased Structures]]
[[Category: Martin, J.L]]
[[Category: Kurth, F]]
[[Category: Premkumar, L]]