4xwl - Revision history

OCA at 15:31, 8 November 2023

OCA — Wed, 08 Nov 2023 15:31:42 GMT

←Older revision		Revision as of 15:31, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_cellulovorans Clostridium cellulovorans]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4kih 4kih]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XWL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_cellulovorans Clostridium cellulovorans]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4kih 4kih]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XWL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.051Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xwl OCA], [https://pdbe.org/4xwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xwl RCSB], [https://www.ebi.ac.uk/pdbsum/4xwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xwl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xwl OCA], [https://pdbe.org/4xwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xwl RCSB], [https://www.ebi.ac.uk/pdbsum/4xwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xwl ProSAT]</span></td></tr>
	</table>		</table>

OCA at 17:55, 26 April 2023

OCA — Wed, 26 Apr 2023 17:55:13 GMT

←Older revision		Revision as of 17:55, 26 April 2023
Line 3:		Line 3:
	<StructureSection load='4xwl' size='340' side='right'caption='[[4xwl]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4xwl' size='340' side='right'caption='[[4xwl]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xwl]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4kih 4kih]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XWL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XWL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_cellulovorans Clostridium cellulovorans]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4kih 4kih]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XWL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xwm\|4xwm]], [[4xwn\|4xwn]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xwl OCA], [https://pdbe.org/4xwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xwl RCSB], [https://www.ebi.ac.uk/pdbsum/4xwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xwl ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase_(non-reducing_end) Cellulose 1,4-beta-cellobiosidase (non-reducing end)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xwl OCA], [~~http~~://pdbe.org/4xwl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xwl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xwl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xwl ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O65986_CLOCL O65986_CLOCL]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Clostridium cellulovorans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Liaw, Y C]]	+	[[Category: Liaw Y-C]]
-	~~[[Category: Hydrolase~~]]	+

OCA at 23:24, 5 June 2019

OCA — Wed, 05 Jun 2019 23:24:28 GMT

←Older revision		Revision as of 23:24, 5 June 2019
Line 1:		Line 1:

	==Catalytic domain of Clostridium Cellulovorans Exgs==		==Catalytic domain of Clostridium Cellulovorans Exgs==
-	<StructureSection load='4xwl' size='340' side='right' caption='[[4xwl]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='4xwl' size='340' side='right'caption='[[4xwl]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xwl]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4kih 4kih]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XWL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xwl]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4kih 4kih]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XWL FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Liaw, Y C]]		[[Category: Liaw, Y C]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 16:47, 18 August 2017

OCA — Fri, 18 Aug 2017 16:47:53 GMT

←Older revision		Revision as of 16:47, 18 August 2017
Line 1:		Line 1:
		+
	==Catalytic domain of Clostridium Cellulovorans Exgs==		==Catalytic domain of Clostridium Cellulovorans Exgs==
	<StructureSection load='4xwl' size='340' side='right' caption='[[4xwl]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4xwl' size='340' side='right' caption='[[4xwl]], [[Resolution\|resolution]] 2.05Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xwm\|4xwm]], [[4xwn\|4xwn]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xwm\|4xwm]], [[4xwn\|4xwn]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase_(non-reducing_end) Cellulose 1,4-beta-cellobiosidase (non-reducing end)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase_(non-reducing_end) Cellulose 1,4-beta-cellobiosidase (non-reducing end)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xwl OCA], [http://pdbe.org/4xwl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xwl RCSB], [http://www.ebi.ac.uk/pdbsum/4xwl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xwl OCA], [http://pdbe.org/4xwl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xwl RCSB], [http://www.ebi.ac.uk/pdbsum/4xwl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xwl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 04:29, 1 December 2015

OCA — Tue, 01 Dec 2015 04:29:50 GMT

←Older revision		Revision as of 04:29, 1 December 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Catalytic domain of Clostridium Cellulovorans Exgs==
		+	<StructureSection load='4xwl' size='340' side='right' caption='[[4xwl]], [[Resolution\|resolution]] 2.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xwl]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4kih 4kih]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XWL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xwm\|4xwm]], [[4xwn\|4xwn]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_1,4-beta-cellobiosidase_(non-reducing_end) Cellulose 1,4-beta-cellobiosidase (non-reducing end)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.91 3.2.1.91] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xwl OCA], [http://pdbe.org/4xwl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xwl RCSB], [http://www.ebi.ac.uk/pdbsum/4xwl PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Exoglucanase/cellobiohydrolase (EC 3.2.1.176) hydrolyzes a beta-1,4-glycosidic bond from the reducing end of cellulose and releases cellobiose as the major product. Three complex crystal structures of the glycosyl hydrolase 48 (GH48) cellobiohydrolase S (ExgS) from Clostridium cellulovorans with cellobiose, cellotetraose and triethylene glycol molecules were solved. The product cellobiose occupies subsites +1 and +2 in the open active-site cleft of the enzyme-cellotetraose complex structure, indicating an enzymatic hydrolysis function. Moreover, three triethylene glycol molecules and one pentaethylene glycol molecule are located at active-site subsites -2 to -6 in the structure of the ExgS-triethylene glycol complex shown here. Modelling of glucose into subsite -1 in the active site of the ExgS-cellobiose structure revealed that Glu50 acts as a proton donor and Asp222 plays a nucleophilic role.

-	~~The entry 4xwl is ON HOLD~~	+	Structures of exoglucanase from Clostridium cellulovorans: cellotetraose binding and cleavage.,Tsai LC, Amiraslanov I, Chen HR, Chen YW, Lee HL, Liang PH, Liaw YC Acta Crystallogr F Struct Biol Commun. 2015 Oct 1;71(Pt 10):1264-72. doi:, 10.1107/S2053230X15015915. Epub 2015 Sep 23. PMID:26457517<ref>PMID:26457517</ref>

-	~~Authors: liaw~~, Y.-C.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Catalytic domain of Clostridium Cellulovorans Exgs~~	+	<div class="pdbe-citations 4xwl" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
-	[[Category: ~~Liaw, Y.-C~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Liaw, Y C]]
		+	[[Category: Hydrolase]]

OCA at 10:47, 12 February 2015

OCA — Thu, 12 Feb 2015 10:47:11 GMT

←Older revision		Revision as of 10:47, 12 February 2015
Line 3:		Line 3:
	The entry 4xwl is ON HOLD		The entry 4xwl is ON HOLD

-	Authors: liaw, Y.-c.	+	Authors: liaw, Y.-C.

-	Description: ~~CATALYTIC DOMAIN OF CLOSTRIDIUM CELLULOVORANS EXGS~~	+	Description: Catalytic domain of Clostridium Cellulovorans Exgs
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Liaw, Y.-C]]		[[Category: Liaw, Y.-C]]

OCA: Protected "4xwl" [edit=sysop:move=sysop]

OCA — Sat, 07 Feb 2015 14:55:14 GMT

Protected "4xwl" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:55, 7 February 2015

OCA: New page: '''Unreleased structure''' The entry 4xwl is ON HOLD Authors: liaw, Y.-c. Description: CATALYTIC DOMAIN OF CLOSTRIDIUM CELLULOVORANS EXGS Category: Unreleased Structures [[Category...

OCA — Sat, 07 Feb 2015 14:55:12 GMT

New page: '''Unreleased structure''' The entry 4xwl is ON HOLD Authors: liaw, Y.-c. Description: CATALYTIC DOMAIN OF CLOSTRIDIUM CELLULOVORANS EXGS Category: Unreleased Structures [[Category...

New page

'''Unreleased structure'''

The entry 4xwl is ON HOLD

Authors: liaw, Y.-c.

Description: CATALYTIC DOMAIN OF CLOSTRIDIUM CELLULOVORANS EXGS
[[Category: Unreleased Structures]]
[[Category: Liaw, Y.-C]]