4xy9 - Revision history

OCA at 11:30, 9 May 2024

OCA — Thu, 09 May 2024 11:30:21 GMT

←Older revision		Revision as of 11:30, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xy9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XY9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xy9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XY9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=43U:6-(5-BROMO-2-METHOXYPHENYL)-9H-PURIN-2-AMINE'>43U</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.83Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=43U:6-(5-BROMO-2-METHOXYPHENYL)-9H-PURIN-2-AMINE'>43U</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xy9 OCA], [https://pdbe.org/4xy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xy9 RCSB], [https://www.ebi.ac.uk/pdbsum/4xy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xy9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xy9 OCA], [https://pdbe.org/4xy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xy9 RCSB], [https://www.ebi.ac.uk/pdbsum/4xy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xy9 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 17:58, 26 April 2023

OCA — Wed, 26 Apr 2023 17:58:14 GMT

←Older revision		Revision as of 17:58, 26 April 2023
Line 3:		Line 3:
	<StructureSection load='4xy9' size='340' side='right'caption='[[4xy9]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='4xy9' size='340' side='right'caption='[[4xy9]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xy9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XY9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xy9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XY9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43U:6-(5-BROMO-2-METHOXYPHENYL)-9H-PURIN-2-AMINE'>43U</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=43U:6-(5-BROMO-2-METHOXYPHENYL)-9H-PURIN-2-AMINE'>43U</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xy9 OCA], [https://pdbe.org/4xy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xy9 RCSB], [https://www.ebi.ac.uk/pdbsum/4xy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xy9 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xy9 OCA], [~~http~~://pdbe.org/4xy9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xy9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xy9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xy9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Filippakopoulos P]]
-	[[Category: Filippakopoulos, P]]	+	[[Category: Picaud S]]
-	[[Category: Picaud, S]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Structural genomic]]~~	+
-	~~[[Category: Bromodomain]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Ligand]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 23:40, 5 June 2019

OCA — Wed, 05 Jun 2019 23:40:48 GMT

←Older revision		Revision as of 23:40, 5 June 2019
Line 1:		Line 1:

	==Crystal Structure of the first bromodomain of human BRD4 in complex with a 2-amine-9H-purine ligand==		==Crystal Structure of the first bromodomain of human BRD4 in complex with a 2-amine-9H-purine ligand==
-	<StructureSection load='4xy9' size='340' side='right' caption='[[4xy9]], [[Resolution\|resolution]] 1.83Å' scene=''>	+	<StructureSection load='4xy9' size='340' side='right'caption='[[4xy9]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xy9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xy9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XY9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43U:6-(5-BROMO-2-METHOXYPHENYL)-9H-PURIN-2-AMINE'>43U</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43U:6-(5-BROMO-2-METHOXYPHENYL)-9H-PURIN-2-AMINE'>43U</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xy9 OCA], [http://pdbe.org/4xy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xy9 RCSB], [http://www.ebi.ac.uk/pdbsum/4xy9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xy9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xy9 OCA], [http://pdbe.org/4xy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xy9 RCSB], [http://www.ebi.ac.uk/pdbsum/4xy9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xy9 ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:

	==See Also==		==See Also==
-	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]	+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 01:54, 10 March 2017

OCA — Fri, 10 Mar 2017 01:54:16 GMT

←Older revision		Revision as of 01:54, 10 March 2017
Line 1:		Line 1:
		+
	==Crystal Structure of the first bromodomain of human BRD4 in complex with a 2-amine-9H-purine ligand==		==Crystal Structure of the first bromodomain of human BRD4 in complex with a 2-amine-9H-purine ligand==
	<StructureSection load='4xy9' size='340' side='right' caption='[[4xy9]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='4xy9' size='340' side='right' caption='[[4xy9]], [[Resolution\|resolution]] 1.83Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4xy9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XY9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xy9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XY9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43U:6-(5-BROMO-2-METHOXYPHENYL)-9H-PURIN-2-AMINE'>43U</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43U:6-(5-BROMO-2-METHOXYPHENYL)-9H-PURIN-2-AMINE'>43U</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xy9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xy9 RCSB], [http://www.ebi.ac.uk/pdbsum/4xy9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xy9 OCA], [http://pdbe.org/4xy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xy9 RCSB], [http://www.ebi.ac.uk/pdbsum/4xy9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xy9 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4xy9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:44, 11 March 2015

OCA — Wed, 11 Mar 2015 11:44:48 GMT

←Older revision		Revision as of 11:44, 11 March 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal Structure of the first bromodomain of human BRD4 in complex with a 2-amine-9H-purine ligand==
		+	<StructureSection load='4xy9' size='340' side='right' caption='[[4xy9]], [[Resolution\|resolution]] 1.83Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xy9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XY9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43U:6-(5-BROMO-2-METHOXYPHENYL)-9H-PURIN-2-AMINE'>43U</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xy9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xy9 RCSB], [http://www.ebi.ac.uk/pdbsum/4xy9 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The 2-amine-9H-purine scaffold was identified as a weak bromodomain template and was developed via iterative structure based design into a potent nanomolar ligand for the bromodomain of human BRD9 with small residual micromolar affinity toward the bromodomain of BRD4. Binding of the lead compound 11 to the bromodomain of BRD9 results in an unprecedented rearrangement of residues forming the acetyllysine recognition site, affecting plasticity of the protein in an induced-fit pocket. The compound does not exhibit any cytotoxic effect in HEK293 cells and displaces the BRD9 bromodomain from chromatin in bioluminescence proximity assays without affecting the BRD4/histone complex. The 2-amine-9H-purine scaffold represents a novel template that can be further modified to yield highly potent and selective tool compounds to interrogate the biological role of BRD9 in diverse cellular systems.

-	~~The entry 4xy9 is ON HOLD~~	+	9H-Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain.,Picaud S, Strocchia M, Terracciano S, Lauro G, Mendez J, Daniels DL, Riccio R, Bifulco G, Bruno I, Filippakopoulos P J Med Chem. 2015 Mar 5. PMID:25703523<ref>PMID:25703523</ref>

-	~~Authors: Picaud~~, S.~~, von Delft, F~~.~~, Edwards, A.M., Arrowsmith, C.H., Bountra, C., Filippakopoulos, P., Structural Genomics Consortium (SGC)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a 2-amine-9H-purine ligand~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
-	[[Category: ~~Picaud~~, S]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]
-	[[Category: ~~Arrowsmith~~, ~~C.H~~]]	+	[[Category: Delft, F von]]
-	[[Category: ~~Von Delft~~, F]]	+	[[Category: Edwards, A M]]
	[[Category: Filippakopoulos, P]]		[[Category: Filippakopoulos, P]]
-	[[Category: ~~Edwards~~, ~~A.M~~]]	+	[[Category: Picaud, S]]
-	[[Category: Structural ~~Genomics Consortium (~~Sgc)]]	+	[[Category: Structural genomic]]
		+	[[Category: Bromodomain]]
		+	[[Category: Complex]]
		+	[[Category: Ligand]]
		+	[[Category: Sgc]]
		+	[[Category: Transcription]]

OCA: Protected "4xy9" [edit=sysop:move=sysop]

OCA — Thu, 12 Feb 2015 10:51:09 GMT

Protected "4xy9" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:51, 12 February 2015

OCA: New page: '''Unreleased structure''' The entry 4xy9 is ON HOLD Authors: Picaud, S., von Delft, F., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Filippakopoulos, P., Structural Genomics Consortiu...

OCA — Thu, 12 Feb 2015 10:51:08 GMT

New page: '''Unreleased structure''' The entry 4xy9 is ON HOLD Authors: Picaud, S., von Delft, F., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Filippakopoulos, P., Structural Genomics Consortiu...

New page

'''Unreleased structure'''

The entry 4xy9 is ON HOLD

Authors: Picaud, S., von Delft, F., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Filippakopoulos, P., Structural Genomics Consortium (SGC)

Description: Crystal Structure of the first bromodomain of human BRD4 in complex with a 2-amine-9H-purine ligand
[[Category: Unreleased Structures]]
[[Category: Picaud, S]]
[[Category: Bountra, C]]
[[Category: Arrowsmith, C.H]]
[[Category: Von Delft, F]]
[[Category: Filippakopoulos, P]]
[[Category: Edwards, A.M]]
[[Category: Structural Genomics Consortium (Sgc)]]