4xyh - Revision history

OCA at 07:52, 27 September 2023

OCA — Wed, 27 Sep 2023 07:52:01 GMT

←Older revision		Revision as of 07:52, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xyh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_japonicus_yFS275 Schizosaccharomyces japonicus yFS275]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XYH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XYH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xyh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_japonicus_yFS275 Schizosaccharomyces japonicus yFS275]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XYH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XYH FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xyh OCA], [https://pdbe.org/4xyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xyh RCSB], [https://www.ebi.ac.uk/pdbsum/4xyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xyh ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xyh OCA], [https://pdbe.org/4xyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xyh RCSB], [https://www.ebi.ac.uk/pdbsum/4xyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xyh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 17:58, 26 April 2023

OCA — Wed, 26 Apr 2023 17:58:29 GMT

←Older revision		Revision as of 17:58, 26 April 2023
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	==Wild-type full length Mis16 in Schizosaccharomyces japonicus==		==Wild-type full length Mis16 in Schizosaccharomyces japonicus==
-	<StructureSection load='4xyh' size='340' side='right' caption='[[4xyh]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4xyh' size='340' side='right'caption='[[4xyh]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xyh]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Fission_yeast Fission yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XYH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XYH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xyh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_japonicus_yFS275 Schizosaccharomyces japonicus yFS275]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XYH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XYH FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xyi\|4xyi]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xyh OCA], [https://pdbe.org/4xyh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xyh RCSB], [https://www.ebi.ac.uk/pdbsum/4xyh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xyh ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SJAG_03867 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=402676 Fission yeast])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xyh OCA], [~~http~~://pdbe.org/4xyh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xyh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xyh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xyh ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B6K598_SCHJY B6K598_SCHJY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Fission yeast~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~An, S~~]]	+	[[Category: Schizosaccharomyces japonicus yFS275]]
-	[[Category: ~~Cho, U~~ S]]	+	[[Category: An S]]
-	[[Category: ~~Kim, H]]~~	+	[[Category: Cho U-S]]
-	~~[[Category: Cenp~~-a]]	+	[[Category: Kim H]]
-	[[Category: ~~Centromere]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Histone]]~~	+
-	~~[[Category: Kinetochore]]~~	+
-	~~[[Category: Mis18 complex~~]]	+

OCA at 07:57, 14 June 2018

OCA — Thu, 14 Jun 2018 07:57:59 GMT

←Older revision		Revision as of 07:57, 14 June 2018
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	<StructureSection load='4xyh' size='340' side='right' caption='[[4xyh]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4xyh' size='340' side='right' caption='[[4xyh]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xyh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XYH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XYH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xyh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fission_yeast Fission yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XYH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XYH FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xyi\|4xyi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xyi\|4xyi]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xyh OCA], [http://pdbe.org/4xyh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xyh RCSB], [http://www.ebi.ac.uk/pdbsum/4xyh PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SJAG_03867 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=402676 Fission yeast])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xyh OCA], [http://pdbe.org/4xyh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xyh RCSB], [http://www.ebi.ac.uk/pdbsum/4xyh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xyh ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Fission yeast]]
	[[Category: An, S]]		[[Category: An, S]]
	[[Category: Cho, U S]]		[[Category: Cho, U S]]

OCA at 19:11, 20 February 2016

OCA — Sat, 20 Feb 2016 19:11:43 GMT

←Older revision		Revision as of 19:11, 20 February 2016
Line 1:		Line 1:
		+
	==Wild-type full length Mis16 in Schizosaccharomyces japonicus==		==Wild-type full length Mis16 in Schizosaccharomyces japonicus==
	<StructureSection load='4xyh' size='340' side='right' caption='[[4xyh]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4xyh' size='340' side='right' caption='[[4xyh]], [[Resolution\|resolution]] 2.30Å' scene=''>
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xyh OCA], [http://pdbe.org/4xyh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xyh RCSB], [http://www.ebi.ac.uk/pdbsum/4xyh PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xyh OCA], [http://pdbe.org/4xyh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xyh RCSB], [http://www.ebi.ac.uk/pdbsum/4xyh PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CENP-A is a centromere-specific histone H3 variant that is required for kinetochore assembly and accurate chromosome segregation. For it to function properly, CENP-A must be specifically localized to centromeres. In fission yeast, Scm3sp and the Mis18 complex, composed of Mis16, Eic1, and Mis18, function as a CENP-A(Cnp1)-specific chaperone and a recruiting factor, respectively, and together ensure accurate delivery of CENP-A(Cnp1) to centromeres. Although how Scm3sp specifically recognizes CENP-A(Cnp1) has been revealed recently, the recruiting mechanism of CENP-A(Cnp1) via the Mis18 complex remains unknown. In this study, we have determined crystal structures of Schizosaccharomyces japonicus Mis16 alone and in complex with the helix 1 of histone H4 (H4alpha1). Crystal structures followed by mutant analysis and affinity pull-downs have revealed that Mis16 recognizes both H4alpha1 and Scm3sp independently within the CENP-A(Cnp1)/H4:Scm3sp complex. This observation suggests that Mis16 gains CENP-A(Cnp1) specificity by recognizing both Scm3sp and histone H4. Our studies provide insights into the molecular mechanisms underlying specific recruitment of CENP-A(Cnp1)/H4:Scm3sp into centromeres.
		+
		+	Mis16 Independently Recognizes Histone H4 and the CENP-ACnp1-Specific Chaperone Scm3sp.,An S, Kim H, Cho US J Mol Biol. 2015 Oct 9;427(20):3230-40. doi: 10.1016/j.jmb.2015.08.022. Epub 2015, Sep 4. PMID:26343758<ref>PMID:26343758</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4xyh" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:23, 13 January 2016

OCA — Wed, 13 Jan 2016 20:23:43 GMT

←Older revision		Revision as of 20:23, 13 January 2016
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-	'''~~Unreleased structure~~'''	+	==Wild-type full length Mis16 in Schizosaccharomyces japonicus==
-		+	<StructureSection load='4xyh' size='340' side='right' caption='[[4xyh]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~The entry~~ 4xyh is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4xyh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XYH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XYH FirstGlance]. <br>
-	~~Authors~~: ~~An, S~~.~~, Kim, H~~.~~, Cho, U~~.-S.	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xyi\|4xyi]]</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xyh OCA], [http://pdbe.org/4xyh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xyh RCSB], [http://www.ebi.ac.uk/pdbsum/4xyh PDBsum]</span></td></tr>
-	~~Description~~: ~~Wild~~-~~type full length Mis16 in Schizosaccharomyces japonicus~~	+	</table>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	__TOC__
-	[[~~Category~~: ~~Kim~~, H]]	+	</StructureSection>
	[[Category: An, S]]		[[Category: An, S]]
-	[[Category: Cho, U.-S]]	+	[[Category: Cho, U S]]
		+	[[Category: Kim, H]]
		+	[[Category: Cenp-a]]
		+	[[Category: Centromere]]
		+	[[Category: Chaperone]]
		+	[[Category: Histone]]
		+	[[Category: Kinetochore]]
		+	[[Category: Mis18 complex]]

OCA at 23:22, 30 November 2015

OCA — Mon, 30 Nov 2015 23:22:11 GMT

←Older revision		Revision as of 23:22, 30 November 2015
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	Description: Wild-type full length Mis16 in Schizosaccharomyces japonicus		Description: Wild-type full length Mis16 in Schizosaccharomyces japonicus
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Kim, H]]
	[[Category: An, S]]		[[Category: An, S]]
	[[Category: Cho, U.-S]]		[[Category: Cho, U.-S]]
-	[[Category: Kim, H]]

OCA at 12:29, 25 February 2015

OCA — Wed, 25 Feb 2015 12:29:53 GMT

←Older revision		Revision as of 12:29, 25 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xyh is ON HOLD	+	The entry 4xyh is ON HOLD until Paper Publication

-	Authors: An, S., Kim, H., Cho, U-.S.	+	Authors: An, S., Kim, H., Cho, U.-S.

	Description: Wild-type full length Mis16 in Schizosaccharomyces japonicus		Description: Wild-type full length Mis16 in Schizosaccharomyces japonicus
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: An, S]]		[[Category: An, S]]
		+	[[Category: Cho, U.-S]]
	[[Category: Kim, H]]		[[Category: Kim, H]]
-	[[Category: Cho, U-.S]]

OCA: Protected "4xyh" [edit=sysop:move=sysop]

OCA — Thu, 12 Feb 2015 10:51:59 GMT

Protected "4xyh" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:51, 12 February 2015

OCA: New page: '''Unreleased structure''' The entry 4xyh is ON HOLD Authors: An, S., Kim, H., Cho, U-.S. Description: Wild-type full length Mis16 in Schizosaccharomyces japonicus [[Category: Unreleas...

OCA — Thu, 12 Feb 2015 10:51:58 GMT

New page: '''Unreleased structure''' The entry 4xyh is ON HOLD Authors: An, S., Kim, H., Cho, U-.S. Description: Wild-type full length Mis16 in Schizosaccharomyces japonicus [[Category: Unreleas...

New page

'''Unreleased structure'''

The entry 4xyh is ON HOLD

Authors: An, S., Kim, H., Cho, U-.S.

Description: Wild-type full length Mis16 in Schizosaccharomyces japonicus
[[Category: Unreleased Structures]]
[[Category: An, S]]
[[Category: Kim, H]]
[[Category: Cho, U-.S]]