4xzh - Revision history

OCA at 10:51, 10 January 2024

OCA — Wed, 10 Jan 2024 10:51:35 GMT

←Older revision		Revision as of 10:51, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xzh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XZH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xzh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XZH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=48I:[3-(4-CHLORO-3-NITROBENZYL)-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL]ACETIC+ACID'>48I</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=48I:[3-(4-CHLORO-3-NITROBENZYL)-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL]ACETIC+ACID'>48I</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xzh OCA], [https://pdbe.org/4xzh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xzh RCSB], [https://www.ebi.ac.uk/pdbsum/4xzh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xzh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xzh OCA], [https://pdbe.org/4xzh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xzh RCSB], [https://www.ebi.ac.uk/pdbsum/4xzh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xzh ProSAT]</span></td></tr>
	</table>		</table>

OCA at 17:59, 26 April 2023

OCA — Wed, 26 Apr 2023 17:59:44 GMT

←Older revision		Revision as of 17:59, 26 April 2023
Line 3:		Line 3:
	<StructureSection load='4xzh' size='340' side='right'caption='[[4xzh]], [[Resolution\|resolution]] 1.00Å' scene=''>		<StructureSection load='4xzh' size='340' side='right'caption='[[4xzh]], [[Resolution\|resolution]] 1.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xzh]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XZH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xzh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XZH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=48I:[3-(4-CHLORO-3-NITROBENZYL)-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL]ACETIC+ACID'>48I</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=48I:[3-(4-CHLORO-3-NITROBENZYL)-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL]ACETIC+ACID'>48I</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1us0\|1us0]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xzh OCA], [https://pdbe.org/4xzh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xzh RCSB], [https://www.ebi.ac.uk/pdbsum/4xzh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xzh ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AKR1B1, ALDR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xzh OCA], [~~http~~://pdbe.org/4xzh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xzh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xzh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xzh ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN]] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.	+	[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aldehyde reductase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cousido-Siah, A]]	+	[[Category: Cousido-Siah A]]
-	[[Category: Dominguez, M]]	+	[[Category: Dominguez M]]
-	[[Category: Farres, J]]	+	[[Category: Farres J]]
-	~~[[Category: Lera, A R.de~~]]	+	[[Category: Mitschler A]]
-	[[Category: Mitschler, A]]	+	[[Category: Pares X]]
-	[[Category: Pares, X]]	+	[[Category: Podjarny A]]
-	[[Category: Podjarny, A]]	+	[[Category: Ruiz FX]]
-	[[Category: Ruiz~~, F X~~]]	+	[[Category: De Lera AR]]
-	[[Category: ~~Aldose reductase]]~~	+
-	~~[[Category: Cytosolic]]~~	+
-	~~[[Category: Diabetes]]~~	+
-	~~[[Category: Halogenated compound]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Tim barrel~~]]	+

OCA at 23:34, 5 June 2019

OCA — Wed, 05 Jun 2019 23:34:34 GMT

←Older revision		Revision as of 23:34, 5 June 2019
Line 1:		Line 1:
		+
	==Crystal structure of human Aldose Reductase complexed with NADP+ and JF0048==		==Crystal structure of human Aldose Reductase complexed with NADP+ and JF0048==
-	<StructureSection load='4xzh' size='340' side='right' caption='[[4xzh]], [[Resolution\|resolution]] 1.00Å' scene=''>	+	<StructureSection load='4xzh' size='340' side='right'caption='[[4xzh]], [[Resolution\|resolution]] 1.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xzh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XZH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xzh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XZH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=48I:[3-(4-CHLORO-3-NITROBENZYL)-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL]ACETIC+ACID'>48I</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=48I:[3-(4-CHLORO-3-NITROBENZYL)-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL]ACETIC+ACID'>48I</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1us0\|1us0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1us0\|1us0]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AKR1B1, ALDR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xzh OCA], [http://pdbe.org/4xzh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xzh RCSB], [http://www.ebi.ac.uk/pdbsum/4xzh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xzh OCA], [http://pdbe.org/4xzh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xzh RCSB], [http://www.ebi.ac.uk/pdbsum/4xzh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xzh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4xzh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4xzh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aldose reductase 3D structures\|Aldose reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Aldehyde reductase]]		[[Category: Aldehyde reductase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Cousido-Siah, A]]		[[Category: Cousido-Siah, A]]
	[[Category: Dominguez, M]]		[[Category: Dominguez, M]]

OCA at 18:57, 1 December 2015

OCA — Tue, 01 Dec 2015 18:57:02 GMT

←Older revision		Revision as of 18:57, 1 December 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of human Aldose Reductase complexed with NADP+ and JF0048==
		+	<StructureSection load='4xzh' size='340' side='right' caption='[[4xzh]], [[Resolution\|resolution]] 1.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xzh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XZH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=48I:[3-(4-CHLORO-3-NITROBENZYL)-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL]ACETIC+ACID'>48I</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1us0\|1us0]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xzh OCA], [http://pdbe.org/4xzh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xzh RCSB], [http://www.ebi.ac.uk/pdbsum/4xzh PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN]] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human enzymes aldose reductase (AR) and AKR1B10 have been thoroughly explored in terms of their roles in diabetes, inflammatory disorders, and cancer. In this study we identified two new lead compounds, 2-(3-(4-chloro-3-nitrobenzyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetic acid (JF0048, 3) and 2-(2,4-dioxo-3-(2,3,4,5-tetrabromo-6-methoxybenzyl)-3,4-dihydropyrimidin-1(2H)-yl )acetic acid (JF0049, 4), which selectively target these enzymes. Although 3 and 4 share the 3-benzyluracil-1-acetic acid scaffold, they have different substituents in their aryl moieties. Inhibition studies along with thermodynamic and structural characterizations of both enzymes revealed that the chloronitrobenzyl moiety of compound 3 can open the AR specificity pocket but not that of the AKR1B10 cognate. In contrast, the larger atoms at the ortho and/or meta positions of compound 4 prevent the AR specificity pocket from opening due to steric hindrance and provide a tighter fit to the AKR1B10 inhibitor binding pocket, probably enhanced by the displacement of a disordered water molecule trapped in a hydrophobic subpocket, creating an enthalpic signature. Furthermore, this selectivity also occurs in the cell, which enables the development of a more efficient drug design strategy: compound 3 prevents sorbitol accumulation in human retinal ARPE-19 cells, whereas 4 stops proliferation in human lung cancer NCI-H460 cells.

-	~~The entry 4xzh is ON HOLD until Paper Publication~~	+	Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10.,Ruiz FX, Cousido-Siah A, Porte S, Dominguez M, Crespo I, Rechlin C, Mitschler A, de Lera AR, Martin MJ, de la Fuente JA, Klebe G, Pares X, Farres J, Podjarny A ChemMedChem. 2015 Nov 9. doi: 10.1002/cmdc.201500393. PMID:26549844<ref>PMID:26549844</ref>

-	~~Authors: Cousido-Siah~~, A.~~, Ruiz, F~~.~~X., Mitschler, A., Dominguez, M., de Lera, A.R., Farres, J., Pares, X., Podjarny, A~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of human Aldose Reductase complexed with NADP+ and JF0048~~	+	<div class="pdbe-citations 4xzh" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
-	[[Category: ~~Podjarny~~, A]]	+	<references/>
-	[[Category: De Lera, A.R]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Aldehyde reductase]]
		+	[[Category: Cousido-Siah, A]]
		+	[[Category: Dominguez, M]]
		+	[[Category: Farres, J]]
		+	[[Category: Lera, A R.de]]
	[[Category: Mitschler, A]]		[[Category: Mitschler, A]]
-	[[Category: Farres, J]]
	[[Category: Pares, X]]		[[Category: Pares, X]]
-	[[Category: ~~Cousido-Siah~~, A]]	+	[[Category: Podjarny, A]]
-	[[Category: Ruiz, F.X]]	+	[[Category: Ruiz, F X]]
-	[[Category: ~~Dominguez, M~~]]	+	[[Category: Aldose reductase]]
		+	[[Category: Cytosolic]]
		+	[[Category: Diabetes]]
		+	[[Category: Halogenated compound]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Tim barrel]]

OCA at 11:49, 18 February 2015

OCA — Wed, 18 Feb 2015 11:49:45 GMT

←Older revision		Revision as of 11:49, 18 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xzh is ON HOLD	+	The entry 4xzh is ON HOLD until Paper Publication

	Authors: Cousido-Siah, A., Ruiz, F.X., Mitschler, A., Dominguez, M., de Lera, A.R., Farres, J., Pares, X., Podjarny, A.		Authors: Cousido-Siah, A., Ruiz, F.X., Mitschler, A., Dominguez, M., de Lera, A.R., Farres, J., Pares, X., Podjarny, A.

OCA: Protected "4xzh" [edit=sysop:move=sysop]

OCA — Thu, 12 Feb 2015 10:54:42 GMT

Protected "4xzh" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:54, 12 February 2015

OCA: New page: '''Unreleased structure''' The entry 4xzh is ON HOLD Authors: Cousido-Siah, A., Ruiz, F.X., Mitschler, A., Dominguez, M., de Lera, A.R., Farres, J., Pares, X., Podjarny, A. Description...

OCA — Thu, 12 Feb 2015 10:54:41 GMT

New page: '''Unreleased structure''' The entry 4xzh is ON HOLD Authors: Cousido-Siah, A., Ruiz, F.X., Mitschler, A., Dominguez, M., de Lera, A.R., Farres, J., Pares, X., Podjarny, A. Description...

New page

'''Unreleased structure'''

The entry 4xzh is ON HOLD

Authors: Cousido-Siah, A., Ruiz, F.X., Mitschler, A., Dominguez, M., de Lera, A.R., Farres, J., Pares, X., Podjarny, A.

Description: Crystal structure of human Aldose Reductase complexed with NADP+ and JF0048
[[Category: Unreleased Structures]]
[[Category: Podjarny, A]]
[[Category: De Lera, A.R]]
[[Category: Mitschler, A]]
[[Category: Farres, J]]
[[Category: Pares, X]]
[[Category: Cousido-Siah, A]]
[[Category: Ruiz, F.X]]
[[Category: Dominguez, M]]