4xzs - Revision history

OCA at 10:51, 10 January 2024

OCA — Wed, 10 Jan 2024 10:51:42 GMT

←Older revision		Revision as of 10:51, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4xzs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XZS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4xzs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XZS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.12Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xzs OCA], [https://pdbe.org/4xzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xzs RCSB], [https://www.ebi.ac.uk/pdbsum/4xzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xzs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xzs OCA], [https://pdbe.org/4xzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xzs RCSB], [https://www.ebi.ac.uk/pdbsum/4xzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xzs ProSAT]</span></td></tr>
	</table>		</table>

OCA at 18:00, 26 April 2023

OCA — Wed, 26 Apr 2023 18:00:06 GMT

←Older revision		Revision as of 18:00, 26 April 2023
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	<StructureSection load='4xzs' size='340' side='right'caption='[[4xzs]], [[Resolution\|resolution]] 2.12Å' scene=''>		<StructureSection load='4xzs' size='340' side='right'caption='[[4xzs]], [[Resolution\|resolution]] 2.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xzs]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4XZS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xzs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XZS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene><~~/td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">TRIAP1, 15E1.1, HSPC132 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xzs OCA], [https://pdbe.org/4xzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xzs RCSB], [https://www.ebi.ac.uk/pdbsum/4xzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xzs ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4xzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xzs OCA], [~~http~~://pdbe.org/4xzs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4xzs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4xzs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4xzs ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.	+	[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/TRIA1_HUMAN TRIA1_HUMAN] Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003).<ref>PMID:15735003</ref> <ref>PMID:23931759</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Escherichia coli K-12]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Abid-Ali, F]]	+	[[Category: Abid-Ali F]]
-	[[Category: Garnett~~, J A~~]]	+	[[Category: Garnett JA]]
-	[[Category: Matthews~~, S J~~]]	+	[[Category: Matthews SJ]]
-	[[Category: Miliara, X]]	+	[[Category: Miliara X]]
-	[[Category: Perez-Dorado, I]]	+	[[Category: Perez-Dorado I]]
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Cancer]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Cx9cx motif]]~~	+
-	~~[[Category: Lipid]]~~	+
-	~~[[Category: Mitochondria~~]]	+

OCA at 00:10, 6 June 2019

OCA — Thu, 06 Jun 2019 00:10:16 GMT

←Older revision		Revision as of 00:10, 6 June 2019
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		+
	==Crystal Structure of TRIAP1-MBP fusion==		==Crystal Structure of TRIAP1-MBP fusion==
-	<StructureSection load='4xzs' size='340' side='right' caption='[[4xzs]], [[Resolution\|resolution]] 2.12Å' scene=''>	+	<StructureSection load='4xzs' size='340' side='right'caption='[[4xzs]], [[Resolution\|resolution]] 2.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4xzs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XZS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4xzs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XZS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xzs OCA], [http://pdbe.org/4xzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xzs RCSB], [http://www.ebi.ac.uk/pdbsum/4xzs PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRIAP1, 15E1.1, HSPC132 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xzs OCA], [http://pdbe.org/4xzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xzs RCSB], [http://www.ebi.ac.uk/pdbsum/4xzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xzs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Abid-Ali, F]]		[[Category: Abid-Ali, F]]
	[[Category: Garnett, J A]]		[[Category: Garnett, J A]]

OCA at 17:06, 20 January 2016

OCA — Wed, 20 Jan 2016 17:06:57 GMT

←Older revision		Revision as of 17:06, 20 January 2016
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal Structure of TRIAP1-MBP fusion==
		+	<StructureSection load='4xzs' size='340' side='right' caption='[[4xzs]], [[Resolution\|resolution]] 2.12Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4xzs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XZS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xzs OCA], [http://pdbe.org/4xzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xzs RCSB], [http://www.ebi.ac.uk/pdbsum/4xzs PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The composition of the mitochondrial membrane is important for its architecture and proper function. Mitochondria depend on a tightly regulated supply of phospholipid via intra-mitochondrial synthesis and by direct import from the endoplasmic reticulum. The Ups1/PRELI-like family together with its mitochondrial chaperones (TRIAP1/Mdm35) represent a unique heterodimeric lipid transfer system that is evolutionary conserved from yeast to man. Work presented here provides new atomic resolution insight into the function of a human member of this system. Crystal structures of free TRIAP1 and the TRIAP1-SLMO1 complex reveal how the PRELI domain is chaperoned during import into the intermembrane mitochondrial space. The structural resemblance of PRELI-like domain of SLMO1 with that of mammalian phoshatidylinositol transfer proteins (PITPs) suggest that they share similar lipid transfer mechanisms, in which access to a buried phospholipid-binding cavity is regulated by conformationally adaptable loops.

-	~~The entry 4xzs is ON HOLD until Paper Publication~~	+	Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes.,Miliara X, Garnett JA, Tatsuta T, Abid Ali F, Baldie H, Perez-Dorado I, Simpson P, Yague E, Langer T, Matthews S EMBO Rep. 2015 Jul;16(7):824-35. doi: 10.15252/embr.201540229. Epub 2015 Jun 12. PMID:26071602<ref>PMID:26071602</ref>

-	~~Authors: Miliara~~, X.~~, Garnett, J.A., Abid-Ali, F., Perez-Dorado, I., Matthews,~~ S.J.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~:	+	<div class="pdbe-citations 4xzs" style="background-color:#fffaf0;"></div>
-	~~[[Category: Unreleased Structures]]~~	+	== References ==
-	~~[[Category: Matthews, S.J]]~~	+	<references/>
-	~~[[Category: Garnett, J.A]]~~	+	__TOC__
		+	</StructureSection>
	[[Category: Abid-Ali, F]]		[[Category: Abid-Ali, F]]
		+	[[Category: Garnett, J A]]
		+	[[Category: Matthews, S J]]
		+	[[Category: Miliara, X]]
	[[Category: Perez-Dorado, I]]		[[Category: Perez-Dorado, I]]
-	[[Category: ~~Miliara, X~~]]	+	[[Category: Apoptosis]]
		+	[[Category: Cancer]]
		+	[[Category: Chaperone]]
		+	[[Category: Cx9cx motif]]
		+	[[Category: Lipid]]
		+	[[Category: Mitochondria]]

OCA at 23:23, 30 November 2015

OCA — Mon, 30 Nov 2015 23:23:12 GMT

←Older revision		Revision as of 23:23, 30 November 2015
Line 9:		Line 9:
	[[Category: Matthews, S.J]]		[[Category: Matthews, S.J]]
	[[Category: Garnett, J.A]]		[[Category: Garnett, J.A]]
-	[[Category: Perez-Dorado, I]]
	[[Category: Abid-Ali, F]]		[[Category: Abid-Ali, F]]
		+	[[Category: Perez-Dorado, I]]
	[[Category: Miliara, X]]		[[Category: Miliara, X]]

OCA at 13:11, 27 May 2015

OCA — Wed, 27 May 2015 13:11:16 GMT

←Older revision		Revision as of 13:11, 27 May 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4xzs is ON HOLD	+	The entry 4xzs is ON HOLD until Paper Publication

-	Authors: Garnett, J.A~~., Miliara, X~~., Abid-Ali, F., Perez-Dorado, I., Matthews, S.J.	+	Authors: Miliara, X., Garnett, J.A., Abid-Ali, F., Perez-Dorado, I., Matthews, S.J.

	Description:		Description:

OCA: Protected "4xzs" [edit=sysop:move=sysop]

OCA — Thu, 12 Feb 2015 10:55:18 GMT

Protected "4xzs" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:55, 12 February 2015

OCA: New page: '''Unreleased structure''' The entry 4xzs is ON HOLD Authors: Garnett, J.A., Miliara, X., Abid-Ali, F., Perez-Dorado, I., Matthews, S.J. Description: [[Category: Unreleased Structures...

OCA — Thu, 12 Feb 2015 10:55:17 GMT

New page: '''Unreleased structure''' The entry 4xzs is ON HOLD Authors: Garnett, J.A., Miliara, X., Abid-Ali, F., Perez-Dorado, I., Matthews, S.J. Description: [[Category: Unreleased Structures...

New page

'''Unreleased structure'''

The entry 4xzs is ON HOLD

Authors: Garnett, J.A., Miliara, X., Abid-Ali, F., Perez-Dorado, I., Matthews, S.J.

Description:
[[Category: Unreleased Structures]]
[[Category: Matthews, S.J]]
[[Category: Garnett, J.A]]
[[Category: Perez-Dorado, I]]
[[Category: Abid-Ali, F]]
[[Category: Miliara, X]]