4y00 - Revision history

OCA at 15:32, 8 November 2023

OCA — Wed, 08 Nov 2023 15:32:46 GMT

←Older revision		Revision as of 15:32, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4y00]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y00 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4y00]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y00 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y00 OCA], [https://pdbe.org/4y00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y00 RCSB], [https://www.ebi.ac.uk/pdbsum/4y00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y00 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y00 OCA], [https://pdbe.org/4y00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y00 RCSB], [https://www.ebi.ac.uk/pdbsum/4y00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y00 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 18:00, 26 April 2023

OCA — Wed, 26 Apr 2023 18:00:26 GMT

←Older revision		Revision as of 18:00, 26 April 2023
Line 3:		Line 3:
	<StructureSection load='4y00' size='340' side='right'caption='[[4y00]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4y00' size='340' side='right'caption='[[4y00]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4y00]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y00 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Y00 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4y00]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y00 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y0f\|4y0f]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y00 OCA], [https://pdbe.org/4y00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y00 RCSB], [https://www.ebi.ac.uk/pdbsum/4y00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y00 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TARDBP, TDP43 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y00 OCA], [~~http~~://pdbe.org/4y00 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4y00 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4y00 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4y00 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] Defects in TARDBP are the cause of amyotrophic lateral sclerosis type 10 (ALS10) [MIM:[~~http~~://omim.org/entry/612069 612069]]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of ALS is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.<ref>PMID:20740007</ref> <ref>PMID:18288693</ref> <ref>PMID:18438952</ref> <ref>PMID:18396105</ref> <ref>PMID:18372902</ref> <ref>PMID:18309045</ref> <ref>PMID:19350673</ref> <ref>PMID:19224587</ref> <ref>PMID:19655382</ref> <ref>PMID:19695877</ref> <ref>PMID:21220647</ref> <ref>PMID:21418058</ref> <ref>PMID:22456481</ref>	+	[https://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN] Defects in TARDBP are the cause of amyotrophic lateral sclerosis type 10 (ALS10) [MIM:[https://omim.org/entry/612069 612069]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of ALS is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.<ref>PMID:20740007</ref> <ref>PMID:18288693</ref> <ref>PMID:18438952</ref> <ref>PMID:18396105</ref> <ref>PMID:18372902</ref> <ref>PMID:18309045</ref> <ref>PMID:19350673</ref> <ref>PMID:19224587</ref> <ref>PMID:19655382</ref> <ref>PMID:19695877</ref> <ref>PMID:21220647</ref> <ref>PMID:21418058</ref> <ref>PMID:22456481</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.<ref>PMID:17481916</ref> <ref>PMID:11285240</ref>	+	[https://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN] DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.<ref>PMID:17481916</ref> <ref>PMID:11285240</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4y00" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4y00" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Tdp-43\|Tdp-43]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chiang~~, C H~~]]	+	[[Category: Chiang CH]]
-	[[Category: Kuo~~, P H~~]]	+	[[Category: Kuo PH]]
-	[[Category: Yang~~, W Z~~]]	+	[[Category: Yang WZ]]
-	[[Category: Yuan~~, H S]]~~	+	[[Category: Yuan HS]]
-	~~[[Category: Dna binding protein-dna complex]]~~	+
-	~~[[Category: Rna recognition motif 1 complex~~]]	+

OCA at 23:53, 5 June 2019

OCA — Wed, 05 Jun 2019 23:53:04 GMT

←Older revision		Revision as of 23:53, 5 June 2019
Line 1:		Line 1:

	==Crystal Structure of Human TDP-43 RRM1 Domain with D169G Mutation in Complex with an Unmodified Single-stranded DNA==		==Crystal Structure of Human TDP-43 RRM1 Domain with D169G Mutation in Complex with an Unmodified Single-stranded DNA==
-	<StructureSection load='4y00' size='340' side='right' caption='[[4y00]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4y00' size='340' side='right'caption='[[4y00]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4y00]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y00 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4y00]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y00 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y0f\|4y0f]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y0f\|4y0f]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y00 OCA], [http://pdbe.org/4y00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y00 RCSB], [http://www.ebi.ac.uk/pdbsum/4y00 PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TARDBP, TDP43 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y00 OCA], [http://pdbe.org/4y00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y00 RCSB], [http://www.ebi.ac.uk/pdbsum/4y00 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y00 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4y00" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4y00" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tdp-43\|Tdp-43]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chiang, C H]]		[[Category: Chiang, C H]]
	[[Category: Kuo, P H]]		[[Category: Kuo, P H]]

OCA at 20:01, 9 March 2016

OCA — Wed, 09 Mar 2016 20:01:19 GMT

←Older revision		Revision as of 20:01, 9 March 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Human TDP-43 RRM1 Domain with D169G Mutation in Complex with an Unmodified Single-stranded DNA==		==Crystal Structure of Human TDP-43 RRM1 Domain with D169G Mutation in Complex with an Unmodified Single-stranded DNA==
	<StructureSection load='4y00' size='340' side='right' caption='[[4y00]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4y00' size='340' side='right' caption='[[4y00]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 10:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.<ref>PMID:17481916</ref> <ref>PMID:11285240</ref>		[[http://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.<ref>PMID:17481916</ref> <ref>PMID:11285240</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The RNA-binding protein TDP-43 forms intracellular inclusions in amyotrophic lateral sclerosis (ALS). While TDP-43 mutations have been identified in ALS patients, how these mutations are linked to ALS remains unclear. Here we examined the biophysical properties of six ALS-linked TDP-43 mutants and found that one of the mutants, D169G, had higher thermal stability than wild-type TDP-43 and that it was cleaved by caspase 3 more efficiently, producing increased levels of the C-terminal 35 kD fragments (TDP-35) in vitro and in neuroblastoma cells. The crystal structure of the TDP-43 RRM1 domain containing the D169G mutation in complex with DNA along with molecular dynamics simulations reveal that the D169G mutation induces a local conformational change in a beta turn and increases the hydrophobic interactions in the RRM1 core, thus enhancing the thermal stability of the RRM1 domain. Our results provide the first crystal structure of TDP-43 containing a disease-linked D169G mutation and a disease-related mechanism showing that D169G mutant is more susceptible to proteolytic cleavage by caspase 3 into the pathogenic C-terminal 35-kD fragments due to its increased stability in the RRM1 domain. Modulation of TDP-43 stability and caspase cleavage efficiency could present an avenue for prevention and treatment of TDP-43-linked neurodegeneration.
		+
		+	Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation.,Chiang CH, Grauffel C, Wu LS, Kuo PH, Doudeva LG, Lim C, Shen CK, Yuan HS Sci Rep. 2016 Feb 17;6:21581. doi: 10.1038/srep21581. PMID:26883171<ref>PMID:26883171</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4y00" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:22, 10 February 2016

OCA — Wed, 10 Feb 2016 17:22:41 GMT

←Older revision		Revision as of 17:22, 10 February 2016
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure of Human TDP-43 RRM1 Domain with D169G Mutation in Complex with an Unmodified Single-stranded DNA==
-		+	<StructureSection load='4y00' size='340' side='right' caption='[[4y00]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~The entry~~ 4y00 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4y00]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y00 FirstGlance]. <br>
-	~~Authors~~: ~~Chiang~~, C.H., ~~Kuo~~, P.H., ~~Yang, W~~.Z., ~~Yuan, H~~.S.	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y0f\|4y0f]]</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y00 OCA], [http://pdbe.org/4y00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y00 RCSB], [http://www.ebi.ac.uk/pdbsum/4y00 PDBsum]</span></td></tr>
-	~~Description~~: ~~Crystal Structure~~ of ~~Human TDP~~-~~43 RRM1 Domain~~ with ~~D169G Mutation~~ in ~~Complex with an Unmodified Single~~-~~stranded DNA~~	+	</table>
-	[[Category: ~~Unreleased Structures~~]]	+	== Disease ==
-	[[Category: Kuo, P.H]]	+	[[http://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] Defects in TARDBP are the cause of amyotrophic lateral sclerosis type 10 (ALS10) [MIM:[http://omim.org/entry/612069 612069]]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of ALS is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.<ref>PMID:20740007</ref> <ref>PMID:18288693</ref> <ref>PMID:18438952</ref> <ref>PMID:18396105</ref> <ref>PMID:18372902</ref> <ref>PMID:18309045</ref> <ref>PMID:19350673</ref> <ref>PMID:19224587</ref> <ref>PMID:19655382</ref> <ref>PMID:19695877</ref> <ref>PMID:21220647</ref> <ref>PMID:21418058</ref> <ref>PMID:22456481</ref>
-	[[Category: Yuan, H.S]]	+	== Function ==
-	[[Category: ~~Chiang, C.H~~]]	+	[[http://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN]] DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.<ref>PMID:17481916</ref> <ref>PMID:11285240</ref>
-	[[Category: ~~Yang, W.Z~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chiang, C H]]
		+	[[Category: Kuo, P H]]
		+	[[Category: Yang, W Z]]
		+	[[Category: Yuan, H S]]
		+	[[Category: Dna binding protein-dna complex]]
		+	[[Category: Rna recognition motif 1 complex]]

OCA at 10:16, 18 March 2015

OCA — Wed, 18 Mar 2015 10:16:22 GMT

←Older revision		Revision as of 10:16, 18 March 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4y00 is ON HOLD	+	The entry 4y00 is ON HOLD until Paper Publication

	Authors: Chiang, C.H., Kuo, P.H., Yang, W.Z., Yuan, H.S.		Authors: Chiang, C.H., Kuo, P.H., Yang, W.Z., Yuan, H.S.

OCA: Protected "4y00" [edit=sysop:move=sysop]

OCA — Thu, 12 Feb 2015 10:56:11 GMT

Protected "4y00" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:56, 12 February 2015

OCA: New page: '''Unreleased structure''' The entry 4y00 is ON HOLD Authors: Chiang, C.H., Kuo, P.H., Yang, W.Z., Yuan, H.S. Description: Crystal Structure of Human TDP-43 RRM1 Domain with D169G Muta...

OCA — Thu, 12 Feb 2015 10:56:09 GMT

New page: '''Unreleased structure''' The entry 4y00 is ON HOLD Authors: Chiang, C.H., Kuo, P.H., Yang, W.Z., Yuan, H.S. Description: Crystal Structure of Human TDP-43 RRM1 Domain with D169G Muta...

New page

'''Unreleased structure'''

The entry 4y00 is ON HOLD

Authors: Chiang, C.H., Kuo, P.H., Yang, W.Z., Yuan, H.S.

Description: Crystal Structure of Human TDP-43 RRM1 Domain with D169G Mutation in Complex with an Unmodified Single-stranded DNA
[[Category: Unreleased Structures]]
[[Category: Kuo, P.H]]
[[Category: Yuan, H.S]]
[[Category: Chiang, C.H]]
[[Category: Yang, W.Z]]