4y24 - Revision history

OCA at 09:03, 20 March 2024

OCA — Wed, 20 Mar 2024 09:03:06 GMT

←Older revision		Revision as of 09:03, 20 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4y24]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y24 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4y24]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y24 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TD2:3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>TD2</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.32Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TD2:3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>TD2</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y24 OCA], [https://pdbe.org/4y24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y24 RCSB], [https://www.ebi.ac.uk/pdbsum/4y24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y24 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y24 OCA], [https://pdbe.org/4y24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y24 RCSB], [https://www.ebi.ac.uk/pdbsum/4y24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y24 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref>		[https://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Human galectins are promising targets for cancer immunotherapeutic and fibrotic disease-related drugs. We report herein the binding interactions of three thio-digalactosides (TDGs) including TDG itself, TD139 (3,3'-deoxy-3,3'-bis-(4-[m-fluorophenyl]-1H-1,2,3-triazol-1-yl)-thio-digalactosid e, recently approved for the treatment of idiopathic pulmonary fibrosis), and TAZTDG (3-deoxy-3-(4-[m-fluorophenyl]-1H-1,2,3-triazol-1-yl)-thio-digalactoside) with human galectins-1, -3 and -7 as assessed by X-ray crystallography, isothermal titration calorimetry and NMR spectroscopy. Five binding subsites (A-E) make up the carbohydrate-recognition domains of these galectins. We identified novel interactions between an arginine within subsite E of the galectins and an arene group in the ligands. In addition to the interactions contributed by the galactosyl sugar residues bound at subsites C and D, the fluorophenyl group of TAZTDG preferentially bound to subsite B in galectin-3, whereas the same group favored binding at subsite E in galectins-1 and -7. The characterised dual binding modes demonstrate how binding potency, reported as decreased Kd values of the TDG inhibitors from muM to nM, is improved and also offer insights to development of selective inhibitors for individual galectins.
-
-	Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors.,Hsieh TJ, Lin HY, Tu Z, Lin TC, Wu SC, Tseng YY, Liu FT, Hsu ST, Lin CH Sci Rep. 2016 Jul 15;6:29457. doi: 10.1038/srep29457. PMID:27416897<ref>PMID:27416897</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4y24" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 18:03, 26 April 2023

OCA — Wed, 26 Apr 2023 18:03:36 GMT

←Older revision		Revision as of 18:03, 26 April 2023
Line 3:		Line 3:
	<StructureSection load='4y24' size='340' side='right'caption='[[4y24]], [[Resolution\|resolution]] 2.32Å' scene=''>		<StructureSection load='4y24' size='340' side='right'caption='[[4y24]], [[Resolution\|resolution]] 2.32Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4y24]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y24 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Y24 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4y24]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y24 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TD2:3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>TD2</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TD2:3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>TD2</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y1v\|4y1v]], [[4y1z\|4y1z]], [[4y1y\|4y1y]], [[4y1u\|4y1u]], [[4y1x\|4y1x]], [[4y22\|4y22]], [[4y20\|4y20]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y24 OCA], [https://pdbe.org/4y24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y24 RCSB], [https://www.ebi.ac.uk/pdbsum/4y24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y24 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4y24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y24 OCA], [~~http~~://pdbe.org/4y24 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4y24 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4y24 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4y24 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref>	+	[https://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Galectin\|Galectin]]	+	*[[Galectin 3D structures\|Galectin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hsieh~~, T J~~]]	+	[[Category: Hsieh TJ]]
-	[[Category: Lin~~, C H~~]]	+	[[Category: Lin CH]]
-	[[Category: Lin~~, H Y]]~~	+	[[Category: Lin HY]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Galectin-1]]~~	+
-	~~[[Category: Sugar binding protein]]~~	+
-	~~[[Category: Td-139]]~~	+
-	~~[[Category: Tdg~~]]	+

OCA at 00:05, 6 June 2019

OCA — Thu, 06 Jun 2019 00:05:42 GMT

←Older revision		Revision as of 00:05, 6 June 2019
Line 1:		Line 1:

	==Complex of human Galectin-1 and TD-139==		==Complex of human Galectin-1 and TD-139==
-	<StructureSection load='4y24' size='340' side='right' caption='[[4y24]], [[Resolution\|resolution]] 2.32Å' scene=''>	+	<StructureSection load='4y24' size='340' side='right'caption='[[4y24]], [[Resolution\|resolution]] 2.32Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4y24]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y24 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4y24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y24 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TD2:3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>TD2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TD2:3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>TD2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y1v\|4y1v]], [[4y1z\|4y1z]], [[4y1y\|4y1y]], [[4y1u\|4y1u]], [[4y1x\|4y1x]], [[4y22\|4y22]], [[4y20\|4y20]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y1v\|4y1v]], [[4y1z\|4y1z]], [[4y1y\|4y1y]], [[4y1u\|4y1u]], [[4y1x\|4y1x]], [[4y22\|4y22]], [[4y20\|4y20]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LGALS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y24 OCA], [http://pdbe.org/4y24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y24 RCSB], [http://www.ebi.ac.uk/pdbsum/4y24 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y24 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y24 OCA], [http://pdbe.org/4y24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y24 RCSB], [http://www.ebi.ac.uk/pdbsum/4y24 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y24 ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4y24" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4y24" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Galectin\|Galectin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hsieh, T J]]		[[Category: Hsieh, T J]]
	[[Category: Lin, C H]]		[[Category: Lin, C H]]

OCA at 20:41, 3 August 2016

OCA — Wed, 03 Aug 2016 20:41:55 GMT

←Older revision		Revision as of 20:41, 3 August 2016
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref>		[[http://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human galectins are promising targets for cancer immunotherapeutic and fibrotic disease-related drugs. We report herein the binding interactions of three thio-digalactosides (TDGs) including TDG itself, TD139 (3,3'-deoxy-3,3'-bis-(4-[m-fluorophenyl]-1H-1,2,3-triazol-1-yl)-thio-digalactosid e, recently approved for the treatment of idiopathic pulmonary fibrosis), and TAZTDG (3-deoxy-3-(4-[m-fluorophenyl]-1H-1,2,3-triazol-1-yl)-thio-digalactoside) with human galectins-1, -3 and -7 as assessed by X-ray crystallography, isothermal titration calorimetry and NMR spectroscopy. Five binding subsites (A-E) make up the carbohydrate-recognition domains of these galectins. We identified novel interactions between an arginine within subsite E of the galectins and an arene group in the ligands. In addition to the interactions contributed by the galactosyl sugar residues bound at subsites C and D, the fluorophenyl group of TAZTDG preferentially bound to subsite B in galectin-3, whereas the same group favored binding at subsite E in galectins-1 and -7. The characterised dual binding modes demonstrate how binding potency, reported as decreased Kd values of the TDG inhibitors from muM to nM, is improved and also offer insights to development of selective inhibitors for individual galectins.
		+
		+	Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors.,Hsieh TJ, Lin HY, Tu Z, Lin TC, Wu SC, Tseng YY, Liu FT, Hsu ST, Lin CH Sci Rep. 2016 Jul 15;6:29457. doi: 10.1038/srep29457. PMID:27416897<ref>PMID:27416897</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4y24" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:49, 12 July 2016

OCA — Tue, 12 Jul 2016 17:49:31 GMT

←Older revision		Revision as of 17:49, 12 July 2016
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TD2:3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>TD2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TD2:3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>TD2</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y1v\|4y1v]], [[4y1z\|4y1z]], [[4y1y\|4y1y]], [[4y1u\|4y1u]], [[4y1x\|4y1x]], [[4y22\|4y22]], [[4y20\|4y20]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y1v\|4y1v]], [[4y1z\|4y1z]], [[4y1y\|4y1y]], [[4y1u\|4y1u]], [[4y1x\|4y1x]], [[4y22\|4y22]], [[4y20\|4y20]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y24 OCA], [http://pdbe.org/4y24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y24 RCSB], [http://www.ebi.ac.uk/pdbsum/4y24 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y24 OCA], [http://pdbe.org/4y24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y24 RCSB], [http://www.ebi.ac.uk/pdbsum/4y24 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y24 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:57, 13 May 2016

OCA — Fri, 13 May 2016 11:57:32 GMT

←Older revision		Revision as of 11:57, 13 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4y24 is ~~ON HOLD until Paper Publication~~	+	==Complex of human Galectin-1 and TD-139==
-		+	<StructureSection load='4y24' size='340' side='right' caption='[[4y24]], [[Resolution\|resolution]] 2.32Å' scene=''>
-	~~Authors~~: ~~Lin~~, H.Y., ~~Hsieh, T~~.J., ~~Lin~~, C.H.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4y24]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y24 FirstGlance]. <br>
-	~~Description: Complex of human Galectin-1 and TD-139~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TD2:3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-3-[4-(3-FLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1-THIO-BETA-D-GALACTOPYRANOSIDE'>TD2</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y1v\|4y1v]], [[4y1z\|4y1z]], [[4y1y\|4y1y]], [[4y1u\|4y1u]], [[4y1x\|4y1x]], [[4y22\|4y22]], [[4y20\|4y20]]</td></tr>
-	[[Category: Hsieh, T.J]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y24 OCA], [http://pdbe.org/4y24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y24 RCSB], [http://www.ebi.ac.uk/pdbsum/4y24 PDBsum]</span></td></tr>
-	[[Category: Lin, H.Y]]	+	</table>
-	[[Category: Lin, C.H]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hsieh, T J]]
		+	[[Category: Lin, C H]]
		+	[[Category: Lin, H Y]]
		+	[[Category: Complex]]
		+	[[Category: Galectin-1]]
		+	[[Category: Sugar binding protein]]
		+	[[Category: Td-139]]
		+	[[Category: Tdg]]

OCA at 11:28, 8 July 2015

OCA — Wed, 08 Jul 2015 11:28:32 GMT

←Older revision		Revision as of 11:28, 8 July 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4y24 is ON HOLD	+	The entry 4y24 is ON HOLD until Paper Publication

	Authors: Lin, H.Y., Hsieh, T.J., Lin, C.H.		Authors: Lin, H.Y., Hsieh, T.J., Lin, C.H.

OCA: Protected "4y24" [edit=sysop:move=sysop]

OCA — Wed, 18 Feb 2015 11:55:46 GMT

Protected "4y24" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:55, 18 February 2015

OCA: New page: '''Unreleased structure''' The entry 4y24 is ON HOLD Authors: Lin, H.Y., Hsieh, T.J., Lin, C.H. Description: Complex of human Galectin-1 and TD-139 Category: Unreleased Structures ...

OCA — Wed, 18 Feb 2015 11:55:44 GMT

New page: '''Unreleased structure''' The entry 4y24 is ON HOLD Authors: Lin, H.Y., Hsieh, T.J., Lin, C.H. Description: Complex of human Galectin-1 and TD-139 Category: Unreleased Structures ...

New page

'''Unreleased structure'''

The entry 4y24 is ON HOLD

Authors: Lin, H.Y., Hsieh, T.J., Lin, C.H.

Description: Complex of human Galectin-1 and TD-139
[[Category: Unreleased Structures]]
[[Category: Hsieh, T.J]]
[[Category: Lin, H.Y]]
[[Category: Lin, C.H]]