4y32 - Revision history

OCA at 10:52, 10 January 2024

OCA — Wed, 10 Jan 2024 10:52:07 GMT

←Older revision		Revision as of 10:52, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4y32]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y32 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4y32]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y32 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=49F:(2S)-2-(2-METHOXYETHYL)PYRROLIDINE'>49F</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=49F:(2S)-2-(2-METHOXYETHYL)PYRROLIDINE'>49F</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y32 OCA], [https://pdbe.org/4y32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y32 RCSB], [https://www.ebi.ac.uk/pdbsum/4y32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y32 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y32 OCA], [https://pdbe.org/4y32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y32 RCSB], [https://www.ebi.ac.uk/pdbsum/4y32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y32 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 18:04, 26 April 2023

OCA — Wed, 26 Apr 2023 18:04:27 GMT

←Older revision		Revision as of 18:04, 26 April 2023
Line 3:		Line 3:
	<StructureSection load='4y32' size='340' side='right'caption='[[4y32]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4y32' size='340' side='right'caption='[[4y32]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4y32]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y32 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Y32 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4y32]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y32 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=49F:(2S)-2-(2-METHOXYETHYL)PYRROLIDINE'>49F</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=49F:(2S)-2-(2-METHOXYETHYL)PYRROLIDINE'>49F</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y32 OCA], [https://pdbe.org/4y32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y32 RCSB], [https://www.ebi.ac.uk/pdbsum/4y32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y32 ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fl5\|4fl5]], [[4y3b\|4y3b]], [[4y3v\|4y3v]], [[4y5i\|4y5i]]</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SFN, HME1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4y32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y32 OCA], [~~http~~://pdbe.org/4y32 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4y32 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4y32 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4y32 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.	+	[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Microtubule-associated protein\|Microtubule-associated protein]]	+	*[[Microtubule-associated protein 3D structures\|Microtubule-associated protein 3D structures]]
-	*[[Tau protein\|Tau protein]]	+	*[[Tau protein 3D structures\|Tau protein 3D structures]]
	*[[14-3-3 protein 3D structures\|14-3-3 protein 3D structures]]		*[[14-3-3 protein 3D structures\|14-3-3 protein 3D structures]]
	== References ==		== References ==
Line 30:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bartel, M]]	+	[[Category: Bartel M]]
-	[[Category: Bier, D]]	+	[[Category: Bier D]]
-	[[Category: Brunsveld, L]]	+	[[Category: Brunsveld L]]
-	[[Category: Milroy, L]]	+	[[Category: Milroy L]]
-	[[Category: Ottmann, C]]	+	[[Category: Ottmann C]]
-	~~[[Category: 14-3-3]]~~	+
-	~~[[Category: Adapter protein]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Peptide binding protein]]~~	+
-	~~[[Category: Peptide-hybrid]]~~	+
-	~~[[Category: Protein-protein interaction]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 12:29, 13 March 2019

OCA — Wed, 13 Mar 2019 12:29:57 GMT

←Older revision		Revision as of 12:29, 13 March 2019
Line 1:		Line 1:
		+
	==Crystal structure of C-terminal modified Tau peptide-hybrid 109B with 14-3-3sigma==		==Crystal structure of C-terminal modified Tau peptide-hybrid 109B with 14-3-3sigma==
-	<StructureSection load='4y32' size='340' side='right' caption='[[4y32]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4y32' size='340' side='right'caption='[[4y32]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4y32]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y32 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4y32]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y32 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=49F:(2S)-2-(2-METHOXYETHYL)PYRROLIDINE'>49F</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=49F:(2S)-2-(2-METHOXYETHYL)PYRROLIDINE'>49F</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fl5\|4fl5]], [[4y3b\|4y3b]], [[4y3v\|4y3v]], [[4y5i\|4y5i]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fl5\|4fl5]], [[4y3b\|4y3b]], [[4y3v\|4y3v]], [[4y5i\|4y5i]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y32 OCA], [http://pdbe.org/4y32 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y32 RCSB], [http://www.ebi.ac.uk/pdbsum/4y32 PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SFN, HME1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y32 OCA], [http://pdbe.org/4y32 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y32 RCSB], [http://www.ebi.ac.uk/pdbsum/4y32 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y32 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4y32" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4y32" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Microtubule-associated protein\|Microtubule-associated protein]]
		+	*[[Tau protein\|Tau protein]]
		+	*[[14-3-3 protein 3D structures\|14-3-3 protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bartel, M]]		[[Category: Bartel, M]]
	[[Category: Bier, D]]		[[Category: Bier, D]]

OCA at 12:42, 23 December 2015

OCA — Wed, 23 Dec 2015 12:42:18 GMT

←Older revision		Revision as of 12:42, 23 December 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of C-terminal modified Tau peptide-hybrid 109B with 14-3-3sigma==
		+	<StructureSection load='4y32' size='340' side='right' caption='[[4y32]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4y32]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y32 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y32 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=49F:(2S)-2-(2-METHOXYETHYL)PYRROLIDINE'>49F</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fl5\|4fl5]], [[4y3b\|4y3b]], [[4y3v\|4y3v]], [[4y5i\|4y5i]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y32 OCA], [http://pdbe.org/4y32 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y32 RCSB], [http://www.ebi.ac.uk/pdbsum/4y32 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The discovery of novel protein-protein interaction (PPI) modulators represents one of the great molecular challenges of the modern era. PPIs can be modulated by either inhibitor or stabilizer compounds, which target different though proximal regions of the protein interface. In principle, protein-stabilizer complexes can guide the design of PPI inhibitors (and vice versa). In the present work, we combine X-ray crystallographic data from both stabilizer and inhibitor co-crystal complexes of the adapter protein 14-3-3 to characterize, down to the atomic scale, inhibitors of the 14-3-3/Tau PPI, a potential drug target to treat Alzheimer's disease. The most potent compound notably inhibited the binding of phosphorylated full-length Tau to 14-3-3 according to NMR spectroscopy studies. Our work sets a precedent for the rational design of PPI inhibitors guided by PPI stabilizer-protein complexes while potentially enabling access to new synthetically tractable stabilizers of 14-3-3 and other PPIs.

-	~~The entry 4y32 is ON HOLD until Paper Publication~~	+	Stabilizer-Guided Inhibition of Protein-Protein Interactions.,Milroy LG, Bartel M, Henen MA, Leysen S, Adriaans JM, Brunsveld L, Landrieu I, Ottmann C Angew Chem Int Ed Engl. 2015 Nov 5. doi: 10.1002/anie.201507976. PMID:26537010<ref>PMID:26537010</ref>

-	~~Authors: Bartel~~, M.~~, Milroy, L~~.~~, Bier, D., Brunsveld, L., Ottmann, C~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~:	+	<div class="pdbe-citations 4y32" style="background-color:#fffaf0;"></div>
-	~~[[Category: Unreleased Structures]]~~	+	== References ==
-	[[Category: ~~Ottmann~~, C]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bartel, M]]
	[[Category: Bier, D]]		[[Category: Bier, D]]
		+	[[Category: Brunsveld, L]]
	[[Category: Milroy, L]]		[[Category: Milroy, L]]
-	[[Category: ~~Brunsveld~~, L]]	+	[[Category: Ottmann, C]]
-	[[Category: ~~Bartel, M~~]]	+	[[Category: 14-3-3]]
		+	[[Category: Adapter protein]]
		+	[[Category: Inhibitor]]
		+	[[Category: Peptide binding protein]]
		+	[[Category: Peptide-hybrid]]
		+	[[Category: Protein-protein interaction]]
		+	[[Category: Signaling protein]]

OCA at 10:03, 15 July 2015

OCA — Wed, 15 Jul 2015 10:03:29 GMT

←Older revision		Revision as of 10:03, 15 July 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4y32 is ON HOLD	+	The entry 4y32 is ON HOLD until Paper Publication

	Authors: Bartel, M., Milroy, L., Bier, D., Brunsveld, L., Ottmann, C.		Authors: Bartel, M., Milroy, L., Bier, D., Brunsveld, L., Ottmann, C.

OCA: Protected "4y32" [edit=sysop:move=sysop]

OCA — Wed, 18 Feb 2015 11:58:04 GMT

Protected "4y32" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:58, 18 February 2015

OCA: New page: '''Unreleased structure''' The entry 4y32 is ON HOLD Authors: Bartel, M., Milroy, L., Bier, D., Brunsveld, L., Ottmann, C. Description: Category: Unreleased Structures [[Category:...

OCA — Wed, 18 Feb 2015 11:58:03 GMT

New page: '''Unreleased structure''' The entry 4y32 is ON HOLD Authors: Bartel, M., Milroy, L., Bier, D., Brunsveld, L., Ottmann, C. Description: Category: Unreleased Structures [[Category:...

New page

'''Unreleased structure'''

The entry 4y32 is ON HOLD

Authors: Bartel, M., Milroy, L., Bier, D., Brunsveld, L., Ottmann, C.

Description:
[[Category: Unreleased Structures]]
[[Category: Ottmann, C]]
[[Category: Bier, D]]
[[Category: Milroy, L]]
[[Category: Brunsveld, L]]
[[Category: Bartel, M]]