4y59 - Revision history

OCA at 09:03, 20 March 2024

OCA — Wed, 20 Mar 2024 09:03:18 GMT

←Older revision		Revision as of 09:03, 20 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4y59]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y59 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4y59]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y59 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T21:2-[3-(TRIFLUOROMETHYL)PHENYL]FURO[3,2-C]PYRIDIN-4(5H)-ONE'>T21</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.22Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T21:2-[3-(TRIFLUOROMETHYL)PHENYL]FURO[3,2-C]PYRIDIN-4(5H)-ONE'>T21</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y59 OCA], [https://pdbe.org/4y59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y59 RCSB], [https://www.ebi.ac.uk/pdbsum/4y59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y59 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y59 OCA], [https://pdbe.org/4y59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y59 RCSB], [https://www.ebi.ac.uk/pdbsum/4y59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y59 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).		[https://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Artificial ligands of streptavidin (ALiS) with association constants of approximately 10(6) M(-1) were discovered by high-throughput screening of our chemical library, and their binding characteristics, including X-ray crystal structure of the streptavidin complex, were determined. Unlike biotin and its derivatives, ALiS exhibits fast dissociation kinetics and excellent cell permeability. The streptavidin-ALiS system provides a novel, practical compound-dependent methodology for repeated reversible cycling of protein localization between intracellular organella.
-
-	Artificial Ligands of Streptavidin (ALiS): Discovery, Characterization, and Application for Reversible Control of Intracellular Protein Transport.,Terai T, Kohno M, Boncompain G, Sugiyama S, Saito N, Fujikake R, Ueno T, Komatsu T, Hanaoka K, Okabe T, Urano Y, Perez F, Nagano T J Am Chem Soc. 2015 Aug 26;137(33):10464-7. doi: 10.1021/jacs.5b05672. Epub 2015 , Aug 11. PMID:26261872<ref>PMID:26261872</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4y59" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Avidin 3D structures\|Avidin 3D structures]]		*[[Avidin 3D structures\|Avidin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 18:07, 26 April 2023

OCA — Wed, 26 Apr 2023 18:07:00 GMT

←Older revision		Revision as of 18:07, 26 April 2023
Line 3:		Line 3:
	<StructureSection load='4y59' size='340' side='right'caption='[[4y59]], [[Resolution\|resolution]] 1.22Å' scene=''>		<StructureSection load='4y59' size='340' side='right'caption='[[4y59]], [[Resolution\|resolution]] 1.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4y59]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~As_4.1583 As 4.1583~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y59 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Y59 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4y59]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y59 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T21:2-[3-(TRIFLUOROMETHYL)PHENYL]FURO[3,2-C]PYRIDIN-4(5H)-ONE'>T21</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T21:2-[3-(TRIFLUOROMETHYL)PHENYL]FURO[3,2-C]PYRIDIN-4(5H)-ONE'>T21</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y5d\|4y5d]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y59 OCA], [https://pdbe.org/4y59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y59 RCSB], [https://www.ebi.ac.uk/pdbsum/4y59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y59 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4y59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y59 OCA], [~~http~~://pdbe.org/4y59 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4y59 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4y59 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4y59 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV]] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).	+	[https://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: As 4 1583]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ishida, H]]	+	[[Category: Streptomyces avidinii]]
-	[[Category: Kohno, M]]	+	[[Category: Ishida H]]
-	[[Category: Nagano, T]]	+	[[Category: Kohno M]]
-	[[Category: Sugiyama, S]]	+	[[Category: Nagano T]]
-	[[Category: Terai, T]]	+	[[Category: Sugiyama S]]
-	~~[[Category: Biotin-binding protein]]~~	+	[[Category: Terai T]]
-	~~[[Category: Inhibitor~~]]	+

OCA at 08:43, 5 February 2020

OCA — Wed, 05 Feb 2020 08:43:04 GMT

←Older revision		Revision as of 08:43, 5 February 2020
Line 1:		Line 1:

	==Crystal structure of ALiS1-Streptavidin complex==		==Crystal structure of ALiS1-Streptavidin complex==
-	<StructureSection load='4y59' size='340' side='right' caption='[[4y59]], [[Resolution\|resolution]] 1.22Å' scene=''>	+	<StructureSection load='4y59' size='340' side='right'caption='[[4y59]], [[Resolution\|resolution]] 1.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4y59]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1583 As 4.1583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y59 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4y59]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1583 As 4.1583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y59 FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4y59" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4y59" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Avidin 3D structures\|Avidin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: As 4 1583]]		[[Category: As 4 1583]]
		+	[[Category: Large Structures]]
	[[Category: Ishida, H]]		[[Category: Ishida, H]]
	[[Category: Kohno, M]]		[[Category: Kohno, M]]

OCA at 15:21, 16 November 2017

OCA — Thu, 16 Nov 2017 15:21:54 GMT

←Older revision		Revision as of 15:21, 16 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of ALiS1-Streptavidin complex==		==Crystal structure of ALiS1-Streptavidin complex==
	<StructureSection load='4y59' size='340' side='right' caption='[[4y59]], [[Resolution\|resolution]] 1.22Å' scene=''>		<StructureSection load='4y59' size='340' side='right' caption='[[4y59]], [[Resolution\|resolution]] 1.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4y59]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y59 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4y59]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1583 As 4.1583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y59 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T21:2-[3-(TRIFLUOROMETHYL)PHENYL]FURO[3,2-C]PYRIDIN-4(5H)-ONE'>T21</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T21:2-[3-(TRIFLUOROMETHYL)PHENYL]FURO[3,2-C]PYRIDIN-4(5H)-ONE'>T21</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y5d\|4y5d]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y5d\|4y5d]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y59 OCA], [http://pdbe.org/4y59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y59 RCSB], [http://www.ebi.ac.uk/pdbsum/4y59 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y59 OCA], [http://pdbe.org/4y59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y59 RCSB], [http://www.ebi.ac.uk/pdbsum/4y59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y59 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: As 4 1583]]
	[[Category: Ishida, H]]		[[Category: Ishida, H]]
	[[Category: Kohno, M]]		[[Category: Kohno, M]]

OCA at 07:44, 16 December 2015

OCA — Wed, 16 Dec 2015 07:44:20 GMT

←Older revision		Revision as of 07:44, 16 December 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of ALiS1-Streptavidin complex==
		+	<StructureSection load='4y59' size='340' side='right' caption='[[4y59]], [[Resolution\|resolution]] 1.22Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4y59]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y59 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T21:2-[3-(TRIFLUOROMETHYL)PHENYL]FURO[3,2-C]PYRIDIN-4(5H)-ONE'>T21</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y5d\|4y5d]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y59 OCA], [http://pdbe.org/4y59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y59 RCSB], [http://www.ebi.ac.uk/pdbsum/4y59 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV]] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Artificial ligands of streptavidin (ALiS) with association constants of approximately 10(6) M(-1) were discovered by high-throughput screening of our chemical library, and their binding characteristics, including X-ray crystal structure of the streptavidin complex, were determined. Unlike biotin and its derivatives, ALiS exhibits fast dissociation kinetics and excellent cell permeability. The streptavidin-ALiS system provides a novel, practical compound-dependent methodology for repeated reversible cycling of protein localization between intracellular organella.

-	~~The entry 4y59 is ON HOLD~~	+	Artificial Ligands of Streptavidin (ALiS): Discovery, Characterization, and Application for Reversible Control of Intracellular Protein Transport.,Terai T, Kohno M, Boncompain G, Sugiyama S, Saito N, Fujikake R, Ueno T, Komatsu T, Hanaoka K, Okabe T, Urano Y, Perez F, Nagano T J Am Chem Soc. 2015 Aug 26;137(33):10464-7. doi: 10.1021/jacs.5b05672. Epub 2015 , Aug 11. PMID:26261872<ref>PMID:26261872</ref>

-	~~Authors: Sugiyama~~, S.~~, Terai, T., Kohno, M., Ishida, H., Nagano, T~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Crystal structure of ALiS1~~-~~Streptavidin complex~~	+	<div class="pdbe-citations 4y59" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
-	[[Category: ~~Terai~~, T]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ishida, H]]
		+	[[Category: Kohno, M]]
	[[Category: Nagano, T]]		[[Category: Nagano, T]]
-	[[Category: Ishida, H]]
	[[Category: Sugiyama, S]]		[[Category: Sugiyama, S]]
-	[[Category: ~~Kohno~~, M]]	+	[[Category: Terai, T]]
		+	[[Category: Biotin-binding protein]]
		+	[[Category: Inhibitor]]

OCA at 10:18, 11 March 2015

OCA — Wed, 11 Mar 2015 10:18:20 GMT

←Older revision		Revision as of 10:18, 11 March 2015
Line 5:		Line 5:
	Authors: Sugiyama, S., Terai, T., Kohno, M., Ishida, H., Nagano, T.		Authors: Sugiyama, S., Terai, T., Kohno, M., Ishida, H., Nagano, T.

-	Description: ~~CRYSTAL STRUCTURE OF T021964~~-~~STREPTAVIDIN COMPLEX~~	+	Description: Crystal structure of ALiS1-Streptavidin complex
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Terai, T]]		[[Category: Terai, T]]

OCA: Protected "4y59" [edit=sysop:move=sysop]

OCA — Wed, 18 Feb 2015 12:02:43 GMT

Protected "4y59" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:02, 18 February 2015

OCA: New page: '''Unreleased structure''' The entry 4y59 is ON HOLD Authors: Sugiyama, S., Terai, T., Kohno, M., Ishida, H., Nagano, T. Description: CRYSTAL STRUCTURE OF T021964-STREPTAVIDIN COMPLEX ...

OCA — Wed, 18 Feb 2015 12:02:42 GMT

New page: '''Unreleased structure''' The entry 4y59 is ON HOLD Authors: Sugiyama, S., Terai, T., Kohno, M., Ishida, H., Nagano, T. Description: CRYSTAL STRUCTURE OF T021964-STREPTAVIDIN COMPLEX ...

New page

'''Unreleased structure'''

The entry 4y59 is ON HOLD

Authors: Sugiyama, S., Terai, T., Kohno, M., Ishida, H., Nagano, T.

Description: CRYSTAL STRUCTURE OF T021964-STREPTAVIDIN COMPLEX
[[Category: Unreleased Structures]]
[[Category: Terai, T]]
[[Category: Nagano, T]]
[[Category: Ishida, H]]
[[Category: Sugiyama, S]]
[[Category: Kohno, M]]