4y5u - Revision history

OCA at 15:33, 8 November 2023

OCA — Wed, 08 Nov 2023 15:33:51 GMT

←Older revision		Revision as of 15:33, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4y5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y5U FirstGlance]. <br>		<table><tr><td colspan='2'>[[4y5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y5U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.708Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y5u OCA], [https://pdbe.org/4y5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y5u RCSB], [https://www.ebi.ac.uk/pdbsum/4y5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y5u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y5u OCA], [https://pdbe.org/4y5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y5u RCSB], [https://www.ebi.ac.uk/pdbsum/4y5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y5u ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:59, 3 May 2023

OCA — Wed, 03 May 2023 07:59:44 GMT

←Older revision		Revision as of 07:59, 3 May 2023
Line 3:		Line 3:
	<StructureSection load='4y5u' size='340' side='right'caption='[[4y5u]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='4y5u' size='340' side='right'caption='[[4y5u]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4y5u]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y5U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Y5U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4y5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y5U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y5u OCA], [https://pdbe.org/4y5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y5u RCSB], [https://www.ebi.ac.uk/pdbsum/4y5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y5u ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y5w\|4y5w]]</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STAT6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4y5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y5u OCA], [~~http~~://pdbe.org/4y5u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4y5u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4y5u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4y5u ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/STAT6_HUMAN STAT6_HUMAN]] Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.	+	[https://www.uniprot.org/uniprot/STAT6_HUMAN STAT6_HUMAN] Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li, J]]	+	[[Category: Li J]]
-	[[Category: Liu, Z]]	+	[[Category: Liu Z]]
-	[[Category: Niu, F]]	+	[[Category: Niu F]]
-	[[Category: Ouyang, S]]	+	[[Category: Ouyang S]]
-	~~[[Category: Dimerization]]~~	+
-	~~[[Category: Dna binding]]~~	+
-	~~[[Category: Innate immune]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 23:37, 5 June 2019

OCA — Wed, 05 Jun 2019 23:37:27 GMT

←Older revision		Revision as of 23:37, 5 June 2019
Line 1:		Line 1:

	==Transcription factor==		==Transcription factor==
-	<StructureSection load='4y5u' size='340' side='right' caption='[[4y5u]], [[Resolution\|resolution]] 2.71Å' scene=''>	+	<StructureSection load='4y5u' size='340' side='right'caption='[[4y5u]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4y5u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y5U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4y5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y5U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y5w\|4y5w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y5w\|4y5w]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STAT6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y5u OCA], [http://pdbe.org/4y5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y5u RCSB], [http://www.ebi.ac.uk/pdbsum/4y5u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y5u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y5u OCA], [http://pdbe.org/4y5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y5u RCSB], [http://www.ebi.ac.uk/pdbsum/4y5u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y5u ProSAT]</span></td></tr>
	</table>		</table>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Li, J]]		[[Category: Li, J]]
	[[Category: Liu, Z]]		[[Category: Liu, Z]]

OCA at 03:35, 10 December 2016

OCA — Sat, 10 Dec 2016 03:35:10 GMT

←Older revision		Revision as of 03:35, 10 December 2016
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/STAT6_HUMAN STAT6_HUMAN]] Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.		[[http://www.uniprot.org/uniprot/STAT6_HUMAN STAT6_HUMAN]] Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	STAT6 participates in classical IL-4/IL-13 signaling and stimulator of interferon genes-mediated antiviral innate immune responses. Aberrations in STAT6-mediated signaling are linked to development of asthma and diseases of the immune system. In addition, STAT6 remains constitutively active in multiple types of cancer. Therefore, targeting STAT6 is an attractive proposition for treating related diseases. Although a lot is known about the role of STAT6 in transcriptional regulation, molecular details on how STAT6 recognizes and binds specific segments of DNA to exert its function are not clearly understood. Here, we report the crystal structures of a homodimer of phosphorylated STAT6 core fragment (STAT6CF) alone and bound with the N3 and N4 DNA binding site. Analysis of the structures reveals that STAT6 undergoes a dramatic conformational change on DNA binding, which was further validated by performing molecular dynamics simulation studies and small angle X-ray scattering analysis. Our data show that a larger angle at the intersection where the two protomers of STAT meet and the presence of a unique residue, H415, in the DNA-binding domain play important roles in discrimination of the N4 site DNA from the N3 site by STAT6. H415N mutation of STAT6CF decreased affinity of the protein for the N4 site DNA, but increased its affinity for N3 site DNA, both in vitro and in vivo. Results of our structure-function studies on STAT6 shed light on mechanism of DNA recognition by STATs in general and explain the reasons underlying STAT6's preference for N4 site DNA over N3.
		+
		+	Structural basis for DNA recognition by STAT6.,Li J, Rodriguez JP, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13015-13020. Epub 2016 Nov 1. PMID:27803324<ref>PMID:27803324</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4y5u" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:15, 2 November 2016

OCA — Wed, 02 Nov 2016 11:15:56 GMT

←Older revision		Revision as of 11:15, 2 November 2016
Line 7:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y5w\|4y5w]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y5w\|4y5w]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y5u OCA], [http://pdbe.org/4y5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y5u RCSB], [http://www.ebi.ac.uk/pdbsum/4y5u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y5u OCA], [http://pdbe.org/4y5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y5u RCSB], [http://www.ebi.ac.uk/pdbsum/4y5u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y5u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 02:50, 21 February 2016

OCA — Sun, 21 Feb 2016 02:50:42 GMT

←Older revision		Revision as of 02:50, 21 February 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4y5u is ~~ON HOLD until Paper Publication~~	+	==Transcription factor==
-		+	<StructureSection load='4y5u' size='340' side='right' caption='[[4y5u]], [[Resolution\|resolution]] 2.71Å' scene=''>
-	~~Authors~~: Li, J., ~~Niu, F~~., ~~Ouyang, S~~., ~~Liu, Z~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4y5u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y5U FirstGlance]. <br>
-	~~Description: Transcription factor~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y5w\|4y5w]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y5u OCA], [http://pdbe.org/4y5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y5u RCSB], [http://www.ebi.ac.uk/pdbsum/4y5u PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/STAT6_HUMAN STAT6_HUMAN]] Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.
		+	__TOC__
		+	</StructureSection>
	[[Category: Li, J]]		[[Category: Li, J]]
-	[[Category: Ouyang, S]]
	[[Category: Liu, Z]]		[[Category: Liu, Z]]
	[[Category: Niu, F]]		[[Category: Niu, F]]
		+	[[Category: Ouyang, S]]
		+	[[Category: Dimerization]]
		+	[[Category: Dna binding]]
		+	[[Category: Innate immune]]
		+	[[Category: Transcription]]

OCA at 10:19, 11 March 2015

OCA — Wed, 11 Mar 2015 10:19:09 GMT

←Older revision		Revision as of 10:19, 11 March 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4y5u is ON HOLD	+	The entry 4y5u is ON HOLD until Paper Publication

	Authors: Li, J., Niu, F., Ouyang, S., Liu, Z.		Authors: Li, J., Niu, F., Ouyang, S., Liu, Z.

OCA at 10:07, 4 March 2015

OCA — Wed, 04 Mar 2015 10:07:13 GMT

←Older revision		Revision as of 10:07, 4 March 2015
Line 3:		Line 3:
	The entry 4y5u is ON HOLD		The entry 4y5u is ON HOLD

-	Authors: ~~Jing,~~ Li, ~~Fengfeng~~, Niu, ~~Songying~~ Ouyang, ~~Zhi-Jie~~ Liu	+	Authors: Li, J., Niu, F., Ouyang, S., Liu, Z.

	Description: Transcription factor		Description: Transcription factor
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Jing,~~ Li, ~~Fengfeng~~, Niu, ~~Songying Ouyang, Zhi-Jie Liu~~]]	+	[[Category: Li, J]]
		+	[[Category: Ouyang, S]]
		+	[[Category: Liu, Z]]
		+	[[Category: Niu, F]]

OCA: Protected "4y5u" [edit=sysop:move=sysop]

OCA — Wed, 18 Feb 2015 12:04:03 GMT

Protected "4y5u" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:04, 18 February 2015

OCA: New page: '''Unreleased structure''' The entry 4y5u is ON HOLD Authors: Jing, Li, Fengfeng, Niu, Songying Ouyang, Zhi-Jie Liu Description: Transcription factor [[Category: Unreleased Structures]...

OCA — Wed, 18 Feb 2015 12:04:01 GMT

New page: '''Unreleased structure''' The entry 4y5u is ON HOLD Authors: Jing, Li, Fengfeng, Niu, Songying Ouyang, Zhi-Jie Liu Description: Transcription factor [[Category: Unreleased Structures]...

New page

'''Unreleased structure'''

The entry 4y5u is ON HOLD

Authors: Jing, Li, Fengfeng, Niu, Songying Ouyang, Zhi-Jie Liu

Description: Transcription factor
[[Category: Unreleased Structures]]
[[Category: Jing, Li, Fengfeng, Niu, Songying Ouyang, Zhi-Jie Liu]]