4y6s - Revision history

OCA at 11:30, 9 May 2024

OCA — Thu, 09 May 2024 11:30:37 GMT

←Older revision		Revision as of 11:30, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4y6s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y6S FirstGlance]. <br>		<table><tr><td colspan='2'>[[4y6s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y6S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=48S:[(2R)-4-[HYDROXY(METHYL)AMINO]-2-(4-METHYLPHENYL)-4-OXOBUTYL]PHOSPHONIC+ACID'>48S</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=48S:[(2R)-4-[HYDROXY(METHYL)AMINO]-2-(4-METHYLPHENYL)-4-OXOBUTYL]PHOSPHONIC+ACID'>48S</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y6s OCA], [https://pdbe.org/4y6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y6s RCSB], [https://www.ebi.ac.uk/pdbsum/4y6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y6s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y6s OCA], [https://pdbe.org/4y6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y6s RCSB], [https://www.ebi.ac.uk/pdbsum/4y6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y6s ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:01, 3 May 2023

OCA — Wed, 03 May 2023 08:01:08 GMT

←Older revision		Revision as of 08:01, 3 May 2023
Line 3:		Line 3:
	<StructureSection load='4y6s' size='340' side='right'caption='[[4y6s]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4y6s' size='340' side='right'caption='[[4y6s]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4y6s]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y6S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Y6S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4y6s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y6S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y6S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=48S:[(2R)-4-[HYDROXY(METHYL)AMINO]-2-(4-METHYLPHENYL)-4-OXOBUTYL]PHOSPHONIC+ACID'>48S</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=48S:[(2R)-4-[HYDROXY(METHYL)AMINO]-2-(4-METHYLPHENYL)-4-OXOBUTYL]PHOSPHONIC+ACID'>48S</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y67\|4y67]], [[4y6p\|4y6p]], [[4y6r\|4y6r]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y6s OCA], [https://pdbe.org/4y6s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y6s RCSB], [https://www.ebi.ac.uk/pdbsum/4y6s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y6s ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DXR, PF14_0641 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4y6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y6s OCA], [~~http~~://pdbe.org/4y6s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4y6s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4y6s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4y6s ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DXR_PLAF7 DXR_PLAF7]] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).	+	[https://www.uniprot.org/uniprot/DXR_PLAF7 DXR_PLAF7] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[DXP reductoisomerase\|DXP reductoisomerase]]	+	*[[DXP reductoisomerase 3D Structures\|DXP reductoisomerase 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plaf7~~]]	+	[[Category: Plasmodium falciparum 3D7]]
-	[[Category: Bergfors, T]]	+	[[Category: Bergfors T]]
-	[[Category: Jones~~, T A~~]]	+	[[Category: Jones TA]]
-	[[Category: Mowbray~~, S L~~]]	+	[[Category: Mowbray SL]]
-	[[Category: Sooriyaarachchi, S]]	+	[[Category: Sooriyaarachchi S]]
-	~~[[Category: Enzyme-inhibitor complex]]~~	+
-	~~[[Category: Isoprenoid biosynthesis]]~~	+
-	~~[[Category: Mep pathway]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 23:47, 5 June 2019

OCA — Wed, 05 Jun 2019 23:47:55 GMT

←Older revision		Revision as of 23:47, 5 June 2019
Line 1:		Line 1:

	==Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC134, and manganese==		==Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC134, and manganese==
-	<StructureSection load='4y6s' size='340' side='right' caption='[[4y6s]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4y6s' size='340' side='right'caption='[[4y6s]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4y6s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y6S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4y6s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y6S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=48S:[(2R)-4-[HYDROXY(METHYL)AMINO]-2-(4-METHYLPHENYL)-4-OXOBUTYL]PHOSPHONIC+ACID'>48S</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=48S:[(2R)-4-[HYDROXY(METHYL)AMINO]-2-(4-METHYLPHENYL)-4-OXOBUTYL]PHOSPHONIC+ACID'>48S</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y67\|4y67]], [[4y6p\|4y6p]], [[4y6r\|4y6r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y67\|4y67]], [[4y6p\|4y6p]], [[4y6r\|4y6r]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DXR, PF14_0641 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y6s OCA], [http://pdbe.org/4y6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y6s RCSB], [http://www.ebi.ac.uk/pdbsum/4y6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y6s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y6s OCA], [http://pdbe.org/4y6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y6s RCSB], [http://www.ebi.ac.uk/pdbsum/4y6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y6s ProSAT]</span></td></tr>
Line 28:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]		[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
		+	[[Category: Large Structures]]
		+	[[Category: Plaf7]]
	[[Category: Bergfors, T]]		[[Category: Bergfors, T]]
	[[Category: Jones, T A]]		[[Category: Jones, T A]]

OCA at 01:57, 10 March 2017

OCA — Fri, 10 Mar 2017 01:57:48 GMT

←Older revision		Revision as of 01:57, 10 March 2017
Line 1:		Line 1:
		+
	==Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC134, and manganese==		==Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC134, and manganese==
	<StructureSection load='4y6s' size='340' side='right' caption='[[4y6s]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4y6s' size='340' side='right' caption='[[4y6s]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y67\|4y67]], [[4y6p\|4y6p]], [[4y6r\|4y6r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y67\|4y67]], [[4y6p\|4y6p]], [[4y6r\|4y6r]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4y6s RCSB], [http://www.ebi.ac.uk/pdbsum/4y6s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y6s OCA], [http://pdbe.org/4y6s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y6s RCSB], [http://www.ebi.ac.uk/pdbsum/4y6s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y6s ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4y6s" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DXP reductoisomerase\|DXP reductoisomerase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:13, 1 April 2015

OCA — Wed, 01 Apr 2015 13:13:17 GMT

←Older revision		Revision as of 13:13, 1 April 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC134, and manganese==
		+	<StructureSection load='4y6s' size='340' side='right' caption='[[4y6s]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4y6s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y6S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y6S FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=48S:[(2R)-4-[HYDROXY(METHYL)AMINO]-2-(4-METHYLPHENYL)-4-OXOBUTYL]PHOSPHONIC+ACID'>48S</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4y67\|4y67]], [[4y6p\|4y6p]], [[4y6r\|4y6r]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y6s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4y6s RCSB], [http://www.ebi.ac.uk/pdbsum/4y6s PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DXR_PLAF7 DXR_PLAF7]] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Blocking the 2-C-methyl-d-erythrithol-4-phosphate (MEP) pathway for isoprenoid biosynthesis offers interesting prospects for inhibiting Plasmodium or Mycobacterium spp. growth. Fosmidomycin (1) and its homologue FR900098 (2) potently inhibit 1-deoxy-d-xylulose-5-phosphate reductoisomerase (Dxr), a key enzyme in this pathway. Here we introduced aryl or aralkyl substituents at the beta-position of the hydroxamate analogue of 2. While direct addition of a beta-aryl moiety resulted in poor inhibition, longer linkers between the carbon backbone and the phenyl ring were generally associated with better binding to the enzymes. X-ray structures of the parasite Dxr-inhibitor complexes show that the "longer" compounds generate a substantially different flap structure, in which a key tryptophan residue is displaced, and the aromatic group of the ligand lies between the tryptophan and the hydroxamate's methyl group. Although the most promising new Dxr inhibitors lack activity against Escherichia coli and Mycobacterium smegmatis, they proved to be highly potent inhibitors of Plasmodium falciparum in vitro growth.

-	~~The entry 4y6s is ON HOLD until Paper Publication~~	+	Synthesis and Bioactivity of beta-Substituted Fosmidomycin Analogues Targeting 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase.,Chofor R, Sooriyaarachchi S, Risseeuw MD, Bergfors T, Pouyez J, Johny C, Haymond A, Everaert A, Dowd CS, Maes L, Coenye T, Alex A, Couch RD, Jones TA, Wouters J, Mowbray SL, Van Calenbergh S J Med Chem. 2015 Mar 31. PMID:25781377<ref>PMID:25781377</ref>

-	~~Authors: Sooriyaarachchi~~, S.~~, Bergfors, T., Jones, T.A., Mowbray,~~ S.L.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC134, and manganese~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
	[[Category: Bergfors, T]]		[[Category: Bergfors, T]]
-	[[Category: Jones, T.A]]	+	[[Category: Jones, T A]]
-	[[Category: Mowbray, S.L]]	+	[[Category: Mowbray, S L]]
	[[Category: Sooriyaarachchi, S]]		[[Category: Sooriyaarachchi, S]]
		+	[[Category: Enzyme-inhibitor complex]]
		+	[[Category: Isoprenoid biosynthesis]]
		+	[[Category: Mep pathway]]
		+	[[Category: Oxidoreductase]]

OCA at 12:43, 25 February 2015

OCA — Wed, 25 Feb 2015 12:43:54 GMT

←Older revision		Revision as of 12:43, 25 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4y6s is ON HOLD	+	The entry 4y6s is ON HOLD until Paper Publication

-	Authors: Sooriyaarachchi, S., Bergfors, T., Jones, A.T., Mowbray, S.L.	+	Authors: Sooriyaarachchi, S., Bergfors, T., Jones, T.A., Mowbray, S.L.

	Description: Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC134, and manganese		Description: Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC134, and manganese
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Bergfors, T]]		[[Category: Bergfors, T]]
-	[[Category: Jones, A.T]]	+	[[Category: Jones, T.A]]
	[[Category: Mowbray, S.L]]		[[Category: Mowbray, S.L]]
	[[Category: Sooriyaarachchi, S]]		[[Category: Sooriyaarachchi, S]]

OCA: Protected "4y6s" [edit=sysop:move=sysop]

OCA — Wed, 18 Feb 2015 12:06:52 GMT

Protected "4y6s" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:06, 18 February 2015

OCA: New page: '''Unreleased structure''' The entry 4y6s is ON HOLD Authors: Sooriyaarachchi, S., Bergfors, T., Jones, A.T., Mowbray, S.L. Description: Structure of Plasmodium falciparum DXR in compl...

OCA — Wed, 18 Feb 2015 12:06:51 GMT

New page: '''Unreleased structure''' The entry 4y6s is ON HOLD Authors: Sooriyaarachchi, S., Bergfors, T., Jones, A.T., Mowbray, S.L. Description: Structure of Plasmodium falciparum DXR in compl...

New page

'''Unreleased structure'''

The entry 4y6s is ON HOLD

Authors: Sooriyaarachchi, S., Bergfors, T., Jones, A.T., Mowbray, S.L.

Description: Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, RC134, and manganese
[[Category: Unreleased Structures]]
[[Category: Bergfors, T]]
[[Category: Jones, A.T]]
[[Category: Mowbray, S.L]]
[[Category: Sooriyaarachchi, S]]