4y7b - Revision history

OCA at 10:53, 10 January 2024

OCA — Wed, 10 Jan 2024 10:53:36 GMT

←Older revision		Revision as of 10:53, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4y7b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y7B FirstGlance]. <br>		<table><tr><td colspan='2'>[[4y7b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y7B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=44I:6-CHLORO-N-{(3S)-1-[(2S)-1-{(1R,5S)-7-[2-(METHYLAMINO)ETHYL]-3,7-DIAZABICYCLO[3.3.1]NON-3-YL}-1-OXOPROPAN-2-YL]-2-OXOPYRROLIDIN-3-YL}NAPHTHALENE-2-SULFONAMIDE'>44I</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.79Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=44I:6-CHLORO-N-{(3S)-1-[(2S)-1-{(1R,5S)-7-[2-(METHYLAMINO)ETHYL]-3,7-DIAZABICYCLO[3.3.1]NON-3-YL}-1-OXOPROPAN-2-YL]-2-OXOPYRROLIDIN-3-YL}NAPHTHALENE-2-SULFONAMIDE'>44I</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y7b OCA], [https://pdbe.org/4y7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y7b RCSB], [https://www.ebi.ac.uk/pdbsum/4y7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y7b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y7b OCA], [https://pdbe.org/4y7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y7b RCSB], [https://www.ebi.ac.uk/pdbsum/4y7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y7b ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:01, 3 May 2023

OCA — Wed, 03 May 2023 08:01:35 GMT

←Older revision		Revision as of 08:01, 3 May 2023
Line 3:		Line 3:
	<StructureSection load='4y7b' size='340' side='right'caption='[[4y7b]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='4y7b' size='340' side='right'caption='[[4y7b]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4y7b]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y7B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Y7B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4y7b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y7B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=44I:6-CHLORO-N-{(3S)-1-[(2S)-1-{(1R,5S)-7-[2-(METHYLAMINO)ETHYL]-3,7-DIAZABICYCLO[3.3.1]NON-3-YL}-1-OXOPROPAN-2-YL]-2-OXOPYRROLIDIN-3-YL}NAPHTHALENE-2-SULFONAMIDE'>44I</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=44I:6-CHLORO-N-{(3S)-1-[(2S)-1-{(1R,5S)-7-[2-(METHYLAMINO)ETHYL]-3,7-DIAZABICYCLO[3.3.1]NON-3-YL}-1-OXOPROPAN-2-YL]-2-OXOPYRROLIDIN-3-YL}NAPHTHALENE-2-SULFONAMIDE'>44I</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y7b OCA], [https://pdbe.org/4y7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y7b RCSB], [https://www.ebi.ac.uk/pdbsum/4y7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y7b ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4y7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y7b OCA], [~~http~~://pdbe.org/4y7b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4y7b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4y7b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4y7b ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[~~http~~://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>	+	[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.	+	[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Factor Xa inhibitory activities for a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl }sulfonamides with different P1 groups are described. These data provide insight into binding interactions within the S1 primary specificity pocket; rationales are presented for the derived SAR on the basis of electronic interactions through crystal structures of fXa-ligand complexes and molecular modeling studies. A good correlation between in vitro anticoagulant activities with lipophilicity and the extent of human serum albumin binding is observed within this series of potent fXa inhibitors. Pharmacokinetic profiles in rat and dog, together with selectivity over other trypsin-like serine proteases, identified 1f as a candidate for further evaluation.	+
-		+
-	Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl }sulfonamides.,Chan C, Borthwick AD, Brown D, Burns-Kurtis CL, Campbell M, Chaudry L, Chung CW, Convery MA, Hamblin JN, Johnstone L, Kelly HA, Kleanthous S, Patikis A, Patel C, Pateman AJ, Senger S, Shah GP, Toomey JR, Watson NS, Weston HE, Whitworth C, Young RJ, Zhou P J Med Chem. 2007 Apr 5;50(7):1546-57. Epub 2007 Mar 6. PMID:17338508<ref>PMID:17338508</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 4y7b" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
Line 28:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chan, C]]	+	[[Category: Chan C]]
-	[[Category: Convery~~, M A~~]]	+	[[Category: Convery MA]]
-	[[Category: Hamblin~~, J N~~]]	+	[[Category: Hamblin JN]]
-	[[Category: Senger, S]]	+	[[Category: Senger S]]
-	[[Category: Toomey~~, J R~~]]	+	[[Category: Toomey JR]]
-	[[Category: Watson~~, N S~~]]	+	[[Category: Watson NS]]
-	[[Category: Young~~, R J]]~~	+	[[Category: Young RJ]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Inhibitor~~]]	+

OCA at 23:33, 5 June 2019

OCA — Wed, 05 Jun 2019 23:33:49 GMT

←Older revision		Revision as of 23:33, 5 June 2019
Line 1:		Line 1:
		+
	==Factor Xa complex with GTC000441==		==Factor Xa complex with GTC000441==
-	<StructureSection load='4y7b' size='340' side='right' caption='[[4y7b]], [[Resolution\|resolution]] 1.79Å' scene=''>	+	<StructureSection load='4y7b' size='340' side='right'caption='[[4y7b]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4y7b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y7B FirstGlance]. <br>		<table><tr><td colspan='2'>[[4y7b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y7B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=44I:6-CHLORO-N-{(3S)-1-[(2S)-1-{(1R,5S)-7-[2-(METHYLAMINO)ETHYL]-3,7-DIAZABICYCLO[3.3.1]NON-3-YL}-1-OXOPROPAN-2-YL]-2-OXOPYRROLIDIN-3-YL}NAPHTHALENE-2-SULFONAMIDE'>44I</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=44I:6-CHLORO-N-{(3S)-1-[(2S)-1-{(1R,5S)-7-[2-(METHYLAMINO)ETHYL]-3,7-DIAZABICYCLO[3.3.1]NON-3-YL}-1-OXOPROPAN-2-YL]-2-OXOPYRROLIDIN-3-YL}NAPHTHALENE-2-SULFONAMIDE'>44I</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y7b OCA], [http://pdbe.org/4y7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y7b RCSB], [http://www.ebi.ac.uk/pdbsum/4y7b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y7b OCA], [http://pdbe.org/4y7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y7b RCSB], [http://www.ebi.ac.uk/pdbsum/4y7b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y7b ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4y7b" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4y7b" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Factor Xa\|Factor Xa]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 30:
	[[Category: Coagulation factor Xa]]		[[Category: Coagulation factor Xa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Chan, C]]		[[Category: Chan, C]]
	[[Category: Convery, M A]]		[[Category: Convery, M A]]

OCA at 14:35, 30 September 2015

OCA — Wed, 30 Sep 2015 14:35:32 GMT

←Older revision		Revision as of 14:35, 30 September 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Factor Xa complex with GTC000441==
		+	<StructureSection load='4y7b' size='340' side='right' caption='[[4y7b]], [[Resolution\|resolution]] 1.79Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4y7b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y7B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y7B FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=44I:6-CHLORO-N-{(3S)-1-[(2S)-1-{(1R,5S)-7-[2-(METHYLAMINO)ETHYL]-3,7-DIAZABICYCLO[3.3.1]NON-3-YL}-1-OXOPROPAN-2-YL]-2-OXOPYRROLIDIN-3-YL}NAPHTHALENE-2-SULFONAMIDE'>44I</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y7b OCA], [http://pdbe.org/4y7b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y7b RCSB], [http://www.ebi.ac.uk/pdbsum/4y7b PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Factor Xa inhibitory activities for a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl }sulfonamides with different P1 groups are described. These data provide insight into binding interactions within the S1 primary specificity pocket; rationales are presented for the derived SAR on the basis of electronic interactions through crystal structures of fXa-ligand complexes and molecular modeling studies. A good correlation between in vitro anticoagulant activities with lipophilicity and the extent of human serum albumin binding is observed within this series of potent fXa inhibitors. Pharmacokinetic profiles in rat and dog, together with selectivity over other trypsin-like serine proteases, identified 1f as a candidate for further evaluation.

-	~~The entry 4y7b is ON HOLD until Aug 13 2016~~	+	Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl }sulfonamides.,Chan C, Borthwick AD, Brown D, Burns-Kurtis CL, Campbell M, Chaudry L, Chung CW, Convery MA, Hamblin JN, Johnstone L, Kelly HA, Kleanthous S, Patikis A, Patel C, Pateman AJ, Senger S, Shah GP, Toomey JR, Watson NS, Weston HE, Whitworth C, Young RJ, Zhou P J Med Chem. 2007 Apr 5;50(7):1546-57. Epub 2007 Mar 6. PMID:17338508<ref>PMID:17338508</ref>

-	~~Authors: Convery~~, M.~~A., Young, R.J., Senger,~~ S.~~, Hamblin, J~~.~~N.,~~ Chan, C~~., Toomey, J.R., Watson, N.S.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Factor Xa complex with GTC000441~~	+	<div class="pdbe-citations 4y7b" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Coagulation factor Xa]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Chan, C]]
		+	[[Category: Convery, M A]]
		+	[[Category: Hamblin, J N]]
	[[Category: Senger, S]]		[[Category: Senger, S]]
-	[[Category: Toomey, J.R]]	+	[[Category: Toomey, J R]]
-	~~[[Category: Hamblin, J.N~~]]	+	[[Category: Watson, N S]]
-	[[Category: Watson, N.S]]	+	[[Category: Young, R J]]
-	[[Category: Young, R.J]]	+	[[Category: Hydrolase]]
-	[[Category: ~~Convery, M.A~~]]	+	[[Category: Inhibitor]]
-	[[Category: ~~Chan, C~~]]	+

OCA at 10:21, 11 March 2015

OCA — Wed, 11 Mar 2015 10:21:39 GMT

←Older revision		Revision as of 10:21, 11 March 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4y7b is ON HOLD	+	The entry 4y7b is ON HOLD until Aug 13 2016

	Authors: Convery, M.A., Young, R.J., Senger, S., Hamblin, J.N., Chan, C., Toomey, J.R., Watson, N.S.		Authors: Convery, M.A., Young, R.J., Senger, S., Hamblin, J.N., Chan, C., Toomey, J.R., Watson, N.S.

OCA: Protected "4y7b" [edit=sysop:move=sysop]

OCA — Wed, 25 Feb 2015 12:45:00 GMT

Protected "4y7b" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:45, 25 February 2015

OCA: New page: '''Unreleased structure''' The entry 4y7b is ON HOLD Authors: Convery, M.A., Young, R.J., Senger, S., Hamblin, J.N., Chan, C., Toomey, J.R., Watson, N.S. Description: Factor Xa complex...

OCA — Wed, 25 Feb 2015 12:44:59 GMT

New page: '''Unreleased structure''' The entry 4y7b is ON HOLD Authors: Convery, M.A., Young, R.J., Senger, S., Hamblin, J.N., Chan, C., Toomey, J.R., Watson, N.S. Description: Factor Xa complex...

New page

'''Unreleased structure'''

The entry 4y7b is ON HOLD

Authors: Convery, M.A., Young, R.J., Senger, S., Hamblin, J.N., Chan, C., Toomey, J.R., Watson, N.S.

Description: Factor Xa complex with GTC000441
[[Category: Unreleased Structures]]
[[Category: Senger, S]]
[[Category: Toomey, J.R]]
[[Category: Hamblin, J.N]]
[[Category: Watson, N.S]]
[[Category: Young, R.J]]
[[Category: Convery, M.A]]
[[Category: Chan, C]]