4yc5 - Revision history

OCA at 10:54, 10 January 2024

OCA — Wed, 10 Jan 2024 10:54:35 GMT

←Older revision		Revision as of 10:54, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4yc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YC5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4yc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YC5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.755Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yc5 OCA], [https://pdbe.org/4yc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yc5 RCSB], [https://www.ebi.ac.uk/pdbsum/4yc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yc5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yc5 OCA], [https://pdbe.org/4yc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yc5 RCSB], [https://www.ebi.ac.uk/pdbsum/4yc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yc5 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:08, 3 May 2023

OCA — Wed, 03 May 2023 08:08:06 GMT

←Older revision		Revision as of 08:08, 3 May 2023
Line 3:		Line 3:
	<StructureSection load='4yc5' size='340' side='right'caption='[[4yc5]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='4yc5' size='340' side='right'caption='[[4yc5]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yc5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YC5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4YC5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YC5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4yc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yc5 OCA], [~~http~~://pdbe.org/4yc5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4yc5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4yc5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4yc5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yc5 OCA], [https://pdbe.org/4yc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yc5 RCSB], [https://www.ebi.ac.uk/pdbsum/4yc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yc5 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Murray, J W~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Scaffold]]~~	+	[[Category: Murray JW]]
-	~~[[Category: Solenoid]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 06:51, 12 June 2019

OCA — Wed, 12 Jun 2019 06:51:48 GMT

←Older revision		Revision as of 06:51, 12 June 2019
Line 1:		Line 1:

	==Beta1 synthetic solenoid protein==		==Beta1 synthetic solenoid protein==
-	<StructureSection load='4yc5' size='340' side='right' caption='[[4yc5]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='4yc5' size='340' side='right'caption='[[4yc5]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4yc5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YC5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4yc5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YC5 FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Murray, J W]]		[[Category: Murray, J W]]
	[[Category: Scaffold]]		[[Category: Scaffold]]
	[[Category: Solenoid]]		[[Category: Solenoid]]
	[[Category: Structural protein]]		[[Category: Structural protein]]

OCA at 10:05, 19 October 2016

OCA — Wed, 19 Oct 2016 10:05:02 GMT

←Older revision		Revision as of 10:05, 19 October 2016
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[4yc5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YC5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4yc5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YC5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yc5 OCA], [http://pdbe.org/4yc5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yc5 RCSB], [http://www.ebi.ac.uk/pdbsum/4yc5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yc5 OCA], [http://pdbe.org/4yc5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yc5 RCSB], [http://www.ebi.ac.uk/pdbsum/4yc5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yc5 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ability to design and construct structures with atomic level precision is one of the key goals of nanotechnology. Proteins offer an attractive target for atomic design because they can be synthesized chemically or biologically and can self-assemble. However, the generalized protein folding and design problem is unsolved. One approach to simplifying the problem is to use a repetitive protein as a scaffold. Repeat proteins are intrinsically modular, and their folding and structures are better understood than large globular domains. Here, we have developed a class of synthetic repeat proteins based on the pentapeptide repeat family of beta-solenoid proteins. We have constructed length variants of the basic scaffold and computationally designed de novo loops projecting from the scaffold core. The experimentally solved 3.56-A resolution crystal structure of one designed loop matches closely the designed hairpin structure, showing the computational design of a backbone extension onto a synthetic protein core without the use of backbone fragments from known structures. Two other loop designs were not clearly resolved in the crystal structures, and one loop appeared to be in an incorrect conformation. We have also shown that the repeat unit can accommodate whole-domain insertions by inserting a domain into one of the designed loops.
		+
		+	Synthetic beta-solenoid proteins with the fragment-free computational design of a beta-hairpin extension.,MacDonald JT, Kabasakal BV, Godding D, Kraatz S, Henderson L, Barber J, Freemont PS, Murray JW Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10346-51. doi:, 10.1073/pnas.1525308113. Epub 2016 Aug 29. PMID:27573845<ref>PMID:27573845</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4yc5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 03:47, 10 March 2016

OCA — Thu, 10 Mar 2016 03:47:57 GMT

←Older revision		Revision as of 03:47, 10 March 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4yc5 ~~is ON HOLD~~	+	==Beta1 synthetic solenoid protein==
-		+	<StructureSection load='4yc5' size='340' side='right' caption='[[4yc5]], [[Resolution\|resolution]] 1.75Å' scene=''>
-	~~Authors~~: ~~Murray, J~~.W.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4yc5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YC5 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yc5 OCA], [http://pdbe.org/4yc5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yc5 RCSB], [http://www.ebi.ac.uk/pdbsum/4yc5 PDBsum]</span></td></tr>
-	[[Category: Murray, J.W]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Murray, J W]]
		+	[[Category: Scaffold]]
		+	[[Category: Solenoid]]
		+	[[Category: Structural protein]]

OCA: Protected "4yc5" [edit=sysop:move=sysop]

OCA — Wed, 25 Feb 2015 12:58:25 GMT

Protected "4yc5" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:58, 25 February 2015

OCA: New page: '''Unreleased structure''' The entry 4yc5 is ON HOLD Authors: Murray, J.W. Description: Category: Unreleased Structures Category: Murray, J.W

OCA — Wed, 25 Feb 2015 12:58:24 GMT

New page: '''Unreleased structure''' The entry 4yc5 is ON HOLD Authors: Murray, J.W. Description: Category: Unreleased Structures Category: Murray, J.W

New page

'''Unreleased structure'''

The entry 4yc5 is ON HOLD

Authors: Murray, J.W.

Description:
[[Category: Unreleased Structures]]
[[Category: Murray, J.W]]