4ye9 - Revision history

OCA at 07:57, 27 September 2023

OCA — Wed, 27 Sep 2023 07:57:56 GMT

←Older revision		Revision as of 07:57, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ye9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YE9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ye9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YE9 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ye9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ye9 OCA], [https://pdbe.org/4ye9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ye9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ye9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ye9 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ye9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ye9 OCA], [https://pdbe.org/4ye9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ye9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ye9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ye9 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 08:10, 3 May 2023

OCA — Wed, 03 May 2023 08:10:47 GMT

←Older revision		Revision as of 08:10, 3 May 2023
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	<StructureSection load='4ye9' size='340' side='right'caption='[[4ye9]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4ye9' size='340' side='right'caption='[[4ye9]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ye9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YE9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4YE9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ye9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YE9 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ye6\|4ye6]], [[4ye8\|4ye8]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ye9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ye9 OCA], [https://pdbe.org/4ye9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ye9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ye9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ye9 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">QARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--tRNA_ligase Glutamine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.18 6.1.1.18] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ye9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ye9 OCA], [~~http~~://pdbe.org/4ye9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ye9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ye9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ye9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/SYQ_HUMAN SYQ_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/SYQ_HUMAN SYQ_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SYQ_HUMAN SYQ_HUMAN]] Plays a critical role in brain development.<ref>PMID:24656866</ref>	+	[https://www.uniprot.org/uniprot/SYQ_HUMAN SYQ_HUMAN] Plays a critical role in brain development.<ref>PMID:24656866</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glutamine--tRNA ligase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ling, J]]	+	[[Category: Ling J]]
-	[[Category: Ognjenovic, J]]	+	[[Category: Ognjenovic J]]
-	[[Category: Simonovic, M]]	+	[[Category: Simonovic M]]
-	[[Category: Wu, J]]	+	[[Category: Wu J]]
-	~~[[Category: Aminoacyl-trna synthetase]]~~	+
-	~~[[Category: Class i aar]]~~	+
-	~~[[Category: Glutamine]]~~	+
-	~~[[Category: Ligase~~]]	+

OCA at 10:48, 25 December 2019

OCA — Wed, 25 Dec 2019 10:48:03 GMT

←Older revision		Revision as of 10:48, 25 December 2019
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	==The crystal structure of the G45V mutant of human GlnRS==		==The crystal structure of the G45V mutant of human GlnRS==
-	<StructureSection load='4ye9' size='340' side='right' caption='[[4ye9]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4ye9' size='340' side='right'caption='[[4ye9]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ye9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YE9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YE9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ye9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YE9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YE9 FirstGlance]. <br>
Line 22:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 4ye9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ye9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 31:
	[[Category: Glutamine--tRNA ligase]]		[[Category: Glutamine--tRNA ligase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ling, J]]		[[Category: Ling, J]]
	[[Category: Ognjenovic, J]]		[[Category: Ognjenovic, J]]

OCA at 12:19, 6 November 2017

OCA — Mon, 06 Nov 2017 12:19:07 GMT

←Older revision		Revision as of 12:19, 6 November 2017
Line 3:		Line 3:
	<StructureSection load='4ye9' size='340' side='right' caption='[[4ye9]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4ye9' size='340' side='right' caption='[[4ye9]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ye9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YE9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YE9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ye9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YE9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YE9 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ye6\|4ye6]], [[4ye8\|4ye8]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ye6\|4ye6]], [[4ye8\|4ye8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">QARS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--tRNA_ligase Glutamine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.18 6.1.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--tRNA_ligase Glutamine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.18 6.1.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ye9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ye9 OCA], [http://pdbe.org/4ye9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ye9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ye9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ye9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ye9 OCA], [http://pdbe.org/4ye9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ye9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ye9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ye9 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 26:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Glutamine--tRNA ligase]]		[[Category: Glutamine--tRNA ligase]]
		+	[[Category: Human]]
	[[Category: Ling, J]]		[[Category: Ling, J]]
	[[Category: Ognjenovic, J]]		[[Category: Ognjenovic, J]]

OCA at 10:19, 26 February 2016

OCA — Fri, 26 Feb 2016 10:19:44 GMT

←Older revision		Revision as of 10:19, 26 February 2016
Line 12:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SYQ_HUMAN SYQ_HUMAN]] Plays a critical role in brain development.<ref>PMID:24656866</ref>		[[http://www.uniprot.org/uniprot/SYQ_HUMAN SYQ_HUMAN]] Plays a critical role in brain development.<ref>PMID:24656866</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytosolic glutaminyl-tRNA synthetase (GlnRS) is the singular enzyme responsible for translation of glutamine codons. Compound heterozygous mutations in GlnRS cause severe brain disorders by a poorly understood mechanism. Herein, we present crystal structures of the wild type and two pathological mutants of human GlnRS, which reveal, for the first time, the domain organization of the intact enzyme and the structure of the functionally important N-terminal domain (NTD). Pathological mutations mapping in the NTD alter the domain structure, and decrease catalytic activity and stability of GlnRS, whereas missense mutations in the catalytic domain induce misfolding of the enzyme. Our results suggest that the reduced catalytic efficiency and a propensity of GlnRS mutants to misfold trigger the disease development. This report broadens the spectrum of brain pathologies elicited by protein misfolding and provides a paradigm for understanding the role of mutations in aminoacyl-tRNA synthetases in neurological diseases.
		+
		+	The crystal structure of human GlnRS provides basis for the development of neurological disorders.,Ognjenovic J, Wu J, Matthies D, Baxa U, Subramaniam S, Ling J, Simonovic M Nucleic Acids Res. 2016 Feb 10. pii: gkw082. PMID:26869582<ref>PMID:26869582</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4ye9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:50, 21 February 2016

OCA — Sun, 21 Feb 2016 02:50:57 GMT

←Older revision		Revision as of 02:50, 21 February 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 4ye9 is ~~ON HOLD until Paper Publication~~	+	==The crystal structure of the G45V mutant of human GlnRS==
-		+	<StructureSection load='4ye9' size='340' side='right' caption='[[4ye9]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~Authors~~: ~~Ognjenovic~~, J., Wu, J., ~~Ling, J~~., ~~Simonovic, M~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4ye9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YE9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YE9 FirstGlance]. <br>
-	~~Description~~: The ~~crystal structure of~~ the ~~G45V mutant of human GlnRS~~	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ye6\|4ye6]], [[4ye8\|4ye8]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--tRNA_ligase Glutamine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.18 6.1.1.18] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ye9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ye9 OCA], [http://pdbe.org/4ye9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ye9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ye9 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/SYQ_HUMAN SYQ_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SYQ_HUMAN SYQ_HUMAN]] Plays a critical role in brain development.<ref>PMID:24656866</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Glutamine--tRNA ligase]]
	[[Category: Ling, J]]		[[Category: Ling, J]]
	[[Category: Ognjenovic, J]]		[[Category: Ognjenovic, J]]
		+	[[Category: Simonovic, M]]
	[[Category: Wu, J]]		[[Category: Wu, J]]
-	[[Category: ~~Simonovic, M~~]]	+	[[Category: Aminoacyl-trna synthetase]]
		+	[[Category: Class i aar]]
		+	[[Category: Glutamine]]
		+	[[Category: Ligase]]

OCA at 23:33, 30 November 2015

OCA — Mon, 30 Nov 2015 23:33:20 GMT

←Older revision		Revision as of 23:33, 30 November 2015
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Ling, J]]		[[Category: Ling, J]]
-	[[Category: Simonovic, M]]
	[[Category: Ognjenovic, J]]		[[Category: Ognjenovic, J]]
	[[Category: Wu, J]]		[[Category: Wu, J]]
		+	[[Category: Simonovic, M]]

OCA at 12:22, 26 March 2015

OCA — Thu, 26 Mar 2015 12:22:14 GMT

←Older revision		Revision as of 12:22, 26 March 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ye9 is ON HOLD	+	The entry 4ye9 is ON HOLD until Paper Publication

	Authors: Ognjenovic, J., Wu, J., Ling, J., Simonovic, M.		Authors: Ognjenovic, J., Wu, J., Ling, J., Simonovic, M.

OCA: Protected "4ye9" [edit=sysop:move=sysop]

OCA — Wed, 04 Mar 2015 10:22:10 GMT

Protected "4ye9" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:22, 4 March 2015

OCA: New page: '''Unreleased structure''' The entry 4ye9 is ON HOLD Authors: Ognjenovic, J., Wu, J., Ling, J., Simonovic, M. Description: The crystal structure of the G45V mutant of human GlnRS [[Cat...

OCA — Wed, 04 Mar 2015 10:22:09 GMT

New page: '''Unreleased structure''' The entry 4ye9 is ON HOLD Authors: Ognjenovic, J., Wu, J., Ling, J., Simonovic, M. Description: The crystal structure of the G45V mutant of human GlnRS [[Cat...

New page

'''Unreleased structure'''

The entry 4ye9 is ON HOLD

Authors: Ognjenovic, J., Wu, J., Ling, J., Simonovic, M.

Description: The crystal structure of the G45V mutant of human GlnRS
[[Category: Unreleased Structures]]
[[Category: Ling, J]]
[[Category: Simonovic, M]]
[[Category: Ognjenovic, J]]
[[Category: Wu, J]]