4yk4 - Revision history

OCA at 08:01, 27 September 2023

OCA — Wed, 27 Sep 2023 08:01:46 GMT

←Older revision		Revision as of 08:01, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4yk4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Solomon_Islands/3/2006(H1N1)) Influenza A virus (A/Solomon Islands/3/2006(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YK4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4yk4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Solomon_Islands/3/2006(H1N1)) Influenza A virus (A/Solomon Islands/3/2006(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YK4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yk4 OCA], [https://pdbe.org/4yk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yk4 RCSB], [https://www.ebi.ac.uk/pdbsum/4yk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yk4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yk4 OCA], [https://pdbe.org/4yk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yk4 RCSB], [https://www.ebi.ac.uk/pdbsum/4yk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yk4 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:16, 3 May 2023

OCA — Wed, 03 May 2023 08:16:35 GMT

←Older revision		Revision as of 08:16, 3 May 2023
Line 3:		Line 3:
	<StructureSection load='4yk4' size='340' side='right'caption='[[4yk4]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4yk4' size='340' side='right'caption='[[4yk4]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yk4]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Influenza_a_virus_~~(a/~~solomon_islands~~/03/2006(~~h1n1~~)) Influenza a virus (a/~~solomon islands~~/03/2006(~~h1n1~~))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YK4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4YK4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yk4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Solomon_Islands/3/2006(H1N1)) Influenza A virus (A/Solomon Islands/3/2006(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YK4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yjz\|4yjz]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yk4 OCA], [https://pdbe.org/4yk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yk4 RCSB], [https://www.ebi.ac.uk/pdbsum/4yk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yk4 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=464623 Influenza A virus (A/Solomon Islands/03/2006(H1N1))])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4yk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yk4 OCA], [~~http~~://pdbe.org/4yk4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4yk4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4yk4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4yk4 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/A7UPX0_9INFA A7UPX0_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00145386]	+	[https://www.uniprot.org/uniprot/A7UPX0_9INFA A7UPX0_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00145386]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]		*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Harrison~~, S C~~]]	+	[[Category: Harrison SC]]
-	[[Category: Schmidt~~, A G]]~~	+	[[Category: Schmidt AG]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Hemagglutinin]]~~	+
-	~~[[Category: Influenza]]~~	+
-	~~[[Category: Viral protein-immune system complex~~]]	+

OCA at 15:53, 11 December 2019

OCA — Wed, 11 Dec 2019 15:53:00 GMT

←Older revision		Revision as of 15:53, 11 December 2019
Line 3:		Line 3:
	<StructureSection load='4yk4' size='340' side='right'caption='[[4yk4]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4yk4' size='340' side='right'caption='[[4yk4]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yk4]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YK4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yk4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/solomon_islands/03/2006(h1n1)) Influenza a virus (a/solomon islands/03/2006(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YK4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yjz\|4yjz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yjz\|4yjz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=464623 Influenza A virus (A/Solomon Islands/03/2006(H1N1))])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yk4 OCA], [http://pdbe.org/4yk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yk4 RCSB], [http://www.ebi.ac.uk/pdbsum/4yk4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yk4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yk4 OCA], [http://pdbe.org/4yk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yk4 RCSB], [http://www.ebi.ac.uk/pdbsum/4yk4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yk4 ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
-	*[[Hemagglutinin\|Hemagglutinin]]	+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Harrison, S C]]		[[Category: Harrison, S C]]

OCA at 07:26, 10 July 2019

OCA — Wed, 10 Jul 2019 07:26:26 GMT

←Older revision		Revision as of 07:26, 10 July 2019
Line 1:		Line 1:

	==Human antibody 641 I-9 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006==		==Human antibody 641 I-9 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006==
-	<StructureSection load='4yk4' size='340' side='right' caption='[[4yk4]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='4yk4' size='340' side='right'caption='[[4yk4]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4yk4]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YK4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4yk4]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YK4 FirstGlance]. <br>
Line 21:		Line 21:

	==See Also==		==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	*[[Hemagglutinin\|Hemagglutinin]]		*[[Hemagglutinin\|Hemagglutinin]]
-	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Harrison, S C]]		[[Category: Harrison, S C]]
	[[Category: Schmidt, A G]]		[[Category: Schmidt, A G]]

OCA at 06:15, 6 October 2017

OCA — Fri, 06 Oct 2017 06:15:25 GMT

←Older revision		Revision as of 06:15, 6 October 2017
Line 21:		Line 21:

	==See Also==		==See Also==
		+	*[[Hemagglutinin\|Hemagglutinin]]
	*[[3D structures of antibody\|3D structures of antibody]]		*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==

OCA at 10:01, 10 March 2017

OCA — Fri, 10 Mar 2017 10:01:21 GMT

←Older revision		Revision as of 10:01, 10 March 2017
Line 1:		Line 1:
		+
	==Human antibody 641 I-9 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006==		==Human antibody 641 I-9 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006==
	<StructureSection load='4yk4' size='340' side='right' caption='[[4yk4]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4yk4' size='340' side='right' caption='[[4yk4]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yjz\|4yjz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yjz\|4yjz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yk4 RCSB], [http://www.ebi.ac.uk/pdbsum/4yk4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yk4 OCA], [http://pdbe.org/4yk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yk4 RCSB], [http://www.ebi.ac.uk/pdbsum/4yk4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yk4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4yk4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:51, 27 May 2015

OCA — Wed, 27 May 2015 15:51:45 GMT

←Older revision		Revision as of 15:51, 27 May 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Human antibody 641 I-9 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006==
		+	<StructureSection load='4yk4' size='340' side='right' caption='[[4yk4]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4yk4]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YK4 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yjz\|4yjz]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yk4 RCSB], [http://www.ebi.ac.uk/pdbsum/4yk4 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A7UPX0_9INFA A7UPX0_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00145386]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Vaccines for rapidly evolving pathogens will confer lasting immunity if they elicit antibodies recognizing conserved epitopes, such as a receptor-binding site (RBS). From characteristics of an influenza-virus RBS-directed antibody, we devised a signature motif to search for similar antibodies. We identified, from three vaccinees, over 100 candidates encoded by 11 different VH genes. Crystal structures show that antibodies in this class engage the hemagglutinin RBS and mimic binding of the receptor, sialic acid, by supplying a critical dipeptide on their projecting, heavy-chain third complementarity determining region. They share contacts with conserved, receptor-binding residues but contact different residues on the RBS periphery, limiting the likelihood of viral escape when several such antibodies are present. These data show that related modes of RBS recognition can arise from different germline origins and mature through diverse affinity maturation pathways. Immunogens focused on an RBS-directed response will thus have a broad range of B cell targets.

-	~~The entry 4yk4 is ON HOLD~~	+	Viral receptor-binding site antibodies with diverse germline origins.,Schmidt AG, Therkelsen MD, Stewart S, Kepler TB, Liao HX, Moody MA, Haynes BF, Harrison SC Cell. 2015 May 21;161(5):1026-34. doi: 10.1016/j.cell.2015.04.028. Epub 2015 May , 7. PMID:25959776<ref>PMID:25959776</ref>

-	~~Authors: Schmidt~~, ~~A.G~~.~~, Harrison,~~ S.C.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Human antibody 641 I-9 in complex with influenza hemagglutinin H1 Solomon Islands~~/03/~~2006~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: Schmidt, A.G]]	+	__TOC__
-	[[Category: ~~Harrison, S.C~~]]	+	</StructureSection>
		+	[[Category: Harrison, S C]]
		+	[[Category: Schmidt, A G]]
		+	[[Category: Antibody]]
		+	[[Category: Complex]]
		+	[[Category: Hemagglutinin]]
		+	[[Category: Influenza]]
		+	[[Category: Viral protein-immune system complex]]

OCA at 09:34, 8 April 2015

OCA — Wed, 08 Apr 2015 09:34:16 GMT

←Older revision		Revision as of 09:34, 8 April 2015
Line 5:		Line 5:
	Authors: Schmidt, A.G., Harrison, S.C.		Authors: Schmidt, A.G., Harrison, S.C.

-	Description: Human antibody 641-I9 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006	+	Description: Human antibody 641 I-9 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Schmidt, A.G]]		[[Category: Schmidt, A.G]]
	[[Category: Harrison, S.C]]		[[Category: Harrison, S.C]]

OCA at 10:47, 18 March 2015

OCA — Wed, 18 Mar 2015 10:47:53 GMT

←Older revision		Revision as of 10:47, 18 March 2015
Line 5:		Line 5:
	Authors: Schmidt, A.G., Harrison, S.C.		Authors: Schmidt, A.G., Harrison, S.C.

-	Description: Human antibody ~~H2526~~ in complex with influenza hemagglutinin H1 Solomon Islands/03/2006	+	Description: Human antibody 641-I9 in complex with influenza hemagglutinin H1 Solomon Islands/03/2006
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Schmidt, A.G]]		[[Category: Schmidt, A.G]]
	[[Category: Harrison, S.C]]		[[Category: Harrison, S.C]]

OCA: Protected "4yk4" [edit=sysop:move=sysop]

OCA — Wed, 11 Mar 2015 10:44:53 GMT

Protected "4yk4" [edit=sysop:move=sysop]

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Revision as of 10:44, 11 March 2015