4yuw - Revision history

OCA at 15:39, 8 November 2023

OCA — Wed, 08 Nov 2023 15:39:13 GMT

←Older revision		Revision as of 15:39, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4yuw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YUW FirstGlance]. <br>		<table><tr><td colspan='2'>[[4yuw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YUW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4JU:TRANS-4-METHYLCYCLOHEXANAMINE'>4JU</scene>, <scene name='pdbligand=S4M:5-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5-DEOXYADENOSINE'>S4M</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.97Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4JU:TRANS-4-METHYLCYCLOHEXANAMINE'>4JU</scene>, <scene name='pdbligand=S4M:5-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5-DEOXYADENOSINE'>S4M</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yuw OCA], [https://pdbe.org/4yuw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yuw RCSB], [https://www.ebi.ac.uk/pdbsum/4yuw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yuw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yuw OCA], [https://pdbe.org/4yuw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yuw RCSB], [https://www.ebi.ac.uk/pdbsum/4yuw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yuw ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:27, 10 May 2023

OCA — Wed, 10 May 2023 07:27:04 GMT

←Older revision		Revision as of 07:27, 10 May 2023
Line 3:		Line 3:
	<StructureSection load='4yuw' size='340' side='right'caption='[[4yuw]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='4yuw' size='340' side='right'caption='[[4yuw]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yuw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Trycc Trycc~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YUW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4YUW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yuw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YUW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4JU:TRANS-4-METHYLCYCLOHEXANAMINE'>4JU</scene>, <scene name='pdbligand=S4M:5-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5-DEOXYADENOSINE'>S4M</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4JU:TRANS-4-METHYLCYCLOHEXANAMINE'>4JU</scene>, <scene name='pdbligand=S4M:5-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5-DEOXYADENOSINE'>S4M</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yuv\|4yuv]], [[4yux\|4yux]], [[4yuy\|4yuy]], [[4yuz\|4yuz]], [[4yv0\|4yv0]], [[4yv1\|4yv1]], [[4yv2\|4yv2]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yuw OCA], [https://pdbe.org/4yuw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yuw RCSB], [https://www.ebi.ac.uk/pdbsum/4yuw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yuw ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tc00.1047053510339.50 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4yuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yuw OCA], [~~http~~://pdbe.org/4yuw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4yuw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4yuw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4yuw ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q4DA73_TRYCC Q4DA73_TRYCC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Spermidine ~~Synthase~~\|Spermidine ~~Synthase~~]]	+	*[[Spermidine synthase 3D structures\|Spermidine synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Spermidine synthase]]~~	+	[[Category: Trypanosoma cruzi strain CL Brener]]
-	~~[[Category: Trycc~~]]	+	[[Category: Amano Y]]
-	[[Category: Amano, Y]]	+	[[Category: Tateishi Y]]
-	[[Category: Tateishi, Y]]	+
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: Polyamine synthesis]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 10:51, 25 December 2019

OCA — Wed, 25 Dec 2019 10:51:54 GMT

←Older revision		Revision as of 10:51, 25 December 2019
Line 10:		Line 10:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yuw OCA], [http://pdbe.org/4yuw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yuw RCSB], [http://www.ebi.ac.uk/pdbsum/4yuw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yuw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yuw OCA], [http://pdbe.org/4yuw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yuw RCSB], [http://www.ebi.ac.uk/pdbsum/4yuw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yuw ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Trypanosoma cruzi causes Chagas disease, a severe disease affecting 8-10 million people in Latin America. While nifurtimox and benznidazole are used to treat this disease, their efficacy is limited and adverse effects are observed. New therapeutic targets and novel drugs are therefore urgently required. Enzymes in the polyamine-trypanothione pathway are promising targets for the treatment of Chagas disease. Spermidine synthase is a key enzyme in this pathway that catalyzes the transfer of an aminopropyl group from decarboxylated S-adenosylmethionine (dcSAM) to putrescine. Fragment-based drug discovery was therefore conducted to identify novel, potent inhibitors of spermidine synthase from T. cruzi (TcSpdSyn). Here, crystal structures of TcSpdSyn in complex with dcSAM, trans-4-methylcyclohexylamine and hit compounds from fragment screening are reported. The structure of dcSAM complexed with TcSpdSyn indicates that dcSAM stabilizes the conformation of the `gatekeeping' loop to form the putrescine-binding pocket. The structures of fragments bound to TcSpdSyn revealed two fragment-binding sites: the putrescine-binding pocket and the dimer interface. The putrescine-binding pocket was extended by an induced-fit mechanism. The crystal structures indicate that the conformation of the dimer interface is required to stabilize the gatekeeping loop and that fragments binding to this interface inhibit TcSpdSyn by disrupting its conformation. These results suggest that utilizing the dynamic structural changes in TcSpdSyn that occur upon inhibitor binding will facilitate the development of more selective and potent inhibitors.
		+
		+	Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase.,Amano Y, Namatame I, Tateishi Y, Honboh K, Tanabe E, Niimi T, Sakashita H Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1879-89. doi:, 10.1107/S1399004715013048. Epub 2015 Aug 25. PMID:26327378<ref>PMID:26327378</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4yuw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Spermidine Synthase\|Spermidine Synthase]]		*[[Spermidine Synthase\|Spermidine Synthase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:42, 12 June 2019

OCA — Wed, 12 Jun 2019 06:42:16 GMT

←Older revision		Revision as of 06:42, 12 June 2019
Line 1:		Line 1:
		+
	==Crystal structure of Trypanosoma cruzi spermidine synthase in complex with trans-4-methylcyclohexylamine==		==Crystal structure of Trypanosoma cruzi spermidine synthase in complex with trans-4-methylcyclohexylamine==
-	<StructureSection load='4yuw' size='340' side='right' caption='[[4yuw]], [[Resolution\|resolution]] 1.97Å' scene=''>	+	<StructureSection load='4yuw' size='340' side='right'caption='[[4yuw]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yuw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YUW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yuw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YUW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4JU:TRANS-4-METHYLCYCLOHEXANAMINE'>4JU</scene>, <scene name='pdbligand=S4M:5-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5-DEOXYADENOSINE'>S4M</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4JU:TRANS-4-METHYLCYCLOHEXANAMINE'>4JU</scene>, <scene name='pdbligand=S4M:5-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5-DEOXYADENOSINE'>S4M</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yuv\|4yuv]], [[4yux\|4yux]], [[4yuy\|4yuy]], [[4yuz\|4yuz]], [[4yv0\|4yv0]], [[4yv1\|4yv1]], [[4yv2\|4yv2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yuv\|4yuv]], [[4yux\|4yux]], [[4yuy\|4yuy]], [[4yuz\|4yuz]], [[4yv0\|4yv0]], [[4yv1\|4yv1]], [[4yv2\|4yv2]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tc00.1047053510339.50 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yuw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yuw RCSB], [http://www.ebi.ac.uk/pdbsum/4yuw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yuw OCA], [http://pdbe.org/4yuw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yuw RCSB], [http://www.ebi.ac.uk/pdbsum/4yuw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yuw ProSAT]</span></td></tr>
	</table>		</table>
		+
		+	==See Also==
		+	*[[Spermidine Synthase\|Spermidine Synthase]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Spermidine synthase]]		[[Category: Spermidine synthase]]
		+	[[Category: Trycc]]
	[[Category: Amano, Y]]		[[Category: Amano, Y]]
	[[Category: Tateishi, Y]]		[[Category: Tateishi, Y]]

OCA at 11:21, 9 September 2015

OCA — Wed, 09 Sep 2015 11:21:11 GMT

←Older revision		Revision as of 11:21, 9 September 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of Trypanosoma cruzi spermidine synthase in complex with trans-4-methylcyclohexylamine==
-		+	<StructureSection load='4yuw' size='340' side='right' caption='[[4yuw]], [[Resolution\|resolution]] 1.97Å' scene=''>
-	~~The entry~~ 4yuw is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4yuw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YUW FirstGlance]. <br>
-	~~Authors~~: ~~Amano~~, Y., ~~Tateishi~~, Y.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4JU:TRANS-4-METHYLCYCLOHEXANAMINE'>4JU</scene>, <scene name='pdbligand=S4M:5-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5-DEOXYADENOSINE'>S4M</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yuv\|4yuv]], [[4yux\|4yux]], [[4yuy\|4yuy]], [[4yuz\|4yuz]], [[4yv0\|4yv0]], [[4yv1\|4yv1]], [[4yv2\|4yv2]]</td></tr>
-	~~Description~~: ~~Crystal structure of Trypanosoma cruzi spermidine~~ synthase ~~in complex~~ with ~~trans~~-4-~~methylcyclohexylamine~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yuw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yuw RCSB], [http://www.ebi.ac.uk/pdbsum/4yuw PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Spermidine synthase]]
	[[Category: Amano, Y]]		[[Category: Amano, Y]]
	[[Category: Tateishi, Y]]		[[Category: Tateishi, Y]]
		+	[[Category: Methyltransferase]]
		+	[[Category: Polyamine synthesis]]
		+	[[Category: Transferase]]

OCA at 09:50, 8 April 2015

OCA — Wed, 08 Apr 2015 09:50:36 GMT

←Older revision		Revision as of 09:50, 8 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4yuw is ON HOLD	+	The entry 4yuw is ON HOLD until Paper Publication

	Authors: Amano, Y., Tateishi, Y.		Authors: Amano, Y., Tateishi, Y.

OCA: Protected "4yuw" [edit=sysop:move=sysop]

OCA — Thu, 26 Mar 2015 12:53:23 GMT

Protected "4yuw" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:53, 26 March 2015

OCA: New page: '''Unreleased structure''' The entry 4yuw is ON HOLD Authors: Amano, Y., Tateishi, Y. Description: Crystal structure of Trypanosoma cruzi spermidine synthase in complex with trans-4-me...

OCA — Thu, 26 Mar 2015 12:53:21 GMT

New page: '''Unreleased structure''' The entry 4yuw is ON HOLD Authors: Amano, Y., Tateishi, Y. Description: Crystal structure of Trypanosoma cruzi spermidine synthase in complex with trans-4-me...

New page

'''Unreleased structure'''

The entry 4yuw is ON HOLD

Authors: Amano, Y., Tateishi, Y.

Description: Crystal structure of Trypanosoma cruzi spermidine synthase in complex with trans-4-methylcyclohexylamine
[[Category: Unreleased Structures]]
[[Category: Amano, Y]]
[[Category: Tateishi, Y]]