4yv4 - Revision history

OCA at 11:31, 9 May 2024

OCA — Thu, 09 May 2024 11:31:54 GMT

←Older revision		Revision as of 11:31, 9 May 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4yv4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YV4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4yv4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YV4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yv4 OCA], [https://pdbe.org/4yv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yv4 RCSB], [https://www.ebi.ac.uk/pdbsum/4yv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yv4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yv4 OCA], [https://pdbe.org/4yv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yv4 RCSB], [https://www.ebi.ac.uk/pdbsum/4yv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yv4 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:27, 10 May 2023

OCA — Wed, 10 May 2023 07:27:20 GMT

←Older revision		Revision as of 07:27, 10 May 2023
Line 3:		Line 3:
	<StructureSection load='4yv4' size='340' side='right'caption='[[4yv4]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4yv4' size='340' side='right'caption='[[4yv4]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yv4]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Caeel Caeel~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YV4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4YV4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yv4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YV4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ynh\|4ynh]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yv4 OCA], [https://pdbe.org/4yv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yv4 RCSB], [https://www.ebi.ac.uk/pdbsum/4yv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yv4 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sas-5, F35B12.5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4yv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yv4 OCA], [~~http~~://pdbe.org/4yv4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4yv4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4yv4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4yv4 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SAS5_CAEEL SAS5_CAEEL]] Required for centrosome duplication. Essential for daughter-centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis.<ref>PMID:15232593</ref> <ref>PMID:15572125</ref>	+	[https://www.uniprot.org/uniprot/SAS5_CAEEL SAS5_CAEEL] Required for centrosome duplication. Essential for daughter-centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis.<ref>PMID:15232593</ref> <ref>PMID:15572125</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caeel~~]]	+	[[Category: Caenorhabditis elegans]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hatzopoulos~~, G N~~]]	+	[[Category: Hatzopoulos GN]]
-	[[Category: Rogala~~, K B~~]]	+	[[Category: Rogala KB]]
-	[[Category: Vakonakis, I]]	+	[[Category: Vakonakis I]]
-	~~[[Category: A-helical]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Structural protein]]~~	+
-	~~[[Category: Trimer~~]]	+

OCA at 06:37, 12 June 2019

OCA — Wed, 12 Jun 2019 06:37:25 GMT

←Older revision		Revision as of 06:37, 12 June 2019
Line 1:		Line 1:
		+
	==Structure of the C. elegans SAS-5 coiled coil domain==		==Structure of the C. elegans SAS-5 coiled coil domain==
-	<StructureSection load='4yv4' size='340' side='right' caption='[[4yv4]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4yv4' size='340' side='right'caption='[[4yv4]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yv4]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YV4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yv4]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YV4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ynh\|4ynh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ynh\|4ynh]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yv4 RCSB], [http://www.ebi.ac.uk/pdbsum/4yv4 PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sas-5, F35B12.5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yv4 OCA], [http://pdbe.org/4yv4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yv4 RCSB], [http://www.ebi.ac.uk/pdbsum/4yv4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yv4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4yv4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Caeel]]
		+	[[Category: Large Structures]]
	[[Category: Hatzopoulos, G N]]		[[Category: Hatzopoulos, G N]]
	[[Category: Rogala, K B]]		[[Category: Rogala, K B]]

OCA at 14:00, 10 June 2015

OCA — Wed, 10 Jun 2015 14:00:11 GMT

←Older revision		Revision as of 14:00, 10 June 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structure of the C. elegans SAS-5 coiled coil domain==
		+	<StructureSection load='4yv4' size='340' side='right' caption='[[4yv4]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4yv4]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YV4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YV4 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ynh\|4ynh]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yv4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yv4 RCSB], [http://www.ebi.ac.uk/pdbsum/4yv4 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SAS5_CAEEL SAS5_CAEEL]] Required for centrosome duplication. Essential for daughter-centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis.<ref>PMID:15232593</ref> <ref>PMID:15572125</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Centrioles are microtubule-based organelles crucial for cell division, sensing and motility. In C. elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have functional homologs across eukaryotic evolution. Whereas the molecular architecture of SAS-6 and its role in initiating centriole formation are well understood, the mechanisms by which SAS-5 and its relatives function is unclear. Here, we combine biophysical and structural analysis to uncover the architecture of SAS-5 and examine its functional implications in vivo. Our work reveals that two distinct self-associating domains are necessary to form higher-order oligomers of SAS-5: a trimeric coiled coil and a novel globular dimeric Implico domain. Disruption of either domain leads to centriole duplication failure in worm embryos, indicating that large SAS-5 assemblies are necessary for function in vivo.

-	The ~~entry 4yv4 is ON HOLD until Paper Publication~~	+	The protein SAS-5 forms large oligomeric assemblies critical for centriole formation.,Rogala KB, Dynes NJ, Hatzopoulos GN, Yan J, Pong SK, Robinson CV, Deane CM, Gonczy P, Vakonakis I Elife. 2015 May 29;4. doi: 10.7554/eLife.07410. PMID:26023830<ref>PMID:26023830</ref>

-	~~Authors: Rogala~~, K.B., Hatzopoulos, G.N~~., Vakonakis, I.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description:~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hatzopoulos, G N]]
		+	[[Category: Rogala, K B]]
	[[Category: Vakonakis, I]]		[[Category: Vakonakis, I]]
-	[[Category: ~~Hatzopoulos, G.N~~]]	+	[[Category: A-helical]]
-	[[Category: ~~Rogala, K.B~~]]	+	[[Category: Cell cycle]]
		+	[[Category: Coiled coil]]
		+	[[Category: Structural protein]]
		+	[[Category: Trimer]]

OCA at 09:50, 8 April 2015

OCA — Wed, 08 Apr 2015 09:50:56 GMT

←Older revision		Revision as of 09:50, 8 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4yv4 is ON HOLD	+	The entry 4yv4 is ON HOLD until Paper Publication

	Authors: Rogala, K.B., Hatzopoulos, G.N., Vakonakis, I.		Authors: Rogala, K.B., Hatzopoulos, G.N., Vakonakis, I.

OCA: Protected "4yv4" [edit=sysop:move=sysop]

OCA — Thu, 26 Mar 2015 12:53:43 GMT

Protected "4yv4" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:53, 26 March 2015

OCA: New page: '''Unreleased structure''' The entry 4yv4 is ON HOLD Authors: Rogala, K.B., Hatzopoulos, G.N., Vakonakis, I. Description: Category: Unreleased Structures [[Category: Vakonakis, I]...

OCA — Thu, 26 Mar 2015 12:53:42 GMT

New page: '''Unreleased structure''' The entry 4yv4 is ON HOLD Authors: Rogala, K.B., Hatzopoulos, G.N., Vakonakis, I. Description: Category: Unreleased Structures [[Category: Vakonakis, I]...

New page

'''Unreleased structure'''

The entry 4yv4 is ON HOLD

Authors: Rogala, K.B., Hatzopoulos, G.N., Vakonakis, I.

Description:
[[Category: Unreleased Structures]]
[[Category: Vakonakis, I]]
[[Category: Hatzopoulos, G.N]]
[[Category: Rogala, K.B]]