4yv8 - Revision history

OCA at 08:07, 27 September 2023

OCA — Wed, 27 Sep 2023 08:07:41 GMT

←Older revision		Revision as of 08:07, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4yv8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Actinomycete_095-35 Actinomycete 095-35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YV8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4yv8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Actinomycete_095-35 Actinomycete 095-35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YV8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AG2:AGMATINE'>AG2</scene>, <scene name='pdbligand=RGL:ARGINAL'>RGL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AG2:AGMATINE'>AG2</scene>, <scene name='pdbligand=RGL:ARGINAL'>RGL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yv8 OCA], [https://pdbe.org/4yv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yv8 RCSB], [https://www.ebi.ac.uk/pdbsum/4yv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yv8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yv8 OCA], [https://pdbe.org/4yv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yv8 RCSB], [https://www.ebi.ac.uk/pdbsum/4yv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yv8 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:27, 10 May 2023

OCA — Wed, 10 May 2023 07:27:28 GMT

←Older revision		Revision as of 07:27, 10 May 2023
Line 3:		Line 3:
	<StructureSection load='4yv8' size='340' side='right'caption='[[4yv8]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4yv8' size='340' side='right'caption='[[4yv8]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yv8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/Actinomycete_095-35 Actinomycete 095-35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YV8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4YV8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yv8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Actinomycete_095-35 Actinomycete 095-35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YV8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AG2:AGMATINE'>AG2</scene>, <scene name='pdbligand=RGL:ARGINAL'>RGL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
-	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat~~"><scene name='pdbligand=AG2:AGMATINE'>AG2</scene>, <scene name='pdbligand=RGL:ARGINAL'>RGL</scene>, <scene name='pdbligand=~~URE~~:~~UREA~~'>~~URE~~</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yv8 OCA], [https://pdbe.org/4yv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yv8 RCSB], [https://www.ebi.ac.uk/pdbsum/4yv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yv8 ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yva\|4yva]]</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTSK~~, ~~CTSO, CTSO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~<~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4yv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yv8 OCA], [~~http~~://pdbe.org/4yv8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4yv8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4yv8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4yv8 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[~~http~~://omim.org/entry/265800 265800]]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>	+	[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[https://omim.org/entry/265800 265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.	+	[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 32:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Actinomycete 095-35]]		[[Category: Actinomycete 095-35]]
-	[[Category: ~~Cathepsin K]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aguda~~, A H~~]]	+	[[Category: Aguda AH]]
-	[[Category: Brayer~~, G D~~]]	+	[[Category: Brayer GD]]
-	[[Category: Bromme, D]]	+	[[Category: Bromme D]]
-	[[Category: Nguyen~~, N T]]~~	+	[[Category: Nguyen NT]]
-	~~[[Category: Cathepsin k]]~~	+
-	~~[[Category: Hydrolase-inhibitor complex]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Lichostatinal~~]]	+

OCA at 08:00, 21 May 2019

OCA — Tue, 21 May 2019 08:00:47 GMT

←Older revision		Revision as of 08:00, 21 May 2019
Line 1:		Line 1:

	==Crystal structure of cathepsin K bound to the covalent inhibitor lichostatinal==		==Crystal structure of cathepsin K bound to the covalent inhibitor lichostatinal==
-	<StructureSection load='4yv8' size='340' side='right' caption='[[4yv8]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4yv8' size='340' side='right'caption='[[4yv8]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yv8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Actinomycete_095-35 Actinomycete 095-35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YV8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yv8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Actinomycete_095-35 Actinomycete 095-35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YV8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AG2:AGMATINE'>AG2</scene>, <scene name='pdbligand=RGL:ARGINAL'>RGL</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AG2:AGMATINE'>AG2</scene>, <scene name='pdbligand=RGL:ARGINAL'>RGL</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yva\|4yva]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yva\|4yva]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTSK, CTSO, CTSO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yv8 OCA], [http://pdbe.org/4yv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4yv8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yv8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yv8 OCA], [http://pdbe.org/4yv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4yv8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yv8 ProSAT]</span></td></tr>
Line 23:		Line 24:
	</div>		</div>
	<div class="pdbe-citations 4yv8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4yv8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cathepsin 3D structures\|Cathepsin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 33:
	[[Category: Actinomycete 095-35]]		[[Category: Actinomycete 095-35]]
	[[Category: Cathepsin K]]		[[Category: Cathepsin K]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Aguda, A H]]		[[Category: Aguda, A H]]
	[[Category: Brayer, G D]]		[[Category: Brayer, G D]]

OCA at 12:19, 6 November 2017

OCA — Mon, 06 Nov 2017 12:19:56 GMT

←Older revision		Revision as of 12:19, 6 November 2017
Line 23:		Line 23:
	</div>		</div>
	<div class="pdbe-citations 4yv8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4yv8" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Acetyl-CoA synthetase\|Acetyl-CoA synthetase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:42, 27 September 2017

OCA — Wed, 27 Sep 2017 09:42:09 GMT

←Older revision		Revision as of 09:42, 27 September 2017
Line 23:		Line 23:
	</div>		</div>
	<div class="pdbe-citations 4yv8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4yv8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acetyl-CoA synthetase\|Acetyl-CoA synthetase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:24, 9 September 2016

OCA — Fri, 09 Sep 2016 05:24:21 GMT

←Older revision		Revision as of 05:24, 9 September 2016
Line 8:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yva\|4yva]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yva\|4yva]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yv8 OCA], [http://pdbe.org/4yv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4yv8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yv8 OCA], [http://pdbe.org/4yv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4yv8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yv8 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 14:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.		[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Natural products are an important source of novel drug scaffolds. The highly variable and unpredictable timelines associated with isolating novel compounds and elucidating their structures have led to the demise of exploring natural product extract libraries in drug discovery programs. Here we introduce affinity crystallography as a new methodology that significantly shortens the time of the hit to active structure cycle in bioactive natural product discovery research. This affinity crystallography approach is illustrated by using semipure fractions of an actinomycetes culture extract to isolate and identify a cathepsin K inhibitor and to compare the outcome with the traditional assay-guided purification/structural analysis approach. The traditional approach resulted in the identification of the known inhibitor antipain (1) and its new but lower potency dehydration product 2, while the affinity crystallography approach led to the identification of a new high-affinity inhibitor named lichostatinal (3). The structure and potency of lichostatinal (3) was verified by total synthesis and kinetic characterization. To the best of our knowledge, this is the first example of isolating and characterizing a potent enzyme inhibitor from a partially purified crude natural product extract using a protein crystallographic approach.
		+
		+	Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts.,Aguda AH, Lavallee V, Cheng P, Bott TM, Meimetis LG, Law S, Nguyen NT, Williams DE, Kaleta J, Villanueva I, Davies J, Andersen RJ, Brayer GD, Bromme D J Nat Prod. 2016 Aug 26;79(8):1962-70. doi: 10.1021/acs.jnatprod.6b00215. Epub, 2016 Aug 6. PMID:27498895<ref>PMID:27498895</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4yv8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:32, 13 May 2016

OCA — Fri, 13 May 2016 19:32:16 GMT

←Older revision		Revision as of 19:32, 13 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4yv8 is ~~ON HOLD~~	+	==Crystal structure of cathepsin K bound to the covalent inhibitor lichostatinal==
-		+	<StructureSection load='4yv8' size='340' side='right' caption='[[4yv8]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors~~: ~~Aguda~~, A.H., ~~Nguyen~~, N.T., ~~Bromme~~, D., ~~Brayer, G~~.D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4yv8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Actinomycete_095-35 Actinomycete 095-35]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YV8 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~cathepsin K bound to~~ the ~~covalent inhibitor lichostatinal~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AG2:AGMATINE'>AG2</scene>, <scene name='pdbligand=RGL:ARGINAL'>RGL</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
-	[[Category: Brayer, G.D]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4yva\|4yva]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yv8 OCA], [http://pdbe.org/4yv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4yv8 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[http://omim.org/entry/265800 265800]]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Actinomycete 095-35]]
		+	[[Category: Cathepsin K]]
		+	[[Category: Aguda, A H]]
		+	[[Category: Brayer, G D]]
	[[Category: Bromme, D]]		[[Category: Bromme, D]]
-	[[Category: Nguyen, N.T]]	+	[[Category: Nguyen, N T]]
-	[[Category: ~~Aguda, A.H~~]]	+	[[Category: Cathepsin k]]
		+	[[Category: Hydrolase-inhibitor complex]]
		+	[[Category: Inhibitor]]
		+	[[Category: Lichostatinal]]

OCA at 20:48, 9 March 2016

OCA — Wed, 09 Mar 2016 20:48:05 GMT

←Older revision		Revision as of 20:48, 9 March 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4yv8 is ON HOLD ~~until Paper Publication~~	+	The entry 4yv8 is ON HOLD

	Authors: Aguda, A.H., Nguyen, N.T., Bromme, D., Brayer, G.D.		Authors: Aguda, A.H., Nguyen, N.T., Bromme, D., Brayer, G.D.

OCA at 23:45, 30 November 2015

OCA — Mon, 30 Nov 2015 23:45:05 GMT

←Older revision		Revision as of 23:45, 30 November 2015
Line 7:		Line 7:
	Description: Crystal structure of cathepsin K bound to the covalent inhibitor lichostatinal		Description: Crystal structure of cathepsin K bound to the covalent inhibitor lichostatinal
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Bromme, D]]
	[[Category: Brayer, G.D]]		[[Category: Brayer, G.D]]
		+	[[Category: Bromme, D]]
	[[Category: Nguyen, N.T]]		[[Category: Nguyen, N.T]]
	[[Category: Aguda, A.H]]		[[Category: Aguda, A.H]]

OCA at 10:14, 13 May 2015

OCA — Wed, 13 May 2015 10:14:03 GMT

←Older revision		Revision as of 10:14, 13 May 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4yv8 is ON HOLD	+	The entry 4yv8 is ON HOLD until Paper Publication

	Authors: Aguda, A.H., Nguyen, N.T., Bromme, D., Brayer, G.D.		Authors: Aguda, A.H., Nguyen, N.T., Bromme, D., Brayer, G.D.