4ywa - Revision history

OCA at 10:56, 10 January 2024

OCA — Wed, 10 Jan 2024 10:56:23 GMT

←Older revision		Revision as of 10:56, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ywa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YWA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ywa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YWA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4J9:(2R,3R,4S,5R,6R,2R,3R,4S,5R,6R)-2,2-([(2R,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]BIS{1H-1,2,3-TRIAZOLE-1,4-DIYL[(2S,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]-1H-1,2,3-TRIAZOLE-1,4-DIYLMETHANEDIYLOXY})BIS[6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL]'>4J9</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.192Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4J9:(2R,3R,4S,5R,6R,2R,3R,4S,5R,6R)-2,2-([(2R,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]BIS{1H-1,2,3-TRIAZOLE-1,4-DIYL[(2S,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]-1H-1,2,3-TRIAZOLE-1,4-DIYLMETHANEDIYLOXY})BIS[6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL]'>4J9</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ywa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ywa OCA], [https://pdbe.org/4ywa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ywa RCSB], [https://www.ebi.ac.uk/pdbsum/4ywa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ywa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ywa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ywa OCA], [https://pdbe.org/4ywa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ywa RCSB], [https://www.ebi.ac.uk/pdbsum/4ywa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ywa ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:29, 10 May 2023

OCA — Wed, 10 May 2023 07:29:02 GMT

←Older revision		Revision as of 07:29, 10 May 2023
Line 3:		Line 3:
	<StructureSection load='4ywa' size='340' side='right'caption='[[4ywa]], [[Resolution\|resolution]] 1.19Å' scene=''>		<StructureSection load='4ywa' size='340' side='right'caption='[[4ywa]], [[Resolution\|resolution]] 1.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ywa]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YWA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4YWA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ywa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YWA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4J9:(2R,3R,4S,5R,6R,2R,3R,4S,5R,6R)-2,2-([(2R,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]BIS{1H-1,2,3-TRIAZOLE-1,4-DIYL[(2S,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]-1H-1,2,3-TRIAZOLE-1,4-DIYLMETHANEDIYLOXY})BIS[6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL]'>4J9</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4J9:(2R,3R,4S,5R,6R,2R,3R,4S,5R,6R)-2,2-([(2R,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]BIS{1H-1,2,3-TRIAZOLE-1,4-DIYL[(2S,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]-1H-1,2,3-TRIAZOLE-1,4-DIYLMETHANEDIYLOXY})BIS[6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL]'>4J9</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lecA, pa1L, PA2570 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ywa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ywa OCA], [https://pdbe.org/4ywa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ywa RCSB], [https://www.ebi.ac.uk/pdbsum/4ywa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ywa ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ywa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ywa OCA], [~~http~~://pdbe.org/4ywa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ywa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ywa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ywa ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PA1L_PSEAE PA1L_PSEAE]] D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.	+	[https://www.uniprot.org/uniprot/PA1L_PSEAE PA1L_PSEAE] D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4ywa" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ywa" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Galactose-binding lectin\|Galactose-binding lectin]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bergmann, M]]	+	[[Category: Pseudomonas aeruginosa]]
-	[[Category: Darbre, T]]	+	[[Category: Bergmann M]]
-	[[Category: Gillon, E]]	+	[[Category: Darbre T]]
-	[[Category: Imberty, A]]	+	[[Category: Gillon E]]
-	[[Category: Jin, X]]	+	[[Category: Imberty A]]
-	[[Category: Michaud, G]]	+	[[Category: Jin X]]
-	[[Category: Pieters, R]]	+	[[Category: Michaud G]]
-	[[Category: Reymond, J L]]	+	[[Category: Pieters R]]
-	[[Category: Stocker, A]]	+	[[Category: Reymond J-L]]
-	[[Category: Visini, R]]	+	[[Category: Stocker A]]
-	~~[[Category: Galactoside]]~~	+	[[Category: Visini R]]
-	~~[[Category: Lectin]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 06:55, 19 June 2019

OCA — Wed, 19 Jun 2019 06:55:28 GMT

←Older revision		Revision as of 06:55, 19 June 2019
Line 1:		Line 1:
		+
	==Structural Insight into Divalent Galactoside Binding to Pseudomonas aeruginosa lectin LecA==		==Structural Insight into Divalent Galactoside Binding to Pseudomonas aeruginosa lectin LecA==
-	<StructureSection load='4ywa' size='340' side='right' caption='[[4ywa]], [[Resolution\|resolution]] 1.19Å' scene=''>	+	<StructureSection load='4ywa' size='340' side='right'caption='[[4ywa]], [[Resolution\|resolution]] 1.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ywa]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YWA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ywa]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YWA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4J9:(2R,3R,4S,5R,6R,2R,3R,4S,5R,6R)-2,2-([(2R,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]BIS{1H-1,2,3-TRIAZOLE-1,4-DIYL[(2S,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]-1H-1,2,3-TRIAZOLE-1,4-DIYLMETHANEDIYLOXY})BIS[6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL]'>4J9</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4J9:(2R,3R,4S,5R,6R,2R,3R,4S,5R,6R)-2,2-([(2R,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]BIS{1H-1,2,3-TRIAZOLE-1,4-DIYL[(2S,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]-1H-1,2,3-TRIAZOLE-1,4-DIYLMETHANEDIYLOXY})BIS[6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL]'>4J9</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ywa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ywa OCA], [http://pdbe.org/4ywa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ywa RCSB], [http://www.ebi.ac.uk/pdbsum/4ywa PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lecA, pa1L, PA2570 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ywa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ywa OCA], [http://pdbe.org/4ywa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ywa RCSB], [http://www.ebi.ac.uk/pdbsum/4ywa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ywa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Bergmann, M]]		[[Category: Bergmann, M]]
	[[Category: Darbre, T]]		[[Category: Darbre, T]]

OCA at 10:09, 2 December 2015

OCA — Wed, 02 Dec 2015 10:09:49 GMT

←Older revision		Revision as of 10:09, 2 December 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[4ywa]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YWA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ywa]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YWA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4J9:(2R,3R,4S,5R,6R,2R,3R,4S,5R,6R)-2,2-([(2R,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]BIS{1H-1,2,3-TRIAZOLE-1,4-DIYL[(2S,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]-1H-1,2,3-TRIAZOLE-1,4-DIYLMETHANEDIYLOXY})BIS[6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL]'>4J9</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4J9:(2R,3R,4S,5R,6R,2R,3R,4S,5R,6R)-2,2-([(2R,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]BIS{1H-1,2,3-TRIAZOLE-1,4-DIYL[(2S,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]-1H-1,2,3-TRIAZOLE-1,4-DIYLMETHANEDIYLOXY})BIS[6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL]'>4J9</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ywa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ywa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ywa RCSB], [http://www.ebi.ac.uk/pdbsum/4ywa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ywa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ywa OCA], [http://pdbe.org/4ywa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ywa RCSB], [http://www.ebi.ac.uk/pdbsum/4ywa PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ywa" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:14, 9 September 2015

OCA — Wed, 09 Sep 2015 11:14:37 GMT

←Older revision		Revision as of 11:14, 9 September 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structural Insight into Divalent Galactoside Binding to Pseudomonas aeruginosa lectin LecA==
		+	<StructureSection load='4ywa' size='340' side='right' caption='[[4ywa]], [[Resolution\|resolution]] 1.19Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ywa]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YWA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4J9:(2R,3R,4S,5R,6R,2R,3R,4S,5R,6R)-2,2-([(2R,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]BIS{1H-1,2,3-TRIAZOLE-1,4-DIYL[(2S,3R,4S,5S,6S)-3,4-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2,5-DIYL]-1H-1,2,3-TRIAZOLE-1,4-DIYLMETHANEDIYLOXY})BIS[6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL]'>4J9</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ywa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ywa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ywa RCSB], [http://www.ebi.ac.uk/pdbsum/4ywa PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PA1L_PSEAE PA1L_PSEAE]] D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Multivalent galactosides inhibiting Pseudomonas aeruginosa biofilms may help control this problematic pathogen. To understand the binding mode of tetravalent glycopeptide dendrimer GalAG2 [(Gal-beta-OC6H4CO-Lys-Pro-Leu)4(Lys-Phe-Lys-Ile)2Lys-His-Ile-NH2] to its target lectin LecA, crystal structures of LecA complexes with divalent analog GalAG1 [(Gal-beta-OC6H4CO-Lys-Pro-Leu)2Lys-Phe-Lys-Ile-NH2] and related glucose-triazole linked bis-galactosides 3u3 [Gal-beta-O(CH2)n-(C2HN3)-4-Glc-beta-(C2HN3)-[beta-Glc-4-(N3HC2)]2-(CH2)n-O-beta- Gal (n = 1)] and 5u3 (n = 3) were obtained, revealing a chelate bound 3u3, cross-linked 5u3, and monovalently bound GalAG1. Nevertheless, a chelate bound model better explaining their strong LecA binding and the absence of lectin aggregation was obtained by modeling for all three ligands. A model of the chelate bound GalAG2.LecA complex was also obtained rationalizing its unusually tight LecA binding (KD = 2.5 nM) and aggregation by lectin cross-linking. The very weak biofilm inhibition with divalent LecA inhibitors suggests that lectin aggregation is necessary for biofilm inhibition by GalAG2, pointing to multivalent glycoclusters as a unique opportunity to control P. aeruginosa biofilms.

-	~~The entry 4ywa is ON HOLD until Paper Publication~~	+	Structural Insight into Multivalent Galactoside Binding to Pseudomonas aeruginosa Lectin LecA.,Visini R, Jin X, Bergmann M, Michaud G, Pertici F, Fu O, Pukin A, Branson TR, Thies-Weesie DM, Kemmink J, Gillon E, Imberty A, Stocker A, Darbre T, Pieters RJ, Reymond JL ACS Chem Biol. 2015 Aug 28. PMID:26295304<ref>PMID:26295304</ref>

-	~~Authors: Visini~~, R.~~, Jin, X~~.~~, Michaud, G., Bergmann, M., Gillon, E., Imberty, A., Stocker, A., Darbre, T., Pieters, R., Reymond, J.-L~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Structural Insight into Divalent Galactoside Binding to Pseudomonas aeruginosa lectin LecA~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
-	[[Category: ~~Pieters~~, R]]	+	__TOC__
-	[[Category: ~~Michaud~~, G]]	+	</StructureSection>
		+	[[Category: Bergmann, M]]
		+	[[Category: Darbre, T]]
	[[Category: Gillon, E]]		[[Category: Gillon, E]]
-	[[Category: Bergmann, M]]
	[[Category: Imberty, A]]		[[Category: Imberty, A]]
		+	[[Category: Jin, X]]
		+	[[Category: Michaud, G]]
		+	[[Category: Pieters, R]]
		+	[[Category: Reymond, J L]]
		+	[[Category: Stocker, A]]
	[[Category: Visini, R]]		[[Category: Visini, R]]
-	[[Category: ~~Reymond, J.-L~~]]	+	[[Category: Galactoside]]
-	[[Category: ~~Darbre, T~~]]	+	[[Category: Lectin]]
-	[[Category: ~~Stocker, A]]~~	+	[[Category: Sugar binding protein]]
-	~~[[Category: Jin, X~~]]	+

OCA at 10:32, 15 July 2015

OCA — Wed, 15 Jul 2015 10:32:44 GMT

←Older revision		Revision as of 10:32, 15 July 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ywa is ON HOLD until ~~Mar 20 2017~~	+	The entry 4ywa is ON HOLD until Paper Publication

	Authors: Visini, R., Jin, X., Michaud, G., Bergmann, M., Gillon, E., Imberty, A., Stocker, A., Darbre, T., Pieters, R., Reymond, J.-L.		Authors: Visini, R., Jin, X., Michaud, G., Bergmann, M., Gillon, E., Imberty, A., Stocker, A., Darbre, T., Pieters, R., Reymond, J.-L.

OCA: Protected "4ywa" [edit=sysop:move=sysop]

OCA — Wed, 01 Apr 2015 11:58:03 GMT

Protected "4ywa" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:58, 1 April 2015

OCA: New page: '''Unreleased structure''' The entry 4ywa is ON HOLD until Mar 20 2017 Authors: Visini, R., Jin, X., Michaud, G., Bergmann, M., Gillon, E., Imberty, A., Stocker, A., Darbre, T., Pieters...

OCA — Wed, 01 Apr 2015 11:58:02 GMT

New page: '''Unreleased structure''' The entry 4ywa is ON HOLD until Mar 20 2017 Authors: Visini, R., Jin, X., Michaud, G., Bergmann, M., Gillon, E., Imberty, A., Stocker, A., Darbre, T., Pieters...

New page

'''Unreleased structure'''

The entry 4ywa is ON HOLD until Mar 20 2017

Authors: Visini, R., Jin, X., Michaud, G., Bergmann, M., Gillon, E., Imberty, A., Stocker, A., Darbre, T., Pieters, R., Reymond, J.-L.

Description: Structural Insight into Divalent Galactoside Binding to Pseudomonas aeruginosa lectin LecA
[[Category: Unreleased Structures]]
[[Category: Pieters, R]]
[[Category: Michaud, G]]
[[Category: Gillon, E]]
[[Category: Bergmann, M]]
[[Category: Imberty, A]]
[[Category: Visini, R]]
[[Category: Reymond, J.-L]]
[[Category: Darbre, T]]
[[Category: Stocker, A]]
[[Category: Jin, X]]