4yxg - Revision history

OCA at 15:40, 8 November 2023

OCA — Wed, 08 Nov 2023 15:40:39 GMT

←Older revision		Revision as of 15:40, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4yxg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YXG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4yxg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YXG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxg OCA], [https://pdbe.org/4yxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yxg RCSB], [https://www.ebi.ac.uk/pdbsum/4yxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxg OCA], [https://pdbe.org/4yxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yxg RCSB], [https://www.ebi.ac.uk/pdbsum/4yxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxg ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:30, 10 May 2023

OCA — Wed, 10 May 2023 07:30:07 GMT

←Older revision		Revision as of 07:30, 10 May 2023
Line 1:		Line 1:

	==F96Y Mutant of Plasmodium Falciparum Triosephosphate Isomerase==		==F96Y Mutant of Plasmodium Falciparum Triosephosphate Isomerase==
-	<StructureSection load='4yxg' size='340' side='right' caption='[[4yxg]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4yxg' size='340' side='right'caption='[[4yxg]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yxg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4YXG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yxg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YXG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ywi\|4ywi]], [[2vfd\|2vfd]], [[2vfe\|2vfe]], [[2vff\|2vff]], [[2vfg\|2vfg]], [[2vfh\|2vfh]], [[4z0j\|4z0j]], [[4z0s\|4z0s]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxg OCA], [https://pdbe.org/4yxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yxg RCSB], [https://www.ebi.ac.uk/pdbsum/4yxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxg ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TPI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4yxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxg OCA], [~~http~~://pdbe.org/4yxg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4yxg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4yxg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxg ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TPIS_PLAFA TPIS_PLAFA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Triose ~~Phosphate Isomerase~~\|Triose ~~Phosphate Isomerase~~]]	+	*[[Triose phosphate isomerase 3D structures\|Triose phosphate isomerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plafa~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Triose-phosphate isomerase~~]]	+	[[Category: Plasmodium falciparum]]
-	[[Category: Balaram, P]]	+	[[Category: Balaram P]]
-	[[Category: Murthy~~, M R.N~~]]	+	[[Category: Murthy MRN]]
-	[[Category: Pareek, V]]	+	[[Category: Pareek V]]
-	~~[[Category: Beta-alpha barrel]]~~	+
-	~~[[Category: Glycolysis]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Tim barrel~~]]	+

OCA at 13:03, 16 November 2017

OCA — Thu, 16 Nov 2017 13:03:34 GMT

←Older revision		Revision as of 13:03, 16 November 2017
Line 3:		Line 3:
	<StructureSection load='4yxg' size='340' side='right' caption='[[4yxg]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4yxg' size='340' side='right' caption='[[4yxg]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yxg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YXG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yxg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YXG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ywi\|4ywi]], [[2vfd\|2vfd]], [[2vfe\|2vfe]], [[2vff\|2vff]], [[2vfg\|2vfg]], [[2vfh\|2vfh]], [[4z0j\|4z0j]], [[4z0s\|4z0s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ywi\|4ywi]], [[2vfd\|2vfd]], [[2vfe\|2vfe]], [[2vff\|2vff]], [[2vfg\|2vfg]], [[2vfh\|2vfh]], [[4z0j\|4z0j]], [[4z0s\|4z0s]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TPI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxg OCA], [http://pdbe.org/4yxg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yxg RCSB], [http://www.ebi.ac.uk/pdbsum/4yxg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxg OCA], [http://pdbe.org/4yxg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yxg RCSB], [http://www.ebi.ac.uk/pdbsum/4yxg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxg ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4yxg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4yxg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Triose Phosphate Isomerase\|Triose Phosphate Isomerase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Plafa]]
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
	[[Category: Balaram, P]]		[[Category: Balaram, P]]

OCA at 16:07, 10 May 2016

OCA — Tue, 10 May 2016 16:07:00 GMT

←Older revision		Revision as of 16:07, 10 May 2016
Line 1:		Line 1:
		+
	==F96Y Mutant of Plasmodium Falciparum Triosephosphate Isomerase==		==F96Y Mutant of Plasmodium Falciparum Triosephosphate Isomerase==
	<StructureSection load='4yxg' size='340' side='right' caption='[[4yxg]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4yxg' size='340' side='right' caption='[[4yxg]], [[Resolution\|resolution]] 1.90Å' scene=''>

OCA at 15:40, 3 February 2016

OCA — Wed, 03 Feb 2016 15:40:09 GMT

←Older revision		Revision as of 15:40, 3 February 2016
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==F96Y Mutant of Plasmodium Falciparum Triosephosphate Isomerase==
		+	<StructureSection load='4yxg' size='340' side='right' caption='[[4yxg]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4yxg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YXG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ywi\|4ywi]], [[2vfd\|2vfd]], [[2vfe\|2vfe]], [[2vff\|2vff]], [[2vfg\|2vfg]], [[2vfh\|2vfh]], [[4z0j\|4z0j]], [[4z0s\|4z0s]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxg OCA], [http://pdbe.org/4yxg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yxg RCSB], [http://www.ebi.ac.uk/pdbsum/4yxg PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Despite extensive research on triosephosphate isomerase (TIM), there exists a gap in understanding the remarkable conjunction between catalytic loop-6 (residue 166-176) movement and conformational flip of Glu165 (catalytic base) upon substrate binding, thus priming the active site for efficient catalysis. The overwhelming occurrence of Ser at position 96 (98% of the 6277 unique TIM sequences), spatially proximal to E165 and the loop-6 residues, raises questions about its role in catalysis. Notably, Plasmodium falciparum TIM has an extremely rare residue, Phe, at this position and curiously, the mutant F96S was catalytically defective. We provide insights into the influence of residue 96 on the loop-6 dynamics and E165 positioning by combining the kinetic and structural studies on the PfTIM F96 mutants, F96Y, F96A, F96S/S73A and F96S/L167V with sequence conservation analysis and comparative analysis of the available apo and holo structures of the enzyme from diverse organisms.

-	~~The entry 4yxg is ON HOLD until Paper Publication~~	+	Connecting active site loop conformations and catalysis in triosephosphate isomerase: insights from a rare variation at residue 96 in the plasmodial enzyme.,Pareek V, Samanta M, Joshi NV, Balaram H, Murthy MR, Balaram P Chembiochem. 2016 Jan 14. doi: 10.1002/cbic.201500532. PMID:26762569<ref>PMID:26762569</ref>

-	~~Authors: Pareek~~, V.~~, Balaram, P~~.~~, Murthy, M.R.N~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~F96Y Mutant of Plasmodium Falciparum Triosephosphate Isomerase~~	+	<div class="pdbe-citations 4yxg" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Triose-phosphate isomerase]]
	[[Category: Balaram, P]]		[[Category: Balaram, P]]
-	[[Category: Murthy, M.R.N]]	+	[[Category: Murthy, M R.N]]
	[[Category: Pareek, V]]		[[Category: Pareek, V]]
		+	[[Category: Beta-alpha barrel]]
		+	[[Category: Glycolysis]]
		+	[[Category: Isomerase]]
		+	[[Category: Tim barrel]]

OCA at 11:13, 6 May 2015

OCA — Wed, 06 May 2015 11:13:21 GMT

←Older revision		Revision as of 11:13, 6 May 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4yxg is ON HOLD	+	The entry 4yxg is ON HOLD until Paper Publication

	Authors: Pareek, V., Balaram, P., Murthy, M.R.N.		Authors: Pareek, V., Balaram, P., Murthy, M.R.N.

OCA at 11:27, 15 April 2015

OCA — Wed, 15 Apr 2015 11:27:21 GMT

←Older revision		Revision as of 11:27, 15 April 2015
Line 5:		Line 5:
	Authors: Pareek, V., Balaram, P., Murthy, M.R.N.		Authors: Pareek, V., Balaram, P., Murthy, M.R.N.

-	Description: F96Y ~~DOUBLE MUTANT OF PLASMODIUM FALCIPARUM TRIOSEPHOSPHATE ISOMERASE~~	+	Description: F96Y Mutant of Plasmodium Falciparum Triosephosphate Isomerase
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Balaram, P]]		[[Category: Balaram, P]]
	[[Category: Murthy, M.R.N]]		[[Category: Murthy, M.R.N]]
	[[Category: Pareek, V]]		[[Category: Pareek, V]]

OCA: Protected "4yxg" [edit=sysop:move=sysop]

OCA — Wed, 01 Apr 2015 12:00:32 GMT

Protected "4yxg" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:00, 1 April 2015

OCA: New page: '''Unreleased structure''' The entry 4yxg is ON HOLD Authors: Pareek, V., Balaram, P., Murthy, M.R.N. Description: F96Y DOUBLE MUTANT OF PLASMODIUM FALCIPARUM TRIOSEPHOSPHATE ISOMERASE...

OCA — Wed, 01 Apr 2015 12:00:30 GMT

New page: '''Unreleased structure''' The entry 4yxg is ON HOLD Authors: Pareek, V., Balaram, P., Murthy, M.R.N. Description: F96Y DOUBLE MUTANT OF PLASMODIUM FALCIPARUM TRIOSEPHOSPHATE ISOMERASE...

New page

'''Unreleased structure'''

The entry 4yxg is ON HOLD

Authors: Pareek, V., Balaram, P., Murthy, M.R.N.

Description: F96Y DOUBLE MUTANT OF PLASMODIUM FALCIPARUM TRIOSEPHOSPHATE ISOMERASE
[[Category: Unreleased Structures]]
[[Category: Balaram, P]]
[[Category: Murthy, M.R.N]]
[[Category: Pareek, V]]