4yxj - Revision history

OCA at 10:56, 10 January 2024

OCA — Wed, 10 Jan 2024 10:56:31 GMT

←Older revision		Revision as of 10:56, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4yxj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YXJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4yxj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YXJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxj OCA], [https://pdbe.org/4yxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yxj RCSB], [https://www.ebi.ac.uk/pdbsum/4yxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxj OCA], [https://pdbe.org/4yxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yxj RCSB], [https://www.ebi.ac.uk/pdbsum/4yxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxj ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:30, 10 May 2023

OCA — Wed, 10 May 2023 07:30:09 GMT

←Older revision		Revision as of 07:30, 10 May 2023
Line 3:		Line 3:
	<StructureSection load='4yxj' size='340' side='right'caption='[[4yxj]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='4yxj' size='340' side='right'caption='[[4yxj]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yxj]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_43589 Atcc 43589~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4YXJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yxj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YXJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c1y\|3c1y]], [[3c1z\|3c1z]], [[3c21\|3c21]], [[3c23\|3c23]], [[4yvz\|4yvz]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxj OCA], [https://pdbe.org/4yxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yxj RCSB], [https://www.ebi.ac.uk/pdbsum/4yxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxj ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">disA, TM_0200 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diadenylate_cyclase Diadenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.85 2.7.7.85] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4yxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxj OCA], [~~http~~://pdbe.org/4yxj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4yxj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4yxj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxj ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DISA_THEMA DISA_THEMA]] Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity).<ref>PMID:18439896</ref> Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. Does not convert GTP to c-di-GMP.<ref>PMID:18439896</ref>	+	[https://www.uniprot.org/uniprot/DISA_THEMA DISA_THEMA] Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity).<ref>PMID:18439896</ref> Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. Does not convert GTP to c-di-GMP.<ref>PMID:18439896</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 43589]]
-	[[Category: Diadenylate cyclase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Deimling, T]]	+	[[Category: Thermotoga maritima]]
-	[[Category: Hopfner, K P]]	+	[[Category: Deimling T]]
-	[[Category: Mueller, M]]	+	[[Category: Hopfner K-P]]
-	[[Category: Witte, G]]	+	[[Category: Mueller M]]
-	~~[[Category: C-di-amp synthesis]]~~	+	[[Category: Witte G]]
-	~~[[Category: Dac domain]]~~	+
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Pre-reaction state]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:31, 19 June 2019

OCA — Wed, 19 Jun 2019 07:31:43 GMT

←Older revision		Revision as of 07:31, 19 June 2019
Line 1:		Line 1:

	==Structure of Thermotoga maritima DisA in complex with ApCpp==		==Structure of Thermotoga maritima DisA in complex with ApCpp==
-	<StructureSection load='4yxj' size='340' side='right' caption='[[4yxj]], [[Resolution\|resolution]] 2.55Å' scene=''>	+	<StructureSection load='4yxj' size='340' side='right'caption='[[4yxj]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4yxj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YXJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4yxj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YXJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c1y\|3c1y]], [[3c1z\|3c1z]], [[3c21\|3c21]], [[3c23\|3c23]], [[4yvz\|4yvz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c1y\|3c1y]], [[3c1z\|3c1z]], [[3c21\|3c21]], [[3c23\|3c23]], [[4yvz\|4yvz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">disA, TM_0200 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 ATCC 43589])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diadenylate_cyclase Diadenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.85 2.7.7.85] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diadenylate_cyclase Diadenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.85 2.7.7.85] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxj OCA], [http://pdbe.org/4yxj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yxj RCSB], [http://www.ebi.ac.uk/pdbsum/4yxj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxj OCA], [http://pdbe.org/4yxj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yxj RCSB], [http://www.ebi.ac.uk/pdbsum/4yxj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxj ProSAT]</span></td></tr>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 43589]]
	[[Category: Diadenylate cyclase]]		[[Category: Diadenylate cyclase]]
		+	[[Category: Large Structures]]
	[[Category: Deimling, T]]		[[Category: Deimling, T]]
	[[Category: Hopfner, K P]]		[[Category: Hopfner, K P]]

OCA at 13:21, 10 May 2017

OCA — Wed, 10 May 2017 13:21:02 GMT

←Older revision		Revision as of 13:21, 10 May 2017
Line 1:		Line 1:
		+
	==Structure of Thermotoga maritima DisA in complex with ApCpp==		==Structure of Thermotoga maritima DisA in complex with ApCpp==
	<StructureSection load='4yxj' size='340' side='right' caption='[[4yxj]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='4yxj' size='340' side='right' caption='[[4yxj]], [[Resolution\|resolution]] 2.55Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c1y\|3c1y]], [[3c1z\|3c1z]], [[3c21\|3c21]], [[3c23\|3c23]], [[4yvz\|4yvz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c1y\|3c1y]], [[3c1z\|3c1z]], [[3c21\|3c21]], [[3c23\|3c23]], [[4yvz\|4yvz]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diadenylate_cyclase Diadenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.85 2.7.7.85] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diadenylate_cyclase Diadenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.85 2.7.7.85] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yxj RCSB], [http://www.ebi.ac.uk/pdbsum/4yxj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxj OCA], [http://pdbe.org/4yxj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yxj RCSB], [http://www.ebi.ac.uk/pdbsum/4yxj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yxj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4yxj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:33, 10 June 2015

OCA — Wed, 10 Jun 2015 07:33:45 GMT

←Older revision		Revision as of 07:33, 10 June 2015
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DISA_THEMA DISA_THEMA]] Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity).<ref>PMID:18439896</ref> Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. Does not convert GTP to c-di-GMP.<ref>PMID:18439896</ref>		[[http://www.uniprot.org/uniprot/DISA_THEMA DISA_THEMA]] Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity).<ref>PMID:18439896</ref> Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. Does not convert GTP to c-di-GMP.<ref>PMID:18439896</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The identification of the essential bacterial second messenger cyclic-di-AMP synthesized by the DNA-integrity scanning protein DisA opened up a new and emerging field in bacterial signaling. To further analyze the di-adenylate cyclase reaction catalyzed by the DAC domains of DisA, we crystallized Thermotoga maritima DisA in presence of different ATP analogs and metal ions to identify the metal binding site and trap the enzyme in pre- and post-reaction states. Through structural and biochemical assays we identified important residues essential for the reaction in the active site of the DAC domains. Our structures resolve the metal binding site and thus explain the activation of ATP for the DAC reaction. Moreover, we were able to identify a potent inhibitor of the DAC domain. Based on the available structures and homology to annotated DAC domains we propose a common mechanism for c-di-AMP synthesis by DAC domains in c-di-AMP producing species and a possible approach for its effective inhibition.
		+
		+	Structural analysis of the di-adenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.,Muller M, Deimling T, Hopfner KP, Witte G Biochem J. 2015 May 27. PMID:26014055<ref>PMID:26014055</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:48, 3 June 2015

OCA — Wed, 03 Jun 2015 12:48:17 GMT

←Older revision		Revision as of 12:48, 3 June 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure of Thermotoga maritima DisA in complex with ApCpp==
-		+	<StructureSection load='4yxj' size='340' side='right' caption='[[4yxj]], [[Resolution\|resolution]] 2.55Å' scene=''>
-	~~The entry~~ 4yxj is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4yxj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YXJ FirstGlance]. <br>
-	~~Authors~~: ~~Mueller~~, M., ~~Deimling~~, T., ~~Hopfner~~, K.-P., ~~Witte, G~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c1y\|3c1y]], [[3c1z\|3c1z]], [[3c21\|3c21]], [[3c23\|3c23]], [[4yvz\|4yvz]]</td></tr>
-	~~Description~~:	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diadenylate_cyclase Diadenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.85 2.7.7.85] </span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yxj RCSB], [http://www.ebi.ac.uk/pdbsum/4yxj PDBsum]</span></td></tr>
-	[[Category: Hopfner, K.-P]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DISA_THEMA DISA_THEMA]] Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity).<ref>PMID:18439896</ref> Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. Does not convert GTP to c-di-GMP.<ref>PMID:18439896</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Diadenylate cyclase]]
		+	[[Category: Deimling, T]]
		+	[[Category: Hopfner, K P]]
	[[Category: Mueller, M]]		[[Category: Mueller, M]]
	[[Category: Witte, G]]		[[Category: Witte, G]]
-	[[Category: ~~Deimling, T~~]]	+	[[Category: C-di-amp synthesis]]
		+	[[Category: Dac domain]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Inhibitor]]
		+	[[Category: Pre-reaction state]]
		+	[[Category: Transferase]]

OCA: Protected "4yxj" [edit=sysop:move=sysop]

OCA — Wed, 01 Apr 2015 12:00:45 GMT

Protected "4yxj" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:00, 1 April 2015

OCA: New page: '''Unreleased structure''' The entry 4yxj is ON HOLD until Paper Publication Authors: Mueller, M., Deimling, T., Hopfner, K.-P., Witte, G. Description: [[Category: Unreleased Structur...

OCA — Wed, 01 Apr 2015 12:00:42 GMT

New page: '''Unreleased structure''' The entry 4yxj is ON HOLD until Paper Publication Authors: Mueller, M., Deimling, T., Hopfner, K.-P., Witte, G. Description: [[Category: Unreleased Structur...

New page

'''Unreleased structure'''

The entry 4yxj is ON HOLD until Paper Publication

Authors: Mueller, M., Deimling, T., Hopfner, K.-P., Witte, G.

Description:
[[Category: Unreleased Structures]]
[[Category: Hopfner, K.-P]]
[[Category: Mueller, M]]
[[Category: Witte, G]]
[[Category: Deimling, T]]