4yz8 - Revision history

OCA: Redirecting to 5upd

OCA — Sat, 11 Mar 2017 19:02:35 GMT

Redirecting to 5upd

←Older revision		Revision as of 19:02, 11 March 2017
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-		+	#REDIRECT [[5upd]] This PDB entry is obsolete and replaced by 5upd
-	~~==Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1)==~~	+
-	~~<StructureSection load='4yz8' size='340' side='right' caption='~~[[~~4yz8]], [[Resolution\|resolution]] 1.80Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	~~<table><tr><td colspan='2'>[[4yz8~~]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YZ8 FirstGlance]. <br>	+
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yz8 OCA], [http://pdbe.org/4yz8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yz8 RCSB], [http://www.ebi.ac.uk/pdbsum/4yz8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yz8 ProSAT]</span></td></tr>	+
-	~~</table>~~	+
-	~~== Disease ==~~	+
-	[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.<ref>PMID:15983384</ref> Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.	+
-	~~== Function ==~~	+
-	~~[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Histone methyltransferase. Preferentially methylates 'Lys-4'~~ and ~~'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.<ref>PMID:16682010</ref>~~	+
-		+
-	~~==See Also==~~	+
-	*[[Histone methyltransferase\|Histone methyltransferase]]	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Histone-lysine N-methyltransferase]]~~	+
-	~~[[Category: Arrowsmith, C H]]~~	+
-	~~[[Category: Bountra, C]]~~	+
-	~~[[Category: Brown, P J]]~~	+
-	~~[[Category: Cerovina, T]]~~	+
-	~~[[Category: Dong, A]]~~	+
-	~~[[Category: Edwards, A M]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Tempel, W]]~~	+
-	~~[[Category: Wu, H]]~~	+
-	~~[[Category: Yu, W]]~~	+
-	~~[[Category: Methyl transferase]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transferase]]~~	+

OCA at 06:46, 26 July 2016

OCA — Tue, 26 Jul 2016 06:46:04 GMT

←Older revision		Revision as of 06:46, 26 July 2016
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		+
	==Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1)==		==Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1)==
	<StructureSection load='4yz8' size='340' side='right' caption='[[4yz8]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4yz8' size='340' side='right' caption='[[4yz8]], [[Resolution\|resolution]] 1.80Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yz8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yz8 RCSB], [http://www.ebi.ac.uk/pdbsum/4yz8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yz8 OCA], [http://pdbe.org/4yz8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yz8 RCSB], [http://www.ebi.ac.uk/pdbsum/4yz8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yz8 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.<ref>PMID:16682010</ref>		[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.<ref>PMID:16682010</ref>
		+
		+	==See Also==
		+	*[[Histone methyltransferase\|Histone methyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:04, 15 April 2015

OCA — Wed, 15 Apr 2015 13:04:25 GMT

←Older revision		Revision as of 13:04, 15 April 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1)==
-		+	<StructureSection load='4yz8' size='340' side='right' caption='[[4yz8]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~The entry~~ 4yz8 is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4yz8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YZ8 FirstGlance]. <br>
-	~~Authors~~: ~~Tempel, W~~.~~, Yu, W~~.~~, Dong, A~~.~~, Cerovina, T~~.~~, Bountra, C~~., ~~Arrowsmith~~, C.H., ~~Edwards, A~~.M., ~~Brown, P~~.J., ~~Wu, H~~., ~~Structural Genomics Consortium (SGC)~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
-	~~Description: Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1)~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yz8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yz8 RCSB], [http://www.ebi.ac.uk/pdbsum/4yz8 PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Dong, A~~]]	+	== Disease ==
-	[[Category: ~~Yu, W~~]]	+	[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Note=Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.<ref>PMID:15983384</ref> Note=A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.
-	[[Category: Wu, H]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NSD3_HUMAN NSD3_HUMAN]] Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.<ref>PMID:16682010</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Histone-lysine N-methyltransferase]]
		+	[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]
-	~~[[Category: Tempel, W]]~~	+	[[Category: Brown, P J]]
-	~~[[Category: Arrowsmith, C.H]]~~	+
-	[[Category: Brown, P.J]]	+
-	~~[[Category: Edwards, A.M]]~~	+
-	~~[[Category: Structural Genomics Consortium (Sgc)~~]]	+
	[[Category: Cerovina, T]]		[[Category: Cerovina, T]]
		+	[[Category: Dong, A]]
		+	[[Category: Edwards, A M]]
		+	[[Category: Structural genomic]]
		+	[[Category: Tempel, W]]
		+	[[Category: Wu, H]]
		+	[[Category: Yu, W]]
		+	[[Category: Methyl transferase]]
		+	[[Category: Sgc]]
		+	[[Category: Transferase]]

OCA: Protected "4yz8" [edit=sysop:move=sysop]

OCA — Wed, 01 Apr 2015 12:05:01 GMT

Protected "4yz8" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:05, 1 April 2015

OCA: New page: '''Unreleased structure''' The entry 4yz8 is ON HOLD Authors: Tempel, W., Yu, W., Dong, A., Cerovina, T., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural G...

OCA — Wed, 01 Apr 2015 12:05:00 GMT

New page: '''Unreleased structure''' The entry 4yz8 is ON HOLD Authors: Tempel, W., Yu, W., Dong, A., Cerovina, T., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural G...

New page

'''Unreleased structure'''

The entry 4yz8 is ON HOLD

Authors: Tempel, W., Yu, W., Dong, A., Cerovina, T., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC)

Description: Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1)
[[Category: Unreleased Structures]]
[[Category: Dong, A]]
[[Category: Yu, W]]
[[Category: Wu, H]]
[[Category: Bountra, C]]
[[Category: Tempel, W]]
[[Category: Arrowsmith, C.H]]
[[Category: Brown, P.J]]
[[Category: Edwards, A.M]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Cerovina, T]]