4z0v - Revision history

OCA at 08:10, 27 September 2023

OCA — Wed, 27 Sep 2023 08:10:47 GMT

←Older revision		Revision as of 08:10, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4z0v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z0V FirstGlance]. <br>		<table><tr><td colspan='2'>[[4z0v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z0V FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.78Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z0v OCA], [https://pdbe.org/4z0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z0v RCSB], [https://www.ebi.ac.uk/pdbsum/4z0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z0v ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z0v OCA], [https://pdbe.org/4z0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z0v RCSB], [https://www.ebi.ac.uk/pdbsum/4z0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z0v ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:34, 10 May 2023

OCA — Wed, 10 May 2023 07:34:24 GMT

←Older revision		Revision as of 07:34, 10 May 2023
Line 3:		Line 3:
	<StructureSection load='4z0v' size='340' side='right'caption='[[4z0v]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='4z0v' size='340' side='right'caption='[[4z0v]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4z0v]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z0V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Z0V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4z0v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z0V FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4z2b\|4z2b]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z0v OCA], [https://pdbe.org/4z0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z0v RCSB], [https://www.ebi.ac.uk/pdbsum/4z0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z0v ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4z0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z0v OCA], [~~http~~://pdbe.org/4z0v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4z0v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4z0v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4z0v ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PDE12_HUMAN PDE12_HUMAN]] Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.<ref>PMID:15231837</ref> <ref>PMID:21245038</ref> <ref>PMID:21666256</ref> <ref>PMID:22285541</ref>	+	[https://www.uniprot.org/uniprot/PDE12_HUMAN PDE12_HUMAN] Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.<ref>PMID:15231837</ref> <ref>PMID:21245038</ref> <ref>PMID:21666256</ref> <ref>PMID:22285541</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Phosphodiesterase\|Phosphodiesterase]]	+	*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Nolte~~, R T~~]]	+	[[Category: Nolte RT]]
-	[[Category: Wang, L]]	+	[[Category: Wang L]]
-	[[Category: Wisely, B]]	+	[[Category: Wisely B]]
-	[[Category: Wood~~, E R]]~~	+	[[Category: Wood ER]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Pde12 2'-5'a eep nuclease~~]]	+

OCA at 07:05, 19 June 2019

OCA — Wed, 19 Jun 2019 07:05:41 GMT

←Older revision		Revision as of 07:05, 19 June 2019
Line 1:		Line 1:

	==The structure of human PDE12 residues 161-609==		==The structure of human PDE12 residues 161-609==
-	<StructureSection load='4z0v' size='340' side='right' caption='[[4z0v]], [[Resolution\|resolution]] 1.78Å' scene=''>	+	<StructureSection load='4z0v' size='340' side='right'caption='[[4z0v]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4z0v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z0V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z0V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4z0v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z0V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z0V FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4z2b\|4z2b]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4z2b\|4z2b]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z0v OCA], [http://pdbe.org/4z0v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z0v RCSB], [http://www.ebi.ac.uk/pdbsum/4z0v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z0v ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z0v OCA], [http://pdbe.org/4z0v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z0v RCSB], [http://www.ebi.ac.uk/pdbsum/4z0v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z0v ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4z0v" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4z0v" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphodiesterase\|Phosphodiesterase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Nolte, R T]]		[[Category: Nolte, R T]]
	[[Category: Wang, L]]		[[Category: Wang, L]]

OCA at 14:13, 24 May 2017

OCA — Wed, 24 May 2017 14:13:49 GMT

←Older revision		Revision as of 14:13, 24 May 2017
Line 1:		Line 1:
		+
	==The structure of human PDE12 residues 161-609==		==The structure of human PDE12 residues 161-609==
	<StructureSection load='4z0v' size='340' side='right' caption='[[4z0v]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='4z0v' size='340' side='right' caption='[[4z0v]], [[Resolution\|resolution]] 1.78Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4z2b\|4z2b]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4z2b\|4z2b]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z0v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4z0v RCSB], [http://www.ebi.ac.uk/pdbsum/4z0v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z0v OCA], [http://pdbe.org/4z0v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z0v RCSB], [http://www.ebi.ac.uk/pdbsum/4z0v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z0v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4z0v" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:53, 24 June 2015

OCA — Wed, 24 Jun 2015 06:53:38 GMT

←Older revision		Revision as of 06:53, 24 June 2015
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PDE12_HUMAN PDE12_HUMAN]] Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.<ref>PMID:15231837</ref> <ref>PMID:21245038</ref> <ref>PMID:21666256</ref> <ref>PMID:22285541</ref>		[[http://www.uniprot.org/uniprot/PDE12_HUMAN PDE12_HUMAN]] Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.<ref>PMID:15231837</ref> <ref>PMID:21245038</ref> <ref>PMID:21666256</ref> <ref>PMID:22285541</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	2',5'-oligoadenylate synthetase (OAS) enzymes and RNase-L constitute a major effector arm of interferon (IFN) mediated antiviral defense. OAS produces a unique oligonucleotide second messenger, 2',5'-oligoadenylate (2-5A), that binds and activates RNase-L. This pathway is down regulated by viral and host encoded enzymes that degrade 2-5A. Phosphodiesterase 12 (PDE12) was the first cellular 2-5A degrading enzyme to be purified and described at a molecular level. Inhibition of PDE12 may up regulate the OAS/RNase-L pathway in response to viral infection resulting in increased resistance to a variety of viral pathogens. We generated a PDE12 null cell-line, HeLaDeltaPDE12, using transcription activator-like effector nuclease (TALEN) mediated gene inactivation. This cell line has increased 2-5A levels in response to IFN and polyinosinic-polycytidylic acid (poly IC), a double-stranded RNA mimic compared to the parental cell line. Moreover, HeLaDeltaPDE12 cells were resistant to viral pathogens including encephalomyocarditis virus (EMCV), human rhinovirus (HRV), and respiratory syncytial virus (RSV). Based on these results, we used DNA-encoded chemical library screening to identify starting points for inhibitor lead optimization. Compounds derived from this effort raise 2-5A levels and exhibit antiviral activity comparable to the effects observed with PDE12 gene inactivation. The crystal structure of PDE12 complexed with an inhibitor was solved providing insights into the structure activity relationships of inhibitor potency and selectivity.
		+
		+	The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.,Wood ER, Bledsoe R, Chai J, Daka P, Deng H, Ding Y, Harris-Gurley S, Kryn LH, Nartey E, Nichols J, Nolte RT, Prabhu N, Rise C, Sheahan T, Shotwell JB, Smith D, Tai V, Taylor JD, Tomberlin G, Wang L, Wisely B, You S, Xia B, Dickson H J Biol Chem. 2015 Jun 8. pii: jbc.M115.653113. PMID:26055709<ref>PMID:26055709</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:30, 17 June 2015

OCA — Wed, 17 Jun 2015 15:30:55 GMT

←Older revision		Revision as of 15:30, 17 June 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==The structure of human PDE12 residues 161-609==
-		+	<StructureSection load='4z0v' size='340' side='right' caption='[[4z0v]], [[Resolution\|resolution]] 1.78Å' scene=''>
-	~~The entry~~ 4z0v is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4z0v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z0V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z0V FirstGlance]. <br>
-	~~Authors~~: ~~Nolte~~, R.T., ~~Wisely, B~~.~~, Wang, L~~., ~~Wood~~, E.R.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4z2b\|4z2b]]</td></tr>
-	~~Description: The structure of human PDE12 residues 161-609~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z0v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4z0v RCSB], [http://www.ebi.ac.uk/pdbsum/4z0v PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Wood~~, E.R]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PDE12_HUMAN PDE12_HUMAN]] Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.<ref>PMID:15231837</ref> <ref>PMID:21245038</ref> <ref>PMID:21666256</ref> <ref>PMID:22285541</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Nolte, R T]]
	[[Category: Wang, L]]		[[Category: Wang, L]]
	[[Category: Wisely, B]]		[[Category: Wisely, B]]
-	[[Category: ~~Nolte~~, R.T]]	+	[[Category: Wood, E R]]
		+	[[Category: Hydrolase]]
		+	[[Category: Pde12 2'-5'a eep nuclease]]

OCA at 11:34, 10 June 2015

OCA — Wed, 10 Jun 2015 11:34:11 GMT

←Older revision		Revision as of 11:34, 10 June 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4z0v is ON HOLD	+	The entry 4z0v is ON HOLD until Paper Publication

	Authors: Nolte, R.T., Wisely, B., Wang, L., Wood, E.R.		Authors: Nolte, R.T., Wisely, B., Wang, L., Wood, E.R.

OCA at 10:28, 3 June 2015

OCA — Wed, 03 Jun 2015 10:28:36 GMT

←Older revision		Revision as of 10:28, 3 June 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4z0v is ON HOLD ~~until Paper Publication~~	+	The entry 4z0v is ON HOLD

	Authors: Nolte, R.T., Wisely, B., Wang, L., Wood, E.R.		Authors: Nolte, R.T., Wisely, B., Wang, L., Wood, E.R.

OCA at 11:18, 6 May 2015

OCA — Wed, 06 May 2015 11:18:02 GMT

←Older revision		Revision as of 11:18, 6 May 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4z0v is ON HOLD	+	The entry 4z0v is ON HOLD until Paper Publication

	Authors: Nolte, R.T., Wisely, B., Wang, L., Wood, E.R.		Authors: Nolte, R.T., Wisely, B., Wang, L., Wood, E.R.

OCA: Protected "4z0v" [edit=sysop:move=sysop]

OCA — Wed, 01 Apr 2015 12:09:47 GMT

Protected "4z0v" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:09, 1 April 2015