4z2k - Revision history

OCA at 15:41, 8 November 2023

OCA — Wed, 08 Nov 2023 15:41:45 GMT

←Older revision		Revision as of 15:41, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4z2k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z2K FirstGlance]. <br>		<table><tr><td colspan='2'>[[4z2k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z2K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M6E:(1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,17S)-3-ETHYL-2,10-DIHYDROXY-2,6,8,10,12,15,15,17-OCTAMETHYL-5-OXO-9-(PROP-2-YN-1-YLOXY)-4,14,16-TRIOXABICYCLO[11.3.1]HEPTADEC-7-YL+{7-[N-(METHYLCARBAMOYL)CARBAMIMIDAMIDO]HEPTYL}CARBAMATE'>M6E</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M6E:(1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,17S)-3-ETHYL-2,10-DIHYDROXY-2,6,8,10,12,15,15,17-OCTAMETHYL-5-OXO-9-(PROP-2-YN-1-YLOXY)-4,14,16-TRIOXABICYCLO[11.3.1]HEPTADEC-7-YL+{7-[N-(METHYLCARBAMOYL)CARBAMIMIDAMIDO]HEPTYL}CARBAMATE'>M6E</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2k OCA], [https://pdbe.org/4z2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z2k RCSB], [https://www.ebi.ac.uk/pdbsum/4z2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2k OCA], [https://pdbe.org/4z2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z2k RCSB], [https://www.ebi.ac.uk/pdbsum/4z2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2k ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:36, 10 May 2023

OCA — Wed, 10 May 2023 07:36:30 GMT

←Older revision		Revision as of 07:36, 10 May 2023
Line 3:		Line 3:
	<StructureSection load='4z2k' size='340' side='right'caption='[[4z2k]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4z2k' size='340' side='right'caption='[[4z2k]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4z2k]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_marcescens"_(bizio_1823)_trevisan_in_de_toni_and_trevisan_1889 "bacillus~~ marcescens~~" (bizio 1823) trevisan in de toni and trevisan 1889~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4Z2K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4z2k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z2K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M6E:(1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,17S)-3-ETHYL-2,10-DIHYDROXY-2,6,8,10,12,15,15,17-OCTAMETHYL-5-OXO-9-(PROP-2-YN-1-YLOXY)-4,14,16-TRIOXABICYCLO[11.3.1]HEPTADEC-7-YL+{7-[N-(METHYLCARBAMOYL)CARBAMIMIDAMIDO]HEPTYL}CARBAMATE'>M6E</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M6E:(1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,17S)-3-ETHYL-2,10-DIHYDROXY-2,6,8,10,12,15,15,17-OCTAMETHYL-5-OXO-9-(PROP-2-YN-1-YLOXY)-4,14,16-TRIOXABICYCLO[11.3.1]HEPTADEC-7-YL+{7-[N-(METHYLCARBAMOYL)CARBAMIMIDAMIDO]HEPTYL}CARBAMATE'>M6E</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wd0\|3wd0]], [[4z2g\|4z2g]], [[4z2h\|4z2h]], [[4z2i\|4z2i]], [[4z2j\|4z2j]], [[4z2l\|4z2l]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2k OCA], [https://pdbe.org/4z2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z2k RCSB], [https://www.ebi.ac.uk/pdbsum/4z2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2k ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chiB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=615 "Bacillus marcescens" (Bizio 1823) Trevisan in de Toni and Trevisan 1889])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4z2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2k OCA], [~~http~~://pdbe.org/4z2k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4z2k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4z2k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2k ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CHIB_SERMA CHIB_SERMA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Chitinase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Maita, N~~]]	+	[[Category: Serratia marcescens]]
-	[[Category: ~~Sugawara, A~~]]	+	[[Category: Maita N]]
-	[[Category: ~~Sunazuka, T~~]]	+	[[Category: Sugawara A]]
-	[[Category: ~~Hydrolase-hydrolase inhibitor complex]]~~	+	[[Category: Sunazuka T]]
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Macrolide~~]]	+

OCA at 07:12, 19 June 2019

OCA — Wed, 19 Jun 2019 07:12:34 GMT

←Older revision		Revision as of 07:12, 19 June 2019
Line 1:		Line 1:

	==Serratia marcescens Chitinase B complexed with macrolide inhibitor 32==		==Serratia marcescens Chitinase B complexed with macrolide inhibitor 32==
-	<StructureSection load='4z2k' size='340' side='right' caption='[[4z2k]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4z2k' size='340' side='right'caption='[[4z2k]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4z2k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4z2k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_marcescens"_(bizio_1823)_trevisan_in_de_toni_and_trevisan_1889 "bacillus marcescens" (bizio 1823) trevisan in de toni and trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2K FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M6E:(1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,17S)-3-ETHYL-2,10-DIHYDROXY-2,6,8,10,12,15,15,17-OCTAMETHYL-5-OXO-9-(PROP-2-YN-1-YLOXY)-4,14,16-TRIOXABICYCLO[11.3.1]HEPTADEC-7-YL+{7-[N-(METHYLCARBAMOYL)CARBAMIMIDAMIDO]HEPTYL}CARBAMATE'>M6E</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M6E:(1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,17S)-3-ETHYL-2,10-DIHYDROXY-2,6,8,10,12,15,15,17-OCTAMETHYL-5-OXO-9-(PROP-2-YN-1-YLOXY)-4,14,16-TRIOXABICYCLO[11.3.1]HEPTADEC-7-YL+{7-[N-(METHYLCARBAMOYL)CARBAMIMIDAMIDO]HEPTYL}CARBAMATE'>M6E</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wd0\|3wd0]], [[4z2g\|4z2g]], [[4z2h\|4z2h]], [[4z2i\|4z2i]], [[4z2j\|4z2j]], [[4z2l\|4z2l]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wd0\|3wd0]], [[4z2g\|4z2g]], [[4z2h\|4z2h]], [[4z2i\|4z2i]], [[4z2j\|4z2j]], [[4z2l\|4z2l]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chiB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=615 "Bacillus marcescens" (Bizio 1823) Trevisan in de Toni and Trevisan 1889])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2k OCA], [http://pdbe.org/4z2k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z2k RCSB], [http://www.ebi.ac.uk/pdbsum/4z2k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2k OCA], [http://pdbe.org/4z2k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z2k RCSB], [http://www.ebi.ac.uk/pdbsum/4z2k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2k ProSAT]</span></td></tr>
Line 20:		Line 21:

	==See Also==		==See Also==
-	*[[Chitinase\|Chitinase]]	+	*[[Chitinase 3D structures\|Chitinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Chitinase]]		[[Category: Chitinase]]
		+	[[Category: Large Structures]]
	[[Category: Maita, N]]		[[Category: Maita, N]]
	[[Category: Sugawara, A]]		[[Category: Sugawara, A]]
	[[Category: Sunazuka, T]]		[[Category: Sunazuka, T]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
	[[Category: Macrolide]]		[[Category: Macrolide]]

OCA at 12:02, 12 April 2017

OCA — Wed, 12 Apr 2017 12:02:58 GMT

←Older revision		Revision as of 12:02, 12 April 2017
Line 1:		Line 1:
		+
	==Serratia marcescens Chitinase B complexed with macrolide inhibitor 32==		==Serratia marcescens Chitinase B complexed with macrolide inhibitor 32==
	<StructureSection load='4z2k' size='340' side='right' caption='[[4z2k]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4z2k' size='340' side='right' caption='[[4z2k]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wd0\|3wd0]], [[4z2g\|4z2g]], [[4z2h\|4z2h]], [[4z2i\|4z2i]], [[4z2j\|4z2j]], [[4z2l\|4z2l]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wd0\|3wd0]], [[4z2g\|4z2g]], [[4z2h\|4z2h]], [[4z2i\|4z2i]], [[4z2j\|4z2j]], [[4z2l\|4z2l]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4z2k RCSB], [http://www.ebi.ac.uk/pdbsum/4z2k PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2k OCA], [http://pdbe.org/4z2k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z2k RCSB], [http://www.ebi.ac.uk/pdbsum/4z2k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z2k ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4z2k" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Chitinase\|Chitinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:02, 1 July 2015

OCA — Wed, 01 Jul 2015 12:02:38 GMT

←Older revision		Revision as of 12:02, 1 July 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Serratia marcescens Chitinase B complexed with macrolide inhibitor 32==
		+	<StructureSection load='4z2k' size='340' side='right' caption='[[4z2k]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4z2k]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2K FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M6E:(1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,17S)-3-ETHYL-2,10-DIHYDROXY-2,6,8,10,12,15,15,17-OCTAMETHYL-5-OXO-9-(PROP-2-YN-1-YLOXY)-4,14,16-TRIOXABICYCLO[11.3.1]HEPTADEC-7-YL+{7-[N-(METHYLCARBAMOYL)CARBAMIMIDAMIDO]HEPTYL}CARBAMATE'>M6E</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3wd0\|3wd0]], [[4z2g\|4z2g]], [[4z2h\|4z2h]], [[4z2i\|4z2i]], [[4z2j\|4z2j]], [[4z2l\|4z2l]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4z2k RCSB], [http://www.ebi.ac.uk/pdbsum/4z2k PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Argifin, a 17-membered pentapeptide, inhibits chitinase. As argifin has properties that render it unsuitable as a drug development candidate, we devised a mechanism to create the structural component of argifin that bestows the chitinase inhibition and introduce it into a 14-membered macrolide scaffold. Here we describe (1) the designed macrolide, which exhibits approximately 200-fold more potent chitinase inhibition than argifin, (2) the binding modes of the macrolide with Serratia marcescens chitinase B, and (3) the computed analysis explaining the reason for derivatives displaying increased inhibition compared to argifin, the macrolide aglycone displaying inhibition in a nanomolar range. This promises a class of chitinase inhibitors with novel skeletons, providing innovative insight for drug design and the use of macrolides as adaptable, flexible templates for use in drug discovery research and development.

-	~~The entry 4z2k is ON HOLD~~	+	Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase.,Sugawara A, Maita N, Gouda H, Yamamoto T, Hirose T, Kimura S, Saito Y, Nakano H, Kasai T, Nakano H, Shiomi K, Hirono S, Watanabe T, Taniguchi H, Omura S, Sunazuka T J Med Chem. 2015 Jun 25;58(12):4984-4997. Epub 2015 Jun 12. PMID:26030312<ref>PMID:26030312</ref>

-	~~Authors: Maita~~, N.~~, Sugawara, A~~.~~, Sunazuka, T~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Serratia marcescens~~ Chitinase ~~B complexed with macrolide inhibitor 27~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chitinase]]
		+	[[Category: Maita, N]]
		+	[[Category: Sugawara, A]]
	[[Category: Sunazuka, T]]		[[Category: Sunazuka, T]]
-	[[Category: ~~Sugawara, A~~]]	+	[[Category: Inhibitor]]
-	[[Category: ~~Maita, N~~]]	+	[[Category: Macrolide]]

OCA: Protected "4z2k" [edit=sysop:move=sysop]

OCA — Wed, 08 Apr 2015 10:03:22 GMT

Protected "4z2k" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:03, 8 April 2015

OCA: New page: '''Unreleased structure''' The entry 4z2k is ON HOLD Authors: Maita, N., Sugawara, A., Sunazuka, T. Description: Serratia marcescens Chitinase B complexed with macrolide inhibitor 27 [...

OCA — Wed, 08 Apr 2015 10:03:21 GMT

New page: '''Unreleased structure''' The entry 4z2k is ON HOLD Authors: Maita, N., Sugawara, A., Sunazuka, T. Description: Serratia marcescens Chitinase B complexed with macrolide inhibitor 27 [...

New page

'''Unreleased structure'''

The entry 4z2k is ON HOLD

Authors: Maita, N., Sugawara, A., Sunazuka, T.

Description: Serratia marcescens Chitinase B complexed with macrolide inhibitor 27
[[Category: Unreleased Structures]]
[[Category: Sunazuka, T]]
[[Category: Sugawara, A]]
[[Category: Maita, N]]