4zej - Revision history

OCA at 10:59, 10 January 2024

OCA — Wed, 10 Jan 2024 10:59:32 GMT

←Older revision		Revision as of 10:59, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zej]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_stutzeri Pseudomonas stutzeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZEJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zej]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_stutzeri Pseudomonas stutzeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZEJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.79Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zej OCA], [https://pdbe.org/4zej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zej RCSB], [https://www.ebi.ac.uk/pdbsum/4zej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zej ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zej OCA], [https://pdbe.org/4zej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zej RCSB], [https://www.ebi.ac.uk/pdbsum/4zej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zej ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:50, 10 May 2023

OCA — Wed, 10 May 2023 07:50:51 GMT

←Older revision		Revision as of 07:50, 10 May 2023
Line 3:		Line 3:
	<StructureSection load='4zej' size='340' side='right'caption='[[4zej]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='4zej' size='340' side='right'caption='[[4zej]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zej]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"achromobacter_sewerinii"_bergey_et_al._1923 "achromobacter sewerinii" bergey et al. 1923~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZEJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zej]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_stutzeri Pseudomonas stutzeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZEJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4wd6\|4wd6]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zej OCA], [https://pdbe.org/4zej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zej RCSB], [https://www.ebi.ac.uk/pdbsum/4zej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zej ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaDIM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=316 "Achromobacter sewerinii" Bergey et al. 1923])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zej OCA], [~~http~~://pdbe.org/4zej PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zej RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zej PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zej ProSAT]</span></td></tr>	+
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/D5JGF6_STUST D5JGF6_STUST]
-	A carbapenem-resistant Pseudomonas stutzeri strain isolated from a Dutch patient was analyzed in detail. This isolate produced a metallo-beta-lactamase (MBL) whose gene, with 43.5% GC content, was cloned and expressed in Escherichia coli. beta-Lactamase DIM-1 (for Dutch imipenemase) was weakly related to other Ambler class B beta-lactamases, sharing <52% amino acid identity with the most closely related MBL, GIM-1, and 45% identity with IMP-type MBLs. The beta-Lactamase DIM-1 significantly hydrolyzed broad-spectrum cephalosporins and carbapenems and spared aztreonam. This MBL gene was embedded in a class 1 integron containing two other gene cassettes, encoding resistance to aminoglycosides and disinfectants, that was located on a 70-kb plasmid.	+
-		+
-	Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands.,Poirel L, Rodriguez-Martinez JM, Al Naiemi N, Debets-Ossenkopp YJ, Nordmann P Antimicrob Agents Chemother. 2010 Jun;54(6):~~2420-4. doi: 10.1128~~/~~AAC.01456-09., Epub 2010 Mar 22. PMID:20308383<ref>PMID:20308383<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 4zej" style="background-color:#fffaf0;"><~~/~~div>~~	+

	==See Also==		==See Also==
	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]		*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Achromobacter sewerinii bergey et al. 1923]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Booth, M P.S~~]]	+	[[Category: Pseudomonas stutzeri]]
-	[[Category: ~~Kosmopoulou, M~~]]	+	[[Category: Booth MPS]]
-	[[Category: ~~Spencer, J~~]]	+	[[Category: Kosmopoulou M]]
-	[[Category: ~~Hydrolase]]~~	+	[[Category: Spencer J]]
-	~~[[Category: Zinc metalloenzyme~~]]	+

OCA at 06:49, 19 June 2019

OCA — Wed, 19 Jun 2019 06:49:06 GMT

←Older revision		Revision as of 06:49, 19 June 2019
Line 1:		Line 1:

	==Crystal Structure of DIM-1 Metallo-beta-Lactamase exposed to Ceftazidime==		==Crystal Structure of DIM-1 Metallo-beta-Lactamase exposed to Ceftazidime==
-	<StructureSection load='4zej' size='340' side='right' caption='[[4zej]], [[Resolution\|resolution]] 1.79Å' scene=''>	+	<StructureSection load='4zej' size='340' side='right'caption='[[4zej]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zej]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZEJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zej]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"achromobacter_sewerinii"_bergey_et_al._1923 "achromobacter sewerinii" bergey et al. 1923]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZEJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4wd6\|4wd6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4wd6\|4wd6]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blaDIM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=316 "Achromobacter sewerinii" Bergey et al. 1923])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zej OCA], [http://pdbe.org/4zej PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zej RCSB], [http://www.ebi.ac.uk/pdbsum/4zej PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zej ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zej OCA], [http://pdbe.org/4zej PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zej RCSB], [http://www.ebi.ac.uk/pdbsum/4zej PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zej ProSAT]</span></td></tr>
	</table>		</table>
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4zej" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4zej" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Achromobacter sewerinii bergey et al. 1923]]
		+	[[Category: Large Structures]]
	[[Category: Booth, M P.S]]		[[Category: Booth, M P.S]]
	[[Category: Kosmopoulou, M]]		[[Category: Kosmopoulou, M]]

OCA at 09:52, 10 March 2017

OCA — Fri, 10 Mar 2017 09:52:34 GMT

←Older revision		Revision as of 09:52, 10 March 2017
Line 1:		Line 1:
		+
	==Crystal Structure of DIM-1 Metallo-beta-Lactamase exposed to Ceftazidime==		==Crystal Structure of DIM-1 Metallo-beta-Lactamase exposed to Ceftazidime==
	<StructureSection load='4zej' size='340' side='right' caption='[[4zej]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='4zej' size='340' side='right' caption='[[4zej]], [[Resolution\|resolution]] 1.79Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4wd6\|4wd6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4wd6\|4wd6]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zej OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zej RCSB], [http://www.ebi.ac.uk/pdbsum/4zej PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zej OCA], [http://pdbe.org/4zej PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zej RCSB], [http://www.ebi.ac.uk/pdbsum/4zej PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zej ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4zej" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:53, 27 May 2015

OCA — Wed, 27 May 2015 15:53:02 GMT

←Older revision		Revision as of 15:53, 27 May 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal Structure of DIM-1 Metallo-beta-Lactamase exposed to Ceftazidime==
		+	<StructureSection load='4zej' size='340' side='right' caption='[[4zej]], [[Resolution\|resolution]] 1.79Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4zej]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZEJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4wd6\|4wd6]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zej OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zej RCSB], [http://www.ebi.ac.uk/pdbsum/4zej PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A carbapenem-resistant Pseudomonas stutzeri strain isolated from a Dutch patient was analyzed in detail. This isolate produced a metallo-beta-lactamase (MBL) whose gene, with 43.5% GC content, was cloned and expressed in Escherichia coli. beta-Lactamase DIM-1 (for Dutch imipenemase) was weakly related to other Ambler class B beta-lactamases, sharing <52% amino acid identity with the most closely related MBL, GIM-1, and 45% identity with IMP-type MBLs. The beta-Lactamase DIM-1 significantly hydrolyzed broad-spectrum cephalosporins and carbapenems and spared aztreonam. This MBL gene was embedded in a class 1 integron containing two other gene cassettes, encoding resistance to aminoglycosides and disinfectants, that was located on a 70-kb plasmid.

-	~~The entry 4zej is ON HOLD~~	+	Characterization of DIM-1, an integron-encoded metallo-beta-lactamase from a Pseudomonas stutzeri clinical isolate in the Netherlands.,Poirel L, Rodriguez-Martinez JM, Al Naiemi N, Debets-Ossenkopp YJ, Nordmann P Antimicrob Agents Chemother. 2010 Jun;54(6):2420-4. doi: 10.1128/AAC.01456-09., Epub 2010 Mar 22. PMID:20308383<ref>PMID:20308383</ref>

-	~~Authors: Booth~~, ~~M.P~~.S.~~, Kosmopoulou, M., Spencer, J~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal Structure of DIM-1 Metallo-beta-Lactamase exposed to Ceftazidime~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Booth, M P.S]]
		+	[[Category: Kosmopoulou, M]]
	[[Category: Spencer, J]]		[[Category: Spencer, J]]
-	[[Category: ~~Kosmopoulou, M~~]]	+	[[Category: Hydrolase]]
-	[[Category: ~~Booth, M.P.S~~]]	+	[[Category: Zinc metalloenzyme]]

OCA: Protected "4zej" [edit=sysop:move=sysop]

OCA — Thu, 30 Apr 2015 10:15:23 GMT

Protected "4zej" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:15, 30 April 2015

OCA: New page: '''Unreleased structure''' The entry 4zej is ON HOLD Authors: Booth, M.P.S., Kosmopoulou, M., Spencer, J. Description: Crystal Structure of DIM-1 Metallo-beta-Lactamase exposed to Ceft...

OCA — Thu, 30 Apr 2015 10:15:22 GMT

New page: '''Unreleased structure''' The entry 4zej is ON HOLD Authors: Booth, M.P.S., Kosmopoulou, M., Spencer, J. Description: Crystal Structure of DIM-1 Metallo-beta-Lactamase exposed to Ceft...

New page

'''Unreleased structure'''

The entry 4zej is ON HOLD

Authors: Booth, M.P.S., Kosmopoulou, M., Spencer, J.

Description: Crystal Structure of DIM-1 Metallo-beta-Lactamase exposed to Ceftazidime
[[Category: Unreleased Structures]]
[[Category: Spencer, J]]
[[Category: Kosmopoulou, M]]
[[Category: Booth, M.P.S]]