4zfc - Revision history

OCA at 09:04, 20 March 2024

OCA — Wed, 20 Mar 2024 09:04:46 GMT

←Older revision		Revision as of 09:04, 20 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zfc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZFC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zfc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZFC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCZ:N-[(3AR,6AS)-HEXAHYDROCYCLOPENTA[C]PYRROL-2(1H)-YLCARBAMOYL]-4-METHYLBENZENESULFONAMIDE'>GCZ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCZ:N-[(3AR,6AS)-HEXAHYDROCYCLOPENTA[C]PYRROL-2(1H)-YLCARBAMOYL]-4-METHYLBENZENESULFONAMIDE'>GCZ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfc OCA], [https://pdbe.org/4zfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zfc RCSB], [https://www.ebi.ac.uk/pdbsum/4zfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfc OCA], [https://pdbe.org/4zfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zfc RCSB], [https://www.ebi.ac.uk/pdbsum/4zfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.		[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Recent epidemiological studies show conflicting data for the first-line anti-diabetic sulphonylureas drugs in treating cancer progression in type II diabetes patients. How sulphonylureas promote or diminish tumor growth is not fully understood. Here, we report that seven sulphonylureas exhibit different in vitro inhibition towards AKR1Cs (AKR1C1, AKR1C2, AKR1C3), which are critical steroid hormone metabolism enzymes that are related to prostate cancer, breast cancer and endometrial diseases. Interactions of the sulphonylureas and AKR1Cs were analyzed by X-ray crystallography.
-
-	In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis.,Zhao Y, Zheng X, Zhang H, Zhai J, Zhang L, Li C, Zeng K, Chen Y, Li Q, Hu X Chem Biol Interact. 2015 Oct 5;240:310-5. doi: 10.1016/j.cbi.2015.09.006. Epub, 2015 Sep 8. PMID:26362498<ref>PMID:26362498</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4zfc" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Prostaglandin F synthase\|Prostaglandin F synthase]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:54, 10 May 2023

OCA — Wed, 10 May 2023 07:54:13 GMT

←Older revision		Revision as of 07:54, 10 May 2023
Line 3:		Line 3:
	<StructureSection load='4zfc' size='340' side='right'caption='[[4zfc]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4zfc' size='340' side='right'caption='[[4zfc]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zfc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZFC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zfc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZFC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCZ:N-[(3AR,6AS)-HEXAHYDROCYCLOPENTA[C]PYRROL-2(1H)-YLCARBAMOYL]-4-METHYLBENZENESULFONAMIDE'>GCZ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCZ:N-[(3AR,6AS)-HEXAHYDROCYCLOPENTA[C]PYRROL-2(1H)-YLCARBAMOYL]-4-METHYLBENZENESULFONAMIDE'>GCZ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AKR1C3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfc OCA], [https://pdbe.org/4zfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zfc RCSB], [https://www.ebi.ac.uk/pdbsum/4zfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfc ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfc OCA], [~~http~~://pdbe.org/4zfc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zfc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zfc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.	+	[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hu, X]]	+	[[Category: Hu X]]
-	[[Category: Zhao, Y]]	+	[[Category: Zhao Y]]
-	[[Category: Zhrng, X]]	+	[[Category: Zhrng X]]
-	~~[[Category: Akr1c3 inhibitor]]~~	+
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex~~]]	+

OCA at 07:36, 19 June 2019

OCA — Wed, 19 Jun 2019 07:36:34 GMT

←Older revision		Revision as of 07:36, 19 June 2019
Line 1:		Line 1:
		+
	==Crystal structure of AKR1C3 complexed with glicazide==		==Crystal structure of AKR1C3 complexed with glicazide==
-	<StructureSection load='4zfc' size='340' side='right' caption='[[4zfc]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4zfc' size='340' side='right'caption='[[4zfc]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zfc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZFC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zfc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZFC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCZ:N-[(3AR,6AS)-HEXAHYDROCYCLOPENTA[C]PYRROL-2(1H)-YLCARBAMOYL]-4-METHYLBENZENESULFONAMIDE'>GCZ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCZ:N-[(3AR,6AS)-HEXAHYDROCYCLOPENTA[C]PYRROL-2(1H)-YLCARBAMOYL]-4-METHYLBENZENESULFONAMIDE'>GCZ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfc OCA], [http://pdbe.org/4zfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zfc RCSB], [http://www.ebi.ac.uk/pdbsum/4zfc PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AKR1C3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfc OCA], [http://pdbe.org/4zfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zfc RCSB], [http://www.ebi.ac.uk/pdbsum/4zfc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4zfc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4zfc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Prostaglandin F synthase\|Prostaglandin F synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hu, X]]		[[Category: Hu, X]]
	[[Category: Zhao, Y]]		[[Category: Zhao, Y]]

OCA at 04:38, 1 December 2015

OCA — Tue, 01 Dec 2015 04:38:50 GMT

←Older revision		Revision as of 04:38, 1 December 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of AKR1C3 complexed with glicazide==
		+	<StructureSection load='4zfc' size='340' side='right' caption='[[4zfc]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4zfc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZFC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCZ:N-[(3AR,6AS)-HEXAHYDROCYCLOPENTA[C]PYRROL-2(1H)-YLCARBAMOYL]-4-METHYLBENZENESULFONAMIDE'>GCZ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfc OCA], [http://pdbe.org/4zfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zfc RCSB], [http://www.ebi.ac.uk/pdbsum/4zfc PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Recent epidemiological studies show conflicting data for the first-line anti-diabetic sulphonylureas drugs in treating cancer progression in type II diabetes patients. How sulphonylureas promote or diminish tumor growth is not fully understood. Here, we report that seven sulphonylureas exhibit different in vitro inhibition towards AKR1Cs (AKR1C1, AKR1C2, AKR1C3), which are critical steroid hormone metabolism enzymes that are related to prostate cancer, breast cancer and endometrial diseases. Interactions of the sulphonylureas and AKR1Cs were analyzed by X-ray crystallography.

-	~~The entry 4zfc is ON HOLD until Paper Publication~~	+	In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis.,Zhao Y, Zheng X, Zhang H, Zhai J, Zhang L, Li C, Zeng K, Chen Y, Li Q, Hu X Chem Biol Interact. 2015 Oct 5;240:310-5. doi: 10.1016/j.cbi.2015.09.006. Epub, 2015 Sep 8. PMID:26362498<ref>PMID:26362498</ref>

-	~~Authors: Zhao~~, Y.~~, Zhrng, X~~.~~, Hu, X~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of AKR1C3 complexed with glicazide~~	+	<div class="pdbe-citations 4zfc" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hu, X]]
		+	[[Category: Zhao, Y]]
	[[Category: Zhrng, X]]		[[Category: Zhrng, X]]
-	[[Category: ~~Zhao, Y~~]]	+	[[Category: Akr1c3 inhibitor]]
-	[[Category: ~~Hu, X~~]]	+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 11:30, 22 July 2015

OCA — Wed, 22 Jul 2015 11:30:13 GMT

←Older revision		Revision as of 11:30, 22 July 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zfc is ON HOLD	+	The entry 4zfc is ON HOLD until Paper Publication

	Authors: Zhao, Y., Zhrng, X., Hu, X.		Authors: Zhao, Y., Zhrng, X., Hu, X.

OCA at 11:40, 6 May 2015

OCA — Wed, 06 May 2015 11:40:02 GMT

←Older revision		Revision as of 11:40, 6 May 2015
Line 3:		Line 3:
	The entry 4zfc is ON HOLD		The entry 4zfc is ON HOLD

-	Authors: ~~Yining~~ Zhao, ~~Xuehua~~ Zhrng, ~~Xiaopeng~~ Hu	+	Authors: Zhao, Y., Zhrng, X., Hu, X.

	Description: Crystal structure of AKR1C3 complexed with glicazide		Description: Crystal structure of AKR1C3 complexed with glicazide
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Yining Zhao, Xuehua~~ Zhrng, ~~Xiaopeng~~ Hu]]	+	[[Category: Zhrng, X]]
		+	[[Category: Zhao, Y]]
		+	[[Category: Hu, X]]

OCA: Protected "4zfc" [edit=sysop:move=sysop]

OCA — Thu, 30 Apr 2015 10:17:26 GMT

Protected "4zfc" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:17, 30 April 2015

OCA: New page: '''Unreleased structure''' The entry 4zfc is ON HOLD Authors: Yining Zhao, Xuehua Zhrng, Xiaopeng Hu Description: Crystal structure of AKR1C3 complexed with glicazide [[Category: Unrel...

OCA — Thu, 30 Apr 2015 10:17:24 GMT

New page: '''Unreleased structure''' The entry 4zfc is ON HOLD Authors: Yining Zhao, Xuehua Zhrng, Xiaopeng Hu Description: Crystal structure of AKR1C3 complexed with glicazide [[Category: Unrel...

New page

'''Unreleased structure'''

The entry 4zfc is ON HOLD

Authors: Yining Zhao, Xuehua Zhrng, Xiaopeng Hu

Description: Crystal structure of AKR1C3 complexed with glicazide
[[Category: Unreleased Structures]]
[[Category: Yining Zhao, Xuehua Zhrng, Xiaopeng Hu]]