4zfs - Revision history

OCA at 09:27, 15 November 2023

OCA — Wed, 15 Nov 2023 09:27:15 GMT

←Older revision		Revision as of 09:27, 15 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zfs]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Hydrozoa Hydrozoa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZFS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zfs]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Hydrozoa Hydrozoa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZFS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4M9:(4Z)-4-IMINO-4-[(4Z)-4-(1H-INDOL-3-YLMETHYLIDENE)-5-OXO-1-(2-OXOETHYL)-4,5-DIHYDRO-1H-IMIDAZOL-2-YL]BUTANAMIDE'>4M9</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.01Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4M9:(4Z)-4-IMINO-4-[(4Z)-4-(1H-INDOL-3-YLMETHYLIDENE)-5-OXO-1-(2-OXOETHYL)-4,5-DIHYDRO-1H-IMIDAZOL-2-YL]BUTANAMIDE'>4M9</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfs OCA], [https://pdbe.org/4zfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zfs RCSB], [https://www.ebi.ac.uk/pdbsum/4zfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfs OCA], [https://pdbe.org/4zfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zfs RCSB], [https://www.ebi.ac.uk/pdbsum/4zfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfs ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:26, 18 May 2023

OCA — Thu, 18 May 2023 07:26:10 GMT

←Older revision		Revision as of 07:26, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='4zfs' size='340' side='right'caption='[[4zfs]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='4zfs' size='340' side='right'caption='[[4zfs]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zfs]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Hydrozoa Hydrozoa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZFS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zfs]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Hydrozoa Hydrozoa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZFS FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=4M9:(4Z)-4-IMINO-4-[(4Z)-4-(1H-INDOL-3-YLMETHYLIDENE)-5-OXO-1-(2-OXOETHYL)-4,5-DIHYDRO-1H-IMIDAZOL-2-YL]BUTANAMIDE'>4M9</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4M9:(4Z)-4-IMINO-4-[(4Z)-4-(1H-INDOL-3-YLMETHYLIDENE)-5-OXO-1-(2-OXOETHYL)-4,5-DIHYDRO-1H-IMIDAZOL-2-YL]BUTANAMIDE'>4M9</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zbl\|4zbl]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfs OCA], [https://pdbe.org/4zfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zfs RCSB], [https://www.ebi.ac.uk/pdbsum/4zfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfs ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfs OCA], [~~http~~://pdbe.org/4zfs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zfs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zfs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfs ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q2TCH5_9CNID Q2TCH5_9CNID]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 24:
	[[Category: Hydrozoa]]		[[Category: Hydrozoa]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Pletnev, S]]	+	[[Category: Pletnev S]]
-	[[Category: Pletnev~~, V Z~~]]	+	[[Category: Pletnev VZ]]
-	[[Category: Pletneva~~, N V]]~~	+	[[Category: Pletneva NV]]
-	~~[[Category: Chromophore-assisted light inactivation]]~~	+
-	~~[[Category: Fluorescent protein]]~~	+
-	~~[[Category: Genetically encoded photosensitizer~~]]	+

OCA at 07:09, 19 June 2019

OCA — Wed, 19 Jun 2019 07:09:19 GMT

←Older revision		Revision as of 07:09, 19 June 2019
Line 1:		Line 1:
		+
	==Phototoxic Fluorescent Protein KillerOrange==		==Phototoxic Fluorescent Protein KillerOrange==
-	<StructureSection load='4zfs' size='340' side='right' caption='[[4zfs]], [[Resolution\|resolution]] 2.01Å' scene=''>	+	<StructureSection load='4zfs' size='340' side='right'caption='[[4zfs]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zfs]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZFS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zfs]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Hydrozoa Hydrozoa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZFS FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4M9:(4Z)-4-IMINO-4-[(4Z)-4-(1H-INDOL-3-YLMETHYLIDENE)-5-OXO-1-(2-OXOETHYL)-4,5-DIHYDRO-1H-IMIDAZOL-2-YL]BUTANAMIDE'>4M9</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4M9:(4Z)-4-IMINO-4-[(4Z)-4-(1H-INDOL-3-YLMETHYLIDENE)-5-OXO-1-(2-OXOETHYL)-4,5-DIHYDRO-1H-IMIDAZOL-2-YL]BUTANAMIDE'>4M9</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zbl\|4zbl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zbl\|4zbl]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfs OCA], [http://pdbe.org/4zfs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zfs RCSB], [http://www.ebi.ac.uk/pdbsum/4zfs PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfs OCA], [http://pdbe.org/4zfs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zfs RCSB], [http://www.ebi.ac.uk/pdbsum/4zfs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfs ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hydrozoa]]
		+	[[Category: Large Structures]]
	[[Category: Pletnev, S]]		[[Category: Pletnev, S]]
	[[Category: Pletnev, V Z]]		[[Category: Pletnev, V Z]]

OCA at 12:26, 13 January 2016

OCA — Wed, 13 Jan 2016 12:26:43 GMT

←Older revision		Revision as of 12:26, 13 January 2016
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfs OCA], [http://pdbe.org/4zfs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zfs RCSB], [http://www.ebi.ac.uk/pdbsum/4zfs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfs OCA], [http://pdbe.org/4zfs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zfs RCSB], [http://www.ebi.ac.uk/pdbsum/4zfs PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Phototoxic fluorescent proteins represent a sparse group of genetically encoded photosensitizers that could be used for precise light-induced inactivation of target proteins, DNA damage, and cell killing. Only two such GFP-based fluorescent proteins (FPs), KillerRed and its monomeric variant SuperNova, were described up to date. Here, we present a crystallographic study of their two orange successors, dimeric KillerOrange and monomeric mKillerOrange, at 1.81 and 1.57 A resolution, respectively. They are the first orange-emitting protein photosensitizers with a tryptophan-based chromophore (Gln65-Trp66-Gly67). Same as their red progenitors, both orange photosensitizers have a water-filled channel connecting the chromophore to the beta-barrel exterior and enabling transport of ROS. In both proteins, Trp66 of the chromophore adopts an unusual trans-cis conformation stabilized by H-bond with the nearby Gln159. This trans-cis conformation along with the water channel was shown to be a key structural feature providing bright orange emission and phototoxicity of both examined orange photosensitizers.
		+
		+	Crystal Structure of Phototoxic Orange Fluorescent Proteins with a Tryptophan-Based Chromophore.,Pletneva NV, Pletnev VZ, Sarkisyan KS, Gorbachev DA, Egorov ES, Mishin AS, Lukyanov KA, Dauter Z, Pletnev S PLoS One. 2015 Dec 23;10(12):e0145740. doi: 10.1371/journal.pone.0145740., eCollection 2015. PMID:26699366<ref>PMID:26699366</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4zfs" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:47, 23 December 2015

OCA — Wed, 23 Dec 2015 12:47:17 GMT

←Older revision		Revision as of 12:47, 23 December 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Phototoxic Fluorescent Protein KillerOrange==
-		+	<StructureSection load='4zfs' size='340' side='right' caption='[[4zfs]], [[Resolution\|resolution]] 2.01Å' scene=''>
-	~~The entry~~ 4zfs is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4zfs]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZFS FirstGlance]. <br>
-	~~Authors~~: ~~Pletneva, N~~.V.~~, Pletnev, V~~.Z.~~, Pletnev, S~~.	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4M9:(4Z)-4-IMINO-4-[(4Z)-4-(1H-INDOL-3-YLMETHYLIDENE)-5-OXO-1-(2-OXOETHYL)-4,5-DIHYDRO-1H-IMIDAZOL-2-YL]BUTANAMIDE'>4M9</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zbl\|4zbl]]</td></tr>
-	~~Description:~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfs OCA], [http://pdbe.org/4zfs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zfs RCSB], [http://www.ebi.ac.uk/pdbsum/4zfs PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Pletnev, V.Z~~]]	+	__TOC__
-	[[~~Category~~: ~~Pletneva~~, N.V]]	+	</StructureSection>
	[[Category: Pletnev, S]]		[[Category: Pletnev, S]]
		+	[[Category: Pletnev, V Z]]
		+	[[Category: Pletneva, N V]]
		+	[[Category: Chromophore-assisted light inactivation]]
		+	[[Category: Fluorescent protein]]
		+	[[Category: Genetically encoded photosensitizer]]

OCA: Protected "4zfs" [edit=sysop:move=sysop]

OCA — Thu, 30 Apr 2015 10:19:00 GMT

Protected "4zfs" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:19, 30 April 2015

OCA: New page: '''Unreleased structure''' The entry 4zfs is ON HOLD until Paper Publication Authors: Pletneva, N.V., Pletnev, V.Z., Pletnev, S. Description: Category: Unreleased Structures [[Cat...

OCA — Thu, 30 Apr 2015 10:18:58 GMT

New page: '''Unreleased structure''' The entry 4zfs is ON HOLD until Paper Publication Authors: Pletneva, N.V., Pletnev, V.Z., Pletnev, S. Description: Category: Unreleased Structures [[Cat...

New page

'''Unreleased structure'''

The entry 4zfs is ON HOLD until Paper Publication

Authors: Pletneva, N.V., Pletnev, V.Z., Pletnev, S.

Description:
[[Category: Unreleased Structures]]
[[Category: Pletnev, V.Z]]
[[Category: Pletneva, N.V]]
[[Category: Pletnev, S]]