4zfx - Revision history

OCA at 08:17, 27 September 2023

OCA — Wed, 27 Sep 2023 08:17:35 GMT

←Older revision		Revision as of 08:17, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zfx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZFX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zfx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZFX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EB4:N,N,N-[(3S,7S,11S)-2,6,10-TRIOXO-1,5,9-TRIOXACYCLODODECANE-3,7,11-TRIYL]TRIS(2,3-DIHYDROXYBENZAMIDE)'>EB4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TH:THORIUM+ION'>TH</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EB4:N,N,N-[(3S,7S,11S)-2,6,10-TRIOXO-1,5,9-TRIOXACYCLODODECANE-3,7,11-TRIYL]TRIS(2,3-DIHYDROXYBENZAMIDE)'>EB4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TH:THORIUM+ION'>TH</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfx OCA], [https://pdbe.org/4zfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zfx RCSB], [https://www.ebi.ac.uk/pdbsum/4zfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfx OCA], [https://pdbe.org/4zfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zfx RCSB], [https://www.ebi.ac.uk/pdbsum/4zfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfx ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:26, 18 May 2023

OCA — Thu, 18 May 2023 07:26:19 GMT

←Older revision		Revision as of 07:26, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='4zfx' size='340' side='right'caption='[[4zfx]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='4zfx' size='340' side='right'caption='[[4zfx]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zfx]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZFX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zfx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZFX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB4:N,N,N-[(3S,7S,11S)-2,6,10-TRIOXO-1,5,9-TRIOXACYCLODODECANE-3,7,11-TRIYL]TRIS(2,3-DIHYDROXYBENZAMIDE)'>EB4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TH:THORIUM+ION'>TH</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EB4:N,N,N-[(3S,7S,11S)-2,6,10-TRIOXO-1,5,9-TRIOXACYCLODODECANE-3,7,11-TRIYL]TRIS(2,3-DIHYDROXYBENZAMIDE)'>EB4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TH:THORIUM+ION'>TH</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LCN2, HNL, NGAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfx OCA], [https://pdbe.org/4zfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zfx RCSB], [https://www.ebi.ac.uk/pdbsum/4zfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfx ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfx OCA], [~~http~~://pdbe.org/4zfx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zfx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zfx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfx ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NGAL_HUMAN NGAL_HUMAN]] Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.<ref>PMID:12453413</ref>	+	[https://www.uniprot.org/uniprot/NGAL_HUMAN NGAL_HUMAN] Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.<ref>PMID:12453413</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	==See Also==		==See Also==
	*[[Neutrophil gelatinase-associated lipocalin\|Neutrophil gelatinase-associated lipocalin]]		*[[Neutrophil gelatinase-associated lipocalin\|Neutrophil gelatinase-associated lipocalin]]
-	*[[Siderocalin\|Siderocalin]]	+	*[[Siderocalin 3D structures\|Siderocalin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Abergel~~, R J~~]]	+	[[Category: Abergel RJ]]
-	[[Category: Allred~~, B E~~]]	+	[[Category: Allred BE]]
-	[[Category: An~~, D D~~]]	+	[[Category: An DD]]
-	[[Category: Gauny~~, S S~~]]	+	[[Category: Gauny SS]]
-	[[Category: Ralston~~, C Y~~]]	+	[[Category: Ralston CY]]
-	[[Category: Rupert~~, P B~~]]	+	[[Category: Rupert PB]]
-	[[Category: Strong~~, R K~~]]	+	[[Category: Strong RK]]
-	[[Category: Sturzbecher-Hoehne, M]]	+	[[Category: Sturzbecher-Hoehne M]]
-	~~[[Category: Metal binding protein-inhibitor complex~~]]	+

OCA at 07:33, 19 June 2019

OCA — Wed, 19 Jun 2019 07:33:55 GMT

←Older revision		Revision as of 07:33, 19 June 2019
Line 1:		Line 1:
		+
	==Siderocalin-mediated recognition and cellular uptake of actinides==		==Siderocalin-mediated recognition and cellular uptake of actinides==
-	<StructureSection load='4zfx' size='340' side='right' caption='[[4zfx]], [[Resolution\|resolution]] 2.55Å' scene=''>	+	<StructureSection load='4zfx' size='340' side='right'caption='[[4zfx]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zfx]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZFX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zfx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZFX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB4:N,N,N-[(3S,7S,11S)-2,6,10-TRIOXO-1,5,9-TRIOXACYCLODODECANE-3,7,11-TRIYL]TRIS(2,3-DIHYDROXYBENZAMIDE)'>EB4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TH:THORIUM+ION'>TH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB4:N,N,N-[(3S,7S,11S)-2,6,10-TRIOXO-1,5,9-TRIOXACYCLODODECANE-3,7,11-TRIYL]TRIS(2,3-DIHYDROXYBENZAMIDE)'>EB4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TH:THORIUM+ION'>TH</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zfx RCSB], [http://www.ebi.ac.uk/pdbsum/4zfx PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LCN2, HNL, NGAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfx OCA], [http://pdbe.org/4zfx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zfx RCSB], [http://www.ebi.ac.uk/pdbsum/4zfx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zfx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4zfx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Neutrophil gelatinase-associated lipocalin\|Neutrophil gelatinase-associated lipocalin]]
		+	*[[Siderocalin\|Siderocalin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Abergel, R J]]		[[Category: Abergel, R J]]
	[[Category: Allred, B E]]		[[Category: Allred, B E]]

OCA at 06:20, 20 August 2015

OCA — Thu, 20 Aug 2015 06:20:14 GMT

←Older revision		Revision as of 06:20, 20 August 2015
Line 8:		Line 8:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/NGAL_HUMAN NGAL_HUMAN]] Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.<ref>PMID:12453413</ref>		[[http://www.uniprot.org/uniprot/NGAL_HUMAN NGAL_HUMAN]] Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.<ref>PMID:12453413</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Synthetic radionuclides, such as the transuranic actinides plutonium, americium, and curium, present severe health threats as contaminants, and understanding the scope of the biochemical interactions involved in actinide transport is instrumental in managing human contamination. Here we show that siderocalin, a mammalian siderophore-binding protein from the lipocalin family, specifically binds lanthanide and actinide complexes through molecular recognition of the ligands chelating the metal ions. Using crystallography, we structurally characterized the resulting siderocalin-transuranic actinide complexes, providing unprecedented insights into the biological coordination of heavy radioelements. In controlled in vitro assays, we found that intracellular plutonium uptake can occur through siderocalin-mediated endocytosis. We also demonstrated that siderocalin can act as a synergistic antenna to sensitize the luminescence of trivalent lanthanide and actinide ions in ternary protein-ligand complexes, dramatically increasing the brightness and efficiency of intramolecular energy transfer processes that give rise to metal luminescence. Our results identify siderocalin as a potential player in the biological trafficking of f elements, but through a secondary ligand-based metal sequestration mechanism. Beyond elucidating contamination pathways, this work is a starting point for the design of two-stage biomimetic platforms for photoluminescence, separation, and transport applications.
		+
		+	Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides.,Allred BE, Rupert PB, Gauny SS, An DD, Ralston CY, Sturzbecher-Hoehne M, Strong RK, Abergel RJ Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10342-7. doi:, 10.1073/pnas.1508902112. Epub 2015 Aug 3. PMID:26240330<ref>PMID:26240330</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:16, 5 August 2015

OCA — Wed, 05 Aug 2015 20:16:28 GMT

←Older revision		Revision as of 20:16, 5 August 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Siderocalin-mediated recognition and cellular uptake of actinides==
-		+	<StructureSection load='4zfx' size='340' side='right' caption='[[4zfx]], [[Resolution\|resolution]] 2.55Å' scene=''>
-	~~The entry~~ 4zfx is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4zfx]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZFX FirstGlance]. <br>
-	~~Authors~~: ~~Allred~~, B.E., ~~Rupert, P~~.B., ~~Gauny, S~~.S., ~~An, D~~.D., ~~Ralston~~, C.Y., ~~Sturzbecher~~-~~Hoehne~~, M., ~~Strong~~, ~~R.K~~., ~~Abergel~~, ~~R.J~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EB4:N,N,N-[(3S,7S,11S)-2,6,10-TRIOXO-1,5,9-TRIOXACYCLODODECANE-3,7,11-TRIYL]TRIS(2,3-DIHYDROXYBENZAMIDE)'>EB4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TH:THORIUM+ION'>TH</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zfx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zfx RCSB], [http://www.ebi.ac.uk/pdbsum/4zfx PDBsum]</span></td></tr>
-	~~Description~~: ~~Siderocalin-mediated recognition and cellular uptake of actinides~~	+	</table>
-	[[Category: ~~Unreleased Structures~~]]	+	== Function ==
-	[[Category: An, D.D]]	+	[[http://www.uniprot.org/uniprot/NGAL_HUMAN NGAL_HUMAN]] Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.<ref>PMID:12453413</ref>
-	[[Category: ~~Abergel~~, ~~R.J~~]]	+	== References ==
-	[[Category: ~~Allred~~, B.E]]	+	<references/>
-	[[Category: Strong, R.K]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Abergel, R J]]
		+	[[Category: Allred, B E]]
		+	[[Category: An, D D]]
		+	[[Category: Gauny, S S]]
		+	[[Category: Ralston, C Y]]
		+	[[Category: Rupert, P B]]
		+	[[Category: Strong, R K]]
	[[Category: Sturzbecher-Hoehne, M]]		[[Category: Sturzbecher-Hoehne, M]]
-	[[Category: ~~Ralston, C.Y]]~~	+	[[Category: Metal binding protein-inhibitor complex]]
-	~~[[Category: Rupert, P.B]]~~	+
-	~~[[Category: Gauny, S.S~~]]	+

OCA: Protected "4zfx" [edit=sysop:move=sysop]

OCA — Thu, 30 Apr 2015 10:19:12 GMT

Protected "4zfx" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:19, 30 April 2015

OCA: New page: '''Unreleased structure''' The entry 4zfx is ON HOLD Authors: Allred, B.E., Rupert, P.B., Gauny, S.S., An, D.D., Ralston, C.Y., Sturzbecher-Hoehne, M., Strong, R.K., Abergel, R.J. Desc...

OCA — Thu, 30 Apr 2015 10:19:11 GMT

New page: '''Unreleased structure''' The entry 4zfx is ON HOLD Authors: Allred, B.E., Rupert, P.B., Gauny, S.S., An, D.D., Ralston, C.Y., Sturzbecher-Hoehne, M., Strong, R.K., Abergel, R.J. Desc...

New page

'''Unreleased structure'''

The entry 4zfx is ON HOLD

Authors: Allred, B.E., Rupert, P.B., Gauny, S.S., An, D.D., Ralston, C.Y., Sturzbecher-Hoehne, M., Strong, R.K., Abergel, R.J.

Description: Siderocalin-mediated recognition and cellular uptake of actinides
[[Category: Unreleased Structures]]
[[Category: An, D.D]]
[[Category: Abergel, R.J]]
[[Category: Allred, B.E]]
[[Category: Strong, R.K]]
[[Category: Sturzbecher-Hoehne, M]]
[[Category: Ralston, C.Y]]
[[Category: Rupert, P.B]]
[[Category: Gauny, S.S]]