4zkf - Revision history

OCA at 09:04, 20 March 2024

OCA — Wed, 20 Mar 2024 09:04:55 GMT

←Older revision		Revision as of 09:04, 20 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZKF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZKF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.82Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkf OCA], [https://pdbe.org/4zkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zkf RCSB], [https://www.ebi.ac.uk/pdbsum/4zkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zkf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkf OCA], [https://pdbe.org/4zkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zkf RCSB], [https://www.ebi.ac.uk/pdbsum/4zkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zkf ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:31, 18 May 2023

OCA — Thu, 18 May 2023 07:31:28 GMT

←Older revision		Revision as of 07:31, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='4zkf' size='340' side='right'caption='[[4zkf]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='4zkf' size='340' side='right'caption='[[4zkf]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zkf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZKF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zkf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZKF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkf OCA], [https://pdbe.org/4zkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zkf RCSB], [https://www.ebi.ac.uk/pdbsum/4zkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zkf ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkf OCA], [~~http~~://pdbe.org/4zkf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zkf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zkf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zkf ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PDE12_HUMAN PDE12_HUMAN]] Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.<ref>PMID:15231837</ref> <ref>PMID:21245038</ref> <ref>PMID:21666256</ref> <ref>PMID:22285541</ref>	+	[https://www.uniprot.org/uniprot/PDE12_HUMAN PDE12_HUMAN] Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.<ref>PMID:15231837</ref> <ref>PMID:21245038</ref> <ref>PMID:21666256</ref> <ref>PMID:22285541</ref>

	==See Also==		==See Also==
Line 17:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hakoshima, T]]	+	[[Category: Hakoshima T]]
-	[[Category: Kim~~, S Y~~]]	+	[[Category: Kim SY]]
-	[[Category: Kitano, K]]	+	[[Category: Kitano K]]
-	[[Category: Kohno, T]]	+	[[Category: Kohno T]]
-	[[Category: Mori, T]]	+	[[Category: Mori T]]
-	~~[[Category: Diesterase]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 07:03, 19 February 2020

OCA — Wed, 19 Feb 2020 07:03:19 GMT

←Older revision		Revision as of 07:03, 19 February 2020
Line 12:		Line 12:

	==See Also==		==See Also==
-	*[[Phosphodiesterase\|Phosphodiesterase]]	+	*[[Phosphodiesterase 3D structures\|Phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:56, 26 June 2019

OCA — Wed, 26 Jun 2019 07:56:58 GMT

←Older revision		Revision as of 07:56, 26 June 2019
Line 1:		Line 1:

	==Crystal structure of human phosphodiesterase 12==		==Crystal structure of human phosphodiesterase 12==
-	<StructureSection load='4zkf' size='340' side='right' caption='[[4zkf]], [[Resolution\|resolution]] 1.82Å' scene=''>	+	<StructureSection load='4zkf' size='340' side='right'caption='[[4zkf]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zkf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zkf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDE12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkf OCA], [http://pdbe.org/4zkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zkf RCSB], [http://www.ebi.ac.uk/pdbsum/4zkf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zkf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkf OCA], [http://pdbe.org/4zkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zkf RCSB], [http://www.ebi.ac.uk/pdbsum/4zkf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zkf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PDE12_HUMAN PDE12_HUMAN]] Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.<ref>PMID:15231837</ref> <ref>PMID:21245038</ref> <ref>PMID:21666256</ref> <ref>PMID:22285541</ref>		[[http://www.uniprot.org/uniprot/PDE12_HUMAN PDE12_HUMAN]] Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.<ref>PMID:15231837</ref> <ref>PMID:21245038</ref> <ref>PMID:21666256</ref> <ref>PMID:22285541</ref>
		+
		+	==See Also==
		+	*[[Phosphodiesterase\|Phosphodiesterase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hakoshima, T]]		[[Category: Hakoshima, T]]
	[[Category: Kim, S Y]]		[[Category: Kim, S Y]]

OCA at 14:23, 29 March 2017

OCA — Wed, 29 Mar 2017 14:23:05 GMT

←Older revision		Revision as of 14:23, 29 March 2017
Line 1:		Line 1:
		+
	==Crystal structure of human phosphodiesterase 12==		==Crystal structure of human phosphodiesterase 12==
	<StructureSection load='4zkf' size='340' side='right' caption='[[4zkf]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='4zkf' size='340' side='right' caption='[[4zkf]], [[Resolution\|resolution]] 1.82Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4zkf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zkf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zkf RCSB], [http://www.ebi.ac.uk/pdbsum/4zkf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkf OCA], [http://pdbe.org/4zkf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zkf RCSB], [http://www.ebi.ac.uk/pdbsum/4zkf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zkf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 06:46, 24 June 2015

OCA — Wed, 24 Jun 2015 06:46:50 GMT

←Older revision		Revision as of 06:46, 24 June 2015
Line 1:		Line 1:
-	==Crystal structure of human phosphodiesterase==	+	==Crystal structure of human phosphodiesterase 12==
	<StructureSection load='4zkf' size='340' side='right' caption='[[4zkf]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='4zkf' size='340' side='right' caption='[[4zkf]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 15:32, 17 June 2015

OCA — Wed, 17 Jun 2015 15:32:46 GMT

←Older revision		Revision as of 15:32, 17 June 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of human phosphodiesterase==
-		+	<StructureSection load='4zkf' size='340' side='right' caption='[[4zkf]], [[Resolution\|resolution]] 1.82Å' scene=''>
-	~~The entry~~ 4zkf is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4zkf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKF FirstGlance]. <br>
-	~~Authors~~: ~~Kim~~, S.Y., ~~Kohno~~, T., ~~Mori~~, T., ~~Kitano, K~~., ~~Hakoshima, T~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zkf RCSB], [http://www.ebi.ac.uk/pdbsum/4zkf PDBsum]</span></td></tr>
-	~~Description: Crystal structure of human phosphodiesterase~~	+	</table>
-	[[Category: ~~Unreleased Structures~~]]	+	== Function ==
-	[[Category: ~~Kohno~~, T]]	+	[[http://www.uniprot.org/uniprot/PDE12_HUMAN PDE12_HUMAN]] Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.<ref>PMID:15231837</ref> <ref>PMID:21245038</ref> <ref>PMID:21666256</ref> <ref>PMID:22285541</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hakoshima, T]]
		+	[[Category: Kim, S Y]]
	[[Category: Kitano, K]]		[[Category: Kitano, K]]
-	[[Category: ~~Kim~~, ~~S.Y~~]]	+	[[Category: Kohno, T]]
	[[Category: Mori, T]]		[[Category: Mori, T]]
-	[[Category: ~~Hakoshima, T~~]]	+	[[Category: Diesterase]]
		+	[[Category: Hydrolase]]

OCA at 10:50, 20 May 2015

OCA — Wed, 20 May 2015 10:50:28 GMT

←Older revision		Revision as of 10:50, 20 May 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zkf is ON HOLD	+	The entry 4zkf is ON HOLD until Paper Publication

	Authors: Kim, S.Y., Kohno, T., Mori, T., Kitano, K., Hakoshima, T.		Authors: Kim, S.Y., Kohno, T., Mori, T., Kitano, K., Hakoshima, T.

OCA: Protected "4zkf" [edit=sysop:move=sysop]

OCA — Wed, 06 May 2015 11:52:27 GMT

Protected "4zkf" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:52, 6 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zkf is ON HOLD Authors: Kim, S.Y., Kohno, T., Mori, T., Kitano, K., Hakoshima, T. Description: Crystal structure of human phosphodiesterase [[Cate...

OCA — Wed, 06 May 2015 11:52:26 GMT

New page: '''Unreleased structure''' The entry 4zkf is ON HOLD Authors: Kim, S.Y., Kohno, T., Mori, T., Kitano, K., Hakoshima, T. Description: Crystal structure of human phosphodiesterase [[Cate...

New page

'''Unreleased structure'''

The entry 4zkf is ON HOLD

Authors: Kim, S.Y., Kohno, T., Mori, T., Kitano, K., Hakoshima, T.

Description: Crystal structure of human phosphodiesterase
[[Category: Unreleased Structures]]
[[Category: Kohno, T]]
[[Category: Kitano, K]]
[[Category: Kim, S.Y]]
[[Category: Mori, T]]
[[Category: Hakoshima, T]]