4zkq - Revision history

OCA at 07:31, 18 May 2023

OCA — Thu, 18 May 2023 07:31:42 GMT

←Older revision		Revision as of 07:31, 18 May 2023
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	<StructureSection load='4zkq' size='340' side='right'caption='[[4zkq]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4zkq' size='340' side='right'caption='[[4zkq]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zkq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Cricetid_gammaherpesvirus_2 Cricetid gammaherpesvirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZKQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zkq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetid_gammaherpesvirus_2 Cricetid gammaherpesvirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZKQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RHVP-L.R17, RHVP.R17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1605972 Cricetid gammaherpesvirus 2])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkq OCA], [https://pdbe.org/4zkq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zkq RCSB], [https://www.ebi.ac.uk/pdbsum/4zkq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zkq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkq OCA], [~~http~~://pdbe.org/4zkq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zkq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zkq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zkq ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/E9M5R0_9GAMA E9M5R0_9GAMA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Cricetid gammaherpesvirus 2]]		[[Category: Cricetid gammaherpesvirus 2]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fremont~~, D H~~]]	+	[[Category: Fremont DH]]
-	[[Category: Lubman~~, O Y]]~~	+	[[Category: Lubman OY]]
-	~~[[Category: Chemokine binding protein]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 15:55, 11 December 2019

OCA — Wed, 11 Dec 2019 15:55:58 GMT

←Older revision		Revision as of 15:55, 11 December 2019
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	==Viral chemokine binding protein R17 encoded by rodent gammaherpesvirus Peru ( RHVP)==		==Viral chemokine binding protein R17 encoded by rodent gammaherpesvirus Peru ( RHVP)==
-	<StructureSection load='4zkq' size='340' side='right' caption='[[4zkq]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4zkq' size='340' side='right'caption='[[4zkq]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zkq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cricetid_gammaherpesvirus_2 Cricetid gammaherpesvirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zkq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cricetid_gammaherpesvirus_2 Cricetid gammaherpesvirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKQ FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Cricetid gammaherpesvirus 2]]		[[Category: Cricetid gammaherpesvirus 2]]
		+	[[Category: Large Structures]]
	[[Category: Fremont, D H]]		[[Category: Fremont, D H]]
	[[Category: Lubman, O Y]]		[[Category: Lubman, O Y]]
	[[Category: Chemokine binding protein]]		[[Category: Chemokine binding protein]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 09:08, 1 November 2017

OCA — Wed, 01 Nov 2017 09:08:28 GMT

←Older revision		Revision as of 09:08, 1 November 2017
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	<StructureSection load='4zkq' size='340' side='right' caption='[[4zkq]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4zkq' size='340' side='right' caption='[[4zkq]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zkq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zkq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cricetid_gammaherpesvirus_2 Cricetid gammaherpesvirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RHVP-L.R17, RHVP.R17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1605972 Cricetid gammaherpesvirus 2])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkq OCA], [http://pdbe.org/4zkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zkq RCSB], [http://www.ebi.ac.uk/pdbsum/4zkq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zkq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkq OCA], [http://pdbe.org/4zkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zkq RCSB], [http://www.ebi.ac.uk/pdbsum/4zkq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zkq ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cricetid gammaherpesvirus 2]]
	[[Category: Fremont, D H]]		[[Category: Fremont, D H]]
	[[Category: Lubman, O Y]]		[[Category: Lubman, O Y]]
	[[Category: Chemokine binding protein]]		[[Category: Chemokine binding protein]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 12:14, 7 October 2017

OCA — Sat, 07 Oct 2017 12:14:05 GMT

←Older revision		Revision as of 12:14, 7 October 2017
Line 1:		Line 1:
		+
	==Viral chemokine binding protein R17 encoded by rodent gammaherpesvirus Peru ( RHVP)==		==Viral chemokine binding protein R17 encoded by rodent gammaherpesvirus Peru ( RHVP)==
	<StructureSection load='4zkq' size='340' side='right' caption='[[4zkq]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4zkq' size='340' side='right' caption='[[4zkq]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4zkq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zkq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkq OCA], [http://pdbe.org/4zkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zkq RCSB], [http://www.ebi.ac.uk/pdbsum/4zkq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkq OCA], [http://pdbe.org/4zkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zkq RCSB], [http://www.ebi.ac.uk/pdbsum/4zkq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zkq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:42, 30 December 2015

OCA — Wed, 30 Dec 2015 11:42:13 GMT

←Older revision		Revision as of 11:42, 30 December 2015
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkq OCA], [http://pdbe.org/4zkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zkq RCSB], [http://www.ebi.ac.uk/pdbsum/4zkq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkq OCA], [http://pdbe.org/4zkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zkq RCSB], [http://www.ebi.ac.uk/pdbsum/4zkq PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A wide variety of pathogens targets chemokine signaling networks in order to disrupt host immune surveillance and defense. Here, we report a structural and mutational analysis of rodent herpesvirus Peru encoded R17, a potent chemokine inhibitor that sequesters CC and C chemokines with high affinity. R17 consists of a pair of beta-sandwich domains linked together by a bridging sheet, which form an acidic binding cleft for the chemokine CCL3 on the opposite face of a basic surface cluster that binds glycosaminoglycans. R17 promiscuously engages chemokines primarily through the same N-loop determinants used for host receptor recognition while residues located in the chemokine 40s loop drive kinetically stable complex formation. The core fold adopted by R17 is unexpectedly similar to that of the M3 chemokine decoy receptor encoded by MHV-68, although, strikingly, neither the location of ligand engagement nor the stoichiometry of binding is conserved, suggesting that their functions evolved independently.
		+
		+	Parallel Evolution of Chemokine Binding by Structurally Related Herpesvirus Decoy Receptors.,Lubman OY, Fremont DH Structure. 2015 Nov 30. pii: S0969-2126(15)00457-8. doi:, 10.1016/j.str.2015.10.018. PMID:26671708<ref>PMID:26671708</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4zkq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 18:57, 1 December 2015

OCA — Tue, 01 Dec 2015 18:57:55 GMT

←Older revision		Revision as of 18:57, 1 December 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Viral chemokine binding protein R17 encoded by rodent gammaherpesvirus Peru ( RHVP)==
-		+	<StructureSection load='4zkq' size='340' side='right' caption='[[4zkq]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~The entry~~ 4zkq is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4zkq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZKQ FirstGlance]. <br>
-	~~Authors~~: ~~Lubman, Q~~.Y.~~, Fremont, D~~.H.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zkq OCA], [http://pdbe.org/4zkq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zkq RCSB], [http://www.ebi.ac.uk/pdbsum/4zkq PDBsum]</span></td></tr>
-	~~Description~~: ~~Viral chemokine binding protein R17 encoded by rodent gammaherpesvirus Peru ( RHVP)~~	+	</table>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	__TOC__
-	[[Category: Fremont, D.H]]	+	</StructureSection>
-	[[Category: Lubman, Q.Y]]	+	[[Category: Fremont, D H]]
		+	[[Category: Lubman, O Y]]
		+	[[Category: Chemokine binding protein]]
		+	[[Category: Viral protein]]

OCA at 11:04, 13 May 2015

OCA — Wed, 13 May 2015 11:04:06 GMT

←Older revision		Revision as of 11:04, 13 May 2015
Line 3:		Line 3:
	The entry 4zkq is ON HOLD		The entry 4zkq is ON HOLD

-	Authors: ~~Olga~~ Y.~~Lubman~~, ~~Daved~~ H.~~Fremont~~	+	Authors: Lubman, Q.Y., Fremont, D.H.

-	Description: ~~Parallel evolution of~~ chemokine binding by ~~structurally related herpesvirus decoy receptors~~	+	Description: Viral chemokine binding protein R17 encoded by rodent gammaherpesvirus Peru ( RHVP)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Olga Y~~.Lubman, ~~Daved H~~.~~Fremont~~]]	+	[[Category: Fremont, D.H]]
		+	[[Category: Lubman, Q.Y]]

OCA: Protected "4zkq" [edit=sysop:move=sysop]

OCA — Wed, 06 May 2015 11:53:26 GMT

Protected "4zkq" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:53, 6 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zkq is ON HOLD Authors: Olga Y.Lubman, Daved H.Fremont Description: Parallel evolution of chemokine binding by structurally related herpesvirus de...

OCA — Wed, 06 May 2015 11:53:25 GMT

New page: '''Unreleased structure''' The entry 4zkq is ON HOLD Authors: Olga Y.Lubman, Daved H.Fremont Description: Parallel evolution of chemokine binding by structurally related herpesvirus de...

New page

'''Unreleased structure'''

The entry 4zkq is ON HOLD

Authors: Olga Y.Lubman, Daved H.Fremont

Description: Parallel evolution of chemokine binding by structurally related herpesvirus decoy receptors
[[Category: Unreleased Structures]]
[[Category: Olga Y.Lubman, Daved H.Fremont]]