4zlb - Revision history

OCA at 15:45, 8 November 2023

OCA — Wed, 08 Nov 2023 15:45:49 GMT

←Older revision		Revision as of 15:45, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zlb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZLB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zlb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZLB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900004:beta-lactose'>PRD_900004</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900004:beta-lactose'>PRD_900004</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zlb OCA], [https://pdbe.org/4zlb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zlb RCSB], [https://www.ebi.ac.uk/pdbsum/4zlb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zlb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zlb OCA], [https://pdbe.org/4zlb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zlb RCSB], [https://www.ebi.ac.uk/pdbsum/4zlb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zlb ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:32, 18 May 2023

OCA — Thu, 18 May 2023 07:32:18 GMT

←Older revision		Revision as of 07:32, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='4zlb' size='340' side='right'caption='[[4zlb]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='4zlb' size='340' side='right'caption='[[4zlb]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zlb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZLB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZLB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zlb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZLB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZLB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=~~LAT~~:BETA-~~LACTOSE~~'>~~LAT~~</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=~~XYP~~:~~BETA~~-~~D-XYLOPYRANOSE~~'>~~XYP~~</scene><~~/td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900004:beta-lactose'>PRD_900004</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[4za3\|4za3]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zlb OCA], [https://pdbe.org/4zlb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zlb RCSB], [https://www.ebi.ac.uk/pdbsum/4zlb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zlb ProSAT]</span></td></tr>
-	~~<tr id='activity~~'>~~<td class="sblockLbl"><b>Activity:~~</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zlb OCA], [~~http~~://pdbe.org/4zlb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zlb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zlb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zlb ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B7X8M2_MOMCH B7X8M2_MOMCH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Momordica charantia]]		[[Category: Momordica charantia]]
-	~~[[Category: RRNA N-glycosylase]]~~	+	[[Category: Chandran T]]
-	[[Category: Chandran, T]]	+	[[Category: Sharma A]]
-	[[Category: Sharma, A]]	+	[[Category: Vijayan M]]
-	[[Category: Vijayan, M]]	+
-	~~[[Category: Beta-trefoil]]~~	+
-	~~[[Category: Galactose binding lectin]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Type ii rip~~]]	+

OCA at 08:34, 26 June 2019

OCA — Wed, 26 Jun 2019 08:34:30 GMT

←Older revision		Revision as of 08:34, 26 June 2019
Line 1:		Line 1:

	==Structural studies on a non-toxic homologue of type II RIPs from Momordica charantia (bitter gourd) in complex with lactose==		==Structural studies on a non-toxic homologue of type II RIPs from Momordica charantia (bitter gourd) in complex with lactose==
-	<StructureSection load='4zlb' size='340' side='right' caption='[[4zlb]], [[Resolution\|resolution]] 2.55Å' scene=''>	+	<StructureSection load='4zlb' size='340' side='right'caption='[[4zlb]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zlb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZLB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZLB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zlb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZLB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZLB FirstGlance]. <br>
Line 7:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4za3\|4za3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4za3\|4za3]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zlb OCA], [http://pdbe.org/4zlb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zlb RCSB], [http://www.ebi.ac.uk/pdbsum/4zlb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zlb OCA], [http://pdbe.org/4zlb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zlb RCSB], [http://www.ebi.ac.uk/pdbsum/4zlb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zlb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Momordica charantia]]		[[Category: Momordica charantia]]
	[[Category: RRNA N-glycosylase]]		[[Category: RRNA N-glycosylase]]

OCA at 12:58, 11 May 2016

OCA — Wed, 11 May 2016 12:58:21 GMT

←Older revision		Revision as of 12:58, 11 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4zlb is ~~ON HOLD until Paper~~ Publication	+	==Structural studies on a non-toxic homologue of type II RIPs from Momordica charantia (bitter gourd) in complex with lactose==
		+	<StructureSection load='4zlb' size='340' side='right' caption='[[4zlb]], [[Resolution\|resolution]] 2.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4zlb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Momordica_charantia Momordica charantia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZLB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZLB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=LAT:BETA-LACTOSE'>LAT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4za3\|4za3]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zlb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zlb OCA], [http://pdbe.org/4zlb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zlb RCSB], [http://www.ebi.ac.uk/pdbsum/4zlb PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structures of nine independent crystals of bitter gourd seed lectin (BGSL), a non-toxic homologue of type II RIPs, and its sugar complexes have been determined. The four-chain, two-fold symmetric, protein is made up of two identical two-chain modules, each consisting of a catalytic chain and a lectin chain, connected by a disulphide bridge. The lectin chain is made up of two domains. Each domain carries a carbohydrate binding site in type II RIPs of known structure. BGSL has a sugar binding site only on one domain, thus impairing its interaction at the cell surface. The adenine binding site in the catalytic chain is defective. Thus, defects in sugar binding as well as adenine binding appear to contribute to the non-toxicity of the lectin. The plasticity of the molecule is mainly caused by the presence of two possible well defined conformations of a surface loop in the lectin chain. One of them is chosen in the sugar complexes, in a case of conformational selection, as the chosen conformation facilitates an additional interaction with the sugar, involving an arginyl residue in the loop. The N-glycosylation of the lectin involves a plant-specific glycan while that in toxic type II RIPs of known structure involves a glycan which is animal as well as plant specific.

-	~~Authors~~: ~~Chandran~~, T., ~~Sharma~~, A., Vijayan, M.	+	Structural studies on a non-toxic homologue of type II RIPs from bitter gourd: Molecular basis of non-toxicity, conformational selection and glycan structure.,Chandran T, Sharma A, Vijayan M J Biosci. 2015 Dec;40(5):929-41. PMID:26648038<ref>PMID:26648038</ref>

-	~~Description: Structural studies on~~ a ~~non-toxic homologue~~ of ~~type II RIPs from~~ Momordica charantia ~~(bitter gourd) in complex with lactose~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 4zlb" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Momordica charantia]]
		+	[[Category: RRNA N-glycosylase]]
	[[Category: Chandran, T]]		[[Category: Chandran, T]]
-	[[Category: Vijayan, M]]
	[[Category: Sharma, A]]		[[Category: Sharma, A]]
		+	[[Category: Vijayan, M]]
		+	[[Category: Beta-trefoil]]
		+	[[Category: Galactose binding lectin]]
		+	[[Category: Hydrolase]]
		+	[[Category: Type ii rip]]

OCA at 09:22, 16 December 2015

OCA — Wed, 16 Dec 2015 09:22:59 GMT

←Older revision		Revision as of 09:22, 16 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zlb is ON HOLD	+	The entry 4zlb is ON HOLD until Paper Publication

	Authors: Chandran, T., Sharma, A., Vijayan, M.		Authors: Chandran, T., Sharma, A., Vijayan, M.

OCA at 09:12, 9 December 2015

OCA — Wed, 09 Dec 2015 09:12:05 GMT

←Older revision		Revision as of 09:12, 9 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zlb is ON HOLD ~~until Paper Publication~~	+	The entry 4zlb is ON HOLD

	Authors: Chandran, T., Sharma, A., Vijayan, M.		Authors: Chandran, T., Sharma, A., Vijayan, M.

OCA at 12:33, 8 July 2015

OCA — Wed, 08 Jul 2015 12:33:21 GMT

←Older revision		Revision as of 12:33, 8 July 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zlb is ON HOLD	+	The entry 4zlb is ON HOLD until Paper Publication

	Authors: Chandran, T., Sharma, A., Vijayan, M.		Authors: Chandran, T., Sharma, A., Vijayan, M.

OCA at 10:51, 20 May 2015

OCA — Wed, 20 May 2015 10:51:59 GMT

←Older revision		Revision as of 10:51, 20 May 2015
Line 5:		Line 5:
	Authors: Chandran, T., Sharma, A., Vijayan, M.		Authors: Chandran, T., Sharma, A., Vijayan, M.

-	Description: Structural studies on a non-toxic homologue of type II RIPs from Momordica charantia (bitter gourd) in complex with lactose.	+	Description: Structural studies on a non-toxic homologue of type II RIPs from Momordica charantia (bitter gourd) in complex with lactose
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Chandran, T]]		[[Category: Chandran, T]]
	[[Category: Vijayan, M]]		[[Category: Vijayan, M]]
	[[Category: Sharma, A]]		[[Category: Sharma, A]]

OCA: Protected "4zlb" [edit=sysop:move=sysop]

OCA — Wed, 06 May 2015 11:54:55 GMT

Protected "4zlb" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:54, 6 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zlb is ON HOLD Authors: Chandran, T., Sharma, A., Vijayan, M. Description: Structural studies on a non-toxic homologue of type II RIPs from Momord...

OCA — Wed, 06 May 2015 11:54:54 GMT

New page: '''Unreleased structure''' The entry 4zlb is ON HOLD Authors: Chandran, T., Sharma, A., Vijayan, M. Description: Structural studies on a non-toxic homologue of type II RIPs from Momord...

New page

'''Unreleased structure'''

The entry 4zlb is ON HOLD

Authors: Chandran, T., Sharma, A., Vijayan, M.

Description: Structural studies on a non-toxic homologue of type II RIPs from Momordica charantia (bitter gourd) in complex with lactose.
[[Category: Unreleased Structures]]
[[Category: Chandran, T]]
[[Category: Vijayan, M]]
[[Category: Sharma, A]]