4zme - Revision history

OCA at 08:20, 27 September 2023

OCA — Wed, 27 Sep 2023 08:20:57 GMT

←Older revision		Revision as of 08:20, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zme]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZME FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zme]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZME FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PHD:ASPARTYL+PHOSPHATE'>PHD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.98Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PHD:ASPARTYL+PHOSPHATE'>PHD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zme OCA], [https://pdbe.org/4zme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zme RCSB], [https://www.ebi.ac.uk/pdbsum/4zme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zme ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zme OCA], [https://pdbe.org/4zme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zme RCSB], [https://www.ebi.ac.uk/pdbsum/4zme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zme ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:33, 18 May 2023

OCA — Thu, 18 May 2023 07:33:24 GMT

←Older revision		Revision as of 07:33, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='4zme' size='340' side='right'caption='[[4zme]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='4zme' size='340' side='right'caption='[[4zme]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zme]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Dicdi Dicdi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZME OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZME FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zme]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZME FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=~~PO4~~:~~PHOSPHATE~~+~~ION~~'>~~PO4~~</scene>, <scene name='pdbligand=ZN:~~ZINC~~+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PHD:ASPARTYL+PHOSPHATE'>PHD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~PHD~~:~~ASPARTYL~~+~~PHOSPHATE~~'>~~PHD~~</scene~~></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zme OCA], [https://pdbe.org/4zme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zme RCSB], [https://www.ebi.ac.uk/pdbsum/4zme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zme ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lla\|3lla]], [[3lmh\|3lmh]], [[3lkm\|3lkm]], [[3lmi\|3lmi]], [[3pdt\|3pdt]]</td></tr>~~	+
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mhkA, mhckA, DDB_G0291231 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 DICDI])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Myosin_heavy-chain]_kinase [Myosin heavy-chain] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.7 2.7.11.7] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zme OCA], [~~http~~://pdbe.org/4zme PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zme RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zme PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zme ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MHCKA_DICDI MHCKA_DICDI]] Phosphorylates threonine in the C-terminal tail region of myosin II heavy chain. This phosphorylation is critical in regulating the assembly and disassembly of myosin II filament. Requires autophosphorylation for activity.	+	[https://www.uniprot.org/uniprot/MHCKA_DICDI MHCKA_DICDI] Phosphorylates threonine in the C-terminal tail region of myosin II heavy chain. This phosphorylation is critical in regulating the assembly and disassembly of myosin II filament. Requires autophosphorylation for activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dicdi~~]]	+	[[Category: Dictyostelium discoideum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jia, Z]]	+	[[Category: Jia Z]]
-	[[Category: Ye, Q]]	+	[[Category: Ye Q]]
-	~~[[Category: Aspartyl phosphate intermediate]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:13, 26 June 2019

OCA — Wed, 26 Jun 2019 08:13:58 GMT

←Older revision		Revision as of 08:13, 26 June 2019
Line 1:		Line 1:
		+
	==Crystal Structure of the Alpha-kinase Domain of Myosin-II Heavy Chain Kinase A in Complex with Adenosine==		==Crystal Structure of the Alpha-kinase Domain of Myosin-II Heavy Chain Kinase A in Complex with Adenosine==
-	<StructureSection load='4zme' size='340' side='right' caption='[[4zme]], [[Resolution\|resolution]] 1.98Å' scene=''>	+	<StructureSection load='4zme' size='340' side='right'caption='[[4zme]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zme]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZME FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zme]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dicdi Dicdi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZME FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PHD:ASPARTYL+PHOSPHATE'>PHD</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PHD:ASPARTYL+PHOSPHATE'>PHD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lla\|3lla]], [[3lmh\|3lmh]], [[3lkm\|3lkm]], [[3lmi\|3lmi]], [[3pdt\|3pdt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lla\|3lla]], [[3lmh\|3lmh]], [[3lkm\|3lkm]], [[3lmi\|3lmi]], [[3pdt\|3pdt]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mhkA, mhckA, DDB_G0291231 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 DICDI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Myosin_heavy-chain]_kinase [Myosin heavy-chain] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.7 2.7.11.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Myosin_heavy-chain]_kinase [Myosin heavy-chain] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.7 2.7.11.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zme OCA], [http://pdbe.org/4zme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zme RCSB], [http://www.ebi.ac.uk/pdbsum/4zme PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zme OCA], [http://pdbe.org/4zme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zme RCSB], [http://www.ebi.ac.uk/pdbsum/4zme PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zme ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dicdi]]
		+	[[Category: Large Structures]]
	[[Category: Jia, Z]]		[[Category: Jia, Z]]
	[[Category: Ye, Q]]		[[Category: Ye, Q]]
	[[Category: Aspartyl phosphate intermediate]]		[[Category: Aspartyl phosphate intermediate]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:33, 7 October 2015

OCA — Wed, 07 Oct 2015 07:33:28 GMT

←Older revision		Revision as of 07:33, 7 October 2015
Line 7:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lla\|3lla]], [[3lmh\|3lmh]], [[3lkm\|3lkm]], [[3lmi\|3lmi]], [[3pdt\|3pdt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lla\|3lla]], [[3lmh\|3lmh]], [[3lkm\|3lkm]], [[3lmi\|3lmi]], [[3pdt\|3pdt]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Myosin_heavy-chain]_kinase [Myosin heavy-chain] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.7 2.7.11.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Myosin_heavy-chain]_kinase [Myosin heavy-chain] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.7 2.7.11.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zme OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zme RCSB], [http://www.ebi.ac.uk/pdbsum/4zme PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zme OCA], [http://pdbe.org/4zme PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zme RCSB], [http://www.ebi.ac.uk/pdbsum/4zme PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4zme" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:34, 2 September 2015

OCA — Wed, 02 Sep 2015 06:34:05 GMT

←Older revision		Revision as of 06:34, 2 September 2015
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MHCKA_DICDI MHCKA_DICDI]] Phosphorylates threonine in the C-terminal tail region of myosin II heavy chain. This phosphorylation is critical in regulating the assembly and disassembly of myosin II filament. Requires autophosphorylation for activity.		[[http://www.uniprot.org/uniprot/MHCKA_DICDI MHCKA_DICDI]] Phosphorylates threonine in the C-terminal tail region of myosin II heavy chain. This phosphorylation is critical in regulating the assembly and disassembly of myosin II filament. Requires autophosphorylation for activity.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The alpha-kinases are a widely expressed family of serine/threonine protein kinases that exhibit no sequence identity with conventional eukaryotic protein kinases. In this report we provide new information on the catalytic properties of the alpha-kinase domain of Dictyostelium myosin-II heavy chain kinase-A (termed A-CAT). Crystallization of A-CAT in the presence of MgATP yielded structures with AMP or adenosine in the catalytic cleft together with a phosphorylated Asp766 residue. The results show that the beta- and alpha-phosphoryl groups are transferred either directly or indirectly to the catalytically essential Asp766. Biochemical assays confirmed that A-CAT hydrolyzed ATP, ADP and AMP with kcat values of 1.9, 0.6 and 0.32 min-1, respectively, and showed that A-CAT can use ADP to phosphorylate peptides and proteins. Binding assays using fluorescent 2/3-O-(N-Methyl-anthraniloyl) analogs of ATP and ADP yielded Kd values for ATP, ADP, AMP and adenosine of 20, 60, 160 and 45 micromole, respectively. Site-directed mutagenesis showed that Glu713, Leu716 and Lys645, all of which interact with the adenine base, were critical for nucleotide binding. Mutation of the highly conserved Gln758, which chelates a nucleotide-associated Mg2+ ion, eliminated catalytic activity, whereas loss of the highly conserved Lys722 and Arg592 decreased kcat for kinase and ATPase activities by 3-6-fold. Mutation of Asp663 impaired kinase activity to a much greater extent than ATPase, indicating a specific role in peptide substrate binding, whereas mutation of Gln768 doubled ATPase activity, suggesting that it may act to exclude water from the active site.
		+
		+	Characterization of the Catalytic and Nucleotide Binding Properties of the Alpha-kinase domain of Dictyostelium Myosin-II Heavy Chain Kinase A.,Yang Y, Ye Q, Jia Z, Cote GP J Biol Chem. 2015 Aug 10. pii: jbc.M115.672410. PMID:26260792<ref>PMID:26260792</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:26, 20 August 2015

OCA — Thu, 20 Aug 2015 12:26:42 GMT

←Older revision		Revision as of 12:26, 20 August 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure of the Alpha-kinase Domain of Myosin-II Heavy Chain Kinase A in Complex with Adenosine==
-		+	<StructureSection load='4zme' size='340' side='right' caption='[[4zme]], [[Resolution\|resolution]] 1.98Å' scene=''>
-	~~The entry~~ 4zme is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4zme]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZME OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZME FirstGlance]. <br>
-	~~Authors~~: Ye, Q., ~~Jia~~, Z.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PHD:ASPARTYL+PHOSPHATE'>PHD</scene></td></tr>
-	~~Description~~: ~~Crystal Structure of the Alpha~~-~~kinase Domain of~~ Myosin-~~II Heavy Chain Kinase A in Complex~~ with ~~Adenosine~~	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lla\|3lla]], [[3lmh\|3lmh]], [[3lkm\|3lkm]], [[3lmi\|3lmi]], [[3pdt\|3pdt]]</td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Myosin_heavy-chain]_kinase [Myosin heavy-chain] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.7 2.7.11.7] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zme OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zme RCSB], [http://www.ebi.ac.uk/pdbsum/4zme PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MHCKA_DICDI MHCKA_DICDI]] Phosphorylates threonine in the C-terminal tail region of myosin II heavy chain. This phosphorylation is critical in regulating the assembly and disassembly of myosin II filament. Requires autophosphorylation for activity.
		+	__TOC__
		+	</StructureSection>
	[[Category: Jia, Z]]		[[Category: Jia, Z]]
	[[Category: Ye, Q]]		[[Category: Ye, Q]]
		+	[[Category: Aspartyl phosphate intermediate]]
		+	[[Category: Transferase]]

OCA at 09:59, 1 July 2015

OCA — Wed, 01 Jul 2015 09:59:08 GMT

←Older revision		Revision as of 09:59, 1 July 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zme is ON HOLD	+	The entry 4zme is ON HOLD until Paper Publication

	Authors: Ye, Q., Jia, Z.		Authors: Ye, Q., Jia, Z.

OCA: Protected "4zme" [edit=sysop:move=sysop]

OCA — Wed, 13 May 2015 11:07:44 GMT

Protected "4zme" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:07, 13 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zme is ON HOLD Authors: Ye, Q., Jia, Z. Description: Crystal Structure of the Alpha-kinase Domain of Myosin-II Heavy Chain Kinase A in Complex wit...

OCA — Wed, 13 May 2015 11:07:42 GMT

New page: '''Unreleased structure''' The entry 4zme is ON HOLD Authors: Ye, Q., Jia, Z. Description: Crystal Structure of the Alpha-kinase Domain of Myosin-II Heavy Chain Kinase A in Complex wit...

New page

'''Unreleased structure'''

The entry 4zme is ON HOLD

Authors: Ye, Q., Jia, Z.

Description: Crystal Structure of the Alpha-kinase Domain of Myosin-II Heavy Chain Kinase A in Complex with Adenosine
[[Category: Unreleased Structures]]
[[Category: Jia, Z]]
[[Category: Ye, Q]]