4zmj - Revision history

OCA at 08:20, 27 September 2023

OCA — Wed, 27 Sep 2023 08:20:59 GMT

←Older revision		Revision as of 08:20, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zmj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZMJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zmj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZMJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.31Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmj OCA], [https://pdbe.org/4zmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zmj RCSB], [https://www.ebi.ac.uk/pdbsum/4zmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zmj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmj OCA], [https://pdbe.org/4zmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zmj RCSB], [https://www.ebi.ac.uk/pdbsum/4zmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zmj ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:33, 18 May 2023

OCA — Thu, 18 May 2023 07:33:32 GMT

←Older revision		Revision as of 07:33, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='4zmj' size='340' side='right'caption='[[4zmj]], [[Resolution\|resolution]] 3.31Å' scene=''>		<StructureSection load='4zmj' size='340' side='right'caption='[[4zmj]], [[Resolution\|resolution]] 3.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zmj]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZMJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zmj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZMJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">env ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmj OCA], [https://pdbe.org/4zmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zmj RCSB], [https://www.ebi.ac.uk/pdbsum/4zmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zmj ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmj OCA], [~~http~~://pdbe.org/4zmj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zmj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zmj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zmj ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]	+	[https://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kwon~~, Y D~~]]	+	[[Category: Kwon YD]]
-	[[Category: Kwong~~, P D]]~~	+	[[Category: Kwong PD]]
-	~~[[Category: Bg505 sosip]]~~	+
-	~~[[Category: Env trimer]]~~	+
-	~~[[Category: Hiv-1]]~~	+
-	~~[[Category: Unliganded]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 15:56, 11 December 2019

OCA — Wed, 11 Dec 2019 15:56:09 GMT

←Older revision		Revision as of 15:56, 11 December 2019
Line 1:		Line 1:

	==Crystal Structure of Ligand-Free BG505 SOSIP.664 HIV-1 Env Trimer==		==Crystal Structure of Ligand-Free BG505 SOSIP.664 HIV-1 Env Trimer==
-	<StructureSection load='4zmj' size='340' side='right' caption='[[4zmj]], [[Resolution\|resolution]] 3.31Å' scene=''>	+	<StructureSection load='4zmj' size='340' side='right'caption='[[4zmj]], [[Resolution\|resolution]] 3.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zmj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZMJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zmj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZMJ FirstGlance]. <br>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Kwon, Y D]]		[[Category: Kwon, Y D]]
	[[Category: Kwong, P D]]		[[Category: Kwong, P D]]

OCA at 12:21, 6 November 2017

OCA — Mon, 06 Nov 2017 12:21:24 GMT

←Older revision		Revision as of 12:21, 6 November 2017
Line 3:		Line 3:
	<StructureSection load='4zmj' size='340' side='right' caption='[[4zmj]], [[Resolution\|resolution]] 3.31Å' scene=''>		<StructureSection load='4zmj' size='340' side='right' caption='[[4zmj]], [[Resolution\|resolution]] 3.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zmj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZMJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zmj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZMJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">env ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmj OCA], [http://pdbe.org/4zmj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zmj RCSB], [http://www.ebi.ac.uk/pdbsum/4zmj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zmj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmj OCA], [http://pdbe.org/4zmj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zmj RCSB], [http://www.ebi.ac.uk/pdbsum/4zmj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zmj ProSAT]</span></td></tr>
	</table>		</table>

OCA at 13:29, 4 May 2017

OCA — Thu, 04 May 2017 13:29:51 GMT

←Older revision		Revision as of 13:29, 4 May 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Ligand-Free BG505 SOSIP.664 HIV-1 Env Trimer==		==Crystal Structure of Ligand-Free BG505 SOSIP.664 HIV-1 Env Trimer==
	<StructureSection load='4zmj' size='340' side='right' caption='[[4zmj]], [[Resolution\|resolution]] 3.31Å' scene=''>		<StructureSection load='4zmj' size='340' side='right' caption='[[4zmj]], [[Resolution\|resolution]] 3.31Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4zmj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZMJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zmj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZMJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zmj RCSB], [http://www.ebi.ac.uk/pdbsum/4zmj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmj OCA], [http://pdbe.org/4zmj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zmj RCSB], [http://www.ebi.ac.uk/pdbsum/4zmj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zmj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4zmj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:20, 8 July 2015

OCA — Wed, 08 Jul 2015 08:20:49 GMT

←Older revision		Revision as of 08:20, 8 July 2015
Line 8:		Line 8:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]		[[http://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	As the sole viral antigen on the HIV-1-virion surface, trimeric Env is a focus of vaccine efforts. Here we present the structure of the ligand-free HIV-1-Env trimer, fix its conformation and determine its receptor interactions. Epitope analyses revealed trimeric ligand-free Env to be structurally compatible with broadly neutralizing antibodies but not poorly neutralizing ones. We coupled these compatibility considerations with binding antigenicity to engineer conformationally fixed Envs, including a 201C 433C (DS) variant specifically recognized by broadly neutralizing antibodies. DS-Env retained nanomolar affinity for the CD4 receptor, with which it formed an asymmetric intermediate: a closed trimer bound by a single CD4 without the typical antigenic hallmarks of CD4 induction. Antigenicity-guided structural design can thus be used both to delineate mechanism and to fix conformation, with DS-Env trimers in virus-like-particle and soluble formats providing a new generation of vaccine antigens.
		+
		+	Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env.,Do Kwon Y, Pancera M, Acharya P, Georgiev IS, Crooks ET, Gorman J, Joyce MG, Guttman M, Ma X, Narpala S, Soto C, Terry DS, Yang Y, Zhou T, Ahlsen G, Bailer RT, Chambers M, Chuang GY, Doria-Rose NA, Druz A, Hallen MA, Harned A, Kirys T, Louder MK, O'Dell S, Ofek G, Osawa K, Prabhakaran M, Sastry M, Stewart-Jones GB, Stuckey J, Thomas PV, Tittley T, Williams C, Zhang B, Zhao H, Zhou Z, Donald BR, Lee LK, Zolla-Pazner S, Baxa U, Schon A, Freire E, Shapiro L, Lee KK, Arthos J, Munro JB, Blanchard SC, Mothes W, Binley JM, McDermott AB, Mascola JR, Kwong PD Nat Struct Mol Biol. 2015 Jul;22(7):522-31. doi: 10.1038/nsmb.3051. Epub 2015 Jun, 22. PMID:26098315<ref>PMID:26098315</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:04, 24 June 2015

OCA — Wed, 24 Jun 2015 13:04:45 GMT

←Older revision		Revision as of 13:04, 24 June 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure of Ligand-Free BG505 SOSIP.664 HIV-1 Env Trimer==
-		+	<StructureSection load='4zmj' size='340' side='right' caption='[[4zmj]], [[Resolution\|resolution]] 3.31Å' scene=''>
-	~~The entry~~ 4zmj is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4zmj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZMJ FirstGlance]. <br>
-	~~Authors~~: ~~Kwon~~, Y.D., ~~Kwong~~, P.D.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zmj RCSB], [http://www.ebi.ac.uk/pdbsum/4zmj PDBsum]</span></td></tr>
-	~~Description~~: ~~Crystal Structure~~ of ~~Ligand~~-~~Free BG505 SOSIP~~.~~664 HIV~~-~~1 Env Trimer~~	+	</table>
-	[~~[Category~~: ~~Unreleased Structures]~~]	+	== Function ==
-	[[Category: Kwon, Y.D]]	+	[[http://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]
-	[[Category: Kwong, P.D]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Kwon, Y D]]
		+	[[Category: Kwong, P D]]
		+	[[Category: Bg505 sosip]]
		+	[[Category: Env trimer]]
		+	[[Category: Hiv-1]]
		+	[[Category: Unliganded]]
		+	[[Category: Viral protein]]

OCA at 11:00, 3 June 2015

OCA — Wed, 03 Jun 2015 11:00:56 GMT

←Older revision		Revision as of 11:00, 3 June 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zmj is ON HOLD	+	The entry 4zmj is ON HOLD until Paper Publication

	Authors: Kwon, Y.D., Kwong, P.D.		Authors: Kwon, Y.D., Kwong, P.D.

OCA at 14:30, 27 May 2015

OCA — Wed, 27 May 2015 14:30:50 GMT

←Older revision		Revision as of 14:30, 27 May 2015
Line 5:		Line 5:
	Authors: Kwon, Y.D., Kwong, P.D.		Authors: Kwon, Y.D., Kwong, P.D.

-	Description: Crystal Structure of ~~the~~ Ligand-Free ~~HIV-1~~ BG505 SOSIP.664 Env Trimer	+	Description: Crystal Structure of Ligand-Free BG505 SOSIP.664 HIV-1 Env Trimer
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Kwon, Y.D]]		[[Category: Kwon, Y.D]]
	[[Category: Kwong, P.D]]		[[Category: Kwong, P.D]]

OCA at 10:53, 20 May 2015

OCA — Wed, 20 May 2015 10:53:58 GMT

←Older revision		Revision as of 10:53, 20 May 2015
Line 5:		Line 5:
	Authors: Kwon, Y.D., Kwong, P.D.		Authors: Kwon, Y.D., Kwong, P.D.

-	Description: Crystal ~~structure~~ of ~~mature unliganded~~ HIV-1 BG505 SOSIP.664 Env	+	Description: Crystal Structure of the Ligand-Free HIV-1 BG505 SOSIP.664 Env Trimer
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Kwon, Y.D]]		[[Category: Kwon, Y.D]]
	[[Category: Kwong, P.D]]		[[Category: Kwong, P.D]]