4zmy - Revision history

OCA at 15:46, 8 November 2023

OCA — Wed, 08 Nov 2023 15:46:23 GMT

←Older revision		Revision as of 15:46, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zmy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZMY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zmy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZMY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmy OCA], [https://pdbe.org/4zmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zmy RCSB], [https://www.ebi.ac.uk/pdbsum/4zmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zmy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmy OCA], [https://pdbe.org/4zmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zmy RCSB], [https://www.ebi.ac.uk/pdbsum/4zmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zmy ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:34, 18 May 2023

OCA — Thu, 18 May 2023 07:34:03 GMT

←Older revision		Revision as of 07:34, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='4zmy' size='340' side='right'caption='[[4zmy]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4zmy' size='340' side='right'caption='[[4zmy]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zmy]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZMY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zmy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZMY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zml\|4zml]], [[4zmn\|4zmn]], [[4zmo\|4zmo]], [[4zmp\|4zmp]], [[4zmq\|4zmq]], [[4zmt\|4zmt]], [[4zmv\|4zmv]], [[4zmw\|4zmw]], [[4zmx\|4zmx]], [[4zmz\|4zmz]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmy OCA], [https://pdbe.org/4zmy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zmy RCSB], [https://www.ebi.ac.uk/pdbsum/4zmy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zmy ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDH3, CDHP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmy OCA], [~~http~~://pdbe.org/4zmy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zmy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zmy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zmy ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CADH3_HUMAN CADH3_HUMAN]] Hypotrichosis with juvenile macular degeneration;EEM syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/CADH3_HUMAN CADH3_HUMAN] Hypotrichosis with juvenile macular degeneration;EEM syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CADH3_HUMAN CADH3_HUMAN]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.	+	[https://www.uniprot.org/uniprot/CADH3_HUMAN CADH3_HUMAN] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Caaveiro~~, J M.M~~]]	+	[[Category: Caaveiro JMM]]
-	[[Category: Kudo, S]]	+	[[Category: Kudo S]]
-	[[Category: Tsumoto, K]]	+	[[Category: Tsumoto K]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Conformational change]]~~	+
-	~~[[Category: Dimerization~~]]	+

OCA at 07:54, 26 June 2019

OCA — Wed, 26 Jun 2019 07:54:58 GMT

←Older revision		Revision as of 07:54, 26 June 2019
Line 1:		Line 1:

	==Crystal structure of human P-cadherin (monomer 1)==		==Crystal structure of human P-cadherin (monomer 1)==
-	<StructureSection load='4zmy' size='340' side='right' caption='[[4zmy]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='4zmy' size='340' side='right'caption='[[4zmy]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zmy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZMY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zmy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZMY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zml\|4zml]], [[4zmn\|4zmn]], [[4zmo\|4zmo]], [[4zmp\|4zmp]], [[4zmq\|4zmq]], [[4zmt\|4zmt]], [[4zmv\|4zmv]], [[4zmw\|4zmw]], [[4zmx\|4zmx]], [[4zmz\|4zmz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zml\|4zml]], [[4zmn\|4zmn]], [[4zmo\|4zmo]], [[4zmp\|4zmp]], [[4zmq\|4zmq]], [[4zmt\|4zmt]], [[4zmv\|4zmv]], [[4zmw\|4zmw]], [[4zmx\|4zmx]], [[4zmz\|4zmz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CDH3, CDHP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmy OCA], [http://pdbe.org/4zmy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zmy RCSB], [http://www.ebi.ac.uk/pdbsum/4zmy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zmy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmy OCA], [http://pdbe.org/4zmy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zmy RCSB], [http://www.ebi.ac.uk/pdbsum/4zmy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zmy ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 4zmy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4zmy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cadherin 3D structures\|Cadherin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Caaveiro, J M.M]]		[[Category: Caaveiro, J M.M]]
	[[Category: Kudo, S]]		[[Category: Kudo, S]]

OCA at 21:00, 10 September 2016

OCA — Sat, 10 Sep 2016 21:00:45 GMT

←Older revision		Revision as of 21:00, 10 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4zmy is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of human P-cadherin (monomer 1)==
		+	<StructureSection load='4zmy' size='340' side='right' caption='[[4zmy]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4zmy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZMY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZMY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zml\|4zml]], [[4zmn\|4zmn]], [[4zmo\|4zmo]], [[4zmp\|4zmp]], [[4zmq\|4zmq]], [[4zmt\|4zmt]], [[4zmv\|4zmv]], [[4zmw\|4zmw]], [[4zmx\|4zmx]], [[4zmz\|4zmz]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zmy OCA], [http://pdbe.org/4zmy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zmy RCSB], [http://www.ebi.ac.uk/pdbsum/4zmy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zmy ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CADH3_HUMAN CADH3_HUMAN]] Hypotrichosis with juvenile macular degeneration;EEM syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CADH3_HUMAN CADH3_HUMAN]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Orderly assembly of classical cadherins governs cell adhesion and tissue maintenance. A key event is the strand-swap dimerization of the extracellular ectodomains of two cadherin molecules from apposing cells. Here we have determined crystal structures of P-cadherin in six different conformational states to elaborate a motion picture of its adhesive dimerization at the atomic level. The snapshots revealed that cell-adhesive dimerization is facilitated by several intermediate states collectively termed X-dimer in analogy to other classical cadherins. Based on previous studies and on the combined structural, kinetic, thermodynamic, biochemical, and cellular data reported herein, we propose that the adhesive dimerization of human P-cadherin is achieved by a stepwise mechanism analogous to that of assembly chaperones. This mechanism, applicable to type I classical cadherins, confers high specificity and fast association rates. We expect these findings to guide innovative therapeutic approaches targeting P-cadherin in cancer.

-	~~Authors~~:	+	Adhesive Dimerization of Human P-Cadherin Catalyzed by a Chaperone-like Mechanism.,Kudo S, Caaveiro JM, Tsumoto K Structure. 2016 Sep 6;24(9):1523-1536. doi: 10.1016/j.str.2016.07.002. Epub 2016 , Aug 18. PMID:27545624<ref>PMID:27545624</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 4zmy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Caaveiro, J M.M]]
		+	[[Category: Kudo, S]]
		+	[[Category: Tsumoto, K]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Conformational change]]
		+	[[Category: Dimerization]]

OCA at 10:41, 15 May 2016

OCA — Sun, 15 May 2016 10:41:09 GMT

←Older revision		Revision as of 10:41, 15 May 2016
Line 3:		Line 3:
	The entry 4zmy is ON HOLD until Paper Publication		The entry 4zmy is ON HOLD until Paper Publication

-	Authors: ~~Caaveiro, J.M.M., Kudo, S., Tsumoto, K.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Tsumoto, K]]
-	[[Category: Caaveiro, J.M.M]]
-	[[Category: Kudo, S]]

OCA at 00:05, 1 December 2015

OCA — Tue, 01 Dec 2015 00:05:52 GMT

←Older revision		Revision as of 00:05, 1 December 2015
Line 7:		Line 7:
	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Tsumoto, K]]
	[[Category: Caaveiro, J.M.M]]		[[Category: Caaveiro, J.M.M]]
	[[Category: Kudo, S]]		[[Category: Kudo, S]]
-	[[Category: Tsumoto, K]]

OCA at 14:31, 27 May 2015

OCA — Wed, 27 May 2015 14:31:31 GMT

←Older revision		Revision as of 14:31, 27 May 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zmy is ON HOLD	+	The entry 4zmy is ON HOLD until Paper Publication

	Authors: Caaveiro, J.M.M., Kudo, S., Tsumoto, K.		Authors: Caaveiro, J.M.M., Kudo, S., Tsumoto, K.

OCA: Protected "4zmy" [edit=sysop:move=sysop]

OCA — Wed, 13 May 2015 11:08:54 GMT

Protected "4zmy" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:08, 13 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zmy is ON HOLD Authors: Caaveiro, J.M.M., Kudo, S., Tsumoto, K. Description: Category: Unreleased Structures Category: Caaveiro, J.M.M [[...

OCA — Wed, 13 May 2015 11:08:52 GMT

New page: '''Unreleased structure''' The entry 4zmy is ON HOLD Authors: Caaveiro, J.M.M., Kudo, S., Tsumoto, K. Description: Category: Unreleased Structures Category: Caaveiro, J.M.M [[...

New page

'''Unreleased structure'''

The entry 4zmy is ON HOLD

Authors: Caaveiro, J.M.M., Kudo, S., Tsumoto, K.

Description:
[[Category: Unreleased Structures]]
[[Category: Caaveiro, J.M.M]]
[[Category: Kudo, S]]
[[Category: Tsumoto, K]]