4zpa - Revision history

OCA at 12:16, 6 March 2024

OCA — Wed, 06 Mar 2024 12:16:28 GMT

←Older revision		Revision as of 12:16, 6 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zpa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_B3 Coxsackievirus B3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZPA FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zpa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_B3 Coxsackievirus B3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZPA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.665Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpa OCA], [https://pdbe.org/4zpa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zpa RCSB], [https://www.ebi.ac.uk/pdbsum/4zpa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zpa ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpa OCA], [https://pdbe.org/4zpa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zpa RCSB], [https://www.ebi.ac.uk/pdbsum/4zpa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zpa ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q5UEA2_9ENTO Q5UEA2_9ENTO]		[https://www.uniprot.org/uniprot/Q5UEA2_9ENTO Q5UEA2_9ENTO]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Positive strand RNA viruses replicate via a virally encoded RNA-dependent RNA polymerase (RdRP) that uses a unique palm domain active site closure mechanism to establish the canonical two-metal geometry needed for catalysis. This mechanism allows these viruses to evolutionarily fine-tune their replication fidelity in order to create an appropriate distribution of genetic variants known as a quasispecies. Prior work has shown that mutations in conserved motif A drastically alter RdRP fidelity, which can be either increased or decreased depending on the viral polymerase background. In the work presented here we extend these studies to motif D, a region that forms the outer edge of the NTP entry channel where it may act as a nucleotide sensor to trigger active site closure. Crystallography, stopped-flow kinetics, quench-flow reactions, and infectious virus studies were used to characterize fifteen engineered mutations in coxsackievirus B3 polymerase. Mutations that interfere with the transport of the metal A Mg2+ ion into the active site had only minor effects on RdRP function, but the stacking interaction between Phe364 and Pro357, which is absolutely conserved in enteroviral polymerases, was found to be critical for processive elongation and virus growth. Mutating Phe364 to tryptophan resulted in a genetically stable high-fidelity virus variant with significantly reduced pathogenesis in mice. The data further illustrate the importance of the palm domain movement for RdRP active site closure and demonstrate that protein engineering can be used to alter viral polymerase function and attenuate virus growth and pathogenesis.
-
-	Design of a Genetically Stable High-Fidelity Coxsackievirus B3 Polymerase That Attenuates Virus Growth in vivo.,McDonald S, Block A, Beaucourt S, Moratorio G, Vignuzzi M, Peersen OB J Biol Chem. 2016 May 2. pii: jbc.M116.726596. PMID:27137934<ref>PMID:27137934</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4zpa" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[RNA polymerase 3D structures\|RNA polymerase 3D structures]]		*[[RNA polymerase 3D structures\|RNA polymerase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:36, 18 May 2023

OCA — Thu, 18 May 2023 07:36:55 GMT

←Older revision		Revision as of 07:36, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='4zpa' size='340' side='right'caption='[[4zpa]], [[Resolution\|resolution]] 2.67Å' scene=''>		<StructureSection load='4zpa' size='340' side='right'caption='[[4zpa]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zpa]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Cvb3 Cvb3~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZPA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZPA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zpa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_B3 Coxsackievirus B3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZPA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zp6\|4zp6]], [[4zp7\|4zp7]], [[4zp8\|4zp8]], [[4zp9\|4zp9]], [[4zpb\|4zpb]], [[4zpc\|4zpc]], [[4zpd\|4zpd]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpa OCA], [https://pdbe.org/4zpa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zpa RCSB], [https://www.ebi.ac.uk/pdbsum/4zpa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zpa ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpa OCA], [~~http~~://pdbe.org/4zpa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zpa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zpa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zpa ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5UEA2_9ENTO Q5UEA2_9ENTO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 20:

	==See Also==		==See Also==
-	*[[RNA polymerase\|RNA polymerase]]	+	*[[RNA polymerase 3D structures\|RNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cvb3~~]]	+	[[Category: Coxsackievirus B3]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: McDonald~~, S M~~]]	+	[[Category: McDonald SM]]
-	[[Category: Peersen~~, O B]]~~	+	[[Category: Peersen OB]]
-	~~[[Category: Rna-dependent rna polymerase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:03, 26 June 2019

OCA — Wed, 26 Jun 2019 08:03:16 GMT

←Older revision		Revision as of 08:03, 26 June 2019
Line 1:		Line 1:

	==Coxsackievirus B3 Polymerase - F364Y mutant==		==Coxsackievirus B3 Polymerase - F364Y mutant==
-	<StructureSection load='4zpa' size='340' side='right' caption='[[4zpa]], [[Resolution\|resolution]] 2.67Å' scene=''>	+	<StructureSection load='4zpa' size='340' side='right'caption='[[4zpa]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zpa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZPA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZPA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zpa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cvb3 Cvb3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZPA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZPA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zp6\|4zp6]], [[4zp7\|4zp7]], [[4zp8\|4zp8]], [[4zp9\|4zp9]], [[4zpb\|4zpb]], [[4zpc\|4zpc]], [[4zpd\|4zpd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zp6\|4zp6]], [[4zp7\|4zp7]], [[4zp8\|4zp8]], [[4zp9\|4zp9]], [[4zpb\|4zpb]], [[4zpc\|4zpc]], [[4zpd\|4zpd]]</td></tr>
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 4zpa" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4zpa" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[RNA polymerase\|RNA polymerase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cvb3]]
		+	[[Category: Large Structures]]
	[[Category: McDonald, S M]]		[[Category: McDonald, S M]]
	[[Category: Peersen, O B]]		[[Category: Peersen, O B]]
	[[Category: Rna-dependent rna polymerase]]		[[Category: Rna-dependent rna polymerase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 03:06, 13 July 2016

OCA — Wed, 13 Jul 2016 03:06:48 GMT

←Older revision		Revision as of 03:06, 13 July 2016
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zp6\|4zp6]], [[4zp7\|4zp7]], [[4zp8\|4zp8]], [[4zp9\|4zp9]], [[4zpb\|4zpb]], [[4zpc\|4zpc]], [[4zpd\|4zpd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zp6\|4zp6]], [[4zp7\|4zp7]], [[4zp8\|4zp8]], [[4zp9\|4zp9]], [[4zpb\|4zpb]], [[4zpc\|4zpc]], [[4zpd\|4zpd]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpa OCA], [http://pdbe.org/4zpa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zpa RCSB], [http://www.ebi.ac.uk/pdbsum/4zpa PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpa OCA], [http://pdbe.org/4zpa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zpa RCSB], [http://www.ebi.ac.uk/pdbsum/4zpa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zpa ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:39, 1 June 2016

OCA — Wed, 01 Jun 2016 07:39:22 GMT

←Older revision		Revision as of 07:39, 1 June 2016
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpa OCA], [http://pdbe.org/4zpa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zpa RCSB], [http://www.ebi.ac.uk/pdbsum/4zpa PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpa OCA], [http://pdbe.org/4zpa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zpa RCSB], [http://www.ebi.ac.uk/pdbsum/4zpa PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Positive strand RNA viruses replicate via a virally encoded RNA-dependent RNA polymerase (RdRP) that uses a unique palm domain active site closure mechanism to establish the canonical two-metal geometry needed for catalysis. This mechanism allows these viruses to evolutionarily fine-tune their replication fidelity in order to create an appropriate distribution of genetic variants known as a quasispecies. Prior work has shown that mutations in conserved motif A drastically alter RdRP fidelity, which can be either increased or decreased depending on the viral polymerase background. In the work presented here we extend these studies to motif D, a region that forms the outer edge of the NTP entry channel where it may act as a nucleotide sensor to trigger active site closure. Crystallography, stopped-flow kinetics, quench-flow reactions, and infectious virus studies were used to characterize fifteen engineered mutations in coxsackievirus B3 polymerase. Mutations that interfere with the transport of the metal A Mg2+ ion into the active site had only minor effects on RdRP function, but the stacking interaction between Phe364 and Pro357, which is absolutely conserved in enteroviral polymerases, was found to be critical for processive elongation and virus growth. Mutating Phe364 to tryptophan resulted in a genetically stable high-fidelity virus variant with significantly reduced pathogenesis in mice. The data further illustrate the importance of the palm domain movement for RdRP active site closure and demonstrate that protein engineering can be used to alter viral polymerase function and attenuate virus growth and pathogenesis.
		+
		+	Design of a Genetically Stable High-Fidelity Coxsackievirus B3 Polymerase That Attenuates Virus Growth in vivo.,McDonald S, Block A, Beaucourt S, Moratorio G, Vignuzzi M, Peersen OB J Biol Chem. 2016 May 2. pii: jbc.M116.726596. PMID:27137934<ref>PMID:27137934</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4zpa" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:03, 15 May 2016

OCA — Sun, 15 May 2016 17:03:27 GMT

←Older revision		Revision as of 17:03, 15 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4zpa ~~is ON HOLD until Paper Publication~~	+	==Coxsackievirus B3 Polymerase - F364Y mutant==
-		+	<StructureSection load='4zpa' size='340' side='right' caption='[[4zpa]], [[Resolution\|resolution]] 2.67Å' scene=''>
-	~~Authors~~: ~~Peersen, O~~.B.~~, McDonald, S~~.M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4zpa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZPA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZPA FirstGlance]. <br>
-	~~Description~~: ~~Coxsackievirus B3 Polymerase -F364Y mutant~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zp6\|4zp6]], [[4zp7\|4zp7]], [[4zp8\|4zp8]], [[4zp9\|4zp9]], [[4zpb\|4zpb]], [[4zpc\|4zpc]], [[4zpd\|4zpd]]</td></tr>
-	[[Category: ~~Mcdonald~~, S.M]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpa OCA], [http://pdbe.org/4zpa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zpa RCSB], [http://www.ebi.ac.uk/pdbsum/4zpa PDBsum]</span></td></tr>
-	[[Category: Peersen, O.B]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: McDonald, S M]]
		+	[[Category: Peersen, O B]]
		+	[[Category: Rna-dependent rna polymerase]]
		+	[[Category: Transferase]]

OCA at 00:08, 1 December 2015

OCA — Tue, 01 Dec 2015 00:08:04 GMT

←Older revision		Revision as of 00:08, 1 December 2015
Line 7:		Line 7:
	Description: Coxsackievirus B3 Polymerase -F364Y mutant		Description: Coxsackievirus B3 Polymerase -F364Y mutant
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Peersen, O.B]]
	[[Category: Mcdonald, S.M]]		[[Category: Mcdonald, S.M]]
		+	[[Category: Peersen, O.B]]

OCA at 11:05, 3 June 2015

OCA — Wed, 03 Jun 2015 11:05:02 GMT

←Older revision		Revision as of 11:05, 3 June 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zpa is ON HOLD	+	The entry 4zpa is ON HOLD until Paper Publication

	Authors: Peersen, O.B., McDonald, S.M.		Authors: Peersen, O.B., McDonald, S.M.

OCA: Protected "4zpa" [edit=sysop:move=sysop]

OCA — Wed, 13 May 2015 11:15:02 GMT

Protected "4zpa" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:15, 13 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zpa is ON HOLD Authors: Peersen, O.B., McDonald, S.M. Description: Coxsackievirus B3 Polymerase -F364Y mutant Category: Unreleased Structures ...

OCA — Wed, 13 May 2015 11:15:00 GMT

New page: '''Unreleased structure''' The entry 4zpa is ON HOLD Authors: Peersen, O.B., McDonald, S.M. Description: Coxsackievirus B3 Polymerase -F364Y mutant Category: Unreleased Structures ...

New page

'''Unreleased structure'''

The entry 4zpa is ON HOLD

Authors: Peersen, O.B., McDonald, S.M.

Description: Coxsackievirus B3 Polymerase -F364Y mutant
[[Category: Unreleased Structures]]
[[Category: Peersen, O.B]]
[[Category: Mcdonald, S.M]]