4zpm - Revision history

OCA at 08:22, 27 September 2023

OCA — Wed, 27 Sep 2023 08:22:15 GMT

←Older revision		Revision as of 08:22, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zpm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZPM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zpm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZPM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpm OCA], [https://pdbe.org/4zpm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zpm RCSB], [https://www.ebi.ac.uk/pdbsum/4zpm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zpm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpm OCA], [https://pdbe.org/4zpm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zpm RCSB], [https://www.ebi.ac.uk/pdbsum/4zpm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zpm ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:37, 18 May 2023

OCA — Thu, 18 May 2023 07:37:13 GMT

←Older revision		Revision as of 07:37, 18 May 2023
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	<StructureSection load='4zpm' size='340' side='right'caption='[[4zpm]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4zpm' size='340' side='right'caption='[[4zpm]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zpm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZPM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZPM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zpm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZPM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zpl\|4zpl]], [[4zpn\|4zpn]], [[4zpo\|4zpo]], [[4zpp\|4zpp]], [[4zpq\|4zpq]], [[4zps\|4zps]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpm OCA], [https://pdbe.org/4zpm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zpm RCSB], [https://www.ebi.ac.uk/pdbsum/4zpm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zpm ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpm OCA], [~~http~~://pdbe.org/4zpm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zpm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zpm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zpm ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/Q91Y09_MOUSE Q91Y09_MOUSE]] Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.[SAAS:SAAS00311819]	+	[https://www.uniprot.org/uniprot/Q91Y09_MOUSE Q91Y09_MOUSE] Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.[SAAS:SAAS00311819]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Goodman, K M~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Mannepalli, S~~]]	+	[[Category: Goodman KM]]
-	[[Category: ~~Shapiro, L~~]]	+	[[Category: Mannepalli S]]
-	[[Category: ~~Cell adhesion~~]]	+	[[Category: Shapiro L]]

OCA at 08:28, 26 June 2019

OCA — Wed, 26 Jun 2019 08:28:17 GMT

←Older revision		Revision as of 08:28, 26 June 2019
Line 1:		Line 1:

	==Crystal Structure of Protocadherin Alpha C2 EC1-3==		==Crystal Structure of Protocadherin Alpha C2 EC1-3==
-	<StructureSection load='4zpm' size='340' side='right' caption='[[4zpm]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='4zpm' size='340' side='right'caption='[[4zpm]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zpm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZPM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZPM FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zpm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZPM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZPM FirstGlance]. <br>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Goodman, K M]]		[[Category: Goodman, K M]]
	[[Category: Mannepalli, S]]		[[Category: Mannepalli, S]]
	[[Category: Shapiro, L]]		[[Category: Shapiro, L]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA at 16:57, 18 August 2017

OCA — Fri, 18 Aug 2017 16:57:23 GMT

←Older revision		Revision as of 16:57, 18 August 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Protocadherin Alpha C2 EC1-3==		==Crystal Structure of Protocadherin Alpha C2 EC1-3==
	<StructureSection load='4zpm' size='340' side='right' caption='[[4zpm]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='4zpm' size='340' side='right' caption='[[4zpm]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zpl\|4zpl]], [[4zpn\|4zpn]], [[4zpo\|4zpo]], [[4zpp\|4zpp]], [[4zpq\|4zpq]], [[4zps\|4zps]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zpl\|4zpl]], [[4zpn\|4zpn]], [[4zpo\|4zpo]], [[4zpp\|4zpp]], [[4zpq\|4zpq]], [[4zps\|4zps]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpm OCA], [http://pdbe.org/4zpm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zpm RCSB], [http://www.ebi.ac.uk/pdbsum/4zpm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpm OCA], [http://pdbe.org/4zpm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zpm RCSB], [http://www.ebi.ac.uk/pdbsum/4zpm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zpm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 20:39, 30 November 2015

OCA — Mon, 30 Nov 2015 20:39:55 GMT

←Older revision		Revision as of 20:39, 30 November 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal Structure of Protocadherin Alpha C2 EC1-3==
		+	<StructureSection load='4zpm' size='340' side='right' caption='[[4zpm]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4zpm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZPM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZPM FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zpl\|4zpl]], [[4zpn\|4zpn]], [[4zpo\|4zpo]], [[4zpp\|4zpp]], [[4zpq\|4zpq]], [[4zps\|4zps]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zpm OCA], [http://pdbe.org/4zpm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zpm RCSB], [http://www.ebi.ac.uk/pdbsum/4zpm PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q91Y09_MOUSE Q91Y09_MOUSE]] Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.[SAAS:SAAS00311819]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Self-avoidance, a process preventing interactions of axons and dendrites from the same neuron during development, is mediated in vertebrates through the stochastic single-neuron expression of clustered protocadherin protein isoforms. Extracellular cadherin (EC) domains mediate isoform-specific homophilic binding between cells, conferring cell recognition through a poorly understood mechanism. Here, we report crystal structures for the EC1-EC3 domain regions from four protocadherin isoforms representing the alpha, beta, and gamma subfamilies. All are rod shaped and monomeric in solution. Biophysical measurements, cell aggregation assays, and computational docking reveal that trans binding between cells depends on the EC1-EC4 domains, which interact in an antiparallel orientation. We also show that the EC6 domains are required for the formation of cis-dimers. Overall, our results are consistent with a model in which protocadherin cis-dimers engage in a head-to-tail interaction between EC1-EC4 domains from apposed cell surfaces, possibly forming a zipper-like protein assembly, and thus providing a size-dependent self-recognition mechanism.

-	~~The entry 4zpm is ON HOLD until Paper Publication~~	+	Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions.,Rubinstein R, Thu CA, Goodman KM, Wolcott HN, Bahna F, Mannepalli S, Ahlsen G, Chevee M, Halim A, Clausen H, Maniatis T, Shapiro L, Honig B Cell. 2015 Oct 22;163(3):629-42. doi: 10.1016/j.cell.2015.09.026. Epub 2015 Oct, 17. PMID:26478182<ref>PMID:26478182</ref>

-	~~Authors: Goodman~~, K.~~M., Mannepalli,~~ S.~~, Shapiro, L~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~:	+	<div class="pdbe-citations 4zpm" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Goodman, K M]]
		+	[[Category: Mannepalli, S]]
	[[Category: Shapiro, L]]		[[Category: Shapiro, L]]
-	[[Category: ~~Mannepalli, S]]~~	+	[[Category: Cell adhesion]]
-	~~[[Category: Goodman, K.M~~]]	+

OCA at 11:05, 3 June 2015

OCA — Wed, 03 Jun 2015 11:05:30 GMT

←Older revision		Revision as of 11:05, 3 June 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zpm is ON HOLD	+	The entry 4zpm is ON HOLD until Paper Publication

	Authors: Goodman, K.M., Mannepalli, S., Shapiro, L.		Authors: Goodman, K.M., Mannepalli, S., Shapiro, L.

OCA: Protected "4zpm" [edit=sysop:move=sysop]

OCA — Wed, 13 May 2015 11:15:36 GMT

Protected "4zpm" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:15, 13 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zpm is ON HOLD Authors: Goodman, K.M., Mannepalli, S., Shapiro, L. Description: Category: Unreleased Structures Category: Shapiro, L [[Ca...

OCA — Wed, 13 May 2015 11:15:35 GMT

New page: '''Unreleased structure''' The entry 4zpm is ON HOLD Authors: Goodman, K.M., Mannepalli, S., Shapiro, L. Description: Category: Unreleased Structures Category: Shapiro, L [[Ca...

New page

'''Unreleased structure'''

The entry 4zpm is ON HOLD

Authors: Goodman, K.M., Mannepalli, S., Shapiro, L.

Description:
[[Category: Unreleased Structures]]
[[Category: Shapiro, L]]
[[Category: Mannepalli, S]]
[[Category: Goodman, K.M]]