4zqy - Revision history

OCA at 15:46, 8 November 2023

OCA — Wed, 08 Nov 2023 15:46:47 GMT

←Older revision		Revision as of 15:46, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zqy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hemachatus_haemachatus Hemachatus haemachatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZQY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zqy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hemachatus_haemachatus Hemachatus haemachatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZQY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqy OCA], [https://pdbe.org/4zqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zqy RCSB], [https://www.ebi.ac.uk/pdbsum/4zqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zqy ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9515Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqy OCA], [https://pdbe.org/4zqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zqy RCSB], [https://www.ebi.ac.uk/pdbsum/4zqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zqy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:38, 18 May 2023

OCA — Thu, 18 May 2023 07:38:27 GMT

←Older revision		Revision as of 07:38, 18 May 2023
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	<StructureSection load='4zqy' size='340' side='right'caption='[[4zqy]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='4zqy' size='340' side='right'caption='[[4zqy]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zqy]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Hemachatus_haemachatus Hemachatus haemachatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZQY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZQY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zqy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hemachatus_haemachatus Hemachatus haemachatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZQY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqy OCA], [~~http~~://pdbe.org/4zqy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zqy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zqy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zqy ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqy OCA], [https://pdbe.org/4zqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zqy RCSB], [https://www.ebi.ac.uk/pdbsum/4zqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zqy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/3SO1_HEMHA 3SO1_HEMHA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Hemachatus haemachatus]]		[[Category: Hemachatus haemachatus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jobichen, C]]	+	[[Category: Jobichen C]]
-	[[Category: Sivaraman, J]]	+	[[Category: Sivaraman J]]
-	~~[[Category: Anticoagulant]]~~	+
-	~~[[Category: Ringhalexin]]~~	+
-	~~[[Category: Three finger toxin]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 07:59, 26 June 2019

OCA — Wed, 26 Jun 2019 07:59:45 GMT

←Older revision		Revision as of 07:59, 26 June 2019
Line 1:		Line 1:

	==Ringhalexin from hemachatus haemachatus: A novel inhibitor of extrinsic tenase complex==		==Ringhalexin from hemachatus haemachatus: A novel inhibitor of extrinsic tenase complex==
-	<StructureSection load='4zqy' size='340' side='right' caption='[[4zqy]], [[Resolution\|resolution]] 2.95Å' scene=''>	+	<StructureSection load='4zqy' size='340' side='right'caption='[[4zqy]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zqy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Hemachatus_haemachatus Hemachatus haemachatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZQY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zqy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Hemachatus_haemachatus Hemachatus haemachatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZQY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqy OCA], [http://pdbe.org/4zqy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zqy RCSB], [http://www.ebi.ac.uk/pdbsum/4zqy PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqy OCA], [http://pdbe.org/4zqy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zqy RCSB], [http://www.ebi.ac.uk/pdbsum/4zqy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zqy ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Hemachatus haemachatus]]		[[Category: Hemachatus haemachatus]]
		+	[[Category: Large Structures]]
	[[Category: Jobichen, C]]		[[Category: Jobichen, C]]
	[[Category: Sivaraman, J]]		[[Category: Sivaraman, J]]

OCA at 07:34, 1 June 2016

OCA — Wed, 01 Jun 2016 07:34:35 GMT

←Older revision		Revision as of 07:34, 1 June 2016
Line 6:		Line 6:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqy OCA], [http://pdbe.org/4zqy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zqy RCSB], [http://www.ebi.ac.uk/pdbsum/4zqy PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqy OCA], [http://pdbe.org/4zqy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zqy RCSB], [http://www.ebi.ac.uk/pdbsum/4zqy PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Anticoagulant therapy is used for the prevention and treatment of thromboembolic disorders. Blood coagulation is initiated by the interaction of factor VIIa (FVIIa) with membrane-bound tissue factor (TF) to form the extrinsic tenase complex which activates FX to FXa. Thus, it is an important target for the development of novel anticoagulants. Here, we report the isolation and characterization of a novel anticoagulant ringhalexin from the venom of Hemachatus haemachatus (African Ringhals Cobra). Amino acid sequence of the protein indicates that it belongs to the three-finger toxin family and exhibits 94% identity to an uncharacterized Neurotoxin-like protein NTL2 from Naja atra. Ringhalexin inhibited FX activation by extrinsic tenase complex with an IC50 of 123.8 +/- 9.54 nM. It is a mixed-type inhibitor with the kinetic constants, Ki and Ki' of 84.25 +/- 3.53 nM and 152.5 +/- 11.32 nM, respectively. Ringhalexin also exhibits a weak, irreversible neurotoxicity on chick biventer cervicis muscle preparations. Subsequently, the three-dimensional structure of ringhalexin was determined at 2.95 A resolution. This study for the first time reports the structure of an anticoagulant three-finger toxin. Thus, ringhalexin is a potent inhibitor of the FX activation by extrinsic tenase complex and a weak, irreversible neurotoxin.
		+
		+	Ringhalexin from Hemachatus haemachatus: A novel inhibitor of extrinsic tenase complex.,Barnwal B, Jobichen C, Girish VM, Foo CS, Sivaraman J, Kini RM Sci Rep. 2016 May 13;6:25935. doi: 10.1038/srep25935. PMID:27173146<ref>PMID:27173146</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4zqy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:03, 15 May 2016

OCA — Sun, 15 May 2016 17:03:44 GMT

←Older revision		Revision as of 17:03, 15 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4zqy ~~is ON HOLD until Paper Publication~~	+	==Ringhalexin from hemachatus haemachatus: A novel inhibitor of extrinsic tenase complex==
-		+	<StructureSection load='4zqy' size='340' side='right' caption='[[4zqy]], [[Resolution\|resolution]] 2.95Å' scene=''>
-	~~Authors~~: ~~Jobichen~~, C., ~~Sivaraman~~, J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4zqy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Hemachatus_haemachatus Hemachatus haemachatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZQY FirstGlance]. <br>
-	~~Description:~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqy OCA], [http://pdbe.org/4zqy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zqy RCSB], [http://www.ebi.ac.uk/pdbsum/4zqy PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hemachatus haemachatus]]
	[[Category: Jobichen, C]]		[[Category: Jobichen, C]]
	[[Category: Sivaraman, J]]		[[Category: Sivaraman, J]]
		+	[[Category: Anticoagulant]]
		+	[[Category: Ringhalexin]]
		+	[[Category: Three finger toxin]]
		+	[[Category: Toxin]]

OCA at 10:40, 30 September 2015

OCA — Wed, 30 Sep 2015 10:40:29 GMT

←Older revision		Revision as of 10:40, 30 September 2015
Line 3:		Line 3:
	The entry 4zqy is ON HOLD until Paper Publication		The entry 4zqy is ON HOLD until Paper Publication

-	Authors: ~~Sivaraman~~, J., ~~Jobichen~~, C.	+	Authors: Jobichen, C., Sivaraman, J.

	Description:		Description:

OCA at 11:07, 3 June 2015

OCA — Wed, 03 Jun 2015 11:07:42 GMT

←Older revision		Revision as of 11:07, 3 June 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zqy is ON HOLD	+	The entry 4zqy is ON HOLD until Paper Publication

	Authors: Sivaraman, J., Jobichen, C.		Authors: Sivaraman, J., Jobichen, C.

OCA at 14:37, 27 May 2015

OCA — Wed, 27 May 2015 14:37:45 GMT

←Older revision		Revision as of 14:37, 27 May 2015
Line 3:		Line 3:
	The entry 4zqy is ON HOLD		The entry 4zqy is ON HOLD

-	Authors: ~~Chacko Jobichen~~, J ~~Sivaraman~~	+	Authors: Sivaraman, J., Jobichen, C.

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Chacko~~ Jobichen, J Sivaraman]]	+	[[Category: Jobichen, C]]
		+	[[Category: Sivaraman, J]]

OCA: Protected "4zqy" [edit=sysop:move=sysop]

OCA — Wed, 20 May 2015 11:02:05 GMT

Protected "4zqy" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:02, 20 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zqy is ON HOLD Authors: Chacko Jobichen, J Sivaraman Description: Category: Unreleased Structures Category: Chacko Jobichen, J Sivaraman

OCA — Wed, 20 May 2015 11:02:03 GMT

New page: '''Unreleased structure''' The entry 4zqy is ON HOLD Authors: Chacko Jobichen, J Sivaraman Description: Category: Unreleased Structures Category: Chacko Jobichen, J Sivaraman

New page

'''Unreleased structure'''

The entry 4zqy is ON HOLD

Authors: Chacko Jobichen, J Sivaraman

Description:
[[Category: Unreleased Structures]]
[[Category: Chacko Jobichen, J Sivaraman]]