4ztg - Revision history

OCA at 12:16, 6 March 2024

OCA — Wed, 06 Mar 2024 12:16:48 GMT

←Older revision		Revision as of 12:16, 6 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ztg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_-_Mayinga,_Zaire,_1976 Ebola virus - Mayinga, Zaire, 1976]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZTG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ztg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_-_Mayinga,_Zaire,_1976 Ebola virus - Mayinga, Zaire, 1976]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZTG FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ztg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ztg OCA], [https://pdbe.org/4ztg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ztg RCSB], [https://www.ebi.ac.uk/pdbsum/4ztg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ztg ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ztg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ztg OCA], [https://pdbe.org/4ztg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ztg RCSB], [https://www.ebi.ac.uk/pdbsum/4ztg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ztg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:41, 18 May 2023

OCA — Thu, 18 May 2023 07:41:03 GMT

←Older revision		Revision as of 07:41, 18 May 2023
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	<StructureSection load='4ztg' size='340' side='right'caption='[[4ztg]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4ztg' size='340' side='right'caption='[[4ztg]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ztg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ebov~~-~~may Ebov~~-~~may~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZTG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZTG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ztg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_-_Mayinga,_Zaire,_1976 Ebola virus - Mayinga, Zaire, 1976]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZTG FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zta\|4zta]], [[4zti\|4zti]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ztg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ztg OCA], [https://pdbe.org/4ztg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ztg RCSB], [https://www.ebi.ac.uk/pdbsum/4ztg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ztg ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VP35, NP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=128952 EBOV-May])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ztg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ztg OCA], [~~http~~://pdbe.org/4ztg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ztg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ztg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ztg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM]] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref>	+	[https://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref> [https://www.uniprot.org/uniprot/NCAP_EBOZM NCAP_EBOZM] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid and serves as template for transcription and replication. During replication, encapsidation by NP is coupled to RNA synthesis and all replicative products are resistant to nucleases.
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ebov~~-~~may~~]]	+	[[Category: Ebola virus - Mayinga, Zaire, 1976]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Abelson~~, D M~~]]	+	[[Category: Abelson DM]]
-	[[Category: Kirchdoerfer~~, R N~~]]	+	[[Category: Kirchdoerfer RN]]
-	[[Category: Saphire~~, E O]]~~	+	[[Category: Saphire EO]]
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Nucleoprotein]]~~	+
-	~~[[Category: Rna-bindng]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 08:50, 4 December 2019

OCA — Wed, 04 Dec 2019 08:50:46 GMT

←Older revision		Revision as of 08:50, 4 December 2019
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	==Ebola virus nucleoprotein bound to VP35 chaperoning peptide P22121==		==Ebola virus nucleoprotein bound to VP35 chaperoning peptide P22121==
-	<StructureSection load='4ztg' size='340' side='right' caption='[[4ztg]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='4ztg' size='340' side='right'caption='[[4ztg]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ztg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebov-may Ebov-may]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZTG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ztg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebov-may Ebov-may]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZTG FirstGlance]. <br>
Line 15:		Line 15:
	</StructureSection>		</StructureSection>
	[[Category: Ebov-may]]		[[Category: Ebov-may]]
		+	[[Category: Large Structures]]
	[[Category: Abelson, D M]]		[[Category: Abelson, D M]]
	[[Category: Kirchdoerfer, R N]]		[[Category: Kirchdoerfer, R N]]

OCA at 12:21, 6 November 2017

OCA — Mon, 06 Nov 2017 12:21:53 GMT

←Older revision		Revision as of 12:21, 6 November 2017
Line 3:		Line 3:
	<StructureSection load='4ztg' size='340' side='right' caption='[[4ztg]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4ztg' size='340' side='right' caption='[[4ztg]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ztg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZTG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ztg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebov-may Ebov-may]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZTG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zta\|4zta]], [[4zti\|4zti]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zta\|4zta]], [[4zti\|4zti]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VP35, NP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=128952 EBOV-May])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ztg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ztg OCA], [http://pdbe.org/4ztg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ztg RCSB], [http://www.ebi.ac.uk/pdbsum/4ztg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ztg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ztg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ztg OCA], [http://pdbe.org/4ztg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ztg RCSB], [http://www.ebi.ac.uk/pdbsum/4ztg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ztg ProSAT]</span></td></tr>
	</table>		</table>
Line 13:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ebov-may]]
	[[Category: Abelson, D M]]		[[Category: Abelson, D M]]
	[[Category: Kirchdoerfer, R N]]		[[Category: Kirchdoerfer, R N]]
Line 19:		Line 21:
	[[Category: Nucleoprotein]]		[[Category: Nucleoprotein]]
	[[Category: Rna-bindng]]		[[Category: Rna-bindng]]
		+	[[Category: Viral protein]]

OCA at 09:56, 10 March 2017

OCA — Fri, 10 Mar 2017 09:56:34 GMT

←Older revision		Revision as of 09:56, 10 March 2017
Line 1:		Line 1:
		+
	==Ebola virus nucleoprotein bound to VP35 chaperoning peptide P22121==		==Ebola virus nucleoprotein bound to VP35 chaperoning peptide P22121==
	<StructureSection load='4ztg' size='340' side='right' caption='[[4ztg]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='4ztg' size='340' side='right' caption='[[4ztg]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4ztg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZTG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ztg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZTG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zta\|4zta]], [[4zti\|4zti]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zta\|4zta]], [[4zti\|4zti]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ztg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ztg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ztg RCSB], [http://www.ebi.ac.uk/pdbsum/4ztg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ztg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ztg OCA], [http://pdbe.org/4ztg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ztg RCSB], [http://www.ebi.ac.uk/pdbsum/4ztg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ztg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 16:01, 27 May 2015

OCA — Wed, 27 May 2015 16:01:27 GMT

←Older revision		Revision as of 16:01, 27 May 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Ebola virus nucleoprotein bound to VP35 chaperoning peptide P22121==
-		+	<StructureSection load='4ztg' size='340' side='right' caption='[[4ztg]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~The entry~~ 4ztg is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4ztg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZTG FirstGlance]. <br>
-	~~Authors~~: ~~Kirchdoerfer~~, R.N., ~~Abelson, D~~.M., ~~Saphire, E~~.O.	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zta\|4zta]], [[4zti\|4zti]]</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ztg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ztg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ztg RCSB], [http://www.ebi.ac.uk/pdbsum/4ztg PDBsum]</span></td></tr>
-	~~Description~~: ~~Ebola~~ virus ~~nucleoprotein bound to~~ VP35 ~~chaperoning peptide P202121~~	+	</table>
-	[[Category: ~~Unreleased Structures~~]]	+	== Function ==
-	[[Category: Saphire, E.O]]	+	[[http://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM]] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref>
-	[[Category: ~~Kirchdoerfer, R.N~~]]	+	== References ==
-	[[Category: ~~Abelson, D.M~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Abelson, D M]]
		+	[[Category: Kirchdoerfer, R N]]
		+	[[Category: Saphire, E O]]
		+	[[Category: Chaperone]]
		+	[[Category: Nucleoprotein]]
		+	[[Category: Rna-bindng]]

OCA: Protected "4ztg" [edit=sysop:move=sysop]

OCA — Wed, 20 May 2015 11:09:31 GMT

Protected "4ztg" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:09, 20 May 2015

OCA: New page: '''Unreleased structure''' The entry 4ztg is ON HOLD Authors: Kirchdoerfer, R.N., Abelson, D.M., Saphire, E.O. Description: Ebola virus nucleoprotein bound to VP35 chaperoning peptide ...

OCA — Wed, 20 May 2015 11:09:30 GMT

New page: '''Unreleased structure''' The entry 4ztg is ON HOLD Authors: Kirchdoerfer, R.N., Abelson, D.M., Saphire, E.O. Description: Ebola virus nucleoprotein bound to VP35 chaperoning peptide ...

New page

'''Unreleased structure'''

The entry 4ztg is ON HOLD

Authors: Kirchdoerfer, R.N., Abelson, D.M., Saphire, E.O.

Description: Ebola virus nucleoprotein bound to VP35 chaperoning peptide P202121
[[Category: Unreleased Structures]]
[[Category: Saphire, E.O]]
[[Category: Kirchdoerfer, R.N]]
[[Category: Abelson, D.M]]