4zuw - Revision history

OCA at 15:47, 8 November 2023

OCA — Wed, 08 Nov 2023 15:47:35 GMT

←Older revision		Revision as of 15:47, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zuw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Equine_infectious_anemia_virus Equine infectious anemia virus], [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZUW FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zuw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Equine_infectious_anemia_virus Equine infectious anemia virus], [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZUW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zuw OCA], [https://pdbe.org/4zuw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zuw RCSB], [https://www.ebi.ac.uk/pdbsum/4zuw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zuw ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zuw OCA], [https://pdbe.org/4zuw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zuw RCSB], [https://www.ebi.ac.uk/pdbsum/4zuw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zuw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 07:42, 18 May 2023

OCA — Thu, 18 May 2023 07:42:36 GMT

←Older revision		Revision as of 07:42, 18 May 2023
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	<StructureSection load='4zuw' size='340' side='right'caption='[[4zuw]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4zuw' size='340' side='right'caption='[[4zuw]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zuw]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Equus_caballus Equus caballus] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZUW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZUW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zuw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Equine_infectious_anemia_virus Equine infectious anemia virus], [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZUW FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zus\|4zus]], [[4zut\|4zut]], [[4zuu\|4zuu]], [[4zuv\|4zuv]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zuw OCA], [https://pdbe.org/4zuw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zuw RCSB], [https://www.ebi.ac.uk/pdbsum/4zuw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zuw ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zuw OCA], [~~http~~://pdbe.org/4zuw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zuw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zuw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zuw ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/Q860N6_HORSE Q860N6_HORSE]] Involved in the presentation of foreign antigens to the immune system.[SAAS:SAAS00281819] ~~[[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.~~	+	[https://www.uniprot.org/uniprot/Q860N6_HORSE Q860N6_HORSE] Involved in the presentation of foreign antigens to the immune system.[SAAS:SAAS00281819]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Equine infectious anemia virus]]
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Chen, R]]	+	[[Category: Chen R]]
-	[[Category: Liu, J]]	+	[[Category: Liu J]]
-	[[Category: Liu, Y]]	+	[[Category: Liu Y]]
-	[[Category: Qi, J]]	+	[[Category: Qi J]]
-	[[Category: Xia, C]]	+	[[Category: Xia C]]
-	[[Category: Yao, S]]	+	[[Category: Yao S]]
-	[[Category: Zhang, N]]	+	[[Category: Zhang N]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Lentivirus vaccine~~]]	+

OCA at 08:37, 26 June 2019

OCA — Wed, 26 Jun 2019 08:37:11 GMT

←Older revision		Revision as of 08:37, 26 June 2019
Line 1:		Line 1:

	==Crystal structure of Equine MHC I(Eqca-N*00601) in complexed with equine infectious anaemia virus (EIAV) derived peptide Gag-GW12==		==Crystal structure of Equine MHC I(Eqca-N*00601) in complexed with equine infectious anaemia virus (EIAV) derived peptide Gag-GW12==
-	<StructureSection load='4zuw' size='340' side='right' caption='[[4zuw]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='4zuw' size='340' side='right'caption='[[4zuw]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zuw]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZUW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zuw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZUW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zus\|4zus]], [[4zut\|4zut]], [[4zuu\|4zuu]], [[4zuv\|4zuv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zus\|4zus]], [[4zut\|4zut]], [[4zuu\|4zuu]], [[4zuv\|4zuv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zuw OCA], [http://pdbe.org/4zuw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zuw RCSB], [http://www.ebi.ac.uk/pdbsum/4zuw PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zuw OCA], [http://pdbe.org/4zuw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zuw RCSB], [http://www.ebi.ac.uk/pdbsum/4zuw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zuw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4zuw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4zuw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Equus caballus]]
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Chen, R]]		[[Category: Chen, R]]
	[[Category: Liu, J]]		[[Category: Liu, J]]

OCA at 04:04, 12 May 2016

OCA — Thu, 12 May 2016 04:04:01 GMT

←Older revision		Revision as of 04:04, 12 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4zuw is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Equine MHC I(Eqca-N*00601) in complexed with equine infectious anaemia virus (EIAV) derived peptide Gag-GW12==
		+	<StructureSection load='4zuw' size='340' side='right' caption='[[4zuw]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4zuw]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZUW FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zus\|4zus]], [[4zut\|4zut]], [[4zuu\|4zuu]], [[4zuv\|4zuv]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zuw OCA], [http://pdbe.org/4zuw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zuw RCSB], [http://www.ebi.ac.uk/pdbsum/4zuw PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q860N6_HORSE Q860N6_HORSE]] Involved in the presentation of foreign antigens to the immune system.[SAAS:SAAS00281819] [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	MHC class I (MHC I)-restricted virus-specific CTLs are implicated as critical components in the control of this naturally occurring lentivirus and in the protective immune response to the successfully applied attenuated equine infectious anemia virus vaccine in the horse. Nevertheless, the structural basis for how the equine MHC I presents epitope peptides remains unknown. In this study, we investigated the binding of several equine infectious anemia virus-derived epitope peptides by the ability to refold recombinant molecules and by thermal stability, and then by determining the x-ray structure of five peptide-MHC I complexes: equine MHC class I allele (Eqca)-N00602/Env-RW12, Eqca-N00602/Gag-GW12, Eqca-N00602/Rev-QW11, Eqca-N00602/Gag-CF9, and Eqca-N00601/Gag-GW12. Although Eqca-N00601 and Eqca-N00602 differ by a single amino acid, Eqca-N00601 exhibited a drastically different peptide presentation when binding a similar CTL epitope, Gag-GW12; the result makes the previously reported function clear to be non-cross-recognition between these two alleles. The structures plus Eqca-N*00602 complexed with a 9-mer peptide are particularly noteworthy in that we illuminated differences in apparent flexibility in the center of the epitope peptides for the complexes with Gag-GW12 as compared with Env-RW12, and a strict selection of epitope peptides with normal length. The featured preferences and unconventional presentations of long peptides by equine MHC I molecules provide structural bases to explain the exceptional anti-lentivirus immunity in the horse. We think that the beneficial reference points could serve as an initial platform for other human or animal lentiviruses.

-	~~Authors:~~ Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., ~~Xia~~, C.	+	Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles.,Yao S, Liu J, Qi J, Chen R, Zhang N, Liu Y, Wang J, Wu Y, Gao GF, Xia C J Immunol. 2016 Feb 15;196(4):1943-54. doi: 10.4049/jimmunol.1501352. Epub 2016, Jan 13. PMID:26764037<ref>PMID:26764037</ref>

-	~~Description: Crystal structure~~ of ~~Equine MHC I(Eqca~~-~~N*00601) in complexed with equine infectious anaemia virus (EIAV) derived peptide Gag~~-~~GW12~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	~~[[Category: Yao, S]]~~	+	<div class="pdbe-citations 4zuw" style="background-color:#fffaf0;"></div>
-	~~[[Category: Zhang, N]]~~	+	== References ==
-	~~[[Category: Xia, C]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Chen, R]]		[[Category: Chen, R]]
-	[[Category: Liu, Y]]
	[[Category: Liu, J]]		[[Category: Liu, J]]
		+	[[Category: Liu, Y]]
	[[Category: Qi, J]]		[[Category: Qi, J]]
		+	[[Category: Xia, C]]
		+	[[Category: Yao, S]]
		+	[[Category: Zhang, N]]
		+	[[Category: Immune system]]
		+	[[Category: Lentivirus vaccine]]

OCA at 00:12, 1 December 2015

OCA — Tue, 01 Dec 2015 00:12:18 GMT

←Older revision		Revision as of 00:12, 1 December 2015
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Yao, S]]		[[Category: Yao, S]]
		+	[[Category: Zhang, N]]
		+	[[Category: Xia, C]]
	[[Category: Chen, R]]		[[Category: Chen, R]]
	[[Category: Liu, Y]]		[[Category: Liu, Y]]
	[[Category: Liu, J]]		[[Category: Liu, J]]
-	[[Category: Zhang, N]]
-	[[Category: Xia, C]]
	[[Category: Qi, J]]		[[Category: Qi, J]]

OCA at 11:13, 3 June 2015

OCA — Wed, 03 Jun 2015 11:13:43 GMT

←Older revision		Revision as of 11:13, 3 June 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zuw is ON HOLD	+	The entry 4zuw is ON HOLD until Paper Publication

	Authors: Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C.		Authors: Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C.

OCA: Protected "4zuw" [edit=sysop:move=sysop]

OCA — Wed, 27 May 2015 14:44:45 GMT

Protected "4zuw" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:44, 27 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zuw is ON HOLD Authors: Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C. Description: Crystal structure of Equine MHC I(Eqca-N*0060...

OCA — Wed, 27 May 2015 14:44:44 GMT

New page: '''Unreleased structure''' The entry 4zuw is ON HOLD Authors: Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C. Description: Crystal structure of Equine MHC I(Eqca-N*0060...

New page

'''Unreleased structure'''

The entry 4zuw is ON HOLD

Authors: Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C.

Description: Crystal structure of Equine MHC I(Eqca-N*00601) in complexed with equine infectious anaemia virus (EIAV) derived peptide Gag-GW12
[[Category: Unreleased Structures]]
[[Category: Yao, S]]
[[Category: Chen, R]]
[[Category: Liu, Y]]
[[Category: Liu, J]]
[[Category: Zhang, N]]
[[Category: Xia, C]]
[[Category: Qi, J]]