4zv0 - Revision history

OCA at 09:27, 15 November 2023

OCA — Wed, 15 Nov 2023 09:27:41 GMT

←Older revision		Revision as of 09:27, 15 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zv0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZV0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zv0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZV0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.401Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zv0 OCA], [https://pdbe.org/4zv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zv0 RCSB], [https://www.ebi.ac.uk/pdbsum/4zv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zv0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zv0 OCA], [https://pdbe.org/4zv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zv0 RCSB], [https://www.ebi.ac.uk/pdbsum/4zv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zv0 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:42, 18 May 2023

OCA — Thu, 18 May 2023 07:42:47 GMT

←Older revision		Revision as of 07:42, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='4zv0' size='340' side='right'caption='[[4zv0]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='4zv0' size='340' side='right'caption='[[4zv0]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zv0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZV0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZV0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zv0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZV0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zv0 OCA], [https://pdbe.org/4zv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zv0 RCSB], [https://www.ebi.ac.uk/pdbsum/4zv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zv0 ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zuy\|4zuy]], [[4zv4\|4zv4]]</td></tr>~~	+
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA0093 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE]), PA0092 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zv0 OCA], [~~http~~://pdbe.org/4zv0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zv0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zv0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zv0 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TSE6_PSEAE TSE6_PSEAE] Type VI secretion exported toxin that acts as a glycohydrolase on bacterial target cells and degrades the essential dinucleotides NAD(+) and NADP(+), thereby inducing bacteriostasis. The activity resides in the C-terminal region that is initially neutralized by the cognate immunity protein Tsi6.<ref>PMID:26456113</ref> <ref>PMID:30177742</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pseae~~]]	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	[[Category: Mougous~~, J D~~]]	+	[[Category: Mougous JD]]
-	[[Category: Ralston, C]]	+	[[Category: Ralston C]]
-	[[Category: Sawai, S]]	+	[[Category: Sawai S]]
-	[[Category: Whitney~~, J C]]~~	+	[[Category: Whitney JC]]
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: T6ss effector-immunity pair~~]]	+

OCA at 07:30, 24 April 2019

OCA — Wed, 24 Apr 2019 07:30:58 GMT

←Older revision		Revision as of 07:30, 24 April 2019
Line 1:		Line 1:

	==Structure of Tse6 in complex with Tsi6==		==Structure of Tse6 in complex with Tsi6==
-	<StructureSection load='4zv0' size='340' side='right' caption='[[4zv0]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='4zv0' size='340' side='right'caption='[[4zv0]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zv0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZV0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZV0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zuy\|4zuy]], [[4zv4\|4zv4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zuy\|4zuy]], [[4zv4\|4zv4]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA0093 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE]), PA0092 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zv0 OCA], [http://pdbe.org/4zv0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zv0 RCSB], [http://www.ebi.ac.uk/pdbsum/4zv0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zv0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zv0 OCA], [http://pdbe.org/4zv0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zv0 RCSB], [http://www.ebi.ac.uk/pdbsum/4zv0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zv0 ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Pseae]]
	[[Category: Mougous, J D]]		[[Category: Mougous, J D]]
	[[Category: Ralston, C]]		[[Category: Ralston, C]]

OCA at 04:40, 21 September 2017

OCA — Thu, 21 Sep 2017 04:40:14 GMT

←Older revision		Revision as of 04:40, 21 September 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4zv0 is ~~ON HOLD until Paper~~ Publication	+	==Structure of Tse6 in complex with Tsi6==
		+	<StructureSection load='4zv0' size='340' side='right' caption='[[4zv0]], [[Resolution\|resolution]] 1.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4zv0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZV0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zuy\|4zuy]], [[4zv4\|4zv4]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zv0 OCA], [http://pdbe.org/4zv0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zv0 RCSB], [http://www.ebi.ac.uk/pdbsum/4zv0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zv0 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Type VI secretion (T6S) influences the composition of microbial communities by catalyzing the delivery of toxins between adjacent bacterial cells. Here, we demonstrate that a T6S integral membrane toxin from Pseudomonas aeruginosa, Tse6, acts on target cells by degrading the universally essential dinucleotides NAD(+) and NADP(+). Structural analyses of Tse6 show that it resembles mono-ADP-ribosyltransferase proteins, such as diphtheria toxin, with the exception of a unique loop that both excludes proteinaceous ADP-ribose acceptors and contributes to hydrolysis. We find that entry of Tse6 into target cells requires its binding to an essential housekeeping protein, translation elongation factor Tu (EF-Tu). These proteins participate in a larger assembly that additionally directs toxin export and provides chaperone activity. Visualization of this complex by electron microscopy defines the architecture of a toxin-loaded T6S apparatus and provides mechanistic insight into intercellular membrane protein delivery between bacteria.

-	~~Authors:~~ Whitney, ~~J.C.~~, Sawai, S., ~~Ralston~~, C., ~~Mougous~~, J.D.	+	An interbacterial NAD(P)(+) glycohydrolase toxin requires elongation factor Tu for delivery to target cells.,Whitney JC, Quentin D, Sawai S, LeRoux M, Harding BN, Ledvina HE, Tran BQ, Robinson H, Goo YA, Goodlett DR, Raunser S, Mougous JD Cell. 2015 Oct 22;163(3):607-19. doi: 10.1016/j.cell.2015.09.027. Epub 2015 Oct, 8. PMID:26456113<ref>PMID:26456113</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 4zv0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Mougous, J D]]
	[[Category: Ralston, C]]		[[Category: Ralston, C]]
-	[[Category: Mougous, J.D]]
	[[Category: Sawai, S]]		[[Category: Sawai, S]]
-	[[Category: Whitney, J.C]]	+	[[Category: Whitney, J C]]
		+	[[Category: Protein binding]]
		+	[[Category: T6ss effector-immunity pair]]

OCA at 12:20, 10 June 2015

OCA — Wed, 10 Jun 2015 12:20:42 GMT

←Older revision		Revision as of 12:20, 10 June 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zv0 is ON HOLD	+	The entry 4zv0 is ON HOLD until Paper Publication

	Authors: Whitney, J.C., Sawai, S., Ralston, C., Mougous, J.D.		Authors: Whitney, J.C., Sawai, S., Ralston, C., Mougous, J.D.

OCA: Protected "4zv0" [edit=sysop:move=sysop]

OCA — Wed, 27 May 2015 14:45:09 GMT

Protected "4zv0" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:45, 27 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zv0 is ON HOLD Authors: Whitney, J.C., Sawai, S., Ralston, C., Mougous, J.D. Description: Category: Unreleased Structures [[Category: Ralston...

OCA — Wed, 27 May 2015 14:45:08 GMT

New page: '''Unreleased structure''' The entry 4zv0 is ON HOLD Authors: Whitney, J.C., Sawai, S., Ralston, C., Mougous, J.D. Description: Category: Unreleased Structures [[Category: Ralston...

New page

'''Unreleased structure'''

The entry 4zv0 is ON HOLD

Authors: Whitney, J.C., Sawai, S., Ralston, C., Mougous, J.D.

Description:
[[Category: Unreleased Structures]]
[[Category: Ralston, C]]
[[Category: Mougous, J.D]]
[[Category: Sawai, S]]
[[Category: Whitney, J.C]]