4zv8 - Revision history

OCA at 08:24, 27 September 2023

OCA — Wed, 27 Sep 2023 08:24:50 GMT

←Older revision		Revision as of 08:24, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZV8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZV8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TMH:(+)-ALPHA-PINENE'>TMH</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.24Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TMH:(+)-ALPHA-PINENE'>TMH</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zv8 OCA], [https://pdbe.org/4zv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zv8 RCSB], [https://www.ebi.ac.uk/pdbsum/4zv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zv8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zv8 OCA], [https://pdbe.org/4zv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zv8 RCSB], [https://www.ebi.ac.uk/pdbsum/4zv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zv8 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:43, 18 May 2023

OCA — Thu, 18 May 2023 07:43:00 GMT

←Older revision		Revision as of 07:43, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='4zv8' size='340' side='right'caption='[[4zv8]], [[Resolution\|resolution]] 2.24Å' scene=''>		<StructureSection load='4zv8' size='340' side='right'caption='[[4zv8]], [[Resolution\|resolution]] 2.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zv8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZV8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZV8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZV8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TMH:(+)-ALPHA-PINENE'>TMH</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TMH:(+)-ALPHA-PINENE'>TMH</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i91\|4i91]], [[4rrt\|4rrt]], [[4rql\|4rql]], [[3ibd\|3ibd]], [[3qoa\|3qoa]], [[3qu8\|3qu8]], [[3ua5\|3ua5]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zv8 OCA], [https://pdbe.org/4zv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zv8 RCSB], [https://www.ebi.ac.uk/pdbsum/4zv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zv8 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP2B6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zv8 OCA], [~~http~~://pdbe.org/4zv8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zv8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zv8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zv8 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CP2B6_HUMAN CP2B6_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.<ref>PMID:11695850</ref>	+	[https://www.uniprot.org/uniprot/CP2B6_HUMAN CP2B6_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.<ref>PMID:11695850</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Halpert~~, J R~~]]	+	[[Category: Halpert JR]]
-	[[Category: Liu, J]]	+	[[Category: Liu J]]
-	[[Category: Shah~~, M B~~]]	+	[[Category: Shah MB]]
-	[[Category: Stout~~, C D]]~~	+	[[Category: Stout CD]]
-	~~[[Category: Cytochrome p450 2b6]]~~	+
-	~~[[Category: Monoxygenase]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 11:02, 25 December 2019

OCA — Wed, 25 Dec 2019 11:02:58 GMT

←Older revision		Revision as of 11:02, 25 December 2019
Line 1:		Line 1:

	==Structure of CYP2B6 (Y226H/K262R) with additional mutation Y244W in complex with alpha-Pinene==		==Structure of CYP2B6 (Y226H/K262R) with additional mutation Y244W in complex with alpha-Pinene==
-	<StructureSection load='4zv8' size='340' side='right' caption='[[4zv8]], [[Resolution\|resolution]] 2.24Å' scene=''>	+	<StructureSection load='4zv8' size='340' side='right'caption='[[4zv8]], [[Resolution\|resolution]] 2.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zv8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZV8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zv8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZV8 FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4zv8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4zv8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Halpert, J R]]		[[Category: Halpert, J R]]
	[[Category: Liu, J]]		[[Category: Liu, J]]

OCA at 09:46, 22 November 2017

OCA — Wed, 22 Nov 2017 09:46:41 GMT

←Older revision		Revision as of 09:46, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4zv8' size='340' side='right' caption='[[4zv8]], [[Resolution\|resolution]] 2.24Å' scene=''>		<StructureSection load='4zv8' size='340' side='right' caption='[[4zv8]], [[Resolution\|resolution]] 2.24Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zv8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZV8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zv8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZV8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TMH:(+)-ALPHA-PINENE'>TMH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TMH:(+)-ALPHA-PINENE'>TMH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i91\|4i91]], [[4rrt\|4rrt]], [[4rql\|4rql]], [[3ibd\|3ibd]], [[3qoa\|3qoa]], [[3qu8\|3qu8]], [[3ua5\|3ua5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i91\|4i91]], [[4rrt\|4rrt]], [[4rql\|4rql]], [[3ibd\|3ibd]], [[3qoa\|3qoa]], [[3qu8\|3qu8]], [[3ua5\|3ua5]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP2B6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zv8 OCA], [http://pdbe.org/4zv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4zv8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zv8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zv8 OCA], [http://pdbe.org/4zv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4zv8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zv8 ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4zv8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4zv8" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cytochrome P450\|Cytochrome P450]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Halpert, J R]]		[[Category: Halpert, J R]]
	[[Category: Liu, J]]		[[Category: Liu, J]]

OCA at 03:44, 6 September 2017

OCA — Wed, 06 Sep 2017 03:44:35 GMT

←Older revision		Revision as of 03:44, 6 September 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4zv8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4zv8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cytochrome P450\|Cytochrome P450]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:54, 14 July 2016

OCA — Thu, 14 Jul 2016 11:54:44 GMT

←Older revision		Revision as of 11:54, 14 July 2016
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CP2B6_HUMAN CP2B6_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.<ref>PMID:11695850</ref>		[[http://www.uniprot.org/uniprot/CP2B6_HUMAN CP2B6_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.<ref>PMID:11695850</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Using a combined structural and biochemical approach, the functional importance of a recently described peripheral pocket bounded by the E-, F-, G-, and I-helices in CYP2B4 and 2B6 was probed. Three series of 4-substituted-7-alkoxycoumarin derivatives with -H, -CH3, or -CF3 at the 4 position of the coumarin core were used initially to monitor functional differences between CYP2B4 and 2B6. 7-Ethoxy-4-(trifluoromethyl)coumarin (7-EFC) displayed the highest catalytic efficiency among these substrates. Mutants were made to alter side-chain polarity (V/E194Q) or bulk (F/Y244W) to alter access to the peripheral pocket. Modest increases in catalytic efficiency of 7-EFC O-deethylation by the mutants were magnified considerably by chlorination or bromination of the substrate ethoxy chain. A structure of CYP2B6 Y244W in complex with (+)-alpha-pinene was solved at 2.2 A and showed no CYMAL-5 in the peripheral pocket. A ligand free structure of CYP2B4 F244W was solved at 3.0 A with CYMAL-5 in the peripheral pocket. In both instances, comparison of the respective wild-type and mutant CYP2B enzymes revealed that CYMAL-5 occupancy of the peripheral pocket had little effect on the topology of active site residue side-chains, despite the fact that the peripheral pocket and active site are located on opposite sides of the I-helix. Analysis of available CYP2B structures suggest that the effect of the amino acid substitutions within the peripheral pocket derive from altered interactions between the F and G helices.
		+
		+	Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations.,Liu J, Shah MB, Zhang Q, Stout CD, Halpert JR, Wilderman PR Biochemistry. 2016 Apr 5;55(13):1997-2007. doi: 10.1021/acs.biochem.5b01330. Epub, 2016 Mar 24. PMID:26982502<ref>PMID:26982502</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4zv8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:06, 13 July 2016

OCA — Wed, 13 Jul 2016 03:06:56 GMT

←Older revision		Revision as of 03:06, 13 July 2016
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TMH:(+)-ALPHA-PINENE'>TMH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TMH:(+)-ALPHA-PINENE'>TMH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i91\|4i91]], [[4rrt\|4rrt]], [[4rql\|4rql]], [[3ibd\|3ibd]], [[3qoa\|3qoa]], [[3qu8\|3qu8]], [[3ua5\|3ua5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i91\|4i91]], [[4rrt\|4rrt]], [[4rql\|4rql]], [[3ibd\|3ibd]], [[3qoa\|3qoa]], [[3qu8\|3qu8]], [[3ua5\|3ua5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zv8 OCA], [http://pdbe.org/4zv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4zv8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zv8 OCA], [http://pdbe.org/4zv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4zv8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zv8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 20:27, 11 May 2016

OCA — Wed, 11 May 2016 20:27:48 GMT

←Older revision		Revision as of 20:27, 11 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 4zv8 is ON HOLD until May 18 2017~~	+	==Structure of CYP2B6 (Y226H/K262R) with additional mutation Y244W in complex with alpha-Pinene==
-		+	<StructureSection load='4zv8' size='340' side='right' caption='[[4zv8]], [[Resolution\|resolution]] 2.24Å' scene=''>
-	~~Authors: Liu, J., Shah, M.B., Stout, C.D., Halpert, J.R.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4zv8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZV8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZV8 FirstGlance]. <br>
-	~~Description:~~ Structure of CYP2B6 (Y226H/K262R) with additional mutation Y244W in complex with alpha-Pinene	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TMH:(+)-ALPHA-PINENE'>TMH</scene></td></tr>
-	[[~~Category: Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4i91\|4i91]], [[4rrt\|4rrt]], [[4rql\|4rql]], [[3ibd\|3ibd]], [[3qoa\|3qoa]], [[3qu8\|3qu8]], [[3ua5\|3ua5]]</td></tr>
-	[[~~Category~~: ~~Stout, C~~.D]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zv8 OCA], [http://pdbe.org/4zv8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4zv8 PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Shah~~, M.B]]	+	</table>
-	[[Category: Halpert, J.R]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CP2B6_HUMAN CP2B6_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.<ref>PMID:11695850</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Halpert, J R]]
	[[Category: Liu, J]]		[[Category: Liu, J]]
		+	[[Category: Shah, M B]]
		+	[[Category: Stout, C D]]
		+	[[Category: Cytochrome p450 2b6]]
		+	[[Category: Monoxygenase]]
		+	[[Category: Oxidoreductase]]

OCA at 00:12, 1 December 2015

OCA — Tue, 01 Dec 2015 00:12:41 GMT

←Older revision		Revision as of 00:12, 1 December 2015
Line 7:		Line 7:
	Description: Structure of CYP2B6 (Y226H/K262R) with additional mutation Y244W in complex with alpha-Pinene		Description: Structure of CYP2B6 (Y226H/K262R) with additional mutation Y244W in complex with alpha-Pinene
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Stout, C.D]]
	[[Category: Shah, M.B]]		[[Category: Shah, M.B]]
	[[Category: Halpert, J.R]]		[[Category: Halpert, J.R]]
	[[Category: Liu, J]]		[[Category: Liu, J]]
-	[[Category: Stout, C.D]]

OCA at 12:46, 8 July 2015

OCA — Wed, 08 Jul 2015 12:46:42 GMT

←Older revision		Revision as of 12:46, 8 July 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zv8 is ON HOLD	+	The entry 4zv8 is ON HOLD until May 18 2017

	Authors: Liu, J., Shah, M.B., Stout, C.D., Halpert, J.R.		Authors: Liu, J., Shah, M.B., Stout, C.D., Halpert, J.R.