4zvy - Revision history

OCA at 08:25, 27 September 2023

OCA — Wed, 27 Sep 2023 08:25:11 GMT

←Older revision		Revision as of 08:25, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zvy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZVY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZVY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zvy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZVY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZVY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zvy OCA], [https://pdbe.org/4zvy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zvy RCSB], [https://www.ebi.ac.uk/pdbsum/4zvy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zvy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zvy OCA], [https://pdbe.org/4zvy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zvy RCSB], [https://www.ebi.ac.uk/pdbsum/4zvy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zvy ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:43, 18 May 2023

OCA — Thu, 18 May 2023 07:43:46 GMT

←Older revision		Revision as of 07:43, 18 May 2023
Line 1:		Line 1:

	==Structure of human ALDH7A1 complexed with NAD+ in space group P4212==		==Structure of human ALDH7A1 complexed with NAD+ in space group P4212==
-	<StructureSection load='4zvy' size='340' side='right' caption='[[4zvy]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='4zvy' size='340' side='right'caption='[[4zvy]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zvy]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZVY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZVY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zvy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZVY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZVY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zvw\|4zvw]], [[4zvx\|4zvx]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zvy OCA], [https://pdbe.org/4zvy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zvy RCSB], [https://www.ebi.ac.uk/pdbsum/4zvy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zvy ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ALDH7A1, ATQ1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zvy OCA], [~~http~~://pdbe.org/4zvy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zvy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zvy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zvy ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/AL7A1_HUMAN AL7A1_HUMAN]] Pyridoxine-dependent epilepsy. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/AL7A1_HUMAN AL7A1_HUMAN] Pyridoxine-dependent epilepsy. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/AL7A1_HUMAN AL7A1_HUMAN]] Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.<ref>PMID:16491085</ref> <ref>PMID:20207735</ref>	+	[https://www.uniprot.org/uniprot/AL7A1_HUMAN AL7A1_HUMAN] Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.<ref>PMID:16491085</ref> <ref>PMID:20207735</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4zvy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4zvy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aldehyde dehydrogenase 3D structures\|Aldehyde dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Tanner, J J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Aldehyde dehydrogenase]]~~	+	[[Category: Tanner JJ]]
-	~~[[Category: Lysine catabolism]]~~	+
-	~~[[Category: Nad]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 18:01, 16 November 2017

OCA — Thu, 16 Nov 2017 18:01:21 GMT

←Older revision		Revision as of 18:01, 16 November 2017
Line 1:		Line 1:
		+
	==Structure of human ALDH7A1 complexed with NAD+ in space group P4212==		==Structure of human ALDH7A1 complexed with NAD+ in space group P4212==
	<StructureSection load='4zvy' size='340' side='right' caption='[[4zvy]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='4zvy' size='340' side='right' caption='[[4zvy]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zvy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZVY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZVY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zvy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZVY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZVY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zvw\|4zvw]], [[4zvx\|4zvx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zvw\|4zvw]], [[4zvx\|4zvx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zvy OCA], [http://pdbe.org/4zvy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zvy RCSB], [http://www.ebi.ac.uk/pdbsum/4zvy PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ALDH7A1, ATQ1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zvy OCA], [http://pdbe.org/4zvy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zvy RCSB], [http://www.ebi.ac.uk/pdbsum/4zvy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zvy ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 24:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Tanner, J J]]		[[Category: Tanner, J J]]
	[[Category: Aldehyde dehydrogenase]]		[[Category: Aldehyde dehydrogenase]]

OCA at 06:29, 30 September 2015

OCA — Wed, 30 Sep 2015 06:29:36 GMT

←Older revision		Revision as of 06:29, 30 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zvw\|4zvw]], [[4zvx\|4zvx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zvw\|4zvw]], [[4zvx\|4zvx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zvy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zvy RCSB], [http://www.ebi.ac.uk/pdbsum/4zvy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zvy OCA], [http://pdbe.org/4zvy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zvy RCSB], [http://www.ebi.ac.uk/pdbsum/4zvy PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4zvy" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:29, 26 August 2015

OCA — Wed, 26 Aug 2015 13:29:13 GMT

←Older revision		Revision as of 13:29, 26 August 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structure of human ALDH7A1 complexed with NAD+ in space group P4212==
		+	<StructureSection load='4zvy' size='340' side='right' caption='[[4zvy]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4zvy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZVY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZVY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zvw\|4zvw]], [[4zvx\|4zvx]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zvy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zvy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zvy RCSB], [http://www.ebi.ac.uk/pdbsum/4zvy PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/AL7A1_HUMAN AL7A1_HUMAN]] Pyridoxine-dependent epilepsy. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AL7A1_HUMAN AL7A1_HUMAN]] Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.<ref>PMID:16491085</ref> <ref>PMID:20207735</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aldehyde dehydrogenase 7A1 (ALDH7A1) is part of lysine catabolism and catalyzes the NAD+-dependent oxidation of alpha-aminoadipate semialdehyde to alpha-aminoadipate. Herein, we describe a structural study of human ALDH7A1 focused on substrate recognition. Five crystal structures and small-angle X-ray scattering data are reported, including the first crystal structure of any ALDH7 family member complexed with alpha-aminoadipate. The product binds with the epsilon-carboxylate in the oxyanion hole, the aliphatic chain packed into an aromatic box, and the distal end of the product anchored by electrostatic interactions with five conserved residues. This binding mode resembles that of glutamate bound to the proline catabolic enzyme ALDH4A1. Analysis of ALDH7A1 and ALDH4A1 structures suggests key interactions that underlie substrate discrimination. Structures of apo ALDH7A1 reveal dramatic conformational differences from the product complex. Product binding is associated with a 16 A movement of the C-terminus into the active site, which stabilizes the active conformation of the aldehyde substrate anchor loop. The fact that the C-terminus is part of the active site was hitherto unknown. Interestingly, the C-terminus and aldehyde anchor loop are disordered in a new tetragonal crystal form of the apoenzyme, implying that these parts of the enzyme are highly flexible. Our results suggest that the active site of ALDH7A1 is disassembled when the aldehyde site is vacant, and the C-terminus is a mobile element that forms quaternary structural interactions that aid aldehyde binding. These results are relevant to the c.1512delG genetic deletion associated with pyridoxine-dependent epilepsy, which alters the C-terminus of ALDH7A1.

-	~~The entry 4zvy is ON HOLD until Paper Publication~~	+	Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1.,Luo M, Tanner JJ Biochemistry. 2015 Aug 19. PMID:26260980<ref>PMID:26260980</ref>

-	~~Authors~~: Tanner, J.J.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~:	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: ~~Tanner, J.J~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Tanner, J J]]
		+	[[Category: Aldehyde dehydrogenase]]
		+	[[Category: Lysine catabolism]]
		+	[[Category: Nad]]
		+	[[Category: Oxidoreductase]]

OCA at 12:22, 10 June 2015

OCA — Wed, 10 Jun 2015 12:22:17 GMT

←Older revision		Revision as of 12:22, 10 June 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zvy is ON HOLD	+	The entry 4zvy is ON HOLD until Paper Publication

	Authors: Tanner, J.J.		Authors: Tanner, J.J.

OCA: Protected "4zvy" [edit=sysop:move=sysop]

OCA — Wed, 27 May 2015 14:47:37 GMT

Protected "4zvy" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:47, 27 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zvy is ON HOLD Authors: Tanner, J.J. Description: Category: Unreleased Structures Category: Tanner, J.J

OCA — Wed, 27 May 2015 14:47:36 GMT

New page: '''Unreleased structure''' The entry 4zvy is ON HOLD Authors: Tanner, J.J. Description: Category: Unreleased Structures Category: Tanner, J.J

New page

'''Unreleased structure'''

The entry 4zvy is ON HOLD

Authors: Tanner, J.J.

Description:
[[Category: Unreleased Structures]]
[[Category: Tanner, J.J]]