4zwy - Revision history

OCA at 08:25, 27 September 2023

OCA — Wed, 27 Sep 2023 08:25:39 GMT

←Older revision		Revision as of 08:25, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zwy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZWY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zwy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZWY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4SN:(6S)-1,3,4,5-TETRA-O-ACETYL-2,6-ANHYDRO-6-{[5-(SULFAMOYLOXY)PENTYL]SULFAMOYL}-L-ALTRITOL'>4SN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4SN:(6S)-1,3,4,5-TETRA-O-ACETYL-2,6-ANHYDRO-6-{[5-(SULFAMOYLOXY)PENTYL]SULFAMOYL}-L-ALTRITOL'>4SN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zwy OCA], [https://pdbe.org/4zwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zwy RCSB], [https://www.ebi.ac.uk/pdbsum/4zwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zwy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zwy OCA], [https://pdbe.org/4zwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zwy RCSB], [https://www.ebi.ac.uk/pdbsum/4zwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zwy ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:44, 18 May 2023

OCA — Thu, 18 May 2023 07:44:57 GMT

←Older revision		Revision as of 07:44, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='4zwy' size='340' side='right'caption='[[4zwy]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4zwy' size='340' side='right'caption='[[4zwy]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zwy]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZWY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZWY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zwy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZWY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4SN:(6S)-1,3,4,5-TETRA-O-ACETYL-2,6-ANHYDRO-6-{[5-(SULFAMOYLOXY)PENTYL]SULFAMOYL}-L-ALTRITOL'>4SN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4SN:(6S)-1,3,4,5-TETRA-O-ACETYL-2,6-ANHYDRO-6-{[5-(SULFAMOYLOXY)PENTYL]SULFAMOYL}-L-ALTRITOL'>4SN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zwi\|4zwi]], [[4zwx\|4zwx]], [[4zwz\|4zwz]], [[4zx0\|4zx0]], [[4zx1\|4zx1]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zwy OCA], [https://pdbe.org/4zwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zwy RCSB], [https://www.ebi.ac.uk/pdbsum/4zwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zwy ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zwy OCA], [~~http~~://pdbe.org/4zwy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zwy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zwy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zwy ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[~~http~~://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 30:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carbonate dehydratase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Driscoll~~, J M~~]]	+	[[Category: Driscoll JM]]
-	[[Category: Lomelino~~, C L~~]]	+	[[Category: Lomelino CL]]
-	[[Category: Mahon~~, B P~~]]	+	[[Category: Mahon BP]]
-	[[Category: McKenna, R]]	+	[[Category: McKenna R]]
-	~~[[Category: Carbonic anhydrase ii]]~~	+
-	~~[[Category: Glucosyl sulfamate]]~~	+
-	~~[[Category: Inhibitor complex]]~~	+
-	~~[[Category: Lyase-lyase inhibitor complex~~]]	+

OCA at 08:51, 4 December 2019

OCA — Wed, 04 Dec 2019 08:51:21 GMT

←Older revision		Revision as of 08:51, 4 December 2019
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	<StructureSection load='4zwy' size='340' side='right'caption='[[4zwy]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4zwy' size='340' side='right'caption='[[4zwy]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zwy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZWY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zwy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZWY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4SN:(6S)-1,3,4,5-TETRA-O-ACETYL-2,6-ANHYDRO-6-{[5-(SULFAMOYLOXY)PENTYL]SULFAMOYL}-L-ALTRITOL'>4SN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4SN:(6S)-1,3,4,5-TETRA-O-ACETYL-2,6-ANHYDRO-6-{[5-(SULFAMOYLOXY)PENTYL]SULFAMOYL}-L-ALTRITOL'>4SN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zwi\|4zwi]], [[4zwx\|4zwx]], [[4zwz\|4zwz]], [[4zx0\|4zx0]], [[4zx1\|4zx1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zwi\|4zwi]], [[4zwx\|4zwx]], [[4zwz\|4zwz]], [[4zx0\|4zx0]], [[4zx1\|4zx1]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zwy OCA], [http://pdbe.org/4zwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zwy RCSB], [http://www.ebi.ac.uk/pdbsum/4zwy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zwy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zwy OCA], [http://pdbe.org/4zwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zwy RCSB], [http://www.ebi.ac.uk/pdbsum/4zwy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zwy ProSAT]</span></td></tr>
Line 30:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Driscoll, J M]]		[[Category: Driscoll, J M]]

OCA at 06:52, 10 July 2019

OCA — Wed, 10 Jul 2019 06:52:32 GMT

←Older revision		Revision as of 06:52, 10 July 2019
Line 1:		Line 1:

	==Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor==		==Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor==
-	<StructureSection load='4zwy' size='340' side='right' caption='[[4zwy]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='4zwy' size='340' side='right'caption='[[4zwy]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zwy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZWY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zwy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZWY FirstGlance]. <br>
Line 24:		Line 24:

	==See Also==		==See Also==
-	*[[Carbonic anhydrase\|Carbonic anhydrase]]	+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
		+	[[Category: Large Structures]]
	[[Category: Driscoll, J M]]		[[Category: Driscoll, J M]]
	[[Category: Lomelino, C L]]		[[Category: Lomelino, C L]]

OCA at 06:22, 6 October 2017

OCA — Fri, 06 Oct 2017 06:22:56 GMT

←Older revision		Revision as of 06:22, 6 October 2017
Line 1:		Line 1:
		+
	==Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor==		==Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor==
	<StructureSection load='4zwy' size='340' side='right' caption='[[4zwy]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='4zwy' size='340' side='right' caption='[[4zwy]], [[Resolution\|resolution]] 1.50Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zwi\|4zwi]], [[4zwx\|4zwx]], [[4zwz\|4zwz]], [[4zx0\|4zx0]], [[4zx1\|4zx1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zwi\|4zwi]], [[4zwx\|4zwx]], [[4zwz\|4zwz]], [[4zx0\|4zx0]], [[4zx1\|4zx1]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zwy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zwy RCSB], [http://www.ebi.ac.uk/pdbsum/4zwy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zwy OCA], [http://pdbe.org/4zwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zwy RCSB], [http://www.ebi.ac.uk/pdbsum/4zwy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zwy ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4zwy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carbonic anhydrase\|Carbonic anhydrase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:00, 5 August 2015

OCA — Wed, 05 Aug 2015 20:00:32 GMT

←Older revision		Revision as of 20:00, 5 August 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor==
		+	<StructureSection load='4zwy' size='340' side='right' caption='[[4zwy]], [[Resolution\|resolution]] 1.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4zwy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZWY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4SN:(6S)-1,3,4,5-TETRA-O-ACETYL-2,6-ANHYDRO-6-{[5-(SULFAMOYLOXY)PENTYL]SULFAMOYL}-L-ALTRITOL'>4SN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zwi\|4zwi]], [[4zwx\|4zwx]], [[4zwz\|4zwz]], [[4zx0\|4zx0]], [[4zx1\|4zx1]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zwy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zwy RCSB], [http://www.ebi.ac.uk/pdbsum/4zwy PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inhibition of human carbonic anhydrase IX (hCA IX) has shown to be therapeutically advantageous for treating many types of highly aggressive cancers. However, designing selective inhibitors for hCA IX has been difficult due to its high structural homology and sequence similarity with off-target hCAs. Recently the use of glucosyl sulfamate inhibitors has shown promise as selective inhibitors for hCA IX. In this study we present five X-ray crystal structures, determined to a resolution of 1.7 A or better, of both hCA II (a ubiquitous CA) and an engineered hCA IX-mimic in complex with selected glucosyl sulfamates and structurally rationalize mechanisms for hCA IX selectivity. Results from this study have allowed us, for the first time, to empirically "map" key interactions of the hCA IX active site in order to establish parameters needed to design novel hCA IX selective inhibitors.

-	~~The entry 4zwy is ON HOLD until Paper Publication~~	+	Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX using Structure-Activity Relationships of Glucosyl-Based Sulfamates.,Mahon BP, Lomelino CL, Ladwig J, Rankin GM, Driscoll JM, Salguero AL, Pinard MA, Vullo D, Supuran CT, Poulsen SA, McKenna R J Med Chem. 2015 Jul 23. PMID:26203869<ref>PMID:26203869</ref>

-	~~Authors: Mahon~~, B.P.~~, Lomelino, C.L., Driscoll, J.M., McKenna, R~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: Driscoll, J.M]]	+	__TOC__
-	[[Category: Lomelino, C.L]]	+	</StructureSection>
-	[[Category: ~~Mckenna~~, R]]	+	[[Category: Carbonate dehydratase]]
-	[[Category: ~~Mahon~~, ~~B.P~~]]	+	[[Category: Driscoll, J M]]
		+	[[Category: Lomelino, C L]]
		+	[[Category: Mahon, B P]]
		+	[[Category: McKenna, R]]
		+	[[Category: Carbonic anhydrase ii]]
		+	[[Category: Glucosyl sulfamate]]
		+	[[Category: Inhibitor complex]]
		+	[[Category: Lyase-lyase inhibitor complex]]

OCA at 11:17, 3 June 2015

OCA — Wed, 03 Jun 2015 11:17:07 GMT

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-	The entry 4zwy is ON HOLD	+	The entry 4zwy is ON HOLD until Paper Publication

	Authors: Mahon, B.P., Lomelino, C.L., Driscoll, J.M., McKenna, R.		Authors: Mahon, B.P., Lomelino, C.L., Driscoll, J.M., McKenna, R.

OCA: Protected "4zwy" [edit=sysop:move=sysop]

OCA — Wed, 27 May 2015 14:50:46 GMT

Protected "4zwy" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:50, 27 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zwy is ON HOLD Authors: Mahon, B.P., Lomelino, C.L., Driscoll, J.M., McKenna, R. Description: Human Carbonic Anhydrase II in complex with a glucos...

OCA — Wed, 27 May 2015 14:50:45 GMT

New page: '''Unreleased structure''' The entry 4zwy is ON HOLD Authors: Mahon, B.P., Lomelino, C.L., Driscoll, J.M., McKenna, R. Description: Human Carbonic Anhydrase II in complex with a glucos...

New page

'''Unreleased structure'''

The entry 4zwy is ON HOLD

Authors: Mahon, B.P., Lomelino, C.L., Driscoll, J.M., McKenna, R.

Description: Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor
[[Category: Unreleased Structures]]
[[Category: Driscoll, J.M]]
[[Category: Lomelino, C.L]]
[[Category: Mckenna, R]]
[[Category: Mahon, B.P]]