4zx0 - Revision history

OCA at 12:17, 6 March 2024

OCA — Wed, 06 Mar 2024 12:17:02 GMT

←Older revision		Revision as of 12:17, 6 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zx0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZX0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zx0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZX0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5L2:METHYL+(2S,4R)-1-[(2S,3R,4R,5S,6S)-6-(ACETYLOXYMETHYL)-3,4,5-TRIS(OXIDANYL)OXAN-2-YL]SULFONYL-4-SULFAMOYLOXY-PYRROLIDINE-2-CARBOXYLATE'>5L2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5L2:METHYL+(2S,4R)-1-[(2S,3R,4R,5S,6S)-6-(ACETYLOXYMETHYL)-3,4,5-TRIS(OXIDANYL)OXAN-2-YL]SULFONYL-4-SULFAMOYLOXY-PYRROLIDINE-2-CARBOXYLATE'>5L2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zx0 OCA], [https://pdbe.org/4zx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zx0 RCSB], [https://www.ebi.ac.uk/pdbsum/4zx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zx0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zx0 OCA], [https://pdbe.org/4zx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zx0 RCSB], [https://www.ebi.ac.uk/pdbsum/4zx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zx0 ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>		[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Inhibition of human carbonic anhydrase IX (hCA IX) has shown to be therapeutically advantageous for treating many types of highly aggressive cancers. However, designing selective inhibitors for hCA IX has been difficult due to its high structural homology and sequence similarity with off-target hCAs. Recently the use of glucosyl sulfamate inhibitors has shown promise as selective inhibitors for hCA IX. In this study we present five X-ray crystal structures, determined to a resolution of 1.7 A or better, of both hCA II (a ubiquitous CA) and an engineered hCA IX-mimic in complex with selected glucosyl sulfamates and structurally rationalize mechanisms for hCA IX selectivity. Results from this study have allowed us, for the first time, to empirically "map" key interactions of the hCA IX active site in order to establish parameters needed to design novel hCA IX selective inhibitors.
-
-	Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX using Structure-Activity Relationships of Glucosyl-Based Sulfamates.,Mahon BP, Lomelino CL, Ladwig J, Rankin GM, Driscoll JM, Salguero AL, Pinard MA, Vullo D, Supuran CT, Poulsen SA, McKenna R J Med Chem. 2015 Jul 23. PMID:26203869<ref>PMID:26203869</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4zx0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:45, 18 May 2023

OCA — Thu, 18 May 2023 07:45:03 GMT

←Older revision		Revision as of 07:45, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='4zx0' size='340' side='right'caption='[[4zx0]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='4zx0' size='340' side='right'caption='[[4zx0]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zx0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZX0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZX0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zx0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZX0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5L2:METHYL+(2S,4R)-1-[(2S,3R,4R,5S,6S)-6-(ACETYLOXYMETHYL)-3,4,5-TRIS(OXIDANYL)OXAN-2-YL]SULFONYL-4-SULFAMOYLOXY-PYRROLIDINE-2-CARBOXYLATE'>5L2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5L2:METHYL+(2S,4R)-1-[(2S,3R,4R,5S,6S)-6-(ACETYLOXYMETHYL)-3,4,5-TRIS(OXIDANYL)OXAN-2-YL]SULFONYL-4-SULFAMOYLOXY-PYRROLIDINE-2-CARBOXYLATE'>5L2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zwx\|4zwx]], [[4zwy\|4zwy]], [[4zwz\|4zwz]], [[4zx1\|4zx1]], [[4zwi\|4zwi]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zx0 OCA], [https://pdbe.org/4zx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zx0 RCSB], [https://www.ebi.ac.uk/pdbsum/4zx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zx0 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zx0 OCA], [~~http~~://pdbe.org/4zx0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zx0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zx0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zx0 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[~~http~~://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carbonate dehydratase~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lomelino~~, C L~~]]	+	[[Category: Lomelino CL]]
-	[[Category: Mahon~~, B P~~]]	+	[[Category: Mahon BP]]
-	[[Category: McKenna, R]]	+	[[Category: McKenna R]]
-	[[Category: Pinard~~, M A]]~~	+	[[Category: Pinard MA]]
-	~~[[Category: Carbonic anhydrase ii]]~~	+
-	~~[[Category: Glucosyl sulfamate]]~~	+
-	~~[[Category: Inhibitor complex]]~~	+
-	~~[[Category: Lyase-lyase inhibitor complex~~]]	+

OCA at 08:49, 26 June 2019

OCA — Wed, 26 Jun 2019 08:49:00 GMT

←Older revision		Revision as of 08:49, 26 June 2019
Line 1:		Line 1:

	==Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor==		==Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor==
-	<StructureSection load='4zx0' size='340' side='right' caption='[[4zx0]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='4zx0' size='340' side='right'caption='[[4zx0]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zx0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZX0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zx0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZX0 FirstGlance]. <br>
Line 24:		Line 24:

	==See Also==		==See Also==
-	*[[Carbonic anhydrase\|Carbonic anhydrase]]	+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
		+	[[Category: Large Structures]]
	[[Category: Lomelino, C L]]		[[Category: Lomelino, C L]]
	[[Category: Mahon, B P]]		[[Category: Mahon, B P]]

OCA at 17:06, 18 August 2017

OCA — Fri, 18 Aug 2017 17:06:11 GMT

←Older revision		Revision as of 17:06, 18 August 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4zx0 is ~~ON HOLD~~	+	==Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor==
		+	<StructureSection load='4zx0' size='340' side='right' caption='[[4zx0]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4zx0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZX0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5L2:METHYL+(2S,4R)-1-[(2S,3R,4R,5S,6S)-6-(ACETYLOXYMETHYL)-3,4,5-TRIS(OXIDANYL)OXAN-2-YL]SULFONYL-4-SULFAMOYLOXY-PYRROLIDINE-2-CARBOXYLATE'>5L2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zwx\|4zwx]], [[4zwy\|4zwy]], [[4zwz\|4zwz]], [[4zx1\|4zx1]], [[4zwi\|4zwi]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zx0 OCA], [http://pdbe.org/4zx0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zx0 RCSB], [http://www.ebi.ac.uk/pdbsum/4zx0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zx0 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inhibition of human carbonic anhydrase IX (hCA IX) has shown to be therapeutically advantageous for treating many types of highly aggressive cancers. However, designing selective inhibitors for hCA IX has been difficult due to its high structural homology and sequence similarity with off-target hCAs. Recently the use of glucosyl sulfamate inhibitors has shown promise as selective inhibitors for hCA IX. In this study we present five X-ray crystal structures, determined to a resolution of 1.7 A or better, of both hCA II (a ubiquitous CA) and an engineered hCA IX-mimic in complex with selected glucosyl sulfamates and structurally rationalize mechanisms for hCA IX selectivity. Results from this study have allowed us, for the first time, to empirically "map" key interactions of the hCA IX active site in order to establish parameters needed to design novel hCA IX selective inhibitors.

-	~~Authors: Mahon, B.P~~. , Lomelino, ~~C.L.~~ , Pinard, ~~M.A.~~ , ~~McKenna~~, R.	+	Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX using Structure-Activity Relationships of Glucosyl-Based Sulfamates.,Mahon BP, Lomelino CL, Ladwig J, Rankin GM, Driscoll JM, Salguero AL, Pinard MA, Vullo D, Supuran CT, Poulsen SA, McKenna R J Med Chem. 2015 Jul 23. PMID:26203869<ref>PMID:26203869</ref>

-	~~Description~~: ~~Human~~ Carbonic ~~Anhydrase II in complex with a glucosyl sulfamate inhibitor~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Mahon, B.P. ,~~ Lomelino, C.L. , Pinard, M.A~~. , Mckenna, R~~]]	+	<div class="pdbe-citations 4zx0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carbonic anhydrase\|Carbonic anhydrase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Carbonate dehydratase]]
		+	[[Category: Lomelino, C L]]
		+	[[Category: Mahon, B P]]
		+	[[Category: McKenna, R]]
		+	[[Category: Pinard, M A]]
		+	[[Category: Carbonic anhydrase ii]]
		+	[[Category: Glucosyl sulfamate]]
		+	[[Category: Inhibitor complex]]
		+	[[Category: Lyase-lyase inhibitor complex]]

OCA: Protected "4zx0" [edit=sysop:move=sysop]

OCA — Wed, 27 May 2015 14:50:56 GMT

Protected "4zx0" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:50, 27 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zx0 is ON HOLD Authors: Mahon, B.P. , Lomelino, C.L. , Pinard, M.A. , McKenna, R. Description: Human Carbonic Anhydrase II in complex with a gluco...

OCA — Wed, 27 May 2015 14:50:55 GMT

New page: '''Unreleased structure''' The entry 4zx0 is ON HOLD Authors: Mahon, B.P. , Lomelino, C.L. , Pinard, M.A. , McKenna, R. Description: Human Carbonic Anhydrase II in complex with a gluco...

New page

'''Unreleased structure'''

The entry 4zx0 is ON HOLD

Authors: Mahon, B.P. , Lomelino, C.L. , Pinard, M.A. , McKenna, R.

Description: Human Carbonic Anhydrase II in complex with a glucosyl sulfamate inhibitor
[[Category: Unreleased Structures]]
[[Category: Mahon, B.P. , Lomelino, C.L. , Pinard, M.A. , Mckenna, R]]