4zxx - Revision history

OCA at 08:25, 27 September 2023

OCA — Wed, 27 Sep 2023 08:25:58 GMT

←Older revision		Revision as of 08:25, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zxx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZXX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zxx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZXX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4T0:N-{3-[(2R)-1-{(2R)-2-[(1-AMINOISOQUINOLIN-6-YL)AMINO]-2-PHENYLACETYL}PYRROLIDIN-2-YL]-4-(PROPAN-2-YLSULFONYL)PHENYL}ACETAMIDE'>4T0</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4T0:N-{3-[(2R)-1-{(2R)-2-[(1-AMINOISOQUINOLIN-6-YL)AMINO]-2-PHENYLACETYL}PYRROLIDIN-2-YL]-4-(PROPAN-2-YLSULFONYL)PHENYL}ACETAMIDE'>4T0</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zxx OCA], [https://pdbe.org/4zxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zxx RCSB], [https://www.ebi.ac.uk/pdbsum/4zxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zxx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zxx OCA], [https://pdbe.org/4zxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zxx RCSB], [https://www.ebi.ac.uk/pdbsum/4zxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zxx ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:46, 18 May 2023

OCA — Thu, 18 May 2023 07:46:07 GMT

←Older revision		Revision as of 07:46, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='4zxx' size='340' side='right'caption='[[4zxx]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4zxx' size='340' side='right'caption='[[4zxx]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zxx]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZXX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZXX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zxx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZXX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4T0:N-{3-[(2R)-1-{(2R)-2-[(1-AMINOISOQUINOLIN-6-YL)AMINO]-2-PHENYLACETYL}PYRROLIDIN-2-YL]-4-(PROPAN-2-YLSULFONYL)PHENYL}ACETAMIDE'>4T0</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4T0:N-{3-[(2R)-1-{(2R)-2-[(1-AMINOISOQUINOLIN-6-YL)AMINO]-2-PHENYLACETYL}PYRROLIDIN-2-YL]-4-(PROPAN-2-YLSULFONYL)PHENYL}ACETAMIDE'>4T0</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zxy\|4zxy]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zxx OCA], [https://pdbe.org/4zxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zxx RCSB], [https://www.ebi.ac.uk/pdbsum/4zxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zxx ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">F7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zxx OCA], [~~http~~://pdbe.org/4zxx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zxx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zxx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zxx ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:[~~http~~://omim.org/entry/227500 227500]]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.<ref>PMID:8043443</ref> <ref>PMID:2070047</ref> <ref>PMID:1634227</ref> <ref>PMID:8364544</ref> <ref>PMID:8204879</ref> <ref>PMID:7981691</ref> <ref>PMID:7974346</ref> <ref>PMID:8652821</ref> <ref>PMID:8844208</ref> <ref>PMID:8940045</ref> <ref>PMID:8883260</ref> <ref>PMID:9414278</ref> <ref>PMID:9576180</ref> <ref>PMID:9452082</ref> <ref>PMID:11091194</ref> <ref>PMID:11129332</ref> <ref>PMID:10862079</ref> <ref>PMID:12472587</ref> <ref>PMID:14717781</ref> <ref>PMID:19751712</ref> <ref>PMID:18976247</ref> <ref>PMID:19432927</ref> <ref>PMID:21206266</ref> <ref>PMID:21372693</ref>	+	[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN] Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:[https://omim.org/entry/227500 227500]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.<ref>PMID:8043443</ref> <ref>PMID:2070047</ref> <ref>PMID:1634227</ref> <ref>PMID:8364544</ref> <ref>PMID:8204879</ref> <ref>PMID:7981691</ref> <ref>PMID:7974346</ref> <ref>PMID:8652821</ref> <ref>PMID:8844208</ref> <ref>PMID:8940045</ref> <ref>PMID:8883260</ref> <ref>PMID:9414278</ref> <ref>PMID:9576180</ref> <ref>PMID:9452082</ref> <ref>PMID:11091194</ref> <ref>PMID:11129332</ref> <ref>PMID:10862079</ref> <ref>PMID:12472587</ref> <ref>PMID:14717781</ref> <ref>PMID:19751712</ref> <ref>PMID:18976247</ref> <ref>PMID:19432927</ref> <ref>PMID:21206266</ref> <ref>PMID:21372693</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.	+	[https://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN] Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 30:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Coagulation factor VIIa]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Wei, A]]	+	[[Category: Wei A]]
-	~~[[Category: Blood coagulation factor]]~~	+
-	~~[[Category: Calcium-binding]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Plasma]]~~	+
-	~~[[Category: Protein inhibitor complex]]~~	+
-	~~[[Category: Serine protease~~]]	+

OCA at 08:49, 26 June 2019

OCA — Wed, 26 Jun 2019 08:49:50 GMT

←Older revision		Revision as of 08:49, 26 June 2019
Line 1:		Line 1:
		+
	==FACTOR VIIA IN COMPLEX WITH THE INHIBITOR N-{3-[(2R)-1-{(2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-4-(propan-2-ylsulfonyl)phenyl}acetamide==		==FACTOR VIIA IN COMPLEX WITH THE INHIBITOR N-{3-[(2R)-1-{(2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-4-(propan-2-ylsulfonyl)phenyl}acetamide==
-	<StructureSection load='4zxx' size='340' side='right' caption='[[4zxx]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='4zxx' size='340' side='right'caption='[[4zxx]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zxx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZXX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zxx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZXX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4T0:N-{3-[(2R)-1-{(2R)-2-[(1-AMINOISOQUINOLIN-6-YL)AMINO]-2-PHENYLACETYL}PYRROLIDIN-2-YL]-4-(PROPAN-2-YLSULFONYL)PHENYL}ACETAMIDE'>4T0</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4T0:N-{3-[(2R)-1-{(2R)-2-[(1-AMINOISOQUINOLIN-6-YL)AMINO]-2-PHENYLACETYL}PYRROLIDIN-2-YL]-4-(PROPAN-2-YLSULFONYL)PHENYL}ACETAMIDE'>4T0</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zxy\|4zxy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zxy\|4zxy]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">F7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zxx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zxx RCSB], [http://www.ebi.ac.uk/pdbsum/4zxx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zxx OCA], [http://pdbe.org/4zxx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zxx RCSB], [http://www.ebi.ac.uk/pdbsum/4zxx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zxx ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 22:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4zxx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Factor VIIa 3D structures\|Factor VIIa 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Coagulation factor VIIa]]		[[Category: Coagulation factor VIIa]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Wei, A]]		[[Category: Wei, A]]
	[[Category: Blood coagulation factor]]		[[Category: Blood coagulation factor]]

OCA at 07:38, 26 August 2015

OCA — Wed, 26 Aug 2015 07:38:02 GMT

←Older revision		Revision as of 07:38, 26 August 2015
Line 30:		Line 30:
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Plasma]]		[[Category: Plasma]]
	[[Category: Protein inhibitor complex]]		[[Category: Protein inhibitor complex]]
	[[Category: Serine protease]]		[[Category: Serine protease]]

OCA at 14:08, 22 July 2015

OCA — Wed, 22 Jul 2015 14:08:53 GMT

←Older revision		Revision as of 14:08, 22 July 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==FACTOR VIIA IN COMPLEX WITH THE INHIBITOR N-{3-[(2R)-1-{(2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-4-(propan-2-ylsulfonyl)phenyl}acetamide==
		+	<StructureSection load='4zxx' size='340' side='right' caption='[[4zxx]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4zxx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZXX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4T0:N-{3-[(2R)-1-{(2R)-2-[(1-AMINOISOQUINOLIN-6-YL)AMINO]-2-PHENYLACETYL}PYRROLIDIN-2-YL]-4-(PROPAN-2-YLSULFONYL)PHENYL}ACETAMIDE'>4T0</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4zxy\|4zxy]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_VIIa Coagulation factor VIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.21 3.4.21.21] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zxx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zxx RCSB], [http://www.ebi.ac.uk/pdbsum/4zxx PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Defects in F7 are the cause of factor VII deficiency (FA7D) [MIM:[http://omim.org/entry/227500 227500]]. A hemorrhagic disease with variable presentation. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or repeated hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Finally, numerous subjects are completely asymptomatic despite very low factor VII levels.<ref>PMID:8043443</ref> <ref>PMID:2070047</ref> <ref>PMID:1634227</ref> <ref>PMID:8364544</ref> <ref>PMID:8204879</ref> <ref>PMID:7981691</ref> <ref>PMID:7974346</ref> <ref>PMID:8652821</ref> <ref>PMID:8844208</ref> <ref>PMID:8940045</ref> <ref>PMID:8883260</ref> <ref>PMID:9414278</ref> <ref>PMID:9576180</ref> <ref>PMID:9452082</ref> <ref>PMID:11091194</ref> <ref>PMID:11129332</ref> <ref>PMID:10862079</ref> <ref>PMID:12472587</ref> <ref>PMID:14717781</ref> <ref>PMID:19751712</ref> <ref>PMID:18976247</ref> <ref>PMID:19432927</ref> <ref>PMID:21206266</ref> <ref>PMID:21372693</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FA7_HUMAN FA7_HUMAN]] Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Based on a crystal structure of a phenylpyrrolidine lead and subsequent molecular modeling results, we designed and synthesized a novel series of macrocyclic FVIIa inhibitors. The optimal 16-membered macrocycle was 60-fold more potent than an acyclic analog. Further potency optimization by incorporation of P1 alkyl sulfone and P2 methyl groups provided a macrocycle with TF/FVIIa Ki = 1.6 nM, excellent selectivity against a panel of seven serine proteases, and FVII-deficient prothrombin time EC2x = 1.2 uM. Discovery of this potent, selective macrocyclic scaffold opens new possibilities for the development of orally bioavailable FVIIa inhibitors.

-	~~The entry 4zxx is ON HOLD~~	+	Structure-Based Design of Macrocyclic Coagulation Factor VIIa Inhibitors.,Priestley ES, Cheney DL, DeLucca I, Wei A, Luettgen JM, Rendina AR, Wong PC, Wexler R J Med Chem. 2015 Jul 7. PMID:26151189<ref>PMID:26151189</ref>

-	~~Authors: Wei~~, A.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: FACTOR VIIA IN COMPLEX WITH THE INHIBITOR N-{3-[(2R)-1-{(2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-4-(propan-2-ylsulfonyl)phenyl}acetamide~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Coagulation factor VIIa]]
	[[Category: Wei, A]]		[[Category: Wei, A]]
		+	[[Category: Blood coagulation factor]]
		+	[[Category: Calcium-binding]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Hydrolase]]
		+	[[Category: Plasma]]
		+	[[Category: Protein inhibitor complex]]
		+	[[Category: Serine protease]]

OCA at 12:50, 8 July 2015

OCA — Wed, 08 Jul 2015 12:50:54 GMT

←Older revision		Revision as of 12:50, 8 July 2015
Line 5:		Line 5:
	Authors: Wei, A.		Authors: Wei, A.

-	Description: FACTOR VIIA IN COMPLEX WITH THE INHIBITOR N-{3-[(2R)-1-[(2R)-2-[(1-~~AMINOISOQUINOLIN~~-6-YL)~~AMINO~~]-2-~~PHENYLACETYL] PYRROLIDIN~~-2-YL]-4-(~~PROPANE~~-2-~~SULFONYL~~)~~PHENYL~~}~~ACETAMIDE~~	+	Description: FACTOR VIIA IN COMPLEX WITH THE INHIBITOR N-{3-[(2R)-1-{(2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-phenylacetyl}pyrrolidin-2-yl]-4-(propan-2-ylsulfonyl)phenyl}acetamide
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Wei, A]]		[[Category: Wei, A]]

OCA: Protected "4zxx" [edit=sysop:move=sysop]

OCA — Wed, 27 May 2015 14:53:32 GMT

Protected "4zxx" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:53, 27 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zxx is ON HOLD Authors: Wei, A. Description: FACTOR VIIA IN COMPLEX WITH THE INHIBITOR N-{3-[(2R)-1-[(2R)-2-[(1-AMINOISOQUINOLIN-6-YL)AMINO]-2-PHE...

OCA — Wed, 27 May 2015 14:53:31 GMT

New page: '''Unreleased structure''' The entry 4zxx is ON HOLD Authors: Wei, A. Description: FACTOR VIIA IN COMPLEX WITH THE INHIBITOR N-{3-[(2R)-1-[(2R)-2-[(1-AMINOISOQUINOLIN-6-YL)AMINO]-2-PHE...

New page

'''Unreleased structure'''

The entry 4zxx is ON HOLD

Authors: Wei, A.

Description: FACTOR VIIA IN COMPLEX WITH THE INHIBITOR N-{3-[(2R)-1-[(2R)-2-[(1-AMINOISOQUINOLIN-6-YL)AMINO]-2-PHENYLACETYL] PYRROLIDIN-2-YL]-4-(PROPANE-2-SULFONYL)PHENYL}ACETAMIDE
[[Category: Unreleased Structures]]
[[Category: Wei, A]]