4zy3 - Revision history

OCA at 15:47, 8 November 2023

OCA — Wed, 08 Nov 2023 15:47:47 GMT

←Older revision		Revision as of 15:47, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zy3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZY3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zy3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZY3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=K67:N,N-[2-(2-OXOPROPYL)NAPHTHALENE-1,4-DIYL]BIS(4-ETHOXYBENZENESULFONAMIDE)'>K67</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=K67:N,N-[2-(2-OXOPROPYL)NAPHTHALENE-1,4-DIYL]BIS(4-ETHOXYBENZENESULFONAMIDE)'>K67</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zy3 OCA], [https://pdbe.org/4zy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zy3 RCSB], [https://www.ebi.ac.uk/pdbsum/4zy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zy3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zy3 OCA], [https://pdbe.org/4zy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zy3 RCSB], [https://www.ebi.ac.uk/pdbsum/4zy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zy3 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:46, 18 May 2023

OCA — Thu, 18 May 2023 07:46:17 GMT

←Older revision		Revision as of 07:46, 18 May 2023
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	<StructureSection load='4zy3' size='340' side='right'caption='[[4zy3]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4zy3' size='340' side='right'caption='[[4zy3]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zy3]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZY3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZY3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zy3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZY3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=K67:N,N-[2-(2-OXOPROPYL)NAPHTHALENE-1,4-DIYL]BIS(4-ETHOXYBENZENESULFONAMIDE)'>K67</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=K67:N,N-[2-(2-OXOPROPYL)NAPHTHALENE-1,4-DIYL]BIS(4-ETHOXYBENZENESULFONAMIDE)'>K67</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Keap1, Inrf2, Kiaa0132 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zy3 OCA], [https://pdbe.org/4zy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zy3 RCSB], [https://www.ebi.ac.uk/pdbsum/4zy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zy3 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zy3 OCA], [~~http~~://pdbe.org/4zy3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zy3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zy3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zy3 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE]] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref>	+	[https://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Fukutomi, T]]	+	[[Category: Fukutomi T]]
-	[[Category: Iso, T]]	+	[[Category: Iso T]]
-	[[Category: Komatsu, M]]	+	[[Category: Komatsu M]]
-	[[Category: Mizushima, T]]	+	[[Category: Mizushima T]]
-	[[Category: Suzuki, T]]	+	[[Category: Suzuki T]]
-	[[Category: Takagi, K]]	+	[[Category: Takagi K]]
-	[[Category: Yamamoto, M]]	+	[[Category: Yamamoto M]]
-	~~[[Category: Double glycine repeat]]~~	+
-	~~[[Category: Keap1]]~~	+
-	~~[[Category: Kelch domain]]~~	+
-	~~[[Category: Nrf2]]~~	+
-	~~[[Category: P62]]~~	+
-	~~[[Category: Small molecule binding]]~~	+
-	~~[[Category: Stress sensor]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 07:06, 19 February 2020

OCA — Wed, 19 Feb 2020 07:06:06 GMT

←Older revision		Revision as of 07:06, 19 February 2020
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Kelch-like protein\|Kelch-like protein]]	+	*[[Kelch-like protein 3D structures\|Kelch-like protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:37, 26 June 2019

OCA — Wed, 26 Jun 2019 08:37:28 GMT

←Older revision		Revision as of 08:37, 26 June 2019
Line 1:		Line 1:

	==Crystal Structure of Keap1 in Complex with a small chemical compound, K67==		==Crystal Structure of Keap1 in Complex with a small chemical compound, K67==
-	<StructureSection load='4zy3' size='340' side='right' caption='[[4zy3]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4zy3' size='340' side='right'caption='[[4zy3]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zy3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZY3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zy3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZY3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=K67:N,N-[2-(2-OXOPROPYL)NAPHTHALENE-1,4-DIYL]BIS(4-ETHOXYBENZENESULFONAMIDE)'>K67</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=K67:N,N-[2-(2-OXOPROPYL)NAPHTHALENE-1,4-DIYL]BIS(4-ETHOXYBENZENESULFONAMIDE)'>K67</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Keap1, Inrf2, Kiaa0132 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zy3 OCA], [http://pdbe.org/4zy3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zy3 RCSB], [http://www.ebi.ac.uk/pdbsum/4zy3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zy3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zy3 OCA], [http://pdbe.org/4zy3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zy3 RCSB], [http://www.ebi.ac.uk/pdbsum/4zy3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zy3 ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4zy3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4zy3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Kelch-like protein\|Kelch-like protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Fukutomi, T]]		[[Category: Fukutomi, T]]
	[[Category: Iso, T]]		[[Category: Iso, T]]

OCA at 11:54, 14 July 2016

OCA — Thu, 14 Jul 2016 11:54:45 GMT

←Older revision		Revision as of 11:54, 14 July 2016
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE]] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref>		[[http://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE]] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	p62/Sqstm1 is a multifunctional protein involved in cell survival, growth and death, that is degraded by autophagy. Amplification of the p62/Sqstm1 gene, and aberrant accumulation and phosphorylation of p62/Sqstm1, have been implicated in tumour development. Herein, we reveal the molecular mechanism of p62/Sqstm1-dependent malignant progression, and suggest that molecular targeting of p62/Sqstm1 represents a potential chemotherapeutic approach against hepatocellular carcinoma (HCC). Phosphorylation of p62/Sqstm1 at Ser349 directs glucose to the glucuronate pathway, and glutamine towards glutathione synthesis through activation of the transcription factor Nrf2. These changes provide HCC cells with tolerance to anti-cancer drugs and proliferation potency. Phosphorylated p62/Sqstm1 accumulates in tumour regions positive for hepatitis C virus (HCV). An inhibitor of phosphorylated p62-dependent Nrf2 activation suppresses the proliferation and anticancer agent tolerance of HCC. Our data indicate that this Nrf2 inhibitor could be used to make cancer cells less resistant to anticancer drugs, especially in HCV-positive HCC patients.
		+
		+	p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.,Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, Ohishi M, Endo K, Uemura T, Nishito Y, Okuda S, Obata M, Kouno T, Imamura R, Tada Y, Obata R, Yasuda D, Takahashi K, Fujimura T, Pi J, Lee MS, Ueno T, Ohe T, Mashino T, Wakai T, Kojima H, Okabe T, Nagano T, Motohashi H, Waguri S, Soga T, Yamamoto M, Tanaka K, Komatsu M Nat Commun. 2016 Jun 27;7:12030. doi: 10.1038/ncomms12030. PMID:27345495<ref>PMID:27345495</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4zy3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:11, 13 July 2016

OCA — Wed, 13 Jul 2016 03:11:06 GMT

←Older revision		Revision as of 03:11, 13 July 2016
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[4zy3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZY3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zy3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZY3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=K67:N,N-[2-(2-OXOPROPYL)NAPHTHALENE-1,4-DIYL]BIS(4-ETHOXYBENZENESULFONAMIDE)'>K67</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=K67:N,N-[2-(2-OXOPROPYL)NAPHTHALENE-1,4-DIYL]BIS(4-ETHOXYBENZENESULFONAMIDE)'>K67</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zy3 OCA], [http://pdbe.org/4zy3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zy3 RCSB], [http://www.ebi.ac.uk/pdbsum/4zy3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zy3 OCA], [http://pdbe.org/4zy3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zy3 RCSB], [http://www.ebi.ac.uk/pdbsum/4zy3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zy3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 22:52, 1 June 2016

OCA — Wed, 01 Jun 2016 22:52:32 GMT

←Older revision		Revision as of 22:52, 1 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 4zy3 ~~is ON HOLD until Paper Publication~~	+	==Crystal Structure of Keap1 in Complex with a small chemical compound, K67==
-		+	<StructureSection load='4zy3' size='340' side='right' caption='[[4zy3]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~: ~~Fukutomi, T~~.~~, Iso, T~~., ~~Suzuki~~, T., ~~Takagi~~, K., ~~Mizushima, T~~., ~~Komatsu, M~~., ~~Yamamoto, M~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4zy3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZY3 FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of Keap1~~ in ~~Complex with a small chemical compound~~, ~~K67~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=K67:N,N-[2-(2-OXOPROPYL)NAPHTHALENE-1,4-DIYL]BIS(4-ETHOXYBENZENESULFONAMIDE)'>K67</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zy3 OCA], [http://pdbe.org/4zy3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zy3 RCSB], [http://www.ebi.ac.uk/pdbsum/4zy3 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE]] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Fukutomi, T]]
	[[Category: Iso, T]]		[[Category: Iso, T]]
-	[[Category: Yamamoto, M]]
-	[[Category: Fukutomi, T]]
	[[Category: Komatsu, M]]		[[Category: Komatsu, M]]
	[[Category: Mizushima, T]]		[[Category: Mizushima, T]]
	[[Category: Suzuki, T]]		[[Category: Suzuki, T]]
	[[Category: Takagi, K]]		[[Category: Takagi, K]]
		+	[[Category: Yamamoto, M]]
		+	[[Category: Double glycine repeat]]
		+	[[Category: Keap1]]
		+	[[Category: Kelch domain]]
		+	[[Category: Nrf2]]
		+	[[Category: P62]]
		+	[[Category: Small molecule binding]]
		+	[[Category: Stress sensor]]
		+	[[Category: Transcription]]

OCA at 00:15, 1 December 2015

OCA — Tue, 01 Dec 2015 00:15:20 GMT

←Older revision		Revision as of 00:15, 1 December 2015
Line 9:		Line 9:
	[[Category: Iso, T]]		[[Category: Iso, T]]
	[[Category: Yamamoto, M]]		[[Category: Yamamoto, M]]
-	[[Category: Takagi, K]]
	[[Category: Fukutomi, T]]		[[Category: Fukutomi, T]]
	[[Category: Komatsu, M]]		[[Category: Komatsu, M]]
	[[Category: Mizushima, T]]		[[Category: Mizushima, T]]
	[[Category: Suzuki, T]]		[[Category: Suzuki, T]]
		+	[[Category: Takagi, K]]

OCA at 11:06, 24 June 2015

OCA — Wed, 24 Jun 2015 11:06:31 GMT

←Older revision		Revision as of 11:06, 24 June 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zy3 is ON HOLD	+	The entry 4zy3 is ON HOLD until Paper Publication

	Authors: Fukutomi, T., Iso, T., Suzuki, T., Takagi, K., Mizushima, T., Komatsu, M., Yamamoto, M.		Authors: Fukutomi, T., Iso, T., Suzuki, T., Takagi, K., Mizushima, T., Komatsu, M., Yamamoto, M.

OCA: Protected "4zy3" [edit=sysop:move=sysop]

OCA — Wed, 27 May 2015 14:53:53 GMT

Protected "4zy3" [edit=sysop:move=sysop]

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Revision as of 14:53, 27 May 2015