4zz0 - Revision history

OCA at 08:26, 27 September 2023

OCA — Wed, 27 Sep 2023 08:26:43 GMT

←Older revision		Revision as of 08:26, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4zz0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZZ0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4zz0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZZ0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3YE:(S)-2-(8-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)OCTANAMIDO)PENTANEDIOIC+ACID'>3YE</scene>, <scene name='pdbligand=GAR:GLYCINAMIDE+RIBONUCLEOTIDE'>GAR</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3YE:(S)-2-(8-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)OCTANAMIDO)PENTANEDIOIC+ACID'>3YE</scene>, <scene name='pdbligand=GAR:GLYCINAMIDE+RIBONUCLEOTIDE'>GAR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zz0 OCA], [https://pdbe.org/4zz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zz0 RCSB], [https://www.ebi.ac.uk/pdbsum/4zz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zz0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zz0 OCA], [https://pdbe.org/4zz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zz0 RCSB], [https://www.ebi.ac.uk/pdbsum/4zz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zz0 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:47, 18 May 2023

OCA — Thu, 18 May 2023 07:47:17 GMT

←Older revision		Revision as of 07:47, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='4zz0' size='340' side='right'caption='[[4zz0]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='4zz0' size='340' side='right'caption='[[4zz0]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zz0]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZZ0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ZZ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zz0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZZ0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3YE:(S)-2-(8-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)OCTANAMIDO)PENTANEDIOIC+ACID'>3YE</scene>, <scene name='pdbligand=GAR:GLYCINAMIDE+RIBONUCLEOTIDE'>GAR</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3YE:(S)-2-(8-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)OCTANAMIDO)PENTANEDIOIC+ACID'>3YE</scene>, <scene name='pdbligand=GAR:GLYCINAMIDE+RIBONUCLEOTIDE'>GAR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ew2\|4ew2]], [[4ew3\|4ew3]], [[1rbm\|1rbm]], [[1rbq\|1rbq]], [[1rby\|1rby]], [[1rbz\|1rbz]], [[1rc0\|1rc0]], [[1rc1\|1rc1]], [[1njs\|1njs]], [[1men\|1men]], [[1mej\|1mej]], [[1meo\|1meo]], [[1zlx\|1zlx]], [[1zly\|1zly]], [[4zyt\|4zyt]], [[4zyu\|4zyu]], [[4zyv\|4zyv]], [[4zyw\|4zyw]], [[4zyx\|4zyx]], [[4zyy\|4zyy]], [[4zyz\|4zyz]], [[4zz1\|4zz1]], [[4zz2\|4zz2]], [[4zz3\|4zz3]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zz0 OCA], [https://pdbe.org/4zz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zz0 RCSB], [https://www.ebi.ac.uk/pdbsum/4zz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zz0 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GART, PGFT, PRGS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylglycinamide_formyltransferase Phosphoribosylglycinamide formyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.2 2.1.2.2] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4zz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zz0 OCA], [~~http~~://pdbe.org/4zz0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4zz0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4zz0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4zz0 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PUR2_HUMAN PUR2_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Phosphoribosylglycinamide formyltransferase~~]]	+	[[Category: Dann III CE]]
-	[[Category: Deis~~, S M]]~~	+	[[Category: Deis SM]]
-	~~[[Category: III, C E.Dann]]~~	+
-	~~[[Category: Antifolate]]~~	+
-	~~[[Category: Gar transformylase]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 08:51, 4 December 2019

OCA — Wed, 04 Dec 2019 08:51:54 GMT

←Older revision		Revision as of 08:51, 4 December 2019
Line 1:		Line 1:

	==Human GAR transformylase in complex with GAR and (S)-2-(8-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)octanamido)pentanedioic acid (AGF147)==		==Human GAR transformylase in complex with GAR and (S)-2-(8-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)octanamido)pentanedioic acid (AGF147)==
-	<StructureSection load='4zz0' size='340' side='right' caption='[[4zz0]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='4zz0' size='340' side='right'caption='[[4zz0]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4zz0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZZ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4zz0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZZ0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3YE:(S)-2-(8-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)OCTANAMIDO)PENTANEDIOIC+ACID'>3YE</scene>, <scene name='pdbligand=GAR:GLYCINAMIDE+RIBONUCLEOTIDE'>GAR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3YE:(S)-2-(8-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)OCTANAMIDO)PENTANEDIOIC+ACID'>3YE</scene>, <scene name='pdbligand=GAR:GLYCINAMIDE+RIBONUCLEOTIDE'>GAR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ew2\|4ew2]], [[4ew3\|4ew3]], [[1rbm\|1rbm]], [[1rbq\|1rbq]], [[1rby\|1rby]], [[1rbz\|1rbz]], [[1rc0\|1rc0]], [[1rc1\|1rc1]], [[1njs\|1njs]], [[1men\|1men]], [[1mej\|1mej]], [[1meo\|1meo]], [[1zlx\|1zlx]], [[1zly\|1zly]], [[4zyt\|4zyt]], [[4zyu\|4zyu]], [[4zyv\|4zyv]], [[4zyw\|4zyw]], [[4zyx\|4zyx]], [[4zyy\|4zyy]], [[4zyz\|4zyz]], [[4zz1\|4zz1]], [[4zz2\|4zz2]], [[4zz3\|4zz3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ew2\|4ew2]], [[4ew3\|4ew3]], [[1rbm\|1rbm]], [[1rbq\|1rbq]], [[1rby\|1rby]], [[1rbz\|1rbz]], [[1rc0\|1rc0]], [[1rc1\|1rc1]], [[1njs\|1njs]], [[1men\|1men]], [[1mej\|1mej]], [[1meo\|1meo]], [[1zlx\|1zlx]], [[1zly\|1zly]], [[4zyt\|4zyt]], [[4zyu\|4zyu]], [[4zyv\|4zyv]], [[4zyw\|4zyw]], [[4zyx\|4zyx]], [[4zyy\|4zyy]], [[4zyz\|4zyz]], [[4zz1\|4zz1]], [[4zz2\|4zz2]], [[4zz3\|4zz3]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GART, PGFT, PRGS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylglycinamide_formyltransferase Phosphoribosylglycinamide formyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.2 2.1.2.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylglycinamide_formyltransferase Phosphoribosylglycinamide formyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.2 2.1.2.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zz0 OCA], [http://pdbe.org/4zz0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zz0 RCSB], [http://www.ebi.ac.uk/pdbsum/4zz0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zz0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zz0 OCA], [http://pdbe.org/4zz0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zz0 RCSB], [http://www.ebi.ac.uk/pdbsum/4zz0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zz0 ProSAT]</span></td></tr>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Phosphoribosylglycinamide formyltransferase]]		[[Category: Phosphoribosylglycinamide formyltransferase]]
	[[Category: Deis, S M]]		[[Category: Deis, S M]]

OCA at 07:03, 9 March 2017

OCA — Thu, 09 Mar 2017 07:03:32 GMT

←Older revision		Revision as of 07:03, 9 March 2017
Line 7:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ew2\|4ew2]], [[4ew3\|4ew3]], [[1rbm\|1rbm]], [[1rbq\|1rbq]], [[1rby\|1rby]], [[1rbz\|1rbz]], [[1rc0\|1rc0]], [[1rc1\|1rc1]], [[1njs\|1njs]], [[1men\|1men]], [[1mej\|1mej]], [[1meo\|1meo]], [[1zlx\|1zlx]], [[1zly\|1zly]], [[4zyt\|4zyt]], [[4zyu\|4zyu]], [[4zyv\|4zyv]], [[4zyw\|4zyw]], [[4zyx\|4zyx]], [[4zyy\|4zyy]], [[4zyz\|4zyz]], [[4zz1\|4zz1]], [[4zz2\|4zz2]], [[4zz3\|4zz3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ew2\|4ew2]], [[4ew3\|4ew3]], [[1rbm\|1rbm]], [[1rbq\|1rbq]], [[1rby\|1rby]], [[1rbz\|1rbz]], [[1rc0\|1rc0]], [[1rc1\|1rc1]], [[1njs\|1njs]], [[1men\|1men]], [[1mej\|1mej]], [[1meo\|1meo]], [[1zlx\|1zlx]], [[1zly\|1zly]], [[4zyt\|4zyt]], [[4zyu\|4zyu]], [[4zyv\|4zyv]], [[4zyw\|4zyw]], [[4zyx\|4zyx]], [[4zyy\|4zyy]], [[4zyz\|4zyz]], [[4zz1\|4zz1]], [[4zz2\|4zz2]], [[4zz3\|4zz3]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylglycinamide_formyltransferase Phosphoribosylglycinamide formyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.2 2.1.2.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylglycinamide_formyltransferase Phosphoribosylglycinamide formyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.2 2.1.2.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zz0 OCA], [http://pdbe.org/4zz0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zz0 RCSB], [http://www.ebi.ac.uk/pdbsum/4zz0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zz0 OCA], [http://pdbe.org/4zz0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zz0 RCSB], [http://www.ebi.ac.uk/pdbsum/4zz0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zz0 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pemetrexed and methotrexate are antifolates used for cancer chemotherapy and inflammatory diseases. These agents have toxic side effects resulting, in part, from nonspecific cellular transport by the reduced folate carrier (RFC), a ubiquitously expressed facilitative transporter. We previously described 2-amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidine antifolates with modifications of the side chain linker and aromatic ring that are poor substrates for RFC but are efficiently transported via folate receptors (FRs) and the proton-coupled folate transporter (PCFT). These targeted antifolates are cytotoxic in vitro toward FR- and PCFT-expressing tumor cells and in vivo with human tumor xenografts in immune-compromised mice, reflecting selective cellular uptake. Antitumor efficacy is due to inhibition of glycinamide ribonucleotide (GAR) formyltransferase (GARFTase) activity in de novo synthesis of purine nucleotides. This study used purified human GARFTase (formyltransferase domain) to assess in vitro inhibition by eight novel thieno- and pyrrolo[2,3-d]pyrimidine antifolates. Seven analogues (AGF23, AGF71, AGF94, AGF117, AGF118, AGF145, and AGF147) inhibited GARFTase with Ki values in the low- to mid-nanomolar concentration range, whereas AGF50 inhibited GARFTase with micromolar potency similar to that of PMX. On the basis of crystal structures of ternary complexes with GARFTase, beta-GAR, and the monoglutamyl antifolates, differences in inhibitory potencies correlated well with antifolate binding and the positions of the terminal carboxylates. Our data provide a mechanistic basis for differences in inhibitory potencies between these novel antifolates and a framework for future structure-based drug design. These analogues could be more efficacious than clinically used antifolates, reflecting their selective cellular uptake by FRs and PCFT and potent GARFTase inhibition.
		+
		+	Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.,Deis SM, Doshi A, Hou Z, Matherly LH, Gangjee A, Dann CE 3rd Biochemistry. 2016 Aug 16;55(32):4574-82. doi: 10.1021/acs.biochem.6b00412. Epub , 2016 Aug 3. PMID:27439469<ref>PMID:27439469</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4zz0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 18:40, 12 May 2016

OCA — Thu, 12 May 2016 18:40:47 GMT

←Older revision		Revision as of 18:40, 12 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 4zz0 is ON HOLD until Paper Publication~~	+	==Human GAR transformylase in complex with GAR and (S)-2-(8-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)octanamido)pentanedioic acid (AGF147)==
-		+	<StructureSection load='4zz0' size='340' side='right' caption='[[4zz0]], [[Resolution\|resolution]] 1.65Å' scene=''>
-	~~Authors: Deis, S.M., Dann III, C.E.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4zz0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZZ0 FirstGlance]. <br>
-	~~Description:~~ Human GAR transformylase in complex with GAR and (S)-2-(8-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)octanamido)pentanedioic acid (AGF147)	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3YE:(S)-2-(8-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)OCTANAMIDO)PENTANEDIOIC+ACID'>3YE</scene>, <scene name='pdbligand=GAR:GLYCINAMIDE+RIBONUCLEOTIDE'>GAR</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ew2\|4ew2]], [[4ew3\|4ew3]], [[1rbm\|1rbm]], [[1rbq\|1rbq]], [[1rby\|1rby]], [[1rbz\|1rbz]], [[1rc0\|1rc0]], [[1rc1\|1rc1]], [[1njs\|1njs]], [[1men\|1men]], [[1mej\|1mej]], [[1meo\|1meo]], [[1zlx\|1zlx]], [[1zly\|1zly]], [[4zyt\|4zyt]], [[4zyu\|4zyu]], [[4zyv\|4zyv]], [[4zyw\|4zyw]], [[4zyx\|4zyx]], [[4zyy\|4zyy]], [[4zyz\|4zyz]], [[4zz1\|4zz1]], [[4zz2\|4zz2]], [[4zz3\|4zz3]]</td></tr>
-	[[~~Category~~: ~~Dann Iii~~, C.E]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylglycinamide_formyltransferase Phosphoribosylglycinamide formyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.2 2.1.2.2] </span></td></tr>
-	[[Category: Deis, S.M]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zz0 OCA], [http://pdbe.org/4zz0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zz0 RCSB], [http://www.ebi.ac.uk/pdbsum/4zz0 PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Phosphoribosylglycinamide formyltransferase]]
		+	[[Category: Deis, S M]]
		+	[[Category: III, C E.Dann]]
		+	[[Category: Antifolate]]
		+	[[Category: Gar transformylase]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 13:21, 17 June 2015

OCA — Wed, 17 Jun 2015 13:21:52 GMT

←Older revision		Revision as of 13:21, 17 June 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4zz0 is ON HOLD	+	The entry 4zz0 is ON HOLD until Paper Publication

	Authors: Deis, S.M., Dann III, C.E.		Authors: Deis, S.M., Dann III, C.E.

OCA: Protected "4zz0" [edit=sysop:move=sysop]

OCA — Wed, 27 May 2015 14:55:56 GMT

Protected "4zz0" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:55, 27 May 2015

OCA: New page: '''Unreleased structure''' The entry 4zz0 is ON HOLD Authors: Deis, S.M., Dann III, C.E. Description: Human GAR transformylase in complex with GAR and (S)-2-(8-(2-Amino-4-oxo-4,7-dihyd...

OCA — Wed, 27 May 2015 14:55:55 GMT

New page: '''Unreleased structure''' The entry 4zz0 is ON HOLD Authors: Deis, S.M., Dann III, C.E. Description: Human GAR transformylase in complex with GAR and (S)-2-(8-(2-Amino-4-oxo-4,7-dihyd...

New page

'''Unreleased structure'''

The entry 4zz0 is ON HOLD

Authors: Deis, S.M., Dann III, C.E.

Description: Human GAR transformylase in complex with GAR and (S)-2-(8-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)octanamido)pentanedioic acid (AGF147)
[[Category: Unreleased Structures]]
[[Category: Dann Iii, C.E]]
[[Category: Deis, S.M]]