5a0l - Revision history

OCA at 11:34, 9 May 2024

OCA — Thu, 09 May 2024 11:34:48 GMT

←Older revision		Revision as of 11:34, 9 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5a0l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_MGAS2096 Streptococcus pyogenes MGAS2096]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A0L FirstGlance]. <br>		<table><tr><td colspan='2'>[[5a0l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_MGAS2096 Streptococcus pyogenes MGAS2096]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A0L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.35Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a0l OCA], [https://pdbe.org/5a0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a0l RCSB], [https://www.ebi.ac.uk/pdbsum/5a0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a0l ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a0l OCA], [https://pdbe.org/5a0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a0l RCSB], [https://www.ebi.ac.uk/pdbsum/5a0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a0l ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:50, 18 May 2023

OCA — Thu, 18 May 2023 07:50:49 GMT

←Older revision		Revision as of 07:50, 18 May 2023
Line 3:		Line 3:
	<StructureSection load='5a0l' size='340' side='right'caption='[[5a0l]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='5a0l' size='340' side='right'caption='[[5a0l]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5a0l]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Strpb Strpb~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A0L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5A0L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5a0l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_MGAS2096 Streptococcus pyogenes MGAS2096]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A0L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a0d\|5a0d]], [[5a0g\|5a0g]], [[5a0n\|5a0n]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a0l OCA], [https://pdbe.org/5a0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a0l RCSB], [https://www.ebi.ac.uk/pdbsum/5a0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a0l ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5a0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a0l OCA], [~~http~~://pdbe.org/5a0l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5a0l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5a0l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5a0l ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0M3KL43_STRPB A0A0M3KL43_STRPB]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Strpb~~]]	+	[[Category: Streptococcus pyogenes MGAS2096]]
-	[[Category: Banfield~~, M J~~]]	+	[[Category: Banfield MJ]]
-	[[Category: Dziewulska~~, A M~~]]	+	[[Category: Dziewulska AM]]
-	[[Category: Edwards~~, J M~~]]	+	[[Category: Edwards JM]]
-	[[Category: Kan, S Y]]	+	[[Category: Kan S-Y]]
-	[[Category: Schwarz-Linek, U]]	+	[[Category: Schwarz-Linek U]]
-	[[Category: Walden, M]]	+	[[Category: Walden M]]
-	~~[[Category: Adhesin]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Gram-positive]]~~	+
-	~~[[Category: Internal thioester]]~~	+
-	~~[[Category: Surface-associated protein]]~~	+
-	~~[[Category: Thioester domain~~]]	+

OCA at 08:48, 26 June 2019

OCA — Wed, 26 Jun 2019 08:48:03 GMT

←Older revision		Revision as of 08:48, 26 June 2019
Line 1:		Line 1:

	==N-terminal thioester domain of fibronectin-binding protein SfbI from Streptococcus pyogenes==		==N-terminal thioester domain of fibronectin-binding protein SfbI from Streptococcus pyogenes==
-	<StructureSection load='5a0l' size='340' side='right' caption='[[5a0l]], [[Resolution\|resolution]] 1.35Å' scene=''>	+	<StructureSection load='5a0l' size='340' side='right'caption='[[5a0l]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5a0l]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A0L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5a0l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpb Strpb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A0L FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a0d\|5a0d]], [[5a0g\|5a0g]], [[5a0n\|5a0n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a0d\|5a0d]], [[5a0g\|5a0g]], [[5a0n\|5a0n]]</td></tr>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Strpb]]
	[[Category: Banfield, M J]]		[[Category: Banfield, M J]]
	[[Category: Dziewulska, A M]]		[[Category: Dziewulska, A M]]

OCA at 02:05, 11 March 2017

OCA — Sat, 11 Mar 2017 02:05:30 GMT

←Older revision		Revision as of 02:05, 11 March 2017
Line 1:		Line 1:
		+
	==N-terminal thioester domain of fibronectin-binding protein SfbI from Streptococcus pyogenes==		==N-terminal thioester domain of fibronectin-binding protein SfbI from Streptococcus pyogenes==
	<StructureSection load='5a0l' size='340' side='right' caption='[[5a0l]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='5a0l' size='340' side='right' caption='[[5a0l]], [[Resolution\|resolution]] 1.35Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a0d\|5a0d]], [[5a0g\|5a0g]], [[5a0n\|5a0n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a0d\|5a0d]], [[5a0g\|5a0g]], [[5a0n\|5a0n]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a0l RCSB], [http://www.ebi.ac.uk/pdbsum/5a0l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a0l OCA], [http://pdbe.org/5a0l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a0l RCSB], [http://www.ebi.ac.uk/pdbsum/5a0l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a0l ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 5a0l" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:38, 10 June 2015

OCA — Wed, 10 Jun 2015 07:38:03 GMT

←Older revision		Revision as of 07:38, 10 June 2015
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a0l RCSB], [http://www.ebi.ac.uk/pdbsum/5a0l PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a0l RCSB], [http://www.ebi.ac.uk/pdbsum/5a0l PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To cause disease and persist in a host, pathogenic and commensal microbes must adhere to tissues. Colonization and infection depend on specific molecular interactions at the host-microbe interface that involve microbial surface proteins, or adhesins. To date, adhesins are only known to bind to host receptors non-covalently. Here we show that the streptococcal surface protein SfbI mediates covalent interaction with the host protein fibrinogen using an unusual internal thioester bond as a 'chemical harpoon'. This cross-linking reaction allows bacterial attachment to fibrin and SfbI binding to human cells in a model of inflammation. Thioester-containing domains are unexpectedly prevalent in Gram-positive bacteria, including many clinically relevant pathogens. Our findings support bacterial-encoded covalent binding as a new molecular principle in host-microbe interactions. This represents an as yet unexploited target to treat bacterial infection and may also offer novel opportunities for engineering beneficial interactions.
		+
		+	An internal thioester in a pathogen surface protein mediates covalent host binding.,Walden M, Edwards JM, Dziewulska AM, Bergmann R, Saalbach G, Kan SY, Miller OK, Weckener M, Jackson RJ, Shirran SL, Botting CH, Florence GJ, Rohde M, Banfield MJ, Schwarz-Linek U Elife. 2015 Jun 2;4. doi: 10.7554/eLife.06638. PMID:26032562<ref>PMID:26032562</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:50, 3 June 2015

OCA — Wed, 03 Jun 2015 12:50:27 GMT

←Older revision		Revision as of 12:50, 3 June 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==N-terminal thioester domain of fibronectin-binding protein SfbI from Streptococcus pyogenes==
-		+	<StructureSection load='5a0l' size='340' side='right' caption='[[5a0l]], [[Resolution\|resolution]] 1.35Å' scene=''>
-	~~The entry~~ 5a0l is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5a0l]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A0L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A0L FirstGlance]. <br>
-	~~Authors~~: ~~Walden, M~~.~~, Edwards, J~~.M.~~, Dziewulska, A~~.M., ~~Kan~~, S.-Y., ~~Schwarz~~-~~Linek~~, U., ~~Banfield, M~~.J.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5a0d\|5a0d]], [[5a0g\|5a0g]], [[5a0n\|5a0n]]</td></tr>
-	~~Description: N-terminal thioester domain of fibronectin-binding protein SfbI from Streptococcus pyogenes~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a0l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a0l RCSB], [http://www.ebi.ac.uk/pdbsum/5a0l PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Kan~~, ~~S.-Y~~]]	+	__TOC__
-	[[Category: Edwards, J.M]]	+	</StructureSection>
		+	[[Category: Banfield, M J]]
		+	[[Category: Dziewulska, A M]]
		+	[[Category: Edwards, J M]]
		+	[[Category: Kan, S Y]]
	[[Category: Schwarz-Linek, U]]		[[Category: Schwarz-Linek, U]]
	[[Category: Walden, M]]		[[Category: Walden, M]]
-	[[Category: ~~Banfield, M.J~~]]	+	[[Category: Adhesin]]
-	[[Category: ~~Dziewulska, A.M~~]]	+	[[Category: Cell adhesion]]
		+	[[Category: Gram-positive]]
		+	[[Category: Internal thioester]]
		+	[[Category: Surface-associated protein]]
		+	[[Category: Thioester domain]]

OCA at 14:58, 27 May 2015

OCA — Wed, 27 May 2015 14:58:56 GMT

←Older revision		Revision as of 14:58, 27 May 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5a0l is ON HOLD	+	The entry 5a0l is ON HOLD until Paper Publication

	Authors: Walden, M., Edwards, J.M., Dziewulska, A.M., Kan, S.-Y., Schwarz-Linek, U., Banfield, M.J.		Authors: Walden, M., Edwards, J.M., Dziewulska, A.M., Kan, S.-Y., Schwarz-Linek, U., Banfield, M.J.

OCA: Protected "5a0l" [edit=sysop:move=sysop]

OCA — Thu, 30 Apr 2015 10:26:54 GMT

Protected "5a0l" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:26, 30 April 2015

OCA: New page: '''Unreleased structure''' The entry 5a0l is ON HOLD Authors: Walden, M., Edwards, J.M., Dziewulska, A.M., Kan, S.-Y., Schwarz-Linek, U., Banfield, M.J. Description: N-terminal thioest...

OCA — Thu, 30 Apr 2015 10:26:52 GMT

New page: '''Unreleased structure''' The entry 5a0l is ON HOLD Authors: Walden, M., Edwards, J.M., Dziewulska, A.M., Kan, S.-Y., Schwarz-Linek, U., Banfield, M.J. Description: N-terminal thioest...

New page

'''Unreleased structure'''

The entry 5a0l is ON HOLD

Authors: Walden, M., Edwards, J.M., Dziewulska, A.M., Kan, S.-Y., Schwarz-Linek, U., Banfield, M.J.

Description: N-terminal thioester domain of fibronectin-binding protein SfbI from Streptococcus pyogenes
[[Category: Unreleased Structures]]
[[Category: Kan, S.-Y]]
[[Category: Edwards, J.M]]
[[Category: Schwarz-Linek, U]]
[[Category: Walden, M]]
[[Category: Banfield, M.J]]
[[Category: Dziewulska, A.M]]